Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Fauconnier J et al. | Frequency-dependent and proarrhythmogenic effects of FK-506 in rat ventricular cells. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15471978 |
Balasubramaniam R et al. | Caffeine-induced arrhythmias in murine hearts parallel changes in cellular Ca(2+) homeostasis. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15923307 |
Hafizi S et al. | ANG II activates effectors of mTOR via PI3-K signaling in human coronary smooth muscle cells. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15317677 |
Kohno M et al. | A new cardioprotective agent, JTV519, improves defective channel gating of ryanodine receptor in heart failure. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12433661 |
Gómez AM et al. | FKBP12.6 overexpression decreases Ca2+ spark amplitude but enhances [Ca2+]i transient in rat cardiac myocytes. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15271664 |
Sasamori K et al. | Cyclic ADP-ribose, a putative Ca2+-mobilizing second messenger, operates in submucosal gland acinar cells. | 2004 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:14990397 |
Lum H et al. | Protein phosphatase 2B inhibitor potentiates endothelial PKC activity and barrier dysfunction. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11504680 |
Yaghi A and Sims SM | Constrictor-induced translocation of NFAT3 in human and rat pulmonary artery smooth muscle. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16055480 |
Bouvier N et al. | Cyclosporine triggers endoplasmic reticulum stress in endothelial cells: a role for endothelial phenotypic changes and death. | 2009 | Am. J. Physiol. Renal Physiol. | pmid:18987109 |
Ren H et al. | Phosphatase inhibition increases AQP2 accumulation in the rat IMCD apical plasma membrane. | 2016 | Am. J. Physiol. Renal Physiol. | pmid:27488997 |
Thai TL et al. | ADP-ribosyl cyclase and ryanodine receptor activity contribute to basal renal vasomotor tone and agonist-induced renal vasoconstriction in vivo. | 2007 | Am. J. Physiol. Renal Physiol. | pmid:17652368 |
Peherstorfer E et al. | Effects of microinjection of synthetic Bcl-2 domain peptides on apoptosis of renal tubular epithelial cells. | 2002 | Am. J. Physiol. Renal Physiol. | pmid:12060601 |
Axelsson J et al. | Scavengers of reactive oxygen species, paracalcitol, RhoA, and Rac-1 inhibitors and tacrolimus inhibit angiotensin II-induced actions on glomerular permeability. | 2013 | Am. J. Physiol. Renal Physiol. | pmid:23657856 |
Mohebbi N et al. | The calcineurin inhibitor FK506 (tacrolimus) is associated with transient metabolic acidosis and altered expression of renal acid-base transport proteins. | 2009 | Am. J. Physiol. Renal Physiol. | pmid:19439519 |
Cho SG et al. | Drp1 dephosphorylation in ATP depletion-induced mitochondrial injury and tubular cell apoptosis. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:20410216 |
De Miguel C et al. | Infiltrating T lymphocytes in the kidney increase oxidative stress and participate in the development of hypertension and renal disease. | 2011 | Am. J. Physiol. Renal Physiol. | pmid:21159736 |
Rojas-Vega L et al. | Increased phosphorylation of the renal Na+-Cl- cotransporter in male kidney transplant recipient patients with hypertension: a prospective cohort. | 2015 | Am. J. Physiol. Renal Physiol. | pmid:26336164 |
Edinger RS et al. | Effect of immunosuppressive agents on glucocorticoid receptor function in A6 cells. | 2002 | Am. J. Physiol. Renal Physiol. | pmid:12110508 |
Ilori TO et al. | Acute calcineurin inhibition with tacrolimus increases phosphorylated UT-A1. | 2012 | Am. J. Physiol. Renal Physiol. | pmid:22205230 |
Amberg GC et al. | Regulation of A-type potassium channels in murine colonic myocytes by phosphatase activity. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11698261 |
Ahn HS et al. | Calcineurin-independent inhibition of KV1.3 by FK-506 (tacrolimus): a novel pharmacological property. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17166943 |
Wang YX et al. | FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells. | 2004 | Am. J. Physiol., Cell Physiol. | pmid:14592808 |
Sans MD and Williams JA | Calcineurin is required for translational control of protein synthesis in rat pancreatic acini. | 2004 | Am. J. Physiol., Cell Physiol. | pmid:15044154 |
