tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen CH et al. | Comparison of tuberculosis infection rates in a national database of renal transplant patients with data from a single center in Taiwan. | 2014 | Transplant. Proc. | pmid:24656019 |
| Furian L et al. | Everolimus associated with low-dose calcineurin inhibitors, an option in kidney transplant recipients of very old donors. | 2014 | Transplant. Proc. | pmid:25498057 |
| Singh K et al. | Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer. | 2014 | Am. J. Transplant. | pmid:25359003 |
| Siebelt M et al. | FK506 protects against articular cartilage collagenous extra-cellular matrix degradation. | 2014 | Osteoarthr. Cartil. | pmid:24561282 |
| Tang Q | Pharmacokinetics of therapeutic Tregs. | 2014 | Am. J. Transplant. | pmid:25358900 |
| Silva HT et al. | Long-term follow-up of a phase III clinical trial comparing tacrolimus extended-release/MMF, tacrolimus/MMF, and cyclosporine/MMF in de novo kidney transplant recipients. | 2014 | Transplantation | pmid:24521771 |
| Kiiski V et al. | Long-term safety of topical pimecrolimus and topical tacrolimus in atopic blepharoconjunctivitis. | 2014 | JAMA Dermatol | pmid:24500107 |
| McCormack PL | Extended-release tacrolimus: a review of its use in de novo kidney transplantation. | 2014 | Drugs | pmid:25352392 |
| Naganuma M et al. | [Clinical relevance of tacrolimus trough levels in outpatients with active ulcerative colitis]. | 2014 | Nihon Shokakibyo Gakkai Zasshi | pmid:24500317 |
| Sahin S et al. | The protective effects of tacrolimus on rat uteri exposed to ischemia-reperfusion injury: a biochemical and histopathologic evaluation. | 2014 | Fertil. Steril. | pmid:24502894 |
| Ciancio G et al. | Randomized trial of three induction antibodies in kidney transplantation: long-term results. | 2014 | Transplantation | pmid:24477186 |
| Pedroso JA et al. | Elderly kidney transplant recipient with intermittent fever: a case report of leishmaniasis with acute kidney injury during liposomal amphotericin B therapy. | 2014 | Transplant. Proc. | pmid:25242789 |
| Pereira MJ et al. | Cyclosporine A and tacrolimus reduce the amount of GLUT4 at the cell surface in human adipocytes: increased endocytosis as a potential mechanism for the diabetogenic effects of immunosuppressive agents. | 2014 | J. Clin. Endocrinol. Metab. | pmid:25004245 |
| Højfeldt JW et al. | Bifunctional ligands allow deliberate extrinsic reprogramming of the glucocorticoid receptor. | 2014 | Mol. Endocrinol. | pmid:24422633 |
| Mekaj AY et al. | Application of topical pharmacological agents at the site of peripheral nerve injury and methods used for evaluating the success of the regenerative process. | 2014 | J Orthop Surg Res | pmid:25303779 |
| Satoh S et al. | Pharmacokinetic and CYP3A5 pharmacogenetic differences between once- and twice-daily tacrolimus from the first dosing day to 1 year after renal transplantation. | 2014 | Pharmacogenomics | pmid:25303300 |
| Meyer KC et al. | An international ISHLT/ATS/ERS clinical practice guideline: diagnosis and management of bronchiolitis obliterans syndrome. | 2014 | Eur. Respir. J. | pmid:25359357 |
| Souto-RodrÃguez R et al. | Differences in the incidence and clinical evolution of early neurotoxicity after liver transplantation based on tacrolimus formulation used in the immunosuppressive induction protocol. | 2014 | Transplant. Proc. | pmid:25420839 |
| de la Fuente S et al. | Long-term survivors after pediatric liver transplatation are at increased risk for development of cardiovascular disease events: analysis of 30 cases. | 2014 | Transplant. Proc. | pmid:25420837 |
