| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
| Parkinsonian Disorders | D020734 | 20 associated lipids |
Epothilone D
Epothilone d is a lipid of Polyketides (PK) class. Epothilone d is associated with abnormalities such as Tauopathies, Neutropenia, Neuropathy and Hematological Disease. The involved functions are known as Mutation, Apoptosis, Mitotic arrest, Cell Growth and Anabolism. Epothilone d often locates in Cytoskeleton, Axon, Cell Wall, Chromosomes and Spindle. The associated genes with epothilone D are SLC33A1 gene, Chromatin, GTF2I gene and HEXA gene.
Cross Reference
Introduction
To understand associated biological information of Epothilone D, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Epothilone D?
Epothilone D is suspected in Tauopathies, Neutropenia, Neuropathy, Hematological Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Epothilone D
PubChem Associated disorders and diseases
What pathways are associated with Epothilone D
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Epothilone D?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Epothilone D?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Epothilone D?
There are no associated biomedical information in the current reference collection.
What genes are associated with Epothilone D?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Epothilone D?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Epothilone D
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pchitskaya EI et al. | Dynamic Microtubules in Alzheimer's Disease: Association with Dendritic Spine Pathology. | 2018 | Biochemistry Mosc. | pmid:30472945 |
| Woods LM et al. | Synthesis and Biological Evaluation of 7-Deoxy-Epothilone Analogues. | 2017 | Int J Mol Sci | pmid:28304361 |
| Haydl AM and Breit B | The Total Synthesis of Epothilone D as a Yardstick for Probing New Methodologies. | 2017 | Chemistry | pmid:27792853 |
| Penazzi L et al. | Aβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D. | 2016 | Neuropharmacology | pmid:26772969 |
| Bakota L and Brandt R | Tau Biology and Tau-Directed Therapies for Alzheimer's Disease. | 2016 | Drugs | pmid:26729186 |
| Killinger BA and Moszczynska A | Epothilone D prevents binge methamphetamine-mediated loss of striatal dopaminergic markers. | 2016 | J. Neurochem. | pmid:26465779 |
| Ye W et al. | A new approach for improving epothilone B yield in Sorangium cellulosum by the introduction of vgb epoF genes. | 2016 | J. Ind. Microbiol. Biotechnol. | pmid:26803504 |
| Burrell RC et al. | Synthesis of stable isotope-labeled epothilone D using a degradation-reconstruction approach. | 2015 | J Labelled Comp Radiopharm | pmid:26158758 |
| Brizuela M et al. | The microtubule-stabilizing drug Epothilone D increases axonal sprouting following transection injury in vitro. | 2015 | Mol. Cell. Neurosci. | pmid:25684676 |
| Yuan L et al. | Use of a carboxylesterase inhibitor of phenylmethanesulfonyl fluoride to stabilize epothilone D in rat plasma for a validated UHPLC-MS/MS assay. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:25151331 |
| Xiong Y et al. | HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23487739 |
| Cartelli D et al. | Microtubule alterations occur early in experimental parkinsonism and the microtubule stabilizer epothilone D is neuroprotective. | 2013 | Sci Rep | pmid:23670541 |
| Wang C et al. | Molybdenum-based complexes with two aryloxides and a pentafluoroimido ligand: catalysts for efficient Z-selective synthesis of a macrocyclic trisubstituted alkene by ring-closing metathesis. | 2013 | Angew. Chem. Int. Ed. Engl. | pmid:23307513 |
| Wessjohann LA et al. | Total synthesis of epothilone D: the nerol/macroaldolization approach. | 2013 | J. Org. Chem. | pmid:24079664 |
| Sang F et al. | Epothilone D and its 9-Methyl analogues: combinatorial syntheses, conformation, and biological activities. | 2013 | Eur J Med Chem | pmid:23994325 |
| Brunden KR et al. | MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications. | 2013 | ACS Med Chem Lett | pmid:24900764 |
| Konner J et al. | Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma. | 2012 | Invest New Drugs | pmid:22072399 |
| Barten DM et al. | Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. | 2012 | J. Neurosci. | pmid:22623658 |
| Brunden KR et al. | Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies. | 2012 | Biochem. Soc. Trans. | pmid:22817712 |
| Zhang B et al. | The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. | 2012 | J. Neurosci. | pmid:22423084 |
| Fournet V et al. | Both chronic treatments by epothilone D and fluoxetine increase the short-term memory and differentially alter the mood status of STOP/MAP6 KO mice. | 2012 | J. Neurochem. | pmid:23013328 |
