tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Uveomeningoencephalitic Syndrome D014607 1 associated lipids
Lupus Erythematosus, Discoid D008179 1 associated lipids
Cervical Intraepithelial Neoplasia D018290 1 associated lipids
Cardiovirus Infections D018188 3 associated lipids
Fungemia D016469 2 associated lipids
Legionellosis D007876 3 associated lipids
Lung Abscess D008169 1 associated lipids
IgA Deficiency D017098 2 associated lipids
IgG Deficiency D017099 1 associated lipids
Hepatic Veno-Occlusive Disease D006504 1 associated lipids
Alopecia Areata D000506 6 associated lipids
Anemia, Refractory, with Excess of Blasts D000754 2 associated lipids
Hepatitis, Autoimmune D019693 1 associated lipids
Intestinal Fistula D007412 1 associated lipids
Polyendocrinopathies, Autoimmune D016884 1 associated lipids
Meningitis, Cryptococcal D016919 1 associated lipids
Polymyositis D017285 1 associated lipids
Uveitis, Posterior D015866 5 associated lipids
Red-Cell Aplasia, Pure D012010 4 associated lipids
Smooth Muscle Tumor D018235 1 associated lipids
Blepharitis D001762 4 associated lipids
Hearing Loss, Sudden D003639 1 associated lipids
Trichomonas Vaginitis D014247 2 associated lipids
Hypopigmentation D017496 2 associated lipids
Pemphigoid, Benign Mucous Membrane D010390 4 associated lipids
Feline Acquired Immunodeficiency Syndrome D016181 1 associated lipids
Cryptogenic Organizing Pneumonia D018549 3 associated lipids
Amputation, Traumatic D000673 2 associated lipids
Erythema Nodosum D004893 5 associated lipids
Sweet Syndrome D016463 1 associated lipids
Pyoderma Gangrenosum D017511 3 associated lipids
Nervous System Autoimmune Disease, Experimental D020721 3 associated lipids
Deglutition Disorders D003680 2 associated lipids
Oral Ulcer D019226 1 associated lipids
Immunoblastic Lymphadenopathy D007119 2 associated lipids
Leukemia, Myeloid, Chronic-Phase D015466 1 associated lipids
Lupus Erythematosus, Cutaneous D008178 2 associated lipids
Dental Enamel Hypoplasia D003744 2 associated lipids
Fasciitis, Necrotizing D019115 1 associated lipids
Cutis Laxa D003483 1 associated lipids
Rotavirus Infections D012400 1 associated lipids
Epididymitis D004823 1 associated lipids
Orchitis D009920 1 associated lipids
Ichthyosiform Erythroderma, Congenital D016113 1 associated lipids
Polyomavirus Infections D027601 1 associated lipids
Citrullinemia D020159 1 associated lipids
Eye Infections, Viral D015828 1 associated lipids
Hand Injuries D006230 1 associated lipids
Pseudohypoaldosteronism D011546 1 associated lipids
Lichen Planus, Oral D017676 2 associated lipids
Flaviviridae Infections D018178 1 associated lipids
Megacolon, Toxic D008532 1 associated lipids
Lichen Sclerosus et Atrophicus D018459 2 associated lipids
Leukemia, Biphenotypic, Acute D015456 2 associated lipids
Lichenoid Eruptions D017512 1 associated lipids
Herpes Labialis D006560 1 associated lipids
Pemphigus D010392 3 associated lipids
Mutism D009155 1 associated lipids
Neurodermatitis D009450 1 associated lipids
Leukoplakia, Oral D007972 1 associated lipids
Hypertensive Encephalopathy D020343 1 associated lipids
Skin Diseases, Viral D017193 2 associated lipids
Cytomegalovirus Retinitis D017726 2 associated lipids
Rectal Fistula D012003 2 associated lipids
Vestibular Diseases D015837 2 associated lipids
Intestinal Atresia D007409 3 associated lipids
Priapism D011317 1 associated lipids
Kaposi Varicelliform Eruption D007617 1 associated lipids
Echinostomiasis D004451 1 associated lipids
Respiratory Tract Neoplasms D012142 2 associated lipids
Trichomonas Infections D014245 3 associated lipids
Deltaretrovirus Infections D006800 1 associated lipids
West Nile Fever D014901 1 associated lipids
Foot Ulcer D016523 4 associated lipids
Fibroadenoma D018226 2 associated lipids
Tinea Capitis D014006 1 associated lipids
Pancreatic Fistula D010185 2 associated lipids
Facial Nerve Injuries D020220 1 associated lipids
Lymphocele D008210 1 associated lipids