| Tavira B et al. | Mitochondrial DNA haplogroups and risk of new-onset diabetes among tacrolimus-treated renal transplanted patients. | 2014 | Gene | pmid:24445060 |
| Barreiro C and MartÃnez-Castro M | Trends in the biosynthesis and production of the immunosuppressant tacrolimus (FK506). | 2014 | Appl. Microbiol. Biotechnol. | pmid:24272367 |
| Iwanami M et al. | [Orbital apex syndrome due to relapse during steroid tapering in a patient with MPO-ANCA-positive IgG4-related hypertrophic pachymeningitis]. | 2014 | Rinsho Shinkeigaku | pmid:24429649 |
| Masson P et al. | Belatacept for kidney transplant recipients. | 2014 | Cochrane Database Syst Rev | pmid:25416857 |
| Xu W et al. | Toward immunosuppressive effects on liver transplantation in rat model: tacrolimus loaded poly(ethylene glycol)-poly(D,L-lactide) nanoparticle with longer survival time. | 2014 | Int J Pharm | pmid:24172796 |
| Sivakumar V et al. | Role of fludrocortisone in the management of tacrolimus-induced hyperkalemia in a renal transplant recipient. | 2014 | Saudi J Kidney Dis Transpl | pmid:24434399 |
| Salehi-Najafabadi Z et al. | The gamma-butyrolactone receptors BulR1 and BulR2 of Streptomyces tsukubaensis: tacrolimus (FK506) and butyrolactone synthetases production control. | 2014 | Appl. Microbiol. Biotechnol. | pmid:24562179 |
| Yargui L et al. | Metabolic status of 1088 patients after renal transplantation: assessment of twelve years monitoring in Algiers Mustapha Hospital. | 2014 | Saudi J Kidney Dis Transpl | pmid:24434409 |
| Gomez-Moyano E et al. | Periorbital granuloma annulare successfully treated with tacrolimus 0.1% ointment. | 2014 | Int. J. Dermatol. | pmid:23432464 |
| Lalić J et al. | Immunosuppressive medication adherence in kidney transplant patients. | 2014 | Med Princ Pract | pmid:24923773 |
| Gijsen VM et al. | P450 oxidoreductase *28 (POR*28) and tacrolimus disposition in pediatric kidney transplant recipients--a pilot study. | 2014 | Ther Drug Monit | pmid:24089076 |
| Guitard J et al. | An unexpected diagnosis in a renal-transplant patient with proteinuria treated with everolimus: AL amyloidosis. | 2014 | Clin. Nephrol. | pmid:24040781 |
| Schlegel A et al. | Hypothermic Oxygenated Perfusion (HOPE) downregulates the immune response in a rat model of liver transplantation. | 2014 | Ann. Surg. | pmid:25243553 |
| Nasu R et al. | Favorable outcomes of tacrolimus compared with cyclosporine A for GVHD prophylaxis in HSCT for standard-risk hematological diseases. | 2014 | Ann. Hematol. | pmid:24590535 |
| Kujawski S et al. | Calcineurin regulates coordinated outgrowth of zebrafish regenerating fins. | 2014 | Dev. Cell | pmid:24561038 |
| Eguchi R et al. | Recombinant human soluble thrombomodulin attenuates FK506-induced endothelial dysfunction through prevention of Akt inactivation. | 2014 | Exp. Cell Res. | pmid:24582967 |
| Rahman Z et al. | Determination of tacrolimus crystalline fraction in the commercial immediate release amorphous solid dispersion products by a standardized X-ray powder diffraction method with chemometrics. | 2014 | Int J Pharm | pmid:25173870 |
| Baldo A et al. | Vitiligo, NB-UVB and tacrolimus: our experience in Naples. | 2014 | G Ital Dermatol Venereol | pmid:24566573 |
| Jia JJ et al. | ''Minimizing tacrolimus'' strategy and long-term survival after liver transplantation. | 2014 | World J. Gastroenterol. | pmid:25170223 |
| Hao JC et al. | Effect of low-dose tacrolimus with mycophenolate mofetil on renal function following liver transplantation. | 2014 | World J. Gastroenterol. | pmid:25170222 |
