| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| He Z et al. | [Reconstruction of erythromycin macrocyclic lactone synthesis pathway in Escherichia coli]. | 2012 | Sheng Wu Gong Cheng Xue Bao | pmid:22667124 |
| Donadio S et al. | Modular organization of genes required for complex polyketide biosynthesis. | 1991 | Science | pmid:2024119 |
| Kao CM et al. | Engineered biosynthesis of a complete macrolactone in a heterologous host. | 1994 | Science | pmid:8036492 |
| Jacobsen JR et al. | Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase. | 1997 | Science | pmid:9219693 |
| Ferber D | Microbiology. Possible new route to polyketide synthesis. | 2001 | Science | pmid:11253181 |
| Pfeifer BA et al. | Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. | 2001 | Science | pmid:11230695 |
| Cupp-Vickery JR et al. | Preliminary crystallographic analysis of an enzyme involved in erythromycin biosynthesis: cytochrome P450eryF. | 1994 | Proteins | pmid:7846029 |
| Xue Q et al. | A multiplasmid approach to preparing large libraries of polyketides. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10518520 |
| Winn PJ et al. | Comparison of the dynamics of substrate access channels in three cytochrome P450s reveals different opening mechanisms and a novel functional role for a buried arginine. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11959989 |
| Kapur S et al. | Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21127271 |
| Chen D et al. | Identification and characterization of a new erythromycin biosynthetic gene cluster in Actinopolyspora erythraea YIM90600, a novel erythronolide-producing halophilic actinomycete isolated from salt field. | 2014 | PLoS ONE | pmid:25250723 |
| Paterson I and Temal-Laïb T | Toward the combinatorial synthesis of polyketide libraries: asymmetric aldol reactions with alpha-chiral aldehydes on solid support. | 2002 | Org. Lett. | pmid:12123354 |
| Crimmins MT and Slade DJ | Formal synthesis of 6-deoxyerythronolide B. | 2006 | Org. Lett. | pmid:16671814 |
| Pinto A et al. | 6-Deoxyerythronolide B synthase thioesterase-catalyzed macrocyclization is highly stereoselective. | 2012 | Org. Lett. | pmid:22519860 |
| Pieper R et al. | Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases. | 1995 | Nature | pmid:7477343 |
| Cupp-Vickery JR and Poulos TL | Structure of cytochrome P450eryF involved in erythromycin biosynthesis. | 1995 | Nat. Struct. Biol. | pmid:7749919 |
| Akey DL et al. | Structural basis for macrolactonization by the pikromycin thioesterase. | 2006 | Nat. Chem. Biol. | pmid:16969372 |
| Dechert-Schmitt AM et al. | Polyketide construction via hydrohydroxyalkylation and related alcohol C-H functionalizations: reinventing the chemistry of carbonyl addition. | 2014 | Nat Prod Rep | pmid:24514754 |
| Stang EM and White MC | Total synthesis and study of 6-deoxyerythronolide B by late-stage C-H oxidation. | 2009 | Nat Chem | pmid:21378935 |
| Gaisser S et al. | Parallel pathways for oxidation of 14-membered polyketide macrolactones in Saccharopolyspora erythraea. | 2002 | Mol. Microbiol. | pmid:11994157 |
| Hu Z et al. | A specific role of the Saccharopolyspora erythraea thioesterase II gene in the function of modular polyketide synthases. | 2003 | Microbiology (Reading, Engl.) | pmid:12904561 |
| Zhang H et al. | Probing the heterologous metabolism supporting 6-deoxyerythronolide B biosynthesis in Escherichia coli. | 2009 | Microb Biotechnol | pmid:21261933 |
| Wang Y and Pfeifer BA | 6-deoxyerythronolide B production through chromosomal localization of the deoxyerythronolide B synthase genes in E. coli. | 2008 | Metab. Eng. | pmid:17959404 |
| Wu J et al. | Construction and performance of heterologous polyketide-producing K-12- and B-derived Escherichia coli. | 2010 | Lett. Appl. Microbiol. | pmid:20565574 |
| Khosla C | Structures and mechanisms of polyketide synthases. | 2009 | J. Org. Chem. | pmid:19711990 |
| Keatinge-Clay A | Crystal structure of the erythromycin polyketide synthase dehydratase. | 2008 | J. Mol. Biol. | pmid:18952099 |
| Murli S et al. | Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production. | 2003 | J. Ind. Microbiol. Biotechnol. | pmid:12898389 |
| Boghigian BA et al. | Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess. | 2011 | J. Ind. Microbiol. Biotechnol. | pmid:21487833 |
| Ward SL et al. | Precursor-directed biosynthesis of 6-deoxyerythronolide B analogues is improved by removal of the initial catalytic sites of the polyketide synthase. | 2007 | J. Ind. Microbiol. Biotechnol. | pmid:17033784 |
| Carreras C et al. | Saccharopolyspora erythraea-catalyzed bioconversion of 6-deoxyerythronolide B analogs for production of novel erythromycins. | 2002 | J. Biotechnol. | pmid:11689246 |