End Stage Liver Disease D058625 1 associated lipids
Thrombotic Microangiopathies D057049 1 associated lipids
Angiofibroma D018322 2 associated lipids
Posterior Leukoencephalopathy Syndrome D054038 1 associated lipids
Peroneal Neuropathies D020427 1 associated lipids
Hearing Loss, Bilateral D006312 1 associated lipids
Cheilitis D002613 2 associated lipids
Still's Disease, Adult-Onset D016706 2 associated lipids
Hidradenitis Suppurativa D017497 2 associated lipids
Lymphocytic Choriomeningitis D008216 1 associated lipids
Necrobiosis Lipoidica D009335 2 associated lipids
Vulvar Lichen Sclerosus D007724 1 associated lipids
Neuromyelitis Optica D009471 2 associated lipids
Optic Neuritis D009902 1 associated lipids
Dysplastic Nevus Syndrome D004416 1 associated lipids
Epidermolysis Bullosa D004820 3 associated lipids
Dendritic Cell Sarcoma, Interdigitating D054739 1 associated lipids
Epidermolysis Bullosa Dystrophica D016108 1 associated lipids
Churg-Strauss Syndrome D015267 2 associated lipids
Myelinolysis, Central Pontine D017590 1 associated lipids
Balanitis D001446 4 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

Download all related citations
Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Krenzien F et al. Age-Dependent Metabolic and Immunosuppressive Effects of Tacrolimus. 2017 Am. J. Transplant. pmid:27754593
Borrows R et al. Steroid sparing with tacrolimus and mycophenolate mofetil in renal transplantation. 2004 Am. J. Transplant. pmid:15476485
Hirsch HH et al. Polyomavirus BK replication in de novo kidney transplant patients receiving tacrolimus or cyclosporine: a prospective, randomized, multicenter study. 2013 Am. J. Transplant. pmid:23137180
Mujtaba MA et al. Conversion from tacrolimus to belatacept to prevent the progression of chronic kidney disease in pancreas transplantation: case report of two patients. 2014 Am. J. Transplant. pmid:25179306
Alloway RR et al. A randomized pharmacokinetic study of generic tacrolimus versus reference tacrolimus in kidney transplant recipients. 2012 Am. J. Transplant. pmid:22759200
Hesselink DA et al. Cyclosporine interacts with mycophenolic acid by inhibiting the multidrug resistance-associated protein 2. 2005 Am. J. Transplant. pmid:15816878
Byrne GW et al. Warfarin or low-molecular-weight heparin therapy does not prolong pig-to-primate cardiac xenograft function. 2005 Am. J. Transplant. pmid:15816881
Shergill AK et al. Applicability, tolerability and efficacy of preemptive antiviral therapy in hepatitis C-infected patients undergoing liver transplantation. 2005 Am. J. Transplant. pmid:15636619
Tydén G et al. ABO incompatible kidney transplantations without splenectomy, using antigen-specific immunoadsorption and rituximab. 2005 Am. J. Transplant. pmid:15636623
Woodle ES et al. A multicenter pilot study of early (4-day) steroid cessation in renal transplant recipients under simulect, tacrolimus and sirolimus. 2005 Am. J. Transplant. pmid:15636625
Padiyar A et al. Clinical predictors of proteinuria after conversion to sirolimus in kidney transplant recipients. 2010 Am. J. Transplant. pmid:20055793
Hardinger KL et al. BK-virus and the impact of pre-emptive immunosuppression reduction: 5-year results. 2010 Am. J. Transplant. pmid:20055811
Min SI et al. Conversion of twice-daily tacrolimus to once-daily tacrolimus formulation in stable pediatric kidney transplant recipients: pharmacokinetics and efficacy. 2013 Am. J. Transplant. pmid:23734831
Bunnapradist S et al. Conversion from twice-daily tacrolimus to once-daily extended release tacrolimus (LCPT): the phase III randomized MELT trial. 2013 Am. J. Transplant. pmid:23279614
Shapiro R et al. Alemtuzumab pre-conditioning with tacrolimus monotherapy in pediatric renal transplantation. 2007 Am. J. Transplant. pmid:17908272
Rush D et al. Lack of benefit of early protocol biopsies in renal transplant patients receiving TAC and MMF: a randomized study. 2007 Am. J. Transplant. pmid:17908280