| Peng L et al. | The calcineurin inhibitor tacrolimus reduces proteinuria in membranous nephropathy accompanied by a decrease in angiopoietin-like-4. | 2014 | PLoS ONE | pmid:25165975 |
| Favennec C et al. | Consideration of the switch from twice-daily to once-daily tacrolimus in pediatric kidney transplant in daily clinical practice: pharmacokinetic parameters, patient satisfaction and medical practices. | 2014 | Pediatr Transplant | pmid:25164065 |
| Giordanetto F and Kihlberg J | Macrocyclic drugs and clinical candidates: what can medicinal chemists learn from their properties? | 2014 | J. Med. Chem. | pmid:24044773 |
| Murota H et al. | Olopatadine hydrochloride decreases tissue interleukin-31 levels in an atopic dermatitis mouse model. | 2014 | Acta Derm. Venereol. | pmid:23817562 |
| Gupta AK et al. | Efficient neutrophil extracellular trap induction requires mobilization of both intracellular and extracellular calcium pools and is modulated by cyclosporine A. | 2014 | PLoS ONE | pmid:24819773 |
| Vattemi G et al. | Polymyositis in solid organ transplant recipients receiving tacrolimus. | 2014 | J. Neurol. Sci. | pmid:25130930 |
| Narabayashi K et al. | Oral tacrolimus for megacolon in patients with severe ulcerative colitis. | 2014 | Intern. Med. | pmid:25130105 |
| Amanova A et al. | Colchicine levels in chronic kidney diseases and kidney transplant recipients using tacrolimus. | 2014 | Clin Transplant | pmid:25125128 |
| Barnieh L et al. | The cost of kidney transplant over time. | 2014 | Prog Transplant | pmid:25193726 |
| Calo S et al. | Antifungal drug resistance evoked via RNAi-dependent epimutations. | 2014 | Nature | pmid:25079329 |
| Chen SR et al. | Calcineurin inhibitor induces pain hypersensitivity by potentiating pre- and postsynaptic NMDA receptor activity in spinal cords. | 2014 | J. Physiol. (Lond.) | pmid:24081160 |
| Guillén-Gómez E et al. | Monocyte implication in renal allograft dysfunction. | 2014 | Clin. Exp. Immunol. | pmid:24134783 |
| Aulagnon F et al. | Diarrhea after kidney transplantation: a new look at a frequent symptom. | 2014 | Transplantation | pmid:25073040 |
| Han JS et al. | Tacrolimus 0.1% ointment in the treatment of allergic contact dermatitis: a new approach. | 2014 | Int. J. Dermatol. | pmid:25070257 |
| Li T et al. | Effect of FK506 nanospheres on regeneration of allogeneic nerve after transplant. | 2014 | Asian Pac J Trop Med | pmid:25066398 |
| Piao SG et al. | Combined treatment of tacrolimus and everolimus increases oxidative stress by pharmacological interactions. | 2014 | Transplantation | pmid:24825522 |
| Miyauchi T et al. | Evidence for the therapeutic efficacy of either mild hypothermia or oxygen radical scavengers after repetitive mild traumatic brain injury. | 2014 | J. Neurotrauma | pmid:24341607 |
| Gujadhur A et al. | CMV sinusitis in a HIV-negative renal transplant recipient. | 2014 | Transplantation | pmid:24827770 |
| Navas-López VM et al. | Oral tacrolimus for pediatric steroid-resistant ulcerative colitis. | 2014 | J Crohns Colitis | pmid:23582736 |
| Inaba A et al. | Cerebral toxoplasmosis after umbilical cord blood transplantation diagnosed by the detection of anti-toxoplasma specific IgM antibody in cerebrospinal fluid. | 2014 | Rinsho Ketsueki | pmid:24850458 |
| van Gelder T et al. | Pharmacogenetics and immunosuppressive drugs in solid organ transplantation. | 2014 | Nat Rev Nephrol | pmid:25247332 |