Bayguinov O et al. | Muscarinic stimulation increases basal Ca(2+) and inhibits spontaneous Ca(2+) transients in murine colonic myocytes. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11171588 |
Angus LM et al. | Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15930144 |
Zhang Y et al. | K restriction inhibits protein phosphatase 2B (PP2B) and suppression of PP2B decreases ROMK channel activity in the CCD. | 2008 | Am. J. Physiol., Cell Physiol. | pmid:18184875 |
Yue G et al. | The effect of rapamycin on single ENaC channel activity and phosphorylation in A6 cells. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10898719 |
Nam JH et al. | Expression of TASK-2 and its upregulation by B cell receptor stimulation in WEHI-231 mouse immature B cells. | 2011 | Am. J. Physiol., Cell Physiol. | pmid:21307343 |
Nakagawa K et al. | Immunosuppression with tacrolimus improved reproductive outcome of women with repeated implantation failure and elevated peripheral blood TH1/TH2 cell ratios. | 2015 | Am. J. Reprod. Immunol. | pmid:25394810 |
Nakagawa K et al. | Immunosuppressive treatment using tacrolimus promotes pregnancy outcome in infertile women with repeated implantation failures. | 2017 | Am. J. Reprod. Immunol. | pmid:28466977 |
Saito S et al. | Role of Paternal Antigen-Specific Treg Cells in Successful Implantation. | 2016 | Am. J. Reprod. Immunol. | pmid:26706630 |
Kofod L et al. | Endometrial immune markers are potential predictors of normal fertility and pregnancy after in vitro fertilization. | 2017 | Am. J. Reprod. Immunol. | pmid:28440588 |
Tabata C et al. | Calcineurin/NFAT pathway: a novel regulator of parturition. | 2009 | Am. J. Reprod. Immunol. | pmid:19527231 |
Goldthorpe H et al. | Occlusive lung arterial lesions in endothelial-targeted, fas-induced apoptosis transgenic mice. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25879383 |
Fujiki M et al. | Role of T cells in bronchoalveolar space in the development of interstitial pneumonia induced by superantigen in autoimmune-prone mice. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10572064 |
Deuse T et al. | Mechanisms behind local immunosuppression using inhaled tacrolimus in preclinical models of lung transplantation. | 2010 | Am. J. Respir. Cell Mol. Biol. | pmid:19880819 |
Rolfe FG et al. | Cyclosporin A and FK506 reduce interleukin-5 mRNA abundance by inhibiting gene transcription. | 1997 | Am. J. Respir. Cell Mol. Biol. | pmid:9271313 |
Yerkovich ST et al. | Survival after bronchiolitis obliterans syndrome. | 2011 | Am. J. Respir. Crit. Care Med. | pmid:21325085 |
Bhorade S et al. | Comparison of sirolimus with azathioprine in a tacrolimus-based immunosuppressive regimen in lung transplantation. | 2011 | Am. J. Respir. Crit. Care Med. | pmid:20833822 |
Koshika T et al. | Pretreatment with FK506 improves survival rate and gas exchange in canine model of acute lung injury. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11208629 |
Saeki K et al. | Endobronchial Lesions of Mycobacterium abscessus Infection in an Immunocompromised Patient. | 2017 | Am. J. Respir. Crit. Care Med. | pmid:28199133 |
Joshi MS et al. | Calcineurin regulates myocardial function during acute endotoxemia. | 2006 | Am. J. Respir. Crit. Care Med. | pmid:16424445 |
Fauvel H et al. | Protective effects of cyclosporin A from endotoxin-induced myocardial dysfunction and apoptosis in rats. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11850335 |
Spiekerkoetter E et al. | Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension. | 2015 | Am. J. Respir. Crit. Care Med. | pmid:26177174 |
Raofi V et al. | A prospective randomized trial comparing the efficacy of tacrolimus versus cyclosporine in black recipients of primary cadaveric renal transplants. | 1999 | Am. J. Surg. | pmid:10326847 |
Tanaka K et al. | Living related liver transplantation in children. | 1994 | Am. J. Surg. | pmid:7517649 |
Li X et al. | Increased iNOS-expressing macrophage in long-term surviving rat small-bowel grafts. | 2007 | Am. J. Surg. | pmid:17618815 |
Rabkin JM et al. | Immunosuppression impact on long-term cardiovascular complications after liver transplantation. | 2002 | Am. J. Surg. | pmid:12034401 |
Jurim O et al. | Living-donor liver transplantation at UCLA. | 1995 | Am. J. Surg. | pmid:7538267 |
Lee KK et al. | Successful treatment of ongoing intestinal allograft rejection permits recovery of graft structure and function. | 1993 | Am. J. Surg. | pmid:7678188 |