Kofler S et al. Proton pump inhibitors reduce mycophenolate exposure in heart transplant recipients-a prospective case-controlled study. 2009 Am. J. Transplant. pmid:19519820
Arango C et al. A 29-year-old renal transplant recipient with acute respiratory failure. 2012 Am. J. Trop. Med. Hyg. pmid:22665592
Kyles AE et al. Comparison of the in vitro antiproliferative effects of five immunosuppressive drugs on lymphocytes in whole blood from cats. 2000 Am. J. Vet. Res. pmid:10951980
Kyles AE et al. Pharmacokinetics of tacrolimus after multidose oral administration and efficacy in the prevention of allograft rejection in cats with renal transplants. 2003 Am. J. Vet. Res. pmid:12856780
Holmgren G et al. Successful pregnancies and fatherhood in familial amyloidotic polyneuropathy (FAP Val30Met) patients with liver transplantation. 2004 Amyloid pmid:15478469
Fix OK et al. Liver transplant alone without kidney transplant for fibrinogen Aα-chain (AFib) renal amyloidosis. 2016 Amyloid pmid:26972447
Zahdi MR et al. Erosive pustular dermatosis of the scalp successfully treated with oral prednisone and topical tacrolimus. 2013 Sep-Oct An Bras Dermatol pmid:24173187
Delgado L et al. Zoon's plasma cell balanitis: a report of two cases treated with pimecrolimus. 2011 Jul-Aug An Bras Dermatol pmid:22068766
Viana Fde O et al. Acral lichen sclerosus et atrophicus--case report. 2011 Jul-Aug An Bras Dermatol pmid:22068779
Cakici O et al. Periorbital discoid lupus: a rare localization in a patient with systemic lupus erythematosus. An Bras Dermatol pmid:28300917
Lima RS et al. Granuloma faciale: a good therapeutic response with the use of topical tacrolimus. An Bras Dermatol pmid:26560220
Sisti A et al. Effectiveness and safety of topical tacrolimus monotherapy for repigmentation in vitiligo: a comprehensive literature review. 2016 An Bras Dermatol pmid:27192518
Tamler C et al. Tacrolimus 0,1% ointment in the treatment of vitiligo: a series of cases. 2011 Jan-Feb An Bras Dermatol pmid:21437550
Navas López VM et al. [Safety and efficacy of oral tacrolimus in the treatment of paediatric inflammatory bowel disease]. 2009 An Pediatr (Barc) pmid:19427822
Tomás ML [Immunosuppressive agents: side effects]. 1997 An R Acad Nac Med (Madr) pmid:9616947
den Burger JC et al. Analysis of cyclosporin A, tacrolimus, sirolimus, and everolimus in dried blood spot samples using liquid chromatography tandem mass spectrometry. 2012 Anal Bioanal Chem pmid:22899246
Neu V et al. On-line solid-phase extraction high-performance liquid chromatography-tandem mass spectrometry for the quantitative analysis of tacrolimus in whole blood hemolyzate. 2012 Anal Bioanal Chem pmid:22797715
Takahashi T et al. Isolating the whole complex of target proteins of FK506 using affinity resins from novel solid phases. 2006 Anal Bioanal Chem pmid:16601955
Nozaki K et al. Elimination technique for alkali metal ion adducts from an electrospray ionization process using an on-line ion suppressor. 2010 Anal Sci pmid:20543506
Murakami Y et al. On-chip micro-flow polystyrene bead-based immunoassay for quantitative detection of tacrolimus (FK506). 2004 Anal. Biochem. pmid:15464959
Sellar KJ et al. Spectrophotometric assay for calcineurin activity in leukocytes isolated from human blood. 2006 Anal. Biochem. pmid:16979577
Cañadas O et al. Equilibrium studies of a fluorescent tacrolimus binding to surfactant protein A. 2005 Anal. Biochem. pmid:15802130
Carreras CW et al. An FKBP12 binding assay based upon biotinylated FKBP12. 2001 Anal. Biochem. pmid:11673895
Ahn SC et al. A tactic for screening inhibitors of interleukin-2 production. 2002 Anal. Biochem. pmid:12018952
Park JW et al. Liquid chromatography-mass spectrometry characterization of FK506 biosynthetic intermediates in Streptomyces clavuligerus KCTC 10561BP. 2009 Anal. Biochem. pmid:19539594
Sonatore LM et al. The utility of FK506-binding protein as a fusion partner in scintillation proximity assays: application to SH2 domains. 1996 Anal. Biochem. pmid:8811923