| Lau J et al. | Development of a high cell-density fed-batch bioprocess for the heterologous production of 6-deoxyerythronolide B in Escherichia coli. | 2004 | J. Biotechnol. | pmid:15099909 |
| Xiang H et al. | An A245T mutation conveys on cytochrome P450eryF the ability to oxidize alternative substrates. | 2000 | J. Biol. Chem. | pmid:10956654 |
| Ju J and Goo YM | 8-Deoxylankolide from a lankamycin producing Streptomyces spp. | 1997 | J. Antibiot. | pmid:9315083 |
| Ashley GW and Carney JR | API-mass spectrometry of polyketides. II. Fragmentation analysis of 6-deoxyerythronolide B analogs. | 2004 | J. Antibiot. | pmid:15580959 |
| Roddis M et al. | Structural elucidation studies on 14- and 16-membered macrolide aglycones by accurate-mass electrospray sequential mass spectrometry. | 2002 | J. Am. Soc. Mass Spectrom. | pmid:12148810 |
| Gao X et al. | Total synthesis of 6-deoxyerythronolide B via C-C bond-forming transfer hydrogenation. | 2013 | J. Am. Chem. Soc. | pmid:23464668 |
| Donadio S and Katz L | Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea. | 1992 | Gene | pmid:1547954 |
| Rowe CJ et al. | Construction of new vectors for high-level expression in actinomycetes. | 1998 | Gene | pmid:9714812 |
| Chuck JA et al. | Molecular recognition of diketide substrates by a beta-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthase. | 1997 | Chem. Biol. | pmid:9375254 |
| Wilkinson B et al. | Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase. | 2000 | Chem. Biol. | pmid:10662692 |
| Leaf T et al. | Precursor-directed biosynthesis of 6-deoxyerythronolide B analogs in Streptomyces coelicolor: understanding precursor effects. | 2000 Jul-Aug | Biotechnol. Prog. | pmid:10933827 |
| Desai RP et al. | Combining classical, genetic, and process strategies for improved precursor-directed production of 6-deoxyerythronolide B analogues. | 2004 Jan-Feb | Biotechnol. Prog. | pmid:14763821 |
| Pistorino M and Pfeifer BA | Efficient experimental design and micro-scale medium enhancement of 6-deoxyerythronolide B production through Escherichia coli. | 2009 Sep-Oct | Biotechnol. Prog. | pmid:19634176 |
| Lombó F et al. | Enhancing the atom economy of polyketide biosynthetic processes through metabolic engineering. | 2001 Jul-Aug | Biotechnol. Prog. | pmid:11485419 |
| Zhang H et al. | Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in Escherichia coli. | 2010 | Biotechnol. Bioeng. | pmid:19806677 |
| González-Lergier J et al. | Analysis of the maximum theoretical yield for the synthesis of erythromycin precursors in Escherichia coli. | 2006 | Biotechnol. Bioeng. | pmid:16619212 |
| Boghigian BA et al. | Multi-factorial engineering of heterologous polyketide production in Escherichia coli reveals complex pathway interactions. | 2011 | Biotechnol. Bioeng. | pmid:21337322 |
| Meng HL et al. | Construction of polyketide overproducing Escherichia coli strains via synthetic antisense RNAs based on in silico fluxome analysis and comparative transcriptome analysis. | 2016 | Biotechnol J | pmid:26709503 |
| Ziermann R and Betlach MC | Recombinant polyketide synthesis in Streptomyces: engineering of improved host strains. | 1999 | BioTechniques | pmid:9894599 |
| Kim C et al. | The role of serine-246 in cytochrome P450eryF-catalyzed hydroxylation of 6-deoxyerythronolide B. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11388449 |
6-deoxyerythronolide B
6-deoxyerythronolide B is a lipid of Polyketides (PK) class. The involved functions are known as Anabolism, Biosynthetic Pathways and Synthesis. The associated genes with 6-deoxyerythronolide B are LARGE gene. The related lipids are Propionate.
Cross Reference
Introduction
To understand associated biological information of 6-deoxyerythronolide B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 6-deoxyerythronolide B?
There are no associated biomedical information in the current reference collection.
No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with 6-deoxyerythronolide B
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 6-deoxyerythronolide B through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 6-deoxyerythronolide B?
There are no associated biomedical information in the current reference collection.
What functions are associated with 6-deoxyerythronolide B?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 6-deoxyerythronolide B?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 6-deoxyerythronolide B?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 6-deoxyerythronolide B?
There are no associated biomedical information in the current reference collection.