6-deoxyerythronolide B

6-deoxyerythronolide B is a lipid of Polyketides (PK) class. The involved functions are known as Anabolism, Biosynthetic Pathways and Synthesis. The associated genes with 6-deoxyerythronolide B are LARGE gene. The related lipids are Propionate.

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Introduction

To understand associated biological information of 6-deoxyerythronolide B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 6-deoxyerythronolide B?

There are no associated biomedical information in the current reference collection.

No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with 6-deoxyerythronolide B

Lipid pathways are not clear in current pathway databases. We organized associated pathways with 6-deoxyerythronolide B through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 6-deoxyerythronolide B?

There are no associated biomedical information in the current reference collection.

What functions are associated with 6-deoxyerythronolide B?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 6-deoxyerythronolide B?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 6-deoxyerythronolide B?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 6-deoxyerythronolide B?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 6-deoxyerythronolide B

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Authors Title Published Journal PubMed Link
pmid:
Kennedy J and Kealey JT Tools for metabolic engineering in Escherichia coli: inactivation of panD by a point mutation. 2004 Anal. Biochem. pmid:15033515
Khosla C et al. Structure and mechanism of the 6-deoxyerythronolide B synthase. 2007 Annu. Rev. Biochem. pmid:17328673
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Jacobsen JR et al. Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase leads to polyketide biosynthesis. 1998 Biochemistry pmid:9538011
Lau J et al. Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units. 1999 Biochemistry pmid:9931032
Tsuji SY et al. Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules. 2001 Biochemistry pmid:11327852
Tsai SC et al. Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. 2002 Biochemistry pmid:12379102
Murli S et al. Identification of domains within megalomicin and erythromycin polyketide synthase modules responsible for differences in polyketide production levels in Escherichia coli. 2004 Biochemistry pmid:15595843
Kennedy J et al. 6-Deoxyerythronolide B analogue production in Escherichia coli through metabolic pathway engineering. 2003 Biochemistry pmid:14640703
Yuzawa S et al. Role of a conserved arginine residue in linkers between the ketosynthase and acyltransferase domains of multimodular polyketide synthases. 2012 Biochemistry pmid:22509729
Argyropoulos P et al. Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis. 2016 Biochim. Biophys. Acta pmid:26592346