MeSH term | MeSH ID | Detail |
---|---|---|
Retrognathia | D063173 | 1 associated lipids |
Drug-Related Side Effects and Adverse Reactions | D064420 | 3 associated lipids |
Scorpion Stings | D065008 | 1 associated lipids |
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Gao G et al. | Rapamycin inhibits hydrogen peroxide-induced loss of vascular contractility. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21357511 |
Giordano A et al. | Differential effect of atorvastatin and tacrolimus on proliferation of vascular smooth muscle and endothelial cells. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22058159 |
Ogino A et al. | Amlodipine inhibits granulation tissue cell apoptosis through reducing calcineurin activity to attenuate postinfarction cardiac remodeling. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17644576 |
Tang WX et al. | Role of FKBP12.6 in cADPR-induced activation of reconstituted ryanodine receptors from arterial smooth muscle. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11893565 |
Liu Y et al. | Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22408025 |
Sasamori K et al. | Cyclic ADP-ribose, a putative Ca2+-mobilizing second messenger, operates in submucosal gland acinar cells. | 2004 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:14990397 |
Lum H et al. | Protein phosphatase 2B inhibitor potentiates endothelial PKC activity and barrier dysfunction. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11504680 |
Yaghi A and Sims SM | Constrictor-induced translocation of NFAT3 in human and rat pulmonary artery smooth muscle. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16055480 |
Bouvier N et al. | Cyclosporine triggers endoplasmic reticulum stress in endothelial cells: a role for endothelial phenotypic changes and death. | 2009 | Am. J. Physiol. Renal Physiol. | pmid:18987109 |
Ren H et al. | Phosphatase inhibition increases AQP2 accumulation in the rat IMCD apical plasma membrane. | 2016 | Am. J. Physiol. Renal Physiol. | pmid:27488997 |
Thai TL et al. | ADP-ribosyl cyclase and ryanodine receptor activity contribute to basal renal vasomotor tone and agonist-induced renal vasoconstriction in vivo. | 2007 | Am. J. Physiol. Renal Physiol. | pmid:17652368 |
Peherstorfer E et al. | Effects of microinjection of synthetic Bcl-2 domain peptides on apoptosis of renal tubular epithelial cells. | 2002 | Am. J. Physiol. Renal Physiol. | pmid:12060601 |
Axelsson J et al. | Scavengers of reactive oxygen species, paracalcitol, RhoA, and Rac-1 inhibitors and tacrolimus inhibit angiotensin II-induced actions on glomerular permeability. | 2013 | Am. J. Physiol. Renal Physiol. | pmid:23657856 |
Mohebbi N et al. | The calcineurin inhibitor FK506 (tacrolimus) is associated with transient metabolic acidosis and altered expression of renal acid-base transport proteins. | 2009 | Am. J. Physiol. Renal Physiol. | pmid:19439519 |
Cho SG et al. | Drp1 dephosphorylation in ATP depletion-induced mitochondrial injury and tubular cell apoptosis. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:20410216 |
De Miguel C et al. | Infiltrating T lymphocytes in the kidney increase oxidative stress and participate in the development of hypertension and renal disease. | 2011 | Am. J. Physiol. Renal Physiol. | pmid:21159736 |
Rojas-Vega L et al. | Increased phosphorylation of the renal Na+-Cl- cotransporter in male kidney transplant recipient patients with hypertension: a prospective cohort. | 2015 | Am. J. Physiol. Renal Physiol. | pmid:26336164 |
Edinger RS et al. | Effect of immunosuppressive agents on glucocorticoid receptor function in A6 cells. | 2002 | Am. J. Physiol. Renal Physiol. | pmid:12110508 |
Ilori TO et al. | Acute calcineurin inhibition with tacrolimus increases phosphorylated UT-A1. | 2012 | Am. J. Physiol. Renal Physiol. | pmid:22205230 |
Amberg GC et al. | Regulation of A-type potassium channels in murine colonic myocytes by phosphatase activity. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11698261 |
Ahn HS et al. | Calcineurin-independent inhibition of KV1.3 by FK-506 (tacrolimus): a novel pharmacological property. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17166943 |
Wang YX et al. | FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells. | 2004 | Am. J. Physiol., Cell Physiol. | pmid:14592808 |
Sans MD and Williams JA | Calcineurin is required for translational control of protein synthesis in rat pancreatic acini. | 2004 | Am. J. Physiol., Cell Physiol. | pmid:15044154 |
