Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Dickerson JA et al. | Tacrolimus and sirolimus in capillary dried blood spots allows for remote monitoring. | 2015 | Pediatr Transplant | pmid:25414084 |
Rivelli RF et al. | Early withdrawal of calcineurin inhibitor from a sirolimus-based immunosuppression stabilizes fibrosis and the transforming growth factor-β signalling pathway in kidney transplant. | 2015 | Nephrology (Carlton) | pmid:25404086 |
Jahan A et al. | Clinical efficacy and pharmacokinetics of tacrolimus in children with steroid-resistant nephrotic syndrome. | 2015 | Pediatr. Nephrol. | pmid:26135137 |
Marquezan MC et al. | Effect of Topical Tacrolimus in the Treatment of Thygeson's Superficial Punctate Keratitis. | 2015 | Am. J. Ophthalmol. | pmid:26133248 |
Birdwell KA et al. | Assessment of arterial stiffness using pulse wave velocity in tacrolimus users the first year post kidney transplantation: a prospective cohort study. | 2015 | BMC Nephrol | pmid:26133166 |
Cury Martins J et al. | Topical tacrolimus for atopic dermatitis. | 2015 | Cochrane Database Syst Rev | pmid:26132597 |
Prinz V et al. | MRI heralds secondary nigral lesion after brain ischemia in mice: a secondary time window for neuroprotection. | 2015 | J. Cereb. Blood Flow Metab. | pmid:26126863 |
Izumi Y et al. | Two cases of refractory polymyositis accompanied with steroid myopathy. | 2015 | Mod Rheumatol | pmid:24533547 |
Gallon L et al. | Cellular and molecular immune profiles in renal transplant recipients after conversion from tacrolimus to sirolimus. | 2015 | Kidney Int. | pmid:25354238 |
Pamuk F et al. | Evaluation of gingival alterations in rats medicated with cyclosporine A, tacrolimus and sirolimus: a stereological study. | 2015 | J. Periodont. Res. | pmid:25399832 |
Gordon P and Gooptu B | Tacrolimus in idiopathic inflammatory myopathy-associated interstitial lung disease: defining roles and responders. | 2015 | Rheumatology (Oxford) | pmid:25342374 |
Huang X and Xu B | Efficacy and Safety of Tacrolimus versus Pimecrolimus for the Treatment of Atopic Dermatitis in Children: A Network Meta-Analysis. | 2015 | Dermatology (Basel) | pmid:26043855 |
Milam EC et al. | Treatment of Scarring Alopecia in Discoid Variant of Chronic Cutaneous Lupus Erythematosus With Tacrolimus Lotion, 0.3. | 2015 | JAMA Dermatol | pmid:26039539 |
Shi WL et al. | Effects of the CYP3A4*1B Genetic Polymorphism on the Pharmacokinetics of Tacrolimus in Adult Renal Transplant Recipients: A Meta-Analysis. | 2015 | PLoS ONE | pmid:26039043 |
Wozniak LJ et al. | Donor-specific HLA Antibodies Are Associated With Late Allograft Dysfunction After Pediatric Liver Transplantation. | 2015 | Transplantation | pmid:26038872 |
Argudo A et al. | Liver Transplant Patient Carriers of Polymorphism Cyp3a5*1 Donors May Need More Doses of Tacrolimus From the First Month After Transplantation. | 2015 | Transplant. Proc. | pmid:26518936 |
Xia Z et al. | Refractory Dyslipidemia After Liver Transplant: Case Study With Successive Histologic Investigations. | 2015 | Exp Clin Transplant | pmid:25924105 |
Zheng L et al. | Simultaneous determination of cortisol, cortisone, 6β-hydroxycortisol and 6β-hydroxycortisone by HPLC. | 2015 | J Chromatogr Sci | pmid:25628347 |
Gupta G et al. | Safe Conversion From Tacrolimus to Belatacept in High Immunologic Risk Kidney Transplant Recipients With Allograft Dysfunction. | 2015 | Am. J. Transplant. | pmid:25988397 |
Söderlund C and Rådegran G | Safety and efficacy of the switch to generic mycophenolate mofetil and tacrolimus in heart transplant patients. | 2015 | Clin Transplant | pmid:25981927 |