| Monk JP et al. | A phase 1 study of KOS-862 (Epothilone D) co-administered with carboplatin (Paraplatin®) in patients with advanced solid tumors. | 2012 | Invest New Drugs | pmid:21826439 |
| Brunden KR et al. | The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies. | 2011 | Pharmacol. Res. | pmid:21163349 |
| Nakano M et al. | Identification of glycan structure alterations on cell membrane proteins in desoxyepothilone B resistant leukemia cells. | 2011 | Mol. Cell Proteomics | pmid:21859949 |
| Brunden KR et al. | Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. | 2010 | J. Neurosci. | pmid:20943926 |
| Prantz K and Mulzer J | Synthesis of (Z)-trisubstituted olefins by decarboxylative grob-type fragmentations: epothilone D, discodermolide, and peloruside A. | 2010 | Chemistry | pmid:19943284 |
| Zhang SQ et al. | Determination of a novel epothilone D analog (AV-EPO-106) in human plasma using ultra-performance liquid chromatography-tandem mass spectrometry. | 2009 | Biomed. Chromatogr. | pmid:18800336 |
| Zhang C et al. | Simultaneous determination of epothilone D and its hydrolytic metabolite in human plasma by high performance liquid chromatography-tandem mass spectrometry for pharmacokinetic studies. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19775943 |
| Prantz K and Mulzer J | Decarboxylative Grob-type fragmentations in the synthesis of trisubstituted Z olefins: application to peloruside A, discodermolide, and epothilone D. | 2009 | Angew. Chem. Int. Ed. Engl. | pmid:19492384 |
| Frein JD et al. | New sources of chemical diversity inspired by biosynthesis: rational design of a potent epothilone analogue. | 2009 | Org. Lett. | pmid:19572566 |
| Keck GE et al. | Total synthesis of epothilones B and D: stannane equivalents for beta-keto ester dianions. | 2008 | J. Org. Chem. | pmid:18991385 |
| Chen QH et al. | Design, synthesis and biological evaluation of bridged epothilone D analogues. | 2008 | Org. Biomol. Chem. | pmid:19039362 |
| Harrison M and Swanton C | Epothilones and new analogues of the microtubule modulators in taxane-resistant disease. | 2008 | Expert Opin Investig Drugs | pmid:18363517 |
| Burris HA | Preclinical investigations with epothilones in breast cancer models. | 2008 | Semin. Oncol. | pmid:18410795 |
| Vahdat LT | Clinical studies with epothilones for the treatment of metastatic breast cancer. | 2008 | Semin. Oncol. | pmid:18410796 |
| Lee SH et al. | Epothilones induce human colon cancer SW620 cell apoptosis via the tubulin polymerization independent activation of the nuclear factor-kappaB/IkappaB kinase signal pathway. | 2007 | Mol. Cancer Ther. | pmid:17938270 |
| Fumoleau P et al. | Novel tubulin-targeting agents: anticancer activity and pharmacologic profile of epothilones and related analogues. | 2007 | Ann. Oncol. | pmid:17656562 |
| Kim TJ et al. | Epothilone D, a microtubule-stabilizing compound, inhibits neointimal hyperplasia after rat carotid artery injury by cell cycle arrest via regulation of G1-checkpoint proteins. | 2007 | Vascul. Pharmacol. | pmid:17706465 |
| Beer TM et al. | Phase II study of KOS-862 in patients with metastatic androgen independent prostate cancer previously treated with docetaxel. | 2007 | Invest New Drugs | pmid:17618407 |
| Mutka SC et al. | Heterologous production of epothilone C and D in Escherichia coli. | 2006 | Biochemistry | pmid:16430229 |
| Verrills NM et al. | Alterations in gamma-actin and tubulin-targeted drug resistance in childhood leukemia. | 2006 | J. Natl. Cancer Inst. | pmid:17018783 |
| Wang Z et al. | Determination of desoxyepothilone B in nude mice plasma by liquid-liquid extraction and reversed-phase high-performance liquid chromatography. | 2006 | J Pharm Biomed Anal | pmid:16616824 |
| Kuppens IE | Current state of the art of new tubulin inhibitors in the clinic. | 2006 | Curr Clin Pharmacol | pmid:18666378 |
| Frykman SA et al. | Assessment of fed-batch, semicontinuous, and continuous epothilone D production processes. | 2005 Jul-Aug | Biotechnol. Prog. | pmid:16080689 |
| Gaich T and Mulzer J | Synthesis of epothilones via a silicon-tethered RCM reaction. | 2005 | Org. Lett. | pmid:15787494 |
| Wang H et al. | Preclinical pharmacology of epothilone D, a novel tubulin-stabilizing antitumor agent. | 2005 | Cancer Chemother. Pharmacol. | pmid:15868148 |
| Broadrup RL et al. | Total synthesis of 12,13-desoxyepothilone B (Epothilone D). | 2005 | Bioorg. Chem. | pmid:15788167 |
| Hause G et al. | Epothilone D affects cell cycle and microtubular pattern in plant cells. | 2005 | J. Exp. Bot. | pmid:15967777 |
| Schinzer D et al. | Synthesis of furano-epothilone D. | 2004 | Chemistry | pmid:15224330 |
| Jung JC et al. | Total syntheses of epothilones B and d. | 2004 | J. Org. Chem. | pmid:15609966 |