Blanchet B et al. Determination of serine/threonine protein phosphatase type 2B PP2B in lymphocytes by HPLC. 2003 Anal. Biochem. pmid:12479828
Ohtsu Y et al. Selective ligand purification using high-performance affinity beads. 2005 Anal. Biochem. pmid:15745744
Rupprecht KR et al. Development of a dot-blot assay for screening monoclonal antibodies to low-molecular-mass drugs. 2010 Anal. Biochem. pmid:20696124
Wada A et al. Ribosome display and photo-cross-linking techniques for in vitro identification of target proteins of bioactive small molecules. 2014 Anal. Chem. pmid:24380432
Hopper JT and Oldham NJ Alkali metal cation-induced destabilization of gas-phase protein-ligand complexes: consequences and prevention. 2011 Anal. Chem. pmid:21863818
Sage L Fishing for MAGIC targets. 2005 Anal. Chem. pmid:16285140
Menotta M et al. Label-free quantification of Tacrolimus in biological samples by atomic force microscopy. 2015 Anal. Chim. Acta pmid:26073814
Gómez-Ríos GA et al. Rapid determination of immunosuppressive drug concentrations in whole blood by coated blade spray-tandem mass spectrometry (CBS-MS/MS). 2018 Anal. Chim. Acta pmid:29254576
Kim SK et al. Inflammatory mimetic microfluidic chip by immobilization of cell adhesion molecules for T cell adhesion. 2012 Analyst pmid:22822477
Park JY et al. Monitoring the status of T-cell activation in a microfluidic system. 2011 Analyst pmid:21623432
Brecht S et al. FK506 protects against various immune responses and secondary degeneration following cerebral ischemia. 2009 Anat Rec (Hoboken) pmid:19728359
Georgiou GK et al. Calcineurin inhibitors and male fertility after renal transplantation - a review. 2016 Andrologia pmid:26341518
Lang-Lazdunski L et al. The effects of FK506 on neurologic and histopathologic outcome after transient spinal cord ischemia induced by aortic cross-clamping in rats. 2001 Anesth. Analg. pmid:11323353
Siniscalchi A et al. Opioid-induced hyperalgesia and rapid opioid detoxification after tacrolimus administration. 2008 Anesth. Analg. pmid:18227327
Brooksbank RL et al. Treatment of normal skeletal muscle with FK506 or rapamycin results in halothane-induced muscle contracture. 1998 Anesthesiology pmid:9743407
Chini EN and Walker H FK506 (tacrolimus) increases halothane-induced Ca2+ release from skeletal muscle sarcoplasmic reticulum. 2000 Anesthesiology pmid:10781282
Brittain DE et al. Total synthesis of antascomicin B. 2005 Angew. Chem. Int. Ed. Engl. pmid:15806607
Lee KB et al. Direct monitoring of the inhibition of protein-protein interactions in cells by translocation of PKCδ fusion proteins. 2011 Angew. Chem. Int. Ed. Engl. pmid:21290501
McKenzie KM et al. Simultaneous identification of multiple protein targets by using complementary-DNA phage display and a natural-product-mimetic probe. 2004 Angew. Chem. Int. Ed. Engl. pmid:15300693
Feng S et al. A rapidly reversible chemical dimerizer system to study lipid signaling in living cells. 2014 Angew. Chem. Int. Ed. Engl. pmid:24841150
Althoff EA and Cornish VW A bacterial small-molecule three-hybrid system. 2002 Angew. Chem. Int. Ed. Engl. pmid:12203581
Elisaf M and Mikhailidis DP Statins and renal function. 2002 Sep-Oct Angiology pmid:12365855
Wüthrich B et al. Atopic eczema: genetics or environment? 2007 Ann Agric Environ Med pmid:18247450
Sahu MK et al. High blood tacrolimus and hyperkalemia in a heart transplant patient. Ann Card Anaesth pmid:28393798
Philippe F et al. [Drug eluting stents: from evidence based medicine to clinical practice]. 2005 Ann Cardiol Angeiol (Paris) pmid:16104621
Panis Y and Valleur P [Small intestine transplantation. Experimental and clinical results]. 1993 Ann Chir pmid:7504899
Busque S et al. [Hypertrichosis and gingival hypertrophy regression in renal transplants following the substitution of cyclosporin by tacrolimus]. 1999 Ann Chir pmid:10584376
Martin D et al. [First case in the world of autoreplantation of a limb associated with oral administration of an immunosupressant agent (FK 506-Tacrolimus)]. 2005 Ann Chir Plast Esthet pmid:16087038