van Boekel GA et al. | Limited sampling strategy for prolonged-release tacrolimus in renal transplant patients by use of the dried blood spot technique. | 2015 | Eur. J. Clin. Pharmacol. | pmid:25980838 |
de Jonge H et al. | The CYP3A4*22 C>T single nucleotide polymorphism is associated with reduced midazolam and tacrolimus clearance in stable renal allograft recipients. | 2015 | Pharmacogenomics J. | pmid:25287072 |
Jin S et al. | Exposure to Radiocontrast Agents Induces Pancreatic Inflammation by Activation of Nuclear Factor-κB, Calcium Signaling, and Calcineurin. | 2015 | Gastroenterology | pmid:25980752 |
Wiseman AC | Induction Therapy in Renal Transplantation: Why? What Agent? What Dose? We May Never Know. | 2015 | Clin J Am Soc Nephrol | pmid:25979977 |
Ratanatharathorn V et al. | Low-dose antithymocyte globulin enhanced the efficacy of tacrolimus and mycophenolate for GVHD prophylaxis in recipients of unrelated SCT. | 2015 | Bone Marrow Transplant. | pmid:25285804 |
Lin YK et al. | Using Imiquimod-Induced Psoriasis-Like Skin as a Model to Measure the Skin Penetration of Anti-Psoriatic Drugs. | 2015 | PLoS ONE | pmid:26355594 |
Kang YZ et al. | Autoimmune hepatitis-primary biliary cirrhosis concurrent with biliary stricture after liver transplantation. | 2015 | World J. Gastroenterol. | pmid:25717264 |
Andrews LM et al. | Dosing algorithms for initiation of immunosuppressive drugs in solid organ transplant recipients. | 2015 | Expert Opin Drug Metab Toxicol | pmid:25865963 |
Murata M | Prophylactic and therapeutic treatment of graft-versus-host disease in Japan. | 2015 | Int. J. Hematol. | pmid:25864188 |
Cuervas-Mons V et al. | Impact of tacrolimus and mycophenolate mofetil regimen vs. a conventional therapy with steroids on cardiovascular risk in liver transplant patients. | 2015 | Clin Transplant | pmid:25924549 |
Hategan A and Bourgeois JA | Tacrolimus neurotoxicity and the role of the Renin-Angiotensin system. | 2015 | J Neuropsychiatry Clin Neurosci | pmid:25923858 |
Blasco-Morente G et al. | Long-Standing Presternal Plaque. | 2015 | Actas Dermosifiliogr | pmid:25917959 |
Ferraresso M et al. | Relationship between mRNA expression levels of CYP3A4, CYP3A5 and SXR in peripheral mononuclear blood cells and aging in young kidney transplant recipients under tacrolimus treatment. | 2015 | Pharmacogenomics | pmid:25916520 |
Li JS et al. | Angiopoietin-Like-4, a Potential Target of Tacrolimus, Predicts Earlier Podocyte Injury in Minimal Change Disease. | 2015 | PLoS ONE | pmid:26352670 |
Lin S et al. | Interleukin-2 receptor antagonist therapy leads to increased tacrolimus levels after kidney transplantation. | 2015 | Ther Drug Monit | pmid:25162212 |
Zhu L et al. | Effects of CYP3A5 genotypes, ABCB1 C3435T and G2677T/A polymorphism on pharmacokinetics of Tacrolimus in Chinese adult liver transplant patients. | 2015 | Xenobiotica | pmid:25869250 |
Jiang H et al. | An acyltransferase domain of FK506 polyketide synthase recognizing both an acyl carrier protein and coenzyme A as acyl donors to transfer allylmalonyl and ethylmalonyl units. | 2015 | FEBS J. | pmid:25865045 |
Josephson MA et al. | American society of Nephrology Quiz and Questionnaire 2014: transplantation. | 2015 | Clin J Am Soc Nephrol | pmid:25862775 |
Peña C et al. | [Secondary acute myeloid leukemia in a lung allograft recipient. Report of one case]. | 2015 | Rev Med Chil | pmid:25860370 |
