6-deoxyerythronolide B

6-deoxyerythronolide B is a lipid of Polyketides (PK) class. The involved functions are known as Anabolism, Biosynthetic Pathways and Synthesis. The associated genes with 6-deoxyerythronolide B are LARGE gene. The related lipids are Propionate.

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Introduction

To understand associated biological information of 6-deoxyerythronolide B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 6-deoxyerythronolide B?

There are no associated biomedical information in the current reference collection.

No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with 6-deoxyerythronolide B

Lipid pathways are not clear in current pathway databases. We organized associated pathways with 6-deoxyerythronolide B through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 6-deoxyerythronolide B?

There are no associated biomedical information in the current reference collection.

What functions are associated with 6-deoxyerythronolide B?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 6-deoxyerythronolide B?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 6-deoxyerythronolide B?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 6-deoxyerythronolide B?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 6-deoxyerythronolide B

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Authors Title Published Journal PubMed Link
Winn PJ et al. Comparison of the dynamics of substrate access channels in three cytochrome P450s reveals different opening mechanisms and a novel functional role for a buried arginine. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:11959989
Carreras C et al. Saccharopolyspora erythraea-catalyzed bioconversion of 6-deoxyerythronolide B analogs for production of novel erythromycins. 2002 J. Biotechnol. pmid:11689246
Lombó F et al. Enhancing the atom economy of polyketide biosynthetic processes through metabolic engineering. 2001 Jul-Aug Biotechnol. Prog. pmid:11485419
Yin Y et al. Erythromycin biosynthesis. The 4-pro-S hydride of NADPH is utilized for ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase. 2001 Bioorg. Med. Chem. Lett. pmid:11412964
Kim C et al. The role of serine-246 in cytochrome P450eryF-catalyzed hydroxylation of 6-deoxyerythronolide B. 2001 Biosci. Biotechnol. Biochem. pmid:11388449
Tsuji SY et al. Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules. 2001 Biochemistry pmid:11327852
Ferber D Microbiology. Possible new route to polyketide synthesis. 2001 Science pmid:11253181
Pfeifer BA et al. Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. 2001 Science pmid:11230695
Xiang H et al. An A245T mutation conveys on cytochrome P450eryF the ability to oxidize alternative substrates. 2000 J. Biol. Chem. pmid:10956654
Leaf T et al. Precursor-directed biosynthesis of 6-deoxyerythronolide B analogs in Streptomyces coelicolor: understanding precursor effects. 2000 Jul-Aug Biotechnol. Prog. pmid:10933827
Wilkinson B et al. Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase. 2000 Chem. Biol. pmid:10662692
Xue Q et al. A multiplasmid approach to preparing large libraries of polyketides. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10518520
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