| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Leaf T et al. | Precursor-directed biosynthesis of 6-deoxyerythronolide B analogs in Streptomyces coelicolor: understanding precursor effects. | 2000 Jul-Aug | Biotechnol. Prog. | pmid:10933827 |
| Desai RP et al. | Combining classical, genetic, and process strategies for improved precursor-directed production of 6-deoxyerythronolide B analogues. | 2004 Jan-Feb | Biotechnol. Prog. | pmid:14763821 |
| Pistorino M and Pfeifer BA | Efficient experimental design and micro-scale medium enhancement of 6-deoxyerythronolide B production through Escherichia coli. | 2009 Sep-Oct | Biotechnol. Prog. | pmid:19634176 |
| Lombó F et al. | Enhancing the atom economy of polyketide biosynthetic processes through metabolic engineering. | 2001 Jul-Aug | Biotechnol. Prog. | pmid:11485419 |
| Zhang H et al. | Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in Escherichia coli. | 2010 | Biotechnol. Bioeng. | pmid:19806677 |
| González-Lergier J et al. | Analysis of the maximum theoretical yield for the synthesis of erythromycin precursors in Escherichia coli. | 2006 | Biotechnol. Bioeng. | pmid:16619212 |
| Boghigian BA et al. | Multi-factorial engineering of heterologous polyketide production in Escherichia coli reveals complex pathway interactions. | 2011 | Biotechnol. Bioeng. | pmid:21337322 |
| Meng HL et al. | Construction of polyketide overproducing Escherichia coli strains via synthetic antisense RNAs based on in silico fluxome analysis and comparative transcriptome analysis. | 2016 | Biotechnol J | pmid:26709503 |
| Ziermann R and Betlach MC | Recombinant polyketide synthesis in Streptomyces: engineering of improved host strains. | 1999 | BioTechniques | pmid:9894599 |
| Kim C et al. | The role of serine-246 in cytochrome P450eryF-catalyzed hydroxylation of 6-deoxyerythronolide B. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11388449 |
| Yin Y et al. | Erythromycin biosynthesis. The 4-pro-S hydride of NADPH is utilized for ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11412964 |
| Sharma KK and Boddy CN | The thioesterase domain from the pimaricin and erythromycin biosynthetic pathways can catalyze hydrolysis of simple thioester substrates. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17428661 |
| Jacobsen JR et al. | Precursor-directed biosynthesis of 12-ethyl erythromycin. | 1998 | Bioorg. Med. Chem. | pmid:9784859 |
| Argyropoulos P et al. | Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis. | 2016 | Biochim. Biophys. Acta | pmid:26592346 |
| Jacobsen JR et al. | Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase leads to polyketide biosynthesis. | 1998 | Biochemistry | pmid:9538011 |
| Lau J et al. | Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units. | 1999 | Biochemistry | pmid:9931032 |
| Tsuji SY et al. | Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules. | 2001 | Biochemistry | pmid:11327852 |
| Tsai SC et al. | Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. | 2002 | Biochemistry | pmid:12379102 |
| Murli S et al. | Identification of domains within megalomicin and erythromycin polyketide synthase modules responsible for differences in polyketide production levels in Escherichia coli. | 2004 | Biochemistry | pmid:15595843 |
| Yuzawa S et al. | Role of a conserved arginine residue in linkers between the ketosynthase and acyltransferase domains of multimodular polyketide synthases. | 2012 | Biochemistry | pmid:22509729 |
6-deoxyerythronolide B
6-deoxyerythronolide B is a lipid of Polyketides (PK) class. The involved functions are known as Anabolism, Biosynthetic Pathways and Synthesis. The associated genes with 6-deoxyerythronolide B are LARGE gene. The related lipids are Propionate.
Cross Reference
Introduction
To understand associated biological information of 6-deoxyerythronolide B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 6-deoxyerythronolide B?
There are no associated biomedical information in the current reference collection.
No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with 6-deoxyerythronolide B
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 6-deoxyerythronolide B through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 6-deoxyerythronolide B?
There are no associated biomedical information in the current reference collection.
What functions are associated with 6-deoxyerythronolide B?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 6-deoxyerythronolide B?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 6-deoxyerythronolide B?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 6-deoxyerythronolide B?
There are no associated biomedical information in the current reference collection.