| MeSH term | MeSH ID | Detail |
|---|---|---|
| Biliary Tract Neoplasms | D001661 | 7 associated lipids |
| Blepharitis | D001762 | 4 associated lipids |
| Blindness | D001766 | 6 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Bone Diseases | D001847 | 4 associated lipids |
| Bradycardia | D001919 | 13 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Bronchiolitis | D001988 | 6 associated lipids |
| Bronchiolitis Obliterans | D001989 | 8 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gjertson DW et al. | The relative effects of FK506 and cyclosporine on short- and long-term kidney graft survival. | 1995 | Transplantation | pmid:8545861 |
| Vincenti F | A decade of progress in kidney transplantation. | 2004 | Transplantation | pmid:15201687 |
| Shirakata Y et al. | Inhibitory effect of plasma FKBP12 on immunosuppressive activity of FK506. | 1995 | Transplantation | pmid:8545894 |
| Asberg A et al. | Calcineurin inhibitor avoidance with daclizumab, mycophenolate mofetil, and prednisolone in DR-matched de novo kidney transplant recipients. | 2006 | Transplantation | pmid:16861943 |
| Pfitzmann R et al. | Mycophenolatemofetil for immunosuppression after liver transplantation: a follow-up study of 191 patients. | 2003 | Transplantation | pmid:12865798 |
| Moffatt SD et al. | Potential for improved therapeutic index of FK506 in liposomal formulation demonstrated in a mouse cardiac allograft model. | 1999 | Transplantation | pmid:10342309 |
| Krentz AJ et al. | Postoperative glucose metabolism in liver transplant recipients. A two-year prospective randomized study of cyclosporine versus FK506. | 1994 | Transplantation | pmid:7516590 |
| Gonwa T et al. | Randomized trial of tacrolimus + mycophenolate mofetil or azathioprine versus cyclosporine + mycophenolate mofetil after cadaveric kidney transplantation: results at three years. | 2003 | Transplantation | pmid:12829910 |
| Briggs D et al. | Effects of immediate switch from cyclosporine microemulsion to tacrolimus at first acute rejection in renal allograft recipients. | 2003 | Transplantation | pmid:12829912 |
| Bierer BE et al. | Mechanisms of immunosuppression by FK506. Preservation of T cell transmembrane signal transduction. | 1990 | Transplantation | pmid:1694317 |
| Chaftari AM et al. | Comparison of posaconazole versus weekly amphotericin B lipid complex for the prevention of invasive fungal infections in hematopoietic stem-cell transplantation. | 2012 | Transplantation | pmid:22814329 |
| Utsugi R et al. | Induction of transplantation tolerance with a short course of tacrolimus (FK506): I. Rapid and stable tolerance to two-haplotype fully mhc-mismatched kidney allografts in miniature swine. | 2001 | Transplantation | pmid:11391221 |
| Krentz AJ | Posttransplantation Diabetes Mellitus in FK-506-Treated Renal Transplant Recipients: Analysis of Incidence and Risk Factors. Transplantation 2001; 72: 1655. | 2001 | Transplantation | pmid:11726815 |
| Sanchez-Campos S et al. | Cholestasis and alterations of glutathione metabolism induced by tacrolimus (FK506) in the rat. | 1998 | Transplantation | pmid:9679826 |
| Shao X et al. | Tacrolimus-associated ischemic optic neuropathy and posterior reversible encephalopathy syndrome after small bowel transplantation. | 2012 | Transplantation | pmid:23128973 |
| Nicolai S and Bunyavanich S | Hypersensitivity reaction to intravenous but not oral tacrolimus. | 2012 | Transplantation | pmid:23128975 |
| Tsuchiya T et al. | Comparison of pharmacokinetics and pathology for low-dose tacrolimus once-daily and twice-daily in living kidney transplantation: prospective trial in once-daily versus twice-daily tacrolimus. | 2013 | Transplantation | pmid:23792649 |
| Barth RN et al. | Prolonged survival of composite facial allografts in non-human primates associated with posttransplant lymphoproliferative disorder. | 2009 | Transplantation | pmid:19996923 |
| Størset E et al. | Improved Tacrolimus Target Concentration Achievement Using Computerized Dosing in Renal Transplant Recipients--A Prospective, Randomized Study. | 2015 | Transplantation | pmid:25886918 |
| Kaplan B et al. | Frequency of hyperkalemia in recipients of simultaneous pancreas and kidney transplants with bladder drainage. | 1996 | Transplantation | pmid:8900321 |
| Bronster DJ et al. | Tacrolimus-associated mutism after orthotopic liver transplantation. | 2000 | Transplantation | pmid:11014653 |
| Newell KA et al. | Posttransplant lymphoproliferative disease in pediatric liver transplantation. Interplay between primary Epstein-Barr virus infection and immunosuppression. | 1996 | Transplantation | pmid:8779685 |
| Mittal SK et al. | Increased interleukin-10 production without expansion of CD4+CD25+ T-regulatory cells in early stable renal transplant patients on calcineurin inhibitors. | 2009 | Transplantation | pmid:19667950 |
| Muraki T et al. | Effects of cyclosporine and FK506 on in vitro high shear-induced platelet reactivity in rat and human non-anticoagulated blood. | 1998 | Transplantation | pmid:9583878 |