Finn L et al. | Epstein-Barr virus infections in children after transplantation of the small intestine. | 1998 | Am. J. Surg. Pathol. | pmid:9500771 |
Randhawa PS et al. | The histopathological changes associated with allograft rejection and drug toxicity in renal transplant recipients maintained on FK506. Clinical significance and comparison with cyclosporine. | 1993 | Am. J. Surg. Pathol. | pmid:7680544 |
Minervini MI et al. | Acute renal allograft rejection with severe tubulitis (Banff 1997 grade IB). | 2000 | Am. J. Surg. Pathol. | pmid:10757402 |
Randhawa PS et al. | Microvascular changes in renal allografts associated with FK506 (Tacrolimus) therapy. | 1996 | Am. J. Surg. Pathol. | pmid:8772784 |
Campbell PM et al. | Pretransplant HLA antibodies are associated with reduced graft survival after clinical islet transplantation. | 2007 | Am. J. Transplant. | pmid:17456201 |
Boudjema K et al. | Reduced-dose tacrolimus with mycophenolate mofetil vs. standard-dose tacrolimus in liver transplantation: a randomized study. | 2011 | Am. J. Transplant. | pmid:21466650 |
Knechtle SJ | Guidance for liver transplant immunosuppression. | 2011 | Am. J. Transplant. | pmid:21466652 |
Gupta G et al. | Safe Conversion From Tacrolimus to Belatacept in High Immunologic Risk Kidney Transplant Recipients With Allograft Dysfunction. | 2015 | Am. J. Transplant. | pmid:25988397 |
Silva HT et al. | Planned randomized conversion from tacrolimus to sirolimus-based immunosuppressive regimen in de novo kidney transplant recipients. | 2013 | Am. J. Transplant. | pmid:24266969 |
Ricciardelli I et al. | Rapid generation of EBV-specific cytotoxic T lymphocytes resistant to calcineurin inhibitors for adoptive immunotherapy. | 2013 | Am. J. Transplant. | pmid:24266973 |
Suszynski TM et al. | Prospective randomized trial of maintenance immunosuppression with rapid discontinuation of prednisone in adult kidney transplantation. | 2013 | Am. J. Transplant. | pmid:23432755 |
Damon C et al. | Predictive Modeling of Tacrolimus Dose Requirement Based on High-Throughput Genetic Screening. | 2017 | Am. J. Transplant. | pmid:27597269 |
Ferguson R et al. | Immunosuppression with belatacept-based, corticosteroid-avoiding regimens in de novo kidney transplant recipients. | 2011 | Am. J. Transplant. | pmid:21114656 |
McKenna G and Trotter JF | Does early (CNI) conversion lead to eternal (renal) salvation? | 2010 | Am. J. Transplant. | pmid:20928938 |
Shuker N et al. | A Randomized Controlled Trial Comparing the Efficacy of Cyp3a5 Genotype-Based With Body-Weight-Based Tacrolimus Dosing After Living Donor Kidney Transplantation. | 2016 | Am. J. Transplant. | pmid:26714287 |
Forns X and Navasa M | Cyclosporine A or tacrolimus for hepatitis C recurrence? An old debate. | 2011 | Am. J. Transplant. | pmid:21797970 |
Arnold R et al. | Association between calcineurin inhibitor treatment and peripheral nerve dysfunction in renal transplant recipients. | 2013 | Am. J. Transplant. | pmid:23841745 |
Hirsch HH et al. | BK Polyomavirus Replication in Renal Tubular Epithelial Cells Is Inhibited by Sirolimus, but Activated by Tacrolimus Through a Pathway Involving FKBP-12. | 2016 | Am. J. Transplant. | pmid:26639422 |
Bohl DL et al. | Donor origin of BK virus in renal transplantation and role of HLA C7 in susceptibility to sustained BK viremia. | 2005 | Am. J. Transplant. | pmid:16095500 |
Kasahara M et al. | Living-donor liver transplantation for hepatoblastoma. | 2005 | Am. J. Transplant. | pmid:16095502 |
Madeleine MM et al. | HPV-related cancers after solid organ transplantation in the United States. | 2013 | Am. J. Transplant. | pmid:24119294 |
Lemahieu WP et al. | CYP3A4 and P-glycoprotein activity in healthy controls and transplant patients on cyclosporin vs. tacrolimus vs. sirolimus. | 2004 | Am. J. Transplant. | pmid:15307840 |
Bressollette-Bodin C et al. | A prospective longitudinal study of BK virus infection in 104 renal transplant recipients. | 2005 | Am. J. Transplant. | pmid:15996241 |
Augustine JJ et al. | Pre-transplant IFN-gamma ELISPOTs are associated with post-transplant renal function in African American renal transplant recipients. | 2005 | Am. J. Transplant. | pmid:15996247 |
Filler G et al. | Adding sirolimus to tacrolimus-based immunosuppression in pediatric renal transplant recipients reduces tacrolimus exposure. | 2005 | Am. J. Transplant. | pmid:15996252 |
Froud T et al. | Islet transplantation in type 1 diabetes mellitus using cultured islets and steroid-free immunosuppression: Miami experience. | 2005 | Am. J. Transplant. | pmid:15996257 |
