tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Landy J and Hart AL | Commentary: short-term efficacy of tacrolimus in steroid-refractory ulcerative colitis. | 2013 | Aliment. Pharmacol. Ther. | pmid:23336680 |
| Hirai F et al. | Letter: short-term efficacy of tacrolimus in steroid-refractory ulcerative colitis. | 2013 | Aliment. Pharmacol. Ther. | pmid:23336690 |
| Schmidt KJ et al. | Letter: short-term efficacy of tacrolimus in steroid-refractory ulcerative colitis - authors' reply. | 2013 | Aliment. Pharmacol. Ther. | pmid:23336691 |
| Yamamoto T et al. | Tacrolimus vs. anti-tumour necrosis factor agents for moderately to severely active ulcerative colitis: a retrospective observational study. | 2016 | Aliment. Pharmacol. Ther. | pmid:26762838 |
| Ierardi E et al. | Oral tacrolimus long-term therapy in patients with Crohn's disease and steroid resistance. | 2001 | Aliment. Pharmacol. Ther. | pmid:11207512 |
| Travis S | Review article: saving the colon in severe colitis - the case for medical therapy. | 2006 | Aliment. Pharmacol. Ther. | pmid:16961749 |
| Schmidt KJ et al. | Short-term efficacy of tacrolimus in steroid-refractory ulcerative colitis - experience in 130 patients. | 2013 | Aliment. Pharmacol. Ther. | pmid:23121200 |
| McSharry K et al. | Systematic review: the role of tacrolimus in the management of Crohn's disease. | 2011 | Aliment. Pharmacol. Ther. | pmid:21999607 |
| Yamamoto S et al. | Long-term effect of tacrolimus therapy in patients with refractory ulcerative colitis. | 2008 | Aliment. Pharmacol. Ther. | pmid:18549460 |
| O'Leary JG | Editorial: tacrolimus-how low can you go? | 2017 | Aliment. Pharmacol. Ther. | pmid:28589579 |
| Firpi RJ et al. | Sirolimus-induced hyperlipidaemia in liver transplant recipients is not dose-dependent. | 2004 | Aliment. Pharmacol. Ther. | pmid:15113371 |
| Hisanaga Y et al. | Implication of nitric oxide synthase activity in the genesis of water immersion stress-induced gastric lesions in rats: the protective effects of FK506. | 1996 | Aliment. Pharmacol. Ther. | pmid:8971291 |
| Nakase H et al. | Tacrolimus suppresses IL-12/IL23 p40 in Crohn's disease and heals fistulae refractory to anti-TNF-α therapy. | 2011 | Aliment. Pharmacol. Ther. | pmid:21434949 |
| Nakase H et al. | Tacrolimus: rescue therapy or experimental drug for severe ulcerative colitis? | 2011 | Aliment. Pharmacol. Ther. | pmid:21198700 |
| Hoshino H et al. | Effects of FK506 on an experimental model of colitis in rats. | 1995 | Aliment. Pharmacol. Ther. | pmid:7544633 |
| Mehta SJ et al. | Review article: strategies for the management of chronic unremitting ulcerative colitis. | 2013 | Aliment. Pharmacol. Ther. | pmid:23718288 |
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| Mori F et al. | Increase of natural killer cells in children with liver transplantation-acquired food allergy. | Allergol Immunopathol (Madr) | pmid:29456038 | |
| Regueiro-GarcÃa A et al. | Haploidentical stem cell transplantation in a boy with chronic granulomatous disease. | Allergol Immunopathol (Madr) | pmid:29373243 | |
| Inoue Y et al. | Food allergy after cord blood stem cell transplantation with tacrolimus therapy in two patients who developed veno-occlusive disease. | 2012 | Allergol Int | pmid:22722810 |
| Tsuji T et al. | Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator FTY720 ointment (fingolimod) in NC/Nga mice. | 2016 | Allergol Int | pmid:26666476 |
| Miyachi Y et al. | Suplatast/tacrolimus combination therapy for refractory facial erythema in adult patients with atopic dermatitis: a meta-analysis study. | 2007 | Allergol Int | pmid:17582208 |
| Ebihara N et al. | Blood level of tacrolimus in patients with severe allergic conjunctivitis treated by 0.1% tacrolimus ophthalmic suspension. | 2012 | Allergol Int | pmid:22361511 |
| Yamamoto M et al. | A novel atopic dermatitis model induced by topical application with dermatophagoides farinae extract in NC/Nga mice. | 2007 | Allergol Int | pmid:17460441 |
| Wollenberg A et al. | Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment. | 2008 | Allergy | pmid:18445188 |
| Jensen JM et al. | Gene expression is differently affected by pimecrolimus and betamethasone in lesional skin of atopic dermatitis. | 2012 | Allergy | pmid:22142306 |
| Bieber T et al. | Efficacy and safety of methylprednisolone aceponate ointment 0.1% compared to tacrolimus 0.03% in children and adolescents with an acute flare of severe atopic dermatitis. | 2007 | Allergy | pmid:17298428 |
| Wollenberg A et al. | Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment. | 2008 | Allergy | pmid:18592619 |
| Bergstrand H and Lundquist B | Human basophil histamine release is differently affected by inhibitors of calmodulin, diacylglycerol kinase and peptidyl prolyl cis-trans isomerase in a secretagogue specific manner. | 1992 | Allergy | pmid:1280915 |
| Kaufmann R et al. | Onset of pruritus relief with pimecrolimus cream 1% in adult patients with atopic dermatitis: a randomized trial. | 2006 | Allergy | pmid:16436149 |
| Oldhoff JM et al. | Modulation of the atopy patch test: tacrolimus 0.1% compared with triamcinolone acetonide 0.1%. | 2006 | Allergy | pmid:16629794 |
| Simon D et al. | Inflammatory cell numbers and cytokine expression in atopic dermatitis after topical pimecrolimus treatment. | 2005 | Allergy | pmid:15932386 |
| Leonardi S et al. | Efficacy and safety of tacrolimus ointment 0.03% treatment in a 1-month-old "red baby": a case report. | 2006 Nov-Dec | Allergy Asthma Proc | pmid:17176789 |
| Pacor ML et al. | Tacrolimus ointment in nickel sulphate-induced steroid-resistant allergic contact dermatitis. | 2006 Nov-Dec | Allergy Asthma Proc | pmid:17176790 |
| Rico MJ and Lawrence I | Tacrolimus ointment for the treatment of atopic dermatitis: clinical and pharmacologic effects. | 2002 May-Jun | Allergy Asthma Proc | pmid:12125507 |
| Szema AM | Angioedema in a child with a liver transplant, intussusception, and normal c4 levels. | 2010 Jul-Aug | Allergy Asthma Proc | pmid:20615276 |
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| Wilhelmi E et al. | Organotypic brain-slice cultures from adult rats: approaches for a prolonged culture time. | 2002 May-Jun | Altern Lab Anim | pmid:12106005 |
| Mcauliffe EP | Is tacrolimus the best therapy for atopic dermatitis? | 2003 | Am Fam Physician | pmid:12751651 |
| Lane JE and Johnson J | Persistent penile patch. | 2008 | Am Fam Physician | pmid:19007056 |
| Russell JJ | Topical tacrolimus: a new therapy for atopic dermatitis. | 2002 | Am Fam Physician | pmid:12469964 |
| Berke R et al. | Atopic dermatitis: an overview. | 2012 | Am Fam Physician | pmid:22962911 |
| Hitzeman N and Kinnevey C | Topical Tacrolimus for Eczema. | 2016 | Am Fam Physician | pmid:27929217 |
| Baran DA et al. | Calcineurin inhibitor-associated early renal insufficiency in cardiac transplant recipients: risk factors and strategies for prevention and treatment. | 2004 | Am J Cardiovasc Drugs | pmid:14967063 |
| Ramirez R et al. | Posterior Reversible Encephalopathy Syndrome After Orthotopic Heart Transplantation: A Case Report. | 2017 | Am J Case Rep | pmid:28465499 |
| Kawamura H et al. | Rapid Induction Therapy with Oral Tacrolimus in Elderly Patients with Refractory Ulcerative Colitis Can Easily Lead to Elevated Tacrolimus Concentrations in Blood: A Report of 5 Cases. | 2017 | Am J Case Rep | pmid:28411286 |
| Udomkarnjananun S et al. | An Unusual Manifestation of Calcineurin Inhibitor-Induced Pain Syndrome in Kidney Transplantation: A Case Report and Literature Review. | 2018 | Am J Case Rep | pmid:29654227 |
| Iskedjian M et al. | Topical calcineurin inhibitors in the treatment of atopic dermatitis: a meta-analysis of current evidence. | 2004 | Am J Clin Dermatol | pmid:15301573 |
| Wellington K and Noble S | Pimecrolimus: a review of its use in atopic dermatitis. | 2004 | Am J Clin Dermatol | pmid:15663345 |
| Reitamo S et al. | Topical noncorticosteroid immunomodulation in the treatment of atopic dermatitis. | 2002 | Am J Clin Dermatol | pmid:12113647 |