Moncourier M et al. [Granulomatous periocular eruption]. Ann Dermatol Venereol pmid:28410769
Elloudi S et al. [Frontal fibrosing alopecia: A prospective study of 20 cases]. Ann Dermatol Venereol pmid:28258757
Mirkamali A et al. [Ulcerated necrobiosis lipoidica: successful treatment with topical tacrolimus and hydroxychloroquine]. 2010 Aug-Sep Ann Dermatol Venereol pmid:20804904
Parodi A et al. Treatment of rosacea. 2011 Ann Dermatol Venereol pmid:22183101
Schmutz JL et al. [Pimecrolimus and vaccinations]. 2007 Jun-Jul Ann Dermatol Venereol pmid:17702119
Alquier-Bouffard A et al. [Chronic actinic dermatitis: treatment with topical tacrolimus (two cases)]. 2007 Jun-Jul Ann Dermatol Venereol pmid:17657183
Schmutz JL [No increased risk of cancer under pimecrolimus]. 2016 Ann Dermatol Venereol pmid:26708204
Parodi A et al. [Treatment of rosacea]. 2011 Ann Dermatol Venereol pmid:21907876
Mahé E et al. [Plane warts in areas of atopic dermatitis treated with tacrolimus ointment]. 2006 Aug-Sep Ann Dermatol Venereol pmid:17053745
Girault PY et al. [Topical tacrolimus in chronic actinic dermatitis]. 2008 Ann Dermatol Venereol pmid:18929923
Rouxel AM et al. [Tacrolimus mouthwash as second-line treatment for erosive oral lichen planus]. 2010 Ann Dermatol Venereol pmid:20932447
Skowron F et al. [Important systemic absorption of topical tacrolimus during treatment of severe pemphigus vulgaris]. 2005 Ann Dermatol Venereol pmid:15924053
Martel J et al. [Subcutaneous mycosis due to Scopulariopsis brevicaulis in an immunocompromised patient]. 2001 Ann Dermatol Venereol pmid:11275588
Nouchi A et al. [Treatment of angiolymphoid hyperplasia with eosinophilia (ALHE) using topical tacrolimus: Two cases]. 2015 Ann Dermatol Venereol pmid:25778634
Reynaert G et al. [Streptococcal impetigo at topical tacrolimus application sites in a woman with atopic dermatitis]. 2007 Ann Dermatol Venereol pmid:17389853
Al Gain M et al. [Sirolimus-induced lymphedema in a kidney-transplant recipient: Partial recovery after changeover to tacrolimus]. 2015 Ann Dermatol Venereol pmid:25683011
Chiheb S et al. [Behçet's disease]. 2003 Jun-Jul Ann Dermatol Venereol pmid:13679709
Baubion E et al. [Oral lichen planus and treatment with topical tacrolimus rinse]. 2009 Ann Dermatol Venereol pmid:19328313
Schmutz JL et al. [Kaposi's sarcoma in an AIDS patient after application of tacrolimus (Protopic)]. 2006 Ann Dermatol Venereol pmid:16800194
Henno A et al. [Improvement of Netherton syndrome associated erythroderma in two adult sisters through use of topical pimecrolimus]. 2006 Ann Dermatol Venereol pmid:16495860
Michel JL and Gain P [Topical tacrolimus treatment for ocular cicatricial pemphigoid]. 2006 Ann Dermatol Venereol pmid:16508602
Lacour JP [Topical tacrolimus in dermatology: what can one expect?]. 2001 Ann Dermatol Venereol pmid:11908129
Macario-Barrel A et al. [Mouth ulcers in patients receiving tacrolimus]. 2001 Ann Dermatol Venereol pmid:11908135
Firmin D et al. [Tacrolimus ointment in the treatment of chronic cutaneous graft-versus-host disease]. 2008 Ann Dermatol Venereol pmid:18374862
Ferraro V et al. [Efficacy of topical tacrolimus in Hailey-Hailey disease]. 2006 Ann Dermatol Venereol pmid:16760841
Fery-Blanco C et al. [Disseminated molluscum contagiosum during topical treatment of atopic dermatitis with tacrolimus: efficacy of cidofovir]. 2007 Ann Dermatol Venereol pmid:17507844
Schmutz J et al. [Gingival hypertrophy and tacrolimus]. 2000 Jun-Jul Ann Dermatol Venereol pmid:10930868
Lübbe J and Saurat JH [A monograph on topical tacrolimus (Protopic]. 2003 Ann Dermatol Venereol pmid:12700537
de Prost Y [The value of topical immunosuppressors in the treatment of atopic dermatitis in children]. 2005 Ann Dermatol Venereol pmid:15984296
de Prost Y [Can the precautionary principle obstruct therapeutic progress?]. 2005 Aug-Sep Ann Dermatol Venereol pmid:16230911