Kim TJ et al. |
Epothilone D, a microtubule-stabilizing compound, inhibits neointimal hyperplasia after rat carotid artery injury by cell cycle arrest via regulation of G1-checkpoint proteins. |
2007 |
Vascul. Pharmacol. |
pmid:17706465
|
Burris HA |
Preclinical investigations with epothilones in breast cancer models. |
2008 |
Semin. Oncol. |
pmid:18410795
|
Vahdat LT |
Clinical studies with epothilones for the treatment of metastatic breast cancer. |
2008 |
Semin. Oncol. |
pmid:18410796
|
Cartelli D et al. |
Microtubule alterations occur early in experimental parkinsonism and the microtubule stabilizer epothilone D is neuroprotective. |
2013 |
Sci Rep |
pmid:23670541
|
Altmann KH et al. |
4. The natural products epothilones A and B as lead structures for anticancer drug discovery: chemistry, biology, and SAR studies. |
2004 |
Prog Med Chem |
pmid:15003721
|
Chou TC et al. |
Desoxyepothilone B: an efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B. |
1998 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:9689134
|
Chou TC et al. |
Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel. |
1998 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:9861050
|
Lichtner RB et al. |
Subcellular distribution of epothilones in human tumor cells. |
2001 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:11562452
|
Chou TC et al. |
The synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice. |
2001 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:11438750
|
Xiong Y et al. |
HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila. |
2013 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:23487739
|
Brunden KR et al. |
The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies. |
2011 |
Pharmacol. Res. |
pmid:21163349
|
Chappell MD et al. |
En route to a plant scale synthesis of the promising antitumor agent 12,13-desoxyepothilone B. |
2000 |
Org. Lett. |
pmid:10841497
|
Stachel SJ et al. |
On the total synthesis and preliminary biological evaluations of 15(R) and 15(S) aza-dEpoB: a Mitsunobu inversion at C15 in pre-epothilone fragments. |
2000 |
Org. Lett. |
pmid:10841498
|
Taylor RE and Chen Y |
Total synthesis of epothilones B and D. |
2001 |
Org. Lett. |
pmid:11440584
|
Frein JD et al. |
New sources of chemical diversity inspired by biosynthesis: rational design of a potent epothilone analogue. |
2009 |
Org. Lett. |
pmid:19572566
|
Gaich T and Mulzer J |
Synthesis of epothilones via a silicon-tethered RCM reaction. |
2005 |
Org. Lett. |
pmid:15787494
|
Chen QH et al. |
Design, synthesis and biological evaluation of bridged epothilone D analogues. |
2008 |
Org. Biomol. Chem. |
pmid:19039362
|
Penazzi L et al. |
Aβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D. |
2016 |
Neuropharmacology |
pmid:26772969
|
Brizuela M et al. |
The microtubule-stabilizing drug Epothilone D increases axonal sprouting following transection injury in vitro. |
2015 |
Mol. Cell. Neurosci. |
pmid:25684676
|
Nakano M et al. |
Identification of glycan structure alterations on cell membrane proteins in desoxyepothilone B resistant leukemia cells. |
2011 |
Mol. Cell Proteomics |
pmid:21859949
|
Lee SH et al. |
Epothilones induce human colon cancer SW620 cell apoptosis via the tubulin polymerization independent activation of the nuclear factor-kappaB/IkappaB kinase signal pathway. |
2007 |
Mol. Cancer Ther. |
pmid:17938270
|
Chappell MD et al. |
Probing the SAR of dEpoB via chemical synthesis: a total synthesis evaluation of C26-(1,3-dioxolanyl)-12,13-desoxyepothilone B. |
2002 |
J. Org. Chem. |
pmid:12398496
|
Rivkin A et al. |
Total syntheses of [17]- and [18]dehydrodesoxyepothilones B via a concise ring-closing metathesis-based strategy: correlation of ring size with biological activity in the epothilone series. |
2002 |
J. Org. Chem. |
pmid:12398497
|
Mulzer J et al. |
Total syntheses of epothilones B and D. |
2000 |
J. Org. Chem. |
pmid:11076603
|
Keck GE et al. |
Total synthesis of epothilones B and D: stannane equivalents for beta-keto ester dianions. |
