6-deoxyerythronolide B

6-deoxyerythronolide B is a lipid of Polyketides (PK) class. The involved functions are known as Anabolism, Biosynthetic Pathways and Synthesis. The associated genes with 6-deoxyerythronolide B are LARGE gene. The related lipids are Propionate.

Cross Reference

Introduction

To understand associated biological information of 6-deoxyerythronolide B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 6-deoxyerythronolide B?

There are no associated biomedical information in the current reference collection.

No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with 6-deoxyerythronolide B

Lipid pathways are not clear in current pathway databases. We organized associated pathways with 6-deoxyerythronolide B through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 6-deoxyerythronolide B?

There are no associated biomedical information in the current reference collection.

What functions are associated with 6-deoxyerythronolide B?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 6-deoxyerythronolide B?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 6-deoxyerythronolide B?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 6-deoxyerythronolide B?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 6-deoxyerythronolide B

Download all related citations
Per page 10 20 50 100 | Total 73
Authors Title Published Journal PubMed Link
pmid:
Xue Q et al. A multiplasmid approach to preparing large libraries of polyketides. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10518520
Wilkinson B et al. Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase. 2000 Chem. Biol. pmid:10662692
Leaf T et al. Precursor-directed biosynthesis of 6-deoxyerythronolide B analogs in Streptomyces coelicolor: understanding precursor effects. 2000 Jul-Aug Biotechnol. Prog. pmid:10933827
Xiang H et al. An A245T mutation conveys on cytochrome P450eryF the ability to oxidize alternative substrates. 2000 J. Biol. Chem. pmid:10956654
Pfeifer BA et al. Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. 2001 Science pmid:11230695
Ferber D Microbiology. Possible new route to polyketide synthesis. 2001 Science pmid:11253181
Tsuji SY et al. Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules. 2001 Biochemistry pmid:11327852
Kim C et al. The role of serine-246 in cytochrome P450eryF-catalyzed hydroxylation of 6-deoxyerythronolide B. 2001 Biosci. Biotechnol. Biochem. pmid:11388449
Yin Y et al. Erythromycin biosynthesis. The 4-pro-S hydride of NADPH is utilized for ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase. 2001 Bioorg. Med. Chem. Lett. pmid:11412964
Lombó F et al. Enhancing the atom economy of polyketide biosynthetic processes through metabolic engineering. 2001 Jul-Aug Biotechnol. Prog. pmid:11485419
Carreras C et al. Saccharopolyspora erythraea-catalyzed bioconversion of 6-deoxyerythronolide B analogs for production of novel erythromycins. 2002 J. Biotechnol. pmid:11689246
Winn PJ et al. Comparison of the dynamics of substrate access channels in three cytochrome P450s reveals different opening mechanisms and a novel functional role for a buried arginine. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:11959989
Gaisser S et al. Parallel pathways for oxidation of 14-membered polyketide macrolactones in Saccharopolyspora erythraea. 2002 Mol. Microbiol. pmid:11994157
Pfeifer B et al. Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B. 2002 Appl. Environ. Microbiol. pmid:12089005
Paterson I and Temal-Laïb T Toward the combinatorial synthesis of polyketide libraries: asymmetric aldol reactions with alpha-chiral aldehydes on solid support. 2002 Org. Lett. pmid:12123354
Roddis M et al. Structural elucidation studies on 14- and 16-membered macrolide aglycones by accurate-mass electrospray sequential mass spectrometry. 2002 J. Am. Soc. Mass Spectrom. pmid:12148810
Tsai SC et al. Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. 2002 Biochemistry pmid:12379102
Murli S et al. Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production. 2003 J. Ind. Microbiol. Biotechnol. pmid:12898389
Hu Z et al. A specific role of the Saccharopolyspora erythraea thioesterase II gene in the function of modular polyketide synthases. 2003 Microbiology (Reading, Engl.) pmid:12904561
Kennedy J et al. 6-Deoxyerythronolide B analogue production in Escherichia coli through metabolic pathway engineering. 2003 Biochemistry pmid:14640703