Chodoff L and Hamberg KJ | Response to 'Different preparations of tacrolimus and medication errors'. | 2009 | Am. J. Transplant. | pmid:19392982 |
Luther P and Baldwin D | Pioglitazone in the management of diabetes mellitus after transplantation. | 2004 | Am. J. Transplant. | pmid:15575920 |
Cherukuri A et al. | An analysis of lymphocyte phenotype after steroid avoidance with either alemtuzumab or basiliximab induction in renal transplantation. | 2012 | Am. J. Transplant. | pmid:22390816 |
Dahm F et al. | Conversion from cyclosporine to tacrolimus improves quality-of-life indices, renal graft function and cardiovascular risk profile. | 2004 | Am. J. Transplant. | pmid:15575921 |
Pascher A et al. | Protein kinase C inhibitor sotrastaurin in de novo liver transplant recipients: a randomized phase II trial. | 2015 | Am. J. Transplant. | pmid:25677074 |
Barth RN et al. | Vascularized bone marrow-based immunosuppression inhibits rejection of vascularized composite allografts in nonhuman primates. | 2011 | Am. J. Transplant. | pmid:21668624 |
Guirado L et al. | Efficacy and safety of conversion from twice-daily to once-daily tacrolimus in a large cohort of stable kidney transplant recipients. | 2011 | Am. J. Transplant. | pmid:21668633 |
Flechner SM et al. | The ORION study: comparison of two sirolimus-based regimens versus tacrolimus and mycophenolate mofetil in renal allograft recipients. | 2011 | Am. J. Transplant. | pmid:21668635 |
Grenda R et al. | A randomized trial to assess the impact of early steroid withdrawal on growth in pediatric renal transplantation: the TWIST study. | 2010 | Am. J. Transplant. | pmid:20420639 |
Montgomery SP et al. | Efficacy and toxicity of a protocol using sirolimus, tacrolimus and daclizumab in a nonhuman primate renal allotransplant model. | 2002 | Am. J. Transplant. | pmid:12118862 |
van Hooff JP et al. | Glucose metabolic disorder after transplantation. | 2007 | Am. J. Transplant. | pmid:17511670 |
Silva HT et al. | One-year results with extended-release tacrolimus/MMF, tacrolimus/MMF and cyclosporine/MMF in de novo kidney transplant recipients. | 2007 | Am. J. Transplant. | pmid:17217442 |
Heffron TG et al. | Once-daily tacrolimus extended-release formulation: 1-year post-conversion in stable pediatric liver transplant recipients. | 2007 | Am. J. Transplant. | pmid:17511684 |
Moench C et al. | Tacrolimus monotherapy without steroids after liver transplantation--a prospective randomized double-blinded placebo-controlled trial. | 2007 | Am. J. Transplant. | pmid:17511685 |
Patlolla V et al. | Efficacy of anti-IL-2 receptor antibodies compared to no induction and to antilymphocyte antibodies in renal transplantation. | 2007 | Am. J. Transplant. | pmid:17564638 |
Nijhoff MF et al. | Glycemic Stability Through Islet-After-Kidney Transplantation Using an Alemtuzumab-Based Induction Regimen and Long-Term Triple-Maintenance Immunosuppression. | 2016 | Am. J. Transplant. | pmid:26288226 |
Toso C et al. | Sequential kidney/islet transplantation: efficacy and safety assessment of a steroid-free immunosuppression protocol. | 2006 | Am. J. Transplant. | pmid:16611343 |
Lacaille F et al. | Severe dysimmune cytopenia in children treated with tacrolimus after organ transplantation. | 2006 | Am. J. Transplant. | pmid:16611346 |
Chamie K et al. | The effect of sirolimus on prostate-specific antigen (PSA) levels in male renal transplant recipients without prostate cancer. | 2008 | Am. J. Transplant. | pmid:18853950 |
Lefaucheur C et al. | Renal histopathological lesions after lung transplantation in patients with cystic fibrosis. | 2008 | Am. J. Transplant. | pmid:18671673 |
Pech T et al. | Intestinal regeneration, residual function and immunological priming following rescue therapy after rat small bowel transplantation. | 2012 | Am. J. Transplant. | pmid:22974463 |
McDonald RA et al. | Incidence of PTLD in pediatric renal transplant recipients receiving basiliximab, calcineurin inhibitor, sirolimus and steroids. | 2008 | Am. J. Transplant. | pmid:18416737 |
Brennan DC et al. | Incidence of BK with tacrolimus versus cyclosporine and impact of preemptive immunosuppression reduction. | 2005 | Am. J. Transplant. | pmid:15707414 |
Chhabra D et al. | Impact of calcineurin-inhibitor conversion to mTOR inhibitor on renal allograft function in a prednisone-free regimen. | 2013 | Am. J. Transplant. | pmid:24007570 |