2008 |
J. Org. Chem. |
pmid:18991385
|
Jung JC et al. |
Total syntheses of epothilones B and d. |
2004 |
J. Org. Chem. |
pmid:15609966
|
Wessjohann LA et al. |
Total synthesis of epothilone D: the nerol/macroaldolization approach. |
2013 |
J. Org. Chem. |
pmid:24079664
|
Brunden KR et al. |
Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. |
2010 |
J. Neurosci. |
pmid:20943926
|
Barten DM et al. |
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. |
2012 |
J. Neurosci. |
pmid:22623658
|
Zhang B et al. |
The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. |
2012 |
J. Neurosci. |
pmid:22423084
|
Dietzmann A et al. |
Nanomolar concentrations of epothilone D inhibit the proliferation of glioma cells and severely affect their tubulin cytoskeleton. |
2003 |
J. Neurooncol. |
pmid:14686728
|
Killinger BA and Moszczynska A |
Epothilone D prevents binge methamphetamine-mediated loss of striatal dopaminergic markers. |
2016 |
J. Neurochem. |
pmid:26465779
|
Fournet V et al. |
Both chronic treatments by epothilone D and fluoxetine increase the short-term memory and differentially alter the mood status of STOP/MAP6 KO mice. |
2012 |
J. Neurochem. |
pmid:23013328
|
Verrills NM et al. |
Alterations in gamma-actin and tubulin-targeted drug resistance in childhood leukemia. |
2006 |
J. Natl. Cancer Inst. |
pmid:17018783
|
Hardt IH et al. |
New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies. |
2001 |
J. Nat. Prod. |
pmid:11473410
|
Arslanian RL et al. |
A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus. |
2002 |
J. Nat. Prod. |
pmid:12141877
|
Arslanian RL et al. |
Large-scale isolation and crystallization of epothilone D from Myxococcus xanthus cultures. |
2002 |
J. Nat. Prod. |
pmid:11975503
|
Starks CM et al. |
Isolation and characterization of new epothilone analogues from recombinant Myxococcus xanthus fermentations. |
2003 |
J. Nat. Prod. |
pmid:14575429
|
Ye W et al. |
A new approach for improving epothilone B yield in Sorangium cellulosum by the introduction of vgb epoF genes. |
2016 |
J. Ind. Microbiol. Biotechnol. |
pmid:26803504
|
Hause G et al. |
Epothilone D affects cell cycle and microtubular pattern in plant cells. |
2005 |
J. Exp. Bot. |
pmid:15967777
|
Zhang C et al. |
Simultaneous determination of epothilone D and its hydrolytic metabolite in human plasma by high performance liquid chromatography-tandem mass spectrometry for pharmacokinetic studies. |
2009 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:19775943
|
Yuan L et al. |
Use of a carboxylesterase inhibitor of phenylmethanesulfonyl fluoride to stabilize epothilone D in rat plasma for a validated UHPLC-MS/MS assay. |
2014 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:25151331
|
Nagano S et al. |
Crystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoK. |
2003 |
J. Biol. Chem. |
pmid:12933799
|
Tang L et al. |
Generation of novel epothilone analogs with cytotoxic activity by biotransformation. |
2003 |
J. Antibiot. |
pmid:12670045
|
White JD et al. |
Total synthesis of epothilone B, epothilone D, and cis- and trans-9,10-dehydroepothilone D. |
2001 |
J. Am. Chem. Soc. |
pmid:11389619
|
Jumaa M et al. |
Kinetics and mechanism of degradation of epothilone-D: an experimental anticancer agent. |
2004 |
J Pharm Sci |
pmid:15459947
|
Wang Z et al. |
Determination of desoxyepothilone B in nude mice plasma by liquid-liquid extraction and reversed-phase high-performance liquid chromatography. |
2006 |
J Pharm Biomed Anal |
pmid:16616824
|
Burrell RC et al. |
Synthesis of stable isotope-labeled epothilone D using a degradation-reconstruction approach. |
2015 |
J Labelled Comp Radiopharm |
pmid:26158758
|
Bergstralh DT et al. |
A comparison of signaling activities induced by Taxol and desoxyepothilone B. |
2004 |
J Chemother |
pmid:15700849
|
Monk JP et al. |
A phase 1 study of KOS-862 (Epothilone D) co-administered with carboplatin (Paraplatin®) in patients with advanced solid tumors. |
2012 |
Invest New Drugs |
pmid:21826439
|