| Tapirdamaz Ö et al. | Genetic variance in ABCB1 and CYP3A5 does not contribute toward the development of chronic kidney disease after liver transplantation. | 2014 | Pharmacogenet. Genomics | pmid:25014506 |
| Helmschrott M et al. | Superior rejection profile during the first 24 months after heart transplantation under tacrolimus as baseline immunosuppressive regimen. | 2014 | Drug Des Devel Ther | pmid:25246772 |
| Matta C et al. | Ser/Thr-phosphoprotein phosphatases in chondrogenesis: neglected components of a two-player game. | 2014 | Cell. Signal. | pmid:25007994 |
| Parvizi Z et al. | Association between E23K variant in KCNJ11 gene and new-onset diabetes after liver transplantation. | 2014 | Mol. Biol. Rep. | pmid:24996284 |
| Hara H et al. | Hematopoietic chimerism following allotransplantation of the spleen, splenocytes or kidney in pigs. | 2014 | Transpl. Immunol. | pmid:25245436 |
| Picchianti-Diamanti A et al. | P-glycoprotein and drug resistance in systemic autoimmune diseases. | 2014 | Int J Mol Sci | pmid:24658440 |
| Andrade-Sierra J et al. | Early steroid withdrawal in a renal transplant cohort treated with tacrolimus, mycophenolate mofetil and basiliximab. | 2014 | Nefrologia | pmid:24658197 |
| Wolfram D et al. | Insights from computational modeling in inflammation and acute rejection in limb transplantation. | 2014 | PLoS ONE | pmid:24926998 |
| Zhao X et al. | [A retrospective cohort study regarding the effect of sirolimus-based immunosuppression protocol on the long-term survival of hepatocellular carcinoma patients after liver transplantation]. | 2014 | Zhonghua Wai Ke Za Zhi | pmid:24924566 |
| Kanyshkova T et al. | Regionally specific expression of high-voltage-activated calcium channels in thalamic nuclei of epileptic and non-epileptic rats. | 2014 | Mol. Cell. Neurosci. | pmid:24914823 |
| Hebral AL et al. | Pregnancy after kidney transplantation: outcome and anti-human leucocyte antigen alloimmunization risk. | 2014 | Nephrol. Dial. Transplant. | pmid:24914091 |
| Saito E et al. | Efficacy of salvage therapy and its effect on operative outcomes in patients with ulcerative colitis. | 2014 | Digestion | pmid:24458114 |
| Song L et al. | Effects of ASKP1240 combined with tacrolimus or mycophenolate mofetil on renal allograft survival in Cynomolgus monkeys. | 2014 | Transplantation | pmid:24992357 |
| Hayes D et al. | Alternative tacrolimus and sirolimus regimen associated with rapid resolution of posterior reversible encephalopathy syndrome after lung transplantation. | 2014 | Pediatr. Neurol. | pmid:24405697 |
| Lin T et al. | A Chinese girl with novel PLCE1 mutations and proliferation of the mesangium responded to tacrolimus therapy. | 2014 | Nephrology (Carlton) | pmid:24533735 |
| Li H et al. | A promising approach of overcoming the intrinsic resistance of Candida krusei to fluconazole (FLC)--combining tacrolimus with FLC. | 2014 | FEMS Yeast Res. | pmid:24830342 |
| Wang YB et al. | In vitro and in vivo performance of dry powder inhalation formulations: comparison of particles prepared by thin film freezing and micronization. | 2014 | AAPS PharmSciTech | pmid:24824172 |
| Oda K et al. | In vitro experimental system for evaluating inhibitory effect of investigational drugs on P-glycoprotein-mediated transcellular transport of tacrolimus (FK506). | 2014 | Biopharm Drug Dispos | pmid:24822242 |
| Wang Z et al. | Influence of TLR4 rs1927907 locus polymorphisms on tacrolimus pharmacokinetics in the early stage after liver transplantation. | 2014 | Eur. J. Clin. Pharmacol. | pmid:24820765 |
