MeSH term | MeSH ID | Detail |
---|---|---|
Acne Vulgaris | D000152 | 35 associated lipids |
Abortion, Spontaneous | D000022 | 12 associated lipids |
Abnormalities, Multiple | D000015 | 13 associated lipids |
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Yang J et al. | Zinc finger protein A20 protects rats against chronic liver allograft dysfunction. | 2012 | World J. Gastroenterol. | pmid:22826618 |
Chen ZS et al. | Early steroid withdrawal after liver transplantation for hepatocellular carcinoma. | 2007 | World J. Gastroenterol. | pmid:17876900 |
Li DW et al. | Risk factors for new onset diabetes mellitus after liver transplantation: A meta-analysis. | 2015 | World J. Gastroenterol. | pmid:26034369 |
Liu F et al. | Tacrolimus dosage requirements in living donor liver transplant recipients with small-for-size grafts. | 2009 | World J. Gastroenterol. | pmid:19701975 |
Jiang JW et al. | Optimal immunosuppressor induces stable gut microbiota after liver transplantation. | 2018 | World J. Gastroenterol. | pmid:30228781 |
Indriolo A and Ravelli P | Clinical management of inflammatory bowel disease in the organ recipient. | 2014 | World J. Gastroenterol. | pmid:24707135 |
Shen T et al. | Reversible sinusoidal obstruction syndrome associated with tacrolimus following liver transplantation. | 2015 | World J. Gastroenterol. | pmid:26034381 |
Kiyama T et al. | Tacrolimus enhances colon anastomotic healing in rats. | 2002 Sep-Oct | Wound Repair Regen | pmid:12406167 |
Gupta AS et al. | Pyoderma Gangrenosum of the Scalp: A Rare Clinical Variant. | 2018 | Wounds | pmid:29481333 |
Zhou YN et al. | Effect of amlodipine on the pharmacokinetics of tacrolimus in rats. | 2013 | Xenobiotica | pmid:23312000 |
Picard N | The pharmacokinetic interaction between mycophenolic acid and cyclosporine revisited: a commentary on "Mycophenolic acid glucuronide is transported by multidrug resistance-associated protein 2 and this transport is not inhibited by cyclosporine, tacrolimus or sirolimus". | 2013 | Xenobiotica | pmid:23339626 |
Tata PN et al. | Species-dependent hepatic metabolism of immunosuppressive agent tacrolimus (FK-506). | 2009 | Xenobiotica | pmid:19604035 |
Zhang S et al. | Effect of voriconazole and other azole antifungal agents on CYP3A activity and metabolism of tacrolimus in human liver microsomes. | 2012 | Xenobiotica | pmid:22106961 |
Ogawa K et al. | A new approach to predicting human hepatic clearance of CYP3A4 substrates using monkey pharmacokinetic data. | 2013 | Xenobiotica | pmid:23153054 |
Lu XF et al. | Use of a semi-physiological pharmacokinetic model to investigate the influence of itraconazole on tacrolimus absorption, distribution and metabolism in mice. | 2017 | Xenobiotica | pmid:27533047 |
Zhu L et al. | Effects of CYP3A5 genotypes, ABCB1 C3435T and G2677T/A polymorphism on pharmacokinetics of Tacrolimus in Chinese adult liver transplant patients. | 2015 | Xenobiotica | pmid:25869250 |
Lampen A et al. | Catalytic activities, protein- and mRNA-expression of cytochrome P450 isoenzymes in intestinal cell lines. | 1998 | Xenobiotica | pmid:9622846 |
Jeong H and Chiou WL | Role of P-glycoprotein in the hepatic metabolism of tacrolimus. | 2006 | Xenobiotica | pmid:16507509 |
Chitnis SD et al. | Concentration of tacrolimus and major metabolites in kidney transplant recipients as a function of diabetes mellitus and cytochrome P450 3A gene polymorphism. | 2013 | Xenobiotica | pmid:23278282 |
Miura M et al. | Comparison of enantioselective disposition of rabeprazole versus lansoprazole in renal-transplant recipients who are CYP2C19 extensive metabolizers. | 2005 | Xenobiotica | pmid:16012079 |