Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Xia WL et al. | [Effects of ciclosporin and tacrolimus on replication of hepatitis B virus in vitro: a comparative study]. | 2006 | Zhonghua Yi Xue Za Zhi | pmid:16620716 |
Jin J et al. | Impact of multidrug resistance 1 gene polymorphism on tacrolimus dose and concentration-to-dose ratio in Chinese liver transplantation recipients. | 2005 | Zhonghua Yi Xue Yi Chuan Xue Za Zhi | pmid:16331555 |
Xie H et al. | [Effect of FK506 eye-drop combined with keratoplasty on recurrent Mooren's ulcer]. | 2002 | Zhonghua Yan Ke Za Zhi | pmid:11955293 |
Chen J et al. | [The study of FK506 eye drops preventing and treating immune rejection on limbal allograft transplantation]. | 2003 | Zhonghua Yan Ke Za Zhi | pmid:14766087 |
Xiang DM et al. | [The observation of tacrolimus eye drops preventing the early immunological rejection after penetrating keratoplasty for fungal keratitis]. | 2017 | Zhonghua Yan Ke Za Zhi | pmid:28412805 |
Sun YJ et al. | [Systematic review of penetrating keratoplasty rejection treated by immunosuppressants]. | 2010 | Zhonghua Yan Ke Za Zhi | pmid:21211228 |
Shi WY et al. | [Implantation of FK506 drug delivery system into the anterior chamber for inhibiting corneal rejection in high risk rabbit corneal allograft]. | 2006 | Zhonghua Yan Ke Za Zhi | pmid:16762204 |
Fei WL et al. | [The pharmacokinetics of FK506 and its nanoparticles in aqueous humor of rabbits]. | 2006 | Zhonghua Yan Ke Za Zhi | pmid:16762205 |
Lü L et al. | [Experimental studies on the effect of the immunosuppressant FK-506 on penetrating keratoplasty rejection model in rats]. | 1999 | Zhonghua Yan Ke Za Zhi | pmid:11835769 |
Lü L and Zhang W | [Immunopathologic studies on the effects of immunosuppressant FK 506 on penetrating keratoplasty rejection model in rat]. | 1998 | Zhonghua Yan Ke Za Zhi | pmid:11877144 |
DU C et al. | [In vitro effects of tacrolimus on platelet function]. | 2014 | Zhonghua Xue Ye Xue Za Zhi | pmid:25339327 |
Zhao SM et al. | [Long term regulated expansion and committed differentiation of JAK2 gene transfected hematopoietic stem/progenitor cells in vitro]. | 2004 | Zhonghua Xue Ye Xue Za Zhi | pmid:14990041 |
Chen F et al. | [Outcomes of allogeneic hematopoietic stem cell transplantation for 18 patients with paroxysmal nocturnal haemoglobinuria]. | 2015 | Zhonghua Xue Ye Xue Za Zhi | pmid:26759101 |
Sun J et al. | [A preliminary study on the biological characteristics and function of tolerogenic dendritic cells induced by tacrolimus]. | 2014 | Zhonghua Xue Ye Xue Za Zhi | pmid:24985179 |
Cao KJ et al. | [Immunosuppressive therapy after human lung transplantation]. | 2007 | Zhonghua Wai Ke Za Zhi | pmid:17845780 |
Li YX et al. | [Preliminary experience with Campath 1H induction combined with low-dose monotherapy of tacrolimus in small bowel transplantation]. | 2009 | Zhonghua Wai Ke Za Zhi | pmid:19961008 |
Pan F et al. | [Effect of tacrolimus on apoptosis and expression of heat shock protein 70 after acute spinal cord injury in rats]. | 2006 | Zhonghua Wai Ke Za Zhi | pmid:17359722 |
Lü DC et al. | [An experimental study of the neuroprotective effect of FK506 on acute spinal cord injury in dogs]. | 2005 | Zhonghua Wai Ke Za Zhi | pmid:16194341 |
Hu AB et al. | [Evaluation of efficacy and safety on steroid withdraw at the seventh day after liver transplantation]. | 2008 | Zhonghua Wai Ke Za Zhi | pmid:19094670 |
Yang FC et al. | [Influence of combined cyclosporine A and tacrolimus with 5-fluorouracil on hepatocellular carcinoma rats]. | 2003 | Zhonghua Wai Ke Za Zhi | pmid:12895356 |