| Akchurin OM et al. | Medication adherence in the transition of adolescent kidney transplant recipients to the adult care. | 2014 | Pediatr Transplant | pmid:24820521 |
| Yang LM et al. | Experimental research on end-to-side anastomosis of peripheral nerves and effect of FK506 on end-to-side anastomosis. | 2014 | Bratisl Lek Listy | pmid:25573729 |
| Stewart JI et al. | Reverse halo sign on chest imaging in a renal transplant recipient. | 2014 | Transpl Infect Dis | pmid:24289813 |
| Colom H et al. | Pharmacokinetic modeling of enterohepatic circulation of mycophenolic acid in renal transplant recipients. | 2014 | Kidney Int. | pmid:24402086 |
| Castronovo G et al. | The effect of nonsurgical periodontal treatment on the severity of drug-induced gingival overgrowth in transplant patients. | 2014 | Quintessence Int | pmid:24389563 |
| Bergmann TK et al. | Comparison of the influence of cyclosporine and tacrolimus on the pharmacokinetics of prednisolone in adult male kidney transplant recipients. | 2014 | Clin Drug Investig | pmid:24385281 |
| Yap DY et al. | Long-term data on tacrolimus treatment in lupus nephritis. | 2014 | Rheumatology (Oxford) | pmid:24996908 |
| Ishikawa Y and Bächinger HP | A substrate preference for the rough endoplasmic reticulum resident protein FKBP22 during collagen biosynthesis. | 2014 | J. Biol. Chem. | pmid:24821723 |
| Taube D et al. | Generic tacrolimus in solid organ transplantation. | 2014 | Clin Transplant | pmid:24750309 |
| Varghese J et al. | Tacrolimus-related adverse effects in liver transplant recipients: its association with trough concentrations. | 2014 | Indian J Gastroenterol | pmid:24740447 |
| Calabrese B et al. | Activity-dependent dendritic spine shrinkage and growth involve downregulation of cofilin via distinct mechanisms. | 2014 | PLoS ONE | pmid:24740405 |
| Kawaguch K et al. | Successful treatment with allogenic hematopoietic stem cell transplantation of a severe congenital neutropenia patient harboring a novel ELANE mutation. | 2014 | Rinsho Ketsueki | pmid:25501410 |
| Lesche D et al. | CYP3A5*3 and POR*28 genetic variants influence the required dose of tacrolimus in heart transplant recipients. | 2014 | Ther Drug Monit | pmid:24739669 |
| Cvetkovic TP et al. | Gender differences in oxidative and nitrosative stress parameters in kidney transplant patients on tacrolimus-based immunosuppression. | 2014 | Int Urol Nephrol | pmid:24101297 |
| Hässig A et al. | Association of BK viremia with human leukocyte antigen mismatches and acute rejection, but not with type of calcineurin inhibitor. | 2014 | Transpl Infect Dis | pmid:24134704 |
| Manousou P et al. | Reduced fibrosis in recurrent HCV with tacrolimus, azathioprine and steroids versus tacrolimus: randomised trial long term outcomes. | 2014 | Gut | pmid:24131637 |
| Langers P et al. | Limited sampling model for advanced mycophenolic acid therapeutic drug monitoring after liver transplantation. | 2014 | Ther Drug Monit | pmid:24081208 |
| Lee SK et al. | Overexpression of the putative extracytoplasmic function sigma (σ) factor FujE enhances FK506 production in Streptomyces sp. strain KCCM 11116P. | 2014 | Can. J. Microbiol. | pmid:24869633 |
| van der Vusse ML et al. | Helicobacter canis bacteremia in a renal transplant patient. | 2014 | Transpl Infect Dis | pmid:24372779 |
| da Cunha Filho RR et al. | "Angular" plasma cell cheilitis. | 2014 | Dermatol. Online J. | pmid:24656273 |
| Nakamura A et al. | Effects of elevated tacrolimus trough levels in association with infectious enteritis on graft function in renal transplant recipients. | 2014 | Transplant. Proc. | pmid:24656020 |