Bayguinov O et al. | Muscarinic stimulation increases basal Ca(2+) and inhibits spontaneous Ca(2+) transients in murine colonic myocytes. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11171588 |
Angus LM et al. | Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15930144 |
Zhang Y et al. | K restriction inhibits protein phosphatase 2B (PP2B) and suppression of PP2B decreases ROMK channel activity in the CCD. | 2008 | Am. J. Physiol., Cell Physiol. | pmid:18184875 |
Yue G et al. | The effect of rapamycin on single ENaC channel activity and phosphorylation in A6 cells. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10898719 |
Nam JH et al. | Expression of TASK-2 and its upregulation by B cell receptor stimulation in WEHI-231 mouse immature B cells. | 2011 | Am. J. Physiol., Cell Physiol. | pmid:21307343 |
Nakagawa K et al. | Immunosuppression with tacrolimus improved reproductive outcome of women with repeated implantation failure and elevated peripheral blood TH1/TH2 cell ratios. | 2015 | Am. J. Reprod. Immunol. | pmid:25394810 |
Nakagawa K et al. | Immunosuppressive treatment using tacrolimus promotes pregnancy outcome in infertile women with repeated implantation failures. | 2017 | Am. J. Reprod. Immunol. | pmid:28466977 |
Saito S et al. | Role of Paternal Antigen-Specific Treg Cells in Successful Implantation. | 2016 | Am. J. Reprod. Immunol. | pmid:26706630 |
Kofod L et al. | Endometrial immune markers are potential predictors of normal fertility and pregnancy after in vitro fertilization. | 2017 | Am. J. Reprod. Immunol. | pmid:28440588 |
Tabata C et al. | Calcineurin/NFAT pathway: a novel regulator of parturition. | 2009 | Am. J. Reprod. Immunol. | pmid:19527231 |
Goldthorpe H et al. | Occlusive lung arterial lesions in endothelial-targeted, fas-induced apoptosis transgenic mice. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25879383 |
Fujiki M et al. | Role of T cells in bronchoalveolar space in the development of interstitial pneumonia induced by superantigen in autoimmune-prone mice. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10572064 |
Deuse T et al. | Mechanisms behind local immunosuppression using inhaled tacrolimus in preclinical models of lung transplantation. | 2010 | Am. J. Respir. Cell Mol. Biol. | pmid:19880819 |
Rolfe FG et al. | Cyclosporin A and FK506 reduce interleukin-5 mRNA abundance by inhibiting gene transcription. | 1997 | Am. J. Respir. Cell Mol. Biol. | pmid:9271313 |
Yerkovich ST et al. | Survival after bronchiolitis obliterans syndrome. | 2011 | Am. J. Respir. Crit. Care Med. | pmid:21325085 |
Bhorade S et al. | Comparison of sirolimus with azathioprine in a tacrolimus-based immunosuppressive regimen in lung transplantation. | 2011 | Am. J. Respir. Crit. Care Med. | pmid:20833822 |
Koshika T et al. | Pretreatment with FK506 improves survival rate and gas exchange in canine model of acute lung injury. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11208629 |
Saeki K et al. | Endobronchial Lesions of Mycobacterium abscessus Infection in an Immunocompromised Patient. | 2017 | Am. J. Respir. Crit. Care Med. | pmid:28199133 |
Joshi MS et al. | Calcineurin regulates myocardial function during acute endotoxemia. | 2006 | Am. J. Respir. Crit. Care Med. | pmid:16424445 |
Fauvel H et al. | Protective effects of cyclosporin A from endotoxin-induced myocardial dysfunction and apoptosis in rats. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11850335 |
Spiekerkoetter E et al. | Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension. | 2015 | Am. J. Respir. Crit. Care Med. | pmid:26177174 |
Raofi V et al. | A prospective randomized trial comparing the efficacy of tacrolimus versus cyclosporine in black recipients of primary cadaveric renal transplants. | 1999 | Am. J. Surg. | pmid:10326847 |
Tanaka K et al. | Living related liver transplantation in children. | 1994 | Am. J. Surg. | pmid:7517649 |
Li X et al. | Increased iNOS-expressing macrophage in long-term surviving rat small-bowel grafts. | 2007 | Am. J. Surg. | pmid:17618815 |
Rabkin JM et al. | Immunosuppression impact on long-term cardiovascular complications after liver transplantation. | 2002 | Am. J. Surg. | pmid:12034401 |
Jurim O et al. | Living-donor liver transplantation at UCLA. | 1995 | Am. J. Surg. | pmid:7538267 |
Lee KK et al. | Successful treatment of ongoing intestinal allograft rejection permits recovery of graft structure and function. | 1993 | Am. J. Surg. | pmid:7678188 |
Finn L et al. | Epstein-Barr virus infections in children after transplantation of the small intestine. | 1998 | Am. J. Surg. Pathol. | pmid:9500771 |