Liu S et al. | Comparison of tripterygium wilfordii multiglycosides and tacrolimus in the treatment of idiopathic membranous nephropathy: a prospective cohort study. | 2015 | BMC Nephrol | pmid:26637482 |
Watanabe K et al. | The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease. | 2015 | Mol Brain | pmid:26637371 |
Wang L et al. | Effect of CYP3A5 gene polymorphisms on tacrolimus concentration/dosage ratio in adult liver transplant patients. | 2015 | Genet. Mol. Res. | pmid:26634478 |
RodrÃguez-RodrÃguez AE et al. | Glucose homeostasis changes and pancreatic β-cell proliferation after switching to cyclosporin in tacrolimus-induced diabetes mellitus. | 2015 | Nefrologia | pmid:26299169 |
Kurita T et al. | The efficacy of calcineurin inhibitors for the treatment of interstitial lung disease associated with polymyositis/dermatomyositis. | 2015 | Lupus | pmid:25297551 |
Birdwell KA et al. | Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing. | 2015 | Clin. Pharmacol. Ther. | pmid:25801146 |
Solomon SR et al. | Total Body Irradiation-Based Myeloablative Haploidentical Stem Cell Transplantation Is a Safe and Effective Alternative to Unrelated Donor Transplantation in Patients Without Matched Sibling Donors. | 2015 | Biol. Blood Marrow Transplant. | pmid:25797174 |
Shokati T et al. | Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS. | 2015 | J Vis Exp | pmid:26575262 |
Dedinská I et al. | Waist circumference as an independent risk factor for NODAT. | 2015 | Ann. Transplant. | pmid:25791039 |
Furie R et al. | Lessons Learned From the Clinical Trials of Novel Biologics and Small Molecules in Lupus Nephritis. | 2015 | Semin. Nephrol. | pmid:26573553 |
Abe Y et al. | Successful Management of Lupus Nephritis with High Titers of Myeloperoxidase Anti-Neutrophil Cytoplasmic Antibodies Using Tacrolimus. | 2015 | Intern. Med. | pmid:26568012 |
William BM and de Lima M | Sirolimus plus calcineurin inhibitors and methotrexate: is more necessarily better? | 2015 | Leuk. Lymphoma | pmid:25065702 |
Gu L et al. | A retrospective study to compare the use of tacrolimus and cyclosporine in combination with adriamycin in post-transplant liver cancer patients. | 2015 | Cell Biochem. Biophys. | pmid:25287673 |
Ambrosioni J et al. | Role of rhinovirus load in the upper respiratory tract and severity of symptoms in lung transplant recipients. | 2015 | J. Clin. Virol. | pmid:25728070 |
Marcus EA et al. | Successful term pregnancy in an intestine-pancreas transplant recipient with chronic graft dysfunction and parenteral nutrition dependence: a case report. | 2015 | Transplant. Proc. | pmid:25724255 |
Dias PH et al. | Effects of immunosuppression with tacrolimus and mycophenolate mofetil on renal histology and function in single kidney rats submitted to ischemia and reperfusion. | 2015 | Acta Cir Bras | pmid:25714692 |
Guerra Júnior AA et al. | Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil. | 2015 | Rev Saude Publica | pmid:25741648 |
Youbin Z et al. | Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Gene Overexpression Prolongs the Survival of Rat Allogeneic Heart Allografts. | 2015 | Transplant. Proc. | pmid:26518962 |
Schwarz C et al. | Tacrolimus, Mycophenolate Mofetil, and Low-Dose Steroids With or Without Interleukin-2 Receptor Antibody Induction Therapy: A Retrospective Cohort Analysis. | 2015 | Transplant. Proc. | pmid:26518948 |
Ko MS et al. | Tacrolimus therapy causes hepatotoxicity in patients with a history of liver disease. | 2015 | Int J Clin Pharmacol Ther | pmid:25740263 |
