| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
| Parkinsonian Disorders | D020734 | 20 associated lipids |
Epothilone D
Epothilone d is a lipid of Polyketides (PK) class. Epothilone d is associated with abnormalities such as Tauopathies, Neutropenia, Neuropathy and Hematological Disease. The involved functions are known as Mutation, Apoptosis, Mitotic arrest, Cell Growth and Anabolism. Epothilone d often locates in Cytoskeleton, Axon, Cell Wall, Chromosomes and Spindle. The associated genes with epothilone D are SLC33A1 gene, Chromatin, GTF2I gene and HEXA gene.
Cross Reference
Introduction
To understand associated biological information of Epothilone D, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Epothilone D?
Epothilone D is suspected in Tauopathies, Neutropenia, Neuropathy, Hematological Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Epothilone D
PubChem Associated disorders and diseases
What pathways are associated with Epothilone D
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Epothilone D?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Epothilone D?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Epothilone D?
There are no associated biomedical information in the current reference collection.
What genes are associated with Epothilone D?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Epothilone D?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Epothilone D
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mulzer J et al. | Total syntheses of epothilones B and D. | 2000 | J. Org. Chem. | pmid:11076603 |
| Lee SH et al. | Epothilones induce human colon cancer SW620 cell apoptosis via the tubulin polymerization independent activation of the nuclear factor-kappaB/IkappaB kinase signal pathway. | 2007 | Mol. Cancer Ther. | pmid:17938270 |
| Nakano M et al. | Identification of glycan structure alterations on cell membrane proteins in desoxyepothilone B resistant leukemia cells. | 2011 | Mol. Cell Proteomics | pmid:21859949 |
| Brizuela M et al. | The microtubule-stabilizing drug Epothilone D increases axonal sprouting following transection injury in vitro. | 2015 | Mol. Cell. Neurosci. | pmid:25684676 |
| Penazzi L et al. | Aβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D. | 2016 | Neuropharmacology | pmid:26772969 |
| Chen QH et al. | Design, synthesis and biological evaluation of bridged epothilone D analogues. | 2008 | Org. Biomol. Chem. | pmid:19039362 |
| Chappell MD et al. | En route to a plant scale synthesis of the promising antitumor agent 12,13-desoxyepothilone B. | 2000 | Org. Lett. | pmid:10841497 |
| Stachel SJ et al. | On the total synthesis and preliminary biological evaluations of 15(R) and 15(S) aza-dEpoB: a Mitsunobu inversion at C15 in pre-epothilone fragments. | 2000 | Org. Lett. | pmid:10841498 |
| Frein JD et al. | New sources of chemical diversity inspired by biosynthesis: rational design of a potent epothilone analogue. | 2009 | Org. Lett. | pmid:19572566 |
| Gaich T and Mulzer J | Synthesis of epothilones via a silicon-tethered RCM reaction. | 2005 | Org. Lett. | pmid:15787494 |