Randhawa PS et al. | The histopathological changes associated with allograft rejection and drug toxicity in renal transplant recipients maintained on FK506. Clinical significance and comparison with cyclosporine. | 1993 | Am. J. Surg. Pathol. | pmid:7680544 |
Minervini MI et al. | Acute renal allograft rejection with severe tubulitis (Banff 1997 grade IB). | 2000 | Am. J. Surg. Pathol. | pmid:10757402 |
Randhawa PS et al. | Microvascular changes in renal allografts associated with FK506 (Tacrolimus) therapy. | 1996 | Am. J. Surg. Pathol. | pmid:8772784 |
Kim EJ et al. | Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection. | 2014 | Am. J. Transplant. | pmid:24354871 |
Frassetto LA et al. | Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients. | 2007 | Am. J. Transplant. | pmid:17949460 |
Cosio FG and Larson TS | Cardiovascular disease after transplantation: do we know all of the variables? | 2003 | Am. J. Transplant. | pmid:12859523 |
Levitsky J and Feng S | Sirolimus and mTOR inhibitors in liver transplantation: the wheel has come full circle. | 2014 | Am. J. Transplant. | pmid:24620373 |
Krämer BK et al. | Cardiovascular risk factors and estimated risk for CAD in a randomized trial comparing calcineurin inhibitors in renal transplantation. | 2003 | Am. J. Transplant. | pmid:12859533 |
Ciancio G et al. | The use of daclizumab, tacrolimus and mycophenolate mofetil in african-american and Hispanic first renal transplant recipients. | 2003 | Am. J. Transplant. | pmid:12859538 |
Asrani SK et al. | De novo sirolimus and reduced-dose tacrolimus versus standard-dose tacrolimus after liver transplantation: the 2000-2003 phase II prospective randomized trial. | 2014 | Am. J. Transplant. | pmid:24456026 |
Song L et al. | ASP2409, A Next-Generation CTLA4-Ig, Versus Belatacept in Renal Allograft Survival in Cynomolgus Monkeys. | 2017 | Am. J. Transplant. | pmid:27598231 |
Ekberg H et al. | Calcineurin inhibitor minimization in the Symphony study: observational results 3 years after transplantation. | 2009 | Am. J. Transplant. | pmid:19563339 |
Grimm M et al. | Superior prevention of acute rejection by tacrolimus vs. cyclosporine in heart transplant recipients--a large European trial. | 2006 | Am. J. Transplant. | pmid:16686762 |
Sis B et al. | Reproducibility studies on arteriolar hyaline thickening scoring in calcineurin inhibitor-treated renal allograft recipients. | 2006 | Am. J. Transplant. | pmid:16686769 |
Duncan FJ et al. | Clinically relevant immunosuppressants influence UVB-induced tumor size through effects on inflammation and angiogenesis. | 2007 | Am. J. Transplant. | pmid:17941958 |
Hu X et al. | Chimeric Allografts Induced by Short-Term Treatment With Stem Cell-Mobilizing Agents Result in Long-Term Kidney Transplant Survival Without Immunosuppression: A Study in Rats. | 2016 | Am. J. Transplant. | pmid:26749344 |
Cameron AM et al. | Chimeric Allografts Induced by Short-Term Treatment With Stem Cell Mobilizing Agents Result in Long-Term Kidney Transplant Survival Without Immunosuppression: II, Study in Miniature Swine. | 2016 | Am. J. Transplant. | pmid:26748958 |
Bouamar R et al. | Tacrolimus predose concentrations do not predict the risk of acute rejection after renal transplantation: a pooled analysis from three randomized-controlled clinical trials(†). | 2013 | Am. J. Transplant. | pmid:23480233 |
Busque S et al. | The PROMISE study: a phase 2b multicenter study of voclosporin (ISA247) versus tacrolimus in de novo kidney transplantation. | 2011 | Am. J. Transplant. | pmid:21943027 |
Flechner SM et al. | Allotransplantation of cryopreserved parathyroid tissue for severe hypocalcemia in a renal transplant recipient. | 2010 | Am. J. Transplant. | pmid:20883540 |
Shemesh E et al. | The Medication Level Variability Index (MLVI) Predicts Poor Liver Transplant Outcomes: A Prospective Multi-Site Study. | 2017 | Am. J. Transplant. | pmid:28321975 |
Pescovitz MD et al. | A randomized, double-blind, pharmacokinetic study of oral maribavir with tacrolimus in stable renal transplant recipients. | 2009 | Am. J. Transplant. | pmid:19663892 |
Bryan CF et al. | Long-term survival of kidneys transplanted from live A2 donors to O and B recipients. | 2007 | Am. J. Transplant. | pmid:17359511 |
Vincenti F et al. | Results of an international, randomized trial comparing glucose metabolism disorders and outcome with cyclosporine versus tacrolimus. | 2007 | Am. J. Transplant. | pmid:17359512 |