Townamchai N et al. | A Simple Novel Technique to Estimate Tacrolimus Dosages During the Early Post Kidney Transplantation Period. | 2015 | Transplant. Proc. | pmid:26518946 |
San Miguel C et al. | Immunosuppression Strategies in the Treatment of Hepatocellular Carcinoma in Virgen de las Nieves University Hospital. | 2015 | Transplant. Proc. | pmid:26518930 |
Cotton D | Celebrating the ACP centennial: from the Annals archive. | 2015 | Ann. Intern. Med. | pmid:25560715 |
Kadlub N et al. | The calcineurin inhibitor tacrolimus as a new therapy in severe cherubism. | 2015 | J. Bone Miner. Res. | pmid:25491283 |
Katayama K et al. | Inhibition of radiographic joint damage in rheumatoid arthritis patients in DAS28 remission using single- or combined with methotrexate non biological disease-modifying antirheumatic drug therapy in routine clinical practice. | 2015 | Mod Rheumatol | pmid:24983407 |
Ramesh M et al. | A novel phosphatidic acid-protein-tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cells. | 2015 | J. Biol. Chem. | pmid:25681440 |
Pascher A et al. | Protein kinase C inhibitor sotrastaurin in de novo liver transplant recipients: a randomized phase II trial. | 2015 | Am. J. Transplant. | pmid:25677074 |
Tavira B et al. | The donor ABCB1 (MDR-1) C3435T polymorphism is a determinant of the graft glomerular filtration rate among tacrolimus treated kidney transplanted patients. | 2015 | J. Hum. Genet. | pmid:25673014 |
Wang Y et al. | Justification of noninferiority margin: methodology considerations in an exposure-response analysis. | 2015 | Clin. Pharmacol. Ther. | pmid:25670256 |
BuendÃa JA et al. | Combinational Effect of CYP3A5 and MDR-1 Polymorphisms on Tacrolimus Pharmacokinetics in Liver Transplant Patients. | 2015 | Exp Clin Transplant | pmid:26450467 |
Dumortier T et al. | Estimating the contribution of everolimus to immunosuppressive efficacy when combined with tacrolimus in liver transplantation: a model-based approach. | 2015 | Clin. Pharmacol. Ther. | pmid:25669933 |
Kikuchi T et al. | Outcome of reduced-intensity allogeneic hematopoietic stem cell transplantation for multiple myeloma. | 2015 | Int. J. Hematol. | pmid:26440970 |
Dai DS et al. | Protective Effect of Salvia Przewalskii Extract on Puromycin-Induced Podocyte Injury. | 2015 | Am. J. Nephrol. | pmid:26439819 |
Wu SC et al. | Identification of Circulating miRNAs in a Mouse Model of Nerve Allograft Transplantation under FK506 Immunosuppression by Illumina Small RNA Deep Sequencing. | 2015 | Dis. Markers | pmid:26435568 |
Ceberio I et al. | Sirolimus, tacrolimus and low-dose methotrexate based graft-versus-host disease prophylaxis after non-ablative or reduced intensity conditioning in related and unrelated donor allogeneic hematopoietic cell transplant. | 2015 | Leuk. Lymphoma | pmid:24913499 |
Xie X et al. | mTOR inhibitor versus mycophenolic acid as the primary immunosuppression regime combined with calcineurin inhibitor for kidney transplant recipients: a meta-analysis. | 2015 | BMC Nephrol | pmid:26126806 |
Aouam K et al. | Development of Limited Sampling Strategies for the Estimation of Tacrolimus Area Under the Curve in Adult Kidney Transplant Recipients According to the Posttransplantation Time. | 2015 | Ther Drug Monit | pmid:25627405 |
Farhangian ME et al. | Treatment of Alopecia Areata in the United States: A Retrospective Cross-Sectional Study. | 2015 | J Drugs Dermatol | pmid:26355621 |
Oguni H and Hayashi M | [Topics for authorization of new intravenous antiepileptic drugs and tacrolimus for autoimmune epilepsy]. | 2015 | No To Hattatsu | pmid:26349372 |
Dave CN et al. | Innovative use of intravesical tacrolimus for hemorrhagic radiation cystitis. | 2015 | Int Urol Nephrol | pmid:26347076 |
Wu J et al. | MicroRNA-30 family members regulate calcium/calcineurin signaling in podocytes. | 2015 | J. Clin. Invest. | pmid:26436650 |
Kawahara T et al. | The role of NFATc1 in prostate cancer progression: cyclosporine A and tacrolimus inhibit cell proliferation, migration, and invasion. | 2015 | Prostate | pmid:25631176 |
Lemaitre F et al. | Pharmacokinetics and pharmacodynamics of tacrolimus in liver transplant recipients: inside the white blood cells. | 2015 | Clin. Biochem. | pmid:25562187 |
Palanisamy AP et al. | Induction therapy: clinical and quality of life outcomes in aged renal transplant recipients. | 2015 | Clin Transplant | pmid:25557762 |
Bhadauria D et al. | Cryptosporidium infection after renal transplantation in an endemic area. | 2015 | Transpl Infect Dis | pmid:25620388 |
Luger T et al. | Pimecrolimus in atopic dermatitis: consensus on safety and the need to allow use in infants. | 2015 | Pediatr Allergy Immunol | pmid:25557211 |
Burke MT et al. | Genetics and nonmelanoma skin cancer in kidney transplant recipients. | 2015 | Pharmacogenomics | pmid:25616102 |
Schnitzler F et al. | Solid Organ Transplantation in Patients with Inflammatory Bowel Diseases (IBD): Analysis of Transplantation Outcome and IBD Activity in a Large Single Center Cohort. | 2015 | PLoS ONE | pmid:26288187 |
Al-Harbi NO et al. | Treatment with aliskiren ameliorates tacrolimus-induced nephrotoxicity in rats. | 2015 | J Renin Angiotensin Aldosterone Syst | pmid:24737642 |
Lawrence MC et al. | NFAT targets signaling molecules to gene promoters in pancreatic β-cells. | 2015 | Mol. Endocrinol. | pmid:25496032 |
Chakraborty S et al. | Prediction of in vivo drug performance using in vitro dissolution coupled with STELLA: a study with selected drug products. | 2015 | Drug Dev Ind Pharm | pmid:25494535 |
Denardi LB et al. | Synergistic effects of tacrolimus and azole antifungal compounds in fluconazole-susceptible and fluconazole-resistant Candida glabrata isolates. | 2015 | Braz. J. Microbiol. | pmid:26221097 |
Kloster-Jensen K et al. | Intracellular sirolimus concentration is reduced by tacrolimus in human pancreatic islets in vitro. | 2015 | Transpl. Int. | pmid:26046470 |
Scholz FM et al. | Focal metatarsal fistulae syndrome affecting a greyhound dog successfully treated with topical 0.1% tacrolimus ointment. | 2015 | Vet. Dermatol. | pmid:26216245 |
Koster RA et al. | The performance of five different dried blood spot cards for the analysis of six immunosuppressants. | 2015 | Bioanalysis | pmid:26045003 |
Hauch A et al. | Generics: are all immunosuppression agents created equally? | 2015 | Surgery | pmid:26206317 |
Borda B et al. | [Frequency of T-cell mediated rejection in new-onset diabetes after kidney transplantation]. | 2015 | Orv Hetil | pmid:26039918 |
Albring A et al. | Relationship between pharmacokinetics and pharmacodynamics of calcineurin inhibitors in renal transplant patients. | 2015 | Clin Transplant | pmid:25557538 |
Georgakopoulou EA and Scully C | Systemic use of non-biologic agents in orofacial diseases: other immunomodulatory agents. | 2015 | Oral Dis | pmid:24028818 |
Türkoğlu O et al. | Are antimicrobial peptides related to cyclosporine A-induced gingival overgrowth? | 2015 | Arch. Oral Biol. | pmid:25555253 |
Lancia P et al. | Choosing the right dose of tacrolimus. | 2015 | Arch. Dis. Child. | pmid:25416736 |