| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yin Y et al. | Erythromycin biosynthesis. The 4-pro-S hydride of NADPH is utilized for ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11412964 |
| Leaf T et al. | Precursor-directed biosynthesis of 6-deoxyerythronolide B analogs in Streptomyces coelicolor: understanding precursor effects. | 2000 Jul-Aug | Biotechnol. Prog. | pmid:10933827 |
| Wilkinson B et al. | Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase. | 2000 | Chem. Biol. | pmid:10662692 |
| Xiang H et al. | An A245T mutation conveys on cytochrome P450eryF the ability to oxidize alternative substrates. | 2000 | J. Biol. Chem. | pmid:10956654 |
| Ziermann R and Betlach MC | Recombinant polyketide synthesis in Streptomyces: engineering of improved host strains. | 1999 | BioTechniques | pmid:9894599 |
| Xue Q et al. | A multiplasmid approach to preparing large libraries of polyketides. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10518520 |
| Lau J et al. | Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units. | 1999 | Biochemistry | pmid:9931032 |
| Jacobsen JR et al. | Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase leads to polyketide biosynthesis. | 1998 | Biochemistry | pmid:9538011 |
| Rowe CJ et al. | Construction of new vectors for high-level expression in actinomycetes. | 1998 | Gene | pmid:9714812 |
| Jacobsen JR et al. | Precursor-directed biosynthesis of 12-ethyl erythromycin. | 1998 | Bioorg. Med. Chem. | pmid:9784859 |
| Ju J and Goo YM | 8-Deoxylankolide from a lankamycin producing Streptomyces spp. | 1997 | J. Antibiot. | pmid:9315083 |
| Jacobsen JR et al. | Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase. | 1997 | Science | pmid:9219693 |
| Chuck JA et al. | Molecular recognition of diketide substrates by a beta-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthase. | 1997 | Chem. Biol. | pmid:9375254 |
| Kao CM et al. | Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase. | 1996 | Biochemistry | pmid:8823171 |
| Pieper R et al. | Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases. | 1995 | Nature | pmid:7477343 |
| Cupp-Vickery JR and Poulos TL | Structure of cytochrome P450eryF involved in erythromycin biosynthesis. | 1995 | Nat. Struct. Biol. | pmid:7749919 |
| Kao CM et al. | Engineered biosynthesis of a complete macrolactone in a heterologous host. | 1994 | Science | pmid:8036492 |
| Cupp-Vickery JR et al. | Preliminary crystallographic analysis of an enzyme involved in erythromycin biosynthesis: cytochrome P450eryF. | 1994 | Proteins | pmid:7846029 |
| Donadio S and Katz L | Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea. | 1992 | Gene | pmid:1547954 |
| Donadio S et al. | Modular organization of genes required for complex polyketide biosynthesis. | 1991 | Science | pmid:2024119 |
| Shafiee A and Hutchinson CR | Macrolide antibiotic biosynthesis: isolation and properties of two forms of 6-deoxyerythronolide B hydroxylase from Saccharopolyspora erythraea (Streptomyces erythreus). | 1987 | Biochemistry | pmid:2446657 |
| Corcoran JW and Vygantas AM | Accumulation of 6-deoxyerythronolide B in a normal strain of Streptomyces erythreus and hydroxylation at carbon 6 of the erythranolide ring system by a soluble noninduced cell-free enzyme system. | 1982 | Biochemistry | pmid:7074013 |
| pmid: |
6-deoxyerythronolide B
6-deoxyerythronolide B is a lipid of Polyketides (PK) class. The involved functions are known as Anabolism, Biosynthetic Pathways and Synthesis. The associated genes with 6-deoxyerythronolide B are LARGE gene. The related lipids are Propionate.
Cross Reference
Introduction
To understand associated biological information of 6-deoxyerythronolide B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 6-deoxyerythronolide B?
There are no associated biomedical information in the current reference collection.
No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with 6-deoxyerythronolide B
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 6-deoxyerythronolide B through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 6-deoxyerythronolide B?
There are no associated biomedical information in the current reference collection.
What functions are associated with 6-deoxyerythronolide B?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 6-deoxyerythronolide B?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 6-deoxyerythronolide B?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 6-deoxyerythronolide B?
There are no associated biomedical information in the current reference collection.