Diaz-Siso JR et al. | Initial experience of dual maintenance immunosuppression with steroid withdrawal in vascular composite tissue allotransplantation. | 2015 | Am. J. Transplant. | pmid:25777324 |
Cendales L et al. | Tacrolimus to Belatacept Conversion Following Hand Transplantation: A Case Report. | 2015 | Am. J. Transplant. | pmid:25773260 |
Rodriguez-Rodriguez AE et al. | The higher diabetogenic risk of tacrolimus depends on pre-existing insulin resistance. A study in obese and lean Zucker rats. | 2013 | Am. J. Transplant. | pmid:23651473 |
Klintmalm GB et al. | Belatacept-based immunosuppression in de novo liver transplant recipients: 1-year experience from a phase II randomized study. | 2014 | Am. J. Transplant. | pmid:25041339 |
Jaksch P et al. | Alemtuzumab in lung transplantation: an open-label, randomized, prospective single center study. | 2014 | Am. J. Transplant. | pmid:25039364 |
Neuberger JM et al. | Delayed introduction of reduced-dose tacrolimus, and renal function in liver transplantation: the 'ReSpECT' study. | 2009 | Am. J. Transplant. | pmid:19120077 |
Momper JD et al. | The impact of conversion from prograf to generic tacrolimus in liver and kidney transplant recipients with stable graft function. | 2011 | Am. J. Transplant. | pmid:21714845 |
Tan HP et al. | Two hundred living donor kidney transplantations under alemtuzumab induction and tacrolimus monotherapy: 3-year follow-up. | 2009 | Am. J. Transplant. | pmid:19120078 |
TruneÄŒka P et al. | Renal Function in De Novo Liver Transplant Recipients Receiving Different Prolonged-Release Tacrolimus Regimens-The DIAMOND Study. | 2015 | Am. J. Transplant. | pmid:25707487 |
Ashman N et al. | Belatacept as maintenance immunosuppression for postrenal transplant de novo drug-induced thrombotic microangiopathy. | 2009 | Am. J. Transplant. | pmid:19120084 |
Adam R et al. | Improved survival in liver transplant recipients receiving prolonged-release tacrolimus in the European Liver Transplant Registry. | 2015 | Am. J. Transplant. | pmid:25703527 |
Asrani SK and O'Leary JG | Can one pill a day keep rejection away? | 2015 | Am. J. Transplant. | pmid:25703394 |
Carenco C et al. | Tacrolimus and the risk of solid cancers after liver transplant: a dose effect relationship. | 2015 | Am. J. Transplant. | pmid:25648361 |
Mulay AV et al. | Impact of immunosuppressive medication on the risk of renal allograft failure due to recurrent glomerulonephritis. | 2009 | Am. J. Transplant. | pmid:19353768 |
Heller T et al. | Plasma concentrations of mycophenolic acid acyl glucuronide are not associated with diarrhea in renal transplant recipients. | 2007 | Am. J. Transplant. | pmid:17532750 |
Schrepfer S et al. | Effect of inhaled tacrolimus on cellular and humoral rejection to prevent posttransplant obliterative airway disease. | 2007 | Am. J. Transplant. | pmid:17532751 |
Grinyo JM et al. | Pilot randomized study of early tacrolimus withdrawal from a regimen with sirolimus plus tacrolimus in kidney transplantation. | 2004 | Am. J. Transplant. | pmid:15268733 |
Pallet N et al. | Kidney transplant recipients carrying the CYP3A4*22 allelic variant have reduced tacrolimus clearance and often reach supratherapeutic tacrolimus concentrations. | 2015 | Am. J. Transplant. | pmid:25588704 |
Schussler T et al. | Severe hepatitis C infection in a renal transplant recipient following hepatitis C genotype mismatch transplant. | 2004 | Am. J. Transplant. | pmid:15268744 |
Posselt AM et al. | Islet transplantation in type 1 diabetics using an immunosuppressive protocol based on the anti-LFA-1 antibody efalizumab. | 2010 | Am. J. Transplant. | pmid:20659093 |
De Simone P et al. | Everolimus with reduced tacrolimus improves renal function in de novo liver transplant recipients: a randomized controlled trial. | 2012 | Am. J. Transplant. | pmid:22882750 |
Echeverri GJ et al. | Endoscopic gastric submucosal transplantation of islets (ENDO-STI): technique and initial results in diabetic pigs. | 2009 | Am. J. Transplant. | pmid:19775318 |
Gaston RS et al. | Fixed- or controlled-dose mycophenolate mofetil with standard- or reduced-dose calcineurin inhibitors: the Opticept trial. | 2009 | Am. J. Transplant. | pmid:19459794 |
Lake JR et al. | Addition of MMF to dual immunosuppression does not increase the risk of malignant short-term death after liver transplantation. | 2005 | Am. J. Transplant. | pmid:16303011 |
Mandelbrot DA et al. | Effect of Ramipril on Urinary Protein Excretion in Maintenance Renal Transplant Patients Converted to Sirolimus. | 2015 | Am. J. Transplant. | pmid:26176342 |