tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jusko WJ and D'Ambrosio R | Monitoring FK 506 concentrations in plasma and whole blood. | 1991 | Transplant. Proc. | pmid:1721260 |
| Venkataramanan R et al. | Pharmacokinetics of FK 506 in transplant patients. | 1991 | Transplant. Proc. | pmid:1721261 |
| Akselband Y et al. | Rapamycin inhibits spontaneous and fibroblast growth factor beta-stimulated proliferation of endothelial cells and fibroblasts. | 1991 | Transplant. Proc. | pmid:1721292 |
| Schreiber SL et al. | Immunophilin-ligand complexes as probes of intracellular signaling pathways. | 1991 | Transplant. Proc. | pmid:1721293 |
| Jordan ML et al. | Inhibition of T-cell function by FK 506 and cyclosporine is not accompanied by alterations in intracellular calcium. | 1991 | Transplant. Proc. | pmid:1721323 |
| Motta I et al. | FK 506 favors the generation of memory T cells in vitro. | 1991 | Transplant. Proc. | pmid:1721324 |
| Nakata S et al. | Immunosuppressive effect of FK 506 on cytotoxic T lymphocytes and delayed-type hypersensitivity in rats. | 1991 | Transplant. Proc. | pmid:1721325 |
| Whiteside TL et al. | Serial monitoring of immunologic function and phenotype of lymphocytes in the blood of transplanted patients randomized to cyclosporine or FK 506. | 1991 | Transplant. Proc. | pmid:1721356 |
| Frayha HH et al. | Lymphoproliferative disorder in a liver transplant patient on FK 506. | 1991 | Lancet | pmid:1703258 |
| Van Thiel DH et al. | Interferon therapy of hepatitis following liver transplantation under FK 506 or cyclosporine. | 1991 | Transplant. Proc. | pmid:1721357 |
| Burman K and Crawford DH | Effect of FK 506 on Epstein-Barr virus specific cytotoxic T cells. | 1991 | Lancet | pmid:1703259 |
| Winkler M et al. | Association of elevated FK 506 plasma levels with nephrotoxicity in liver-grafted patients. | 1991 | Transplant. Proc. | pmid:1721389 |
| Schmidt RJ et al. | Hemolytic-uremic syndrome in a renal transplant recipient on FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721390 |
| Cooper MH et al. | The induction of pseudo-graft-versus-host disease following syngeneic bone marrow transplantation using FK 506. | 1991 | Transplant. Proc. | pmid:1721419 |
| Boggs S et al. | FK 506 has no short-term effects on endogenous or exogenous myeloid reconstitution in irradiated mice. | 1991 | Transplant. Proc. | pmid:1721420 |
| Goebl MG | The peptidyl-prolyl isomerase, FK506-binding protein, is most likely the 12 kd endogenous inhibitor 2 of protein kinase