Desai RP et al. Combining classical, genetic, and process strategies for improved precursor-directed production of 6-deoxyerythronolide B analogues. 2004 Jan-Feb Biotechnol. Prog. pmid:14763821
Kennedy J and Kealey JT Tools for metabolic engineering in Escherichia coli: inactivation of panD by a point mutation. 2004 Anal. Biochem. pmid:15033515
Lau J et al. Development of a high cell-density fed-batch bioprocess for the heterologous production of 6-deoxyerythronolide B in Escherichia coli. 2004 J. Biotechnol. pmid:15099909
Donadio S and Katz L Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea. 1992 Gene pmid:1547954
Ashley GW and Carney JR API-mass spectrometry of polyketides. II. Fragmentation analysis of 6-deoxyerythronolide B analogs. 2004 J. Antibiot. pmid:15580959
Murli S et al. Identification of domains within megalomicin and erythromycin polyketide synthase modules responsible for differences in polyketide production levels in Escherichia coli. 2004 Biochemistry pmid:15595843
Murli S et al. Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1. 2005 Appl. Environ. Microbiol. pmid:16085842
González-Lergier J et al. Analysis of the maximum theoretical yield for the synthesis of erythromycin precursors in Escherichia coli. 2006 Biotechnol. Bioeng. pmid:16619212
Crimmins MT and Slade DJ Formal synthesis of 6-deoxyerythronolide B. 2006 Org. Lett. pmid:16671814
Akey DL et al. Structural basis for macrolactonization by the pikromycin thioesterase. 2006 Nat. Chem. Biol. pmid:16969372
Ward SL et al. Precursor-directed biosynthesis of 6-deoxyerythronolide B analogues is improved by removal of the initial catalytic sites of the polyketide synthase. 2007 J. Ind. Microbiol. Biotechnol. pmid:17033784
Khosla C et al. Structure and mechanism of the 6-deoxyerythronolide B synthase. 2007 Annu. Rev. Biochem. pmid:17328673
Sharma KK and Boddy CN The thioesterase domain from the pimaricin and erythromycin biosynthetic pathways can catalyze hydrolysis of simple thioester substrates. 2007 Bioorg. Med. Chem. Lett. pmid:17428661
Wang Y et al. Improving heterologous polyketide production in Escherichia coli by overexpression of an S-adenosylmethionine synthetase gene. 2007 Appl. Microbiol. Biotechnol. pmid:17876579
Wang Y and Pfeifer BA 6-deoxyerythronolide B production through chromosomal localization of the deoxyerythronolide B synthase genes in E. coli. 2008 Metab. Eng. pmid:17959404
Keatinge-Clay A Crystal structure of the erythromycin polyketide synthase dehydratase. 2008 J. Mol. Biol. pmid:18952099
Pistorino M and Pfeifer BA Efficient experimental design and micro-scale medium enhancement of 6-deoxyerythronolide B production through Escherichia coli. 2009 Sep-Oct Biotechnol. Prog. pmid:19634176
Khosla C Structures and mechanisms of polyketide synthases. 2009 J. Org. Chem. pmid:19711990
Zhang H et al. Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in Escherichia coli. 2010 Biotechnol. Bioeng. pmid:19806677
Donadio S et al. Modular organization of genes required for complex polyketide biosynthesis. 1991 Science pmid:2024119
Wu J et al. Construction and performance of heterologous polyketide-producing K-12- and B-derived Escherichia coli. 2010 Lett. Appl. Microbiol. pmid:20565574
Kapur S et al. Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:21127271
Zhang H et al. Probing the heterologous metabolism supporting 6-deoxyerythronolide B biosynthesis in Escherichia coli. 2009 Microb Biotechnol pmid:21261933
Boghigian BA et al. Multi-factorial engineering of heterologous polyketide production in Escherichia coli reveals complex pathway interactions. 2011 Biotechnol. Bioeng. pmid:21337322
Stang EM and White MC Total synthesis and study of 6-deoxyerythronolide B by late-stage C-H oxidation. 2009 Nat Chem pmid:21378935
Boghigian BA et al. Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess. 2011 J. Ind. Microbiol. Biotechnol. pmid:21487833
Yuzawa S et al. Role of a conserved arginine residue in linkers between the ketosynthase and acyltransferase domains of multimodular polyketide synthases. 2012 Biochemistry pmid:22509729
Pinto A et al. 6-Deoxyerythronolide B synthase thioesterase-catalyzed macrocyclization is highly stereoselective. 2012 Org. Lett. pmid:22519860
He Z et al. [Reconstruction of erythromycin macrocyclic lactone synthesis pathway in Escherichia coli]. 2012 Sheng Wu Gong Cheng Xue Bao pmid:22667124