| Sato T et al. | Diabetes mellitus after transplant: relationship to pretransplant glucose metabolism and tacrolimus or cyclosporine A-based therapy. | 2003 | Transplantation | pmid:14627910 |
| Hooper DK et al. | Risk of tacrolimus toxicity in CYP3A5 nonexpressors treated with intravenous nicardipine after kidney transplantation. | 2012 | Transplantation | pmid:22491658 |
| Sarwal MM et al. | Continued superior outcomes with modification and lengthened follow-up of a steroid-avoidance pilot with extended daclizumab induction in pediatric renal transplantation. | 2003 | Transplantation | pmid:14627912 |
| Ciancio G et al. | Randomized trial of mycophenolate mofetil versus enteric-coated mycophenolate sodium in primary renal transplant recipients given tacrolimus and daclizumab/thymoglobulin: one year follow-up. | 2008 | Transplantation | pmid:18622280 |
| Inoue T et al. | Lesser reduction in bone mineral density by the immunosuppressant, FK506, compared with cyclosporine in rats. | 2000 | Transplantation | pmid:11003356 |
| Richards KR et al. | Tacrolimus trough level at discharge predicts acute rejection in moderately sensitized renal transplant recipients. | 2014 | Transplantation | pmid:24784360 |
| Klupp J et al. | Indications of mycophenolate mofetil in liver transplantation. | 2005 | Transplantation | pmid:16286893 |
| Nankivell BJ et al. | Calcineurin Inhibitor Nephrotoxicity Through the Lens of Longitudinal Histology: Comparison of Cyclosporine and Tacrolimus Eras. | 2016 | Transplantation | pmid:27306529 |
| Holt S and Moore K | Different effects of tacrolimus and cyclosporine on renal hemodynamics and blood pressure in healthy subjects. | 2002 | Transplantation | pmid:11907407 |
| Yang H et al. | Liposomal encapsulation significantly enchances the immunosuppressive effect of tacrolimus in a discordant islet xenotransplant model. | 2002 | Transplantation | pmid:11907415 |
| St A Nunes FA and Lucey MR | Searching for a balance when applying immunosuppression after liver transplantation. | 2001 | Transplantation | pmid:11258425 |
| Apanay DC et al. | Cyclosporine increases the oxidizability of low-density lipoproteins in renal transplant recipients. | 1994 | Transplantation | pmid:7524202 |
| Neuhaus P et al. | Quadruple tacrolimus-based induction therapy including azathioprine and ALG does not significantly improve outcome after liver transplantation when compared with standard induction with tacrolimus and steroids: results of a prospective, randomized trial. | 2000 | Transplantation | pmid:10868638 |
| Steinmüller TM et al. | The effect of FK506 versus cyclosporine on glucose and lipid metabolism--a randomized trial. | 1994 | Transplantation | pmid:7524203 |
| De Ruvo N et al. | Preliminary results of a "prope" tolerogenic regimen with thymoglobulin pretreatment and hepatitis C virus recurrence in liver transplantation. | 2005 | Transplantation | pmid:16003226 |
| Mohamed MA et al. | TGF-beta expression in renal transplant biopsies: a comparative study between cyclosporin-A and tacrolimus. | 2000 | Transplantation | pmid:10755567 |
| Reich DJ et al. | Mycophenolate mofetil for renal dysfunction in liver transplant recipients on cyclosporine or tacrolimus: randomized, prospective, multicenter pilot study results. | 2005 | Transplantation | pmid:16003228 |
| Roberti I et al. | Evidence that the systematic analysis of bile cytology permits monitoring of hepatic allograft rejection. | 1992 | Transplantation | pmid:1384182 |
| Guthery SL et al. | Determination of risk factors for Epstein-Barr virus-associated posttransplant lymphoproliferative disorder in pediatric liver transplant recipients using objective case ascertainment. | 2003 | Transplantation | pmid:12698085 |
| Guasch A et al. | Assessment of efficacy and safety of FK778 in comparison with standard care in renal transplant recipients with untreated BK nephropathy. | 2010 | Transplantation | pmid:20811320 |
| Ciancio G et al. | A randomized long-term trial of tacrolimus/sirolimus versus tacrolimus/mycophenolate mofetil versus cyclosporine (NEORAL)/sirolimus in renal transplantation. II. Survival, function, and protocol compliance at 1 year. | 2004 | Transplantation | pmid:14742990 |
| Azzola A et al. | Everolimus and mycophenolate mofetil are potent inhibitors of fibroblast proliferation after lung transplantation. | 2004 | Transplantation | pmid:14742993 |
| Murase N et al. | Graft-versus-host disease after brown Norway-to-Lewis and Lewis-to-Brown Norway rat intestinal transplantation under FK506. | 1993 | Transplantation | pmid:7678353 |
| Yilmaz MI et al. | Endothelial functions improve with decrease in asymmetric dimethylarginine (ADMA) levels after renal transplantation. | 2005 | Transplantation | pmid:16378057 |
| Zhang W et al. | Isoglycyrrhizinate Magnesium Enhances Hepatoprotective Effect of FK506 on Ischemia-Reperfusion Injury Through HMGB1 Inhibition in a Rat Model of Liver Transplantation. | 2017 | Transplantation | pmid:28885495 |
| Guitard J et al. | Predictive factors for anemia six and twelve months after orthotopic liver transplantation. | 2006 | Transplantation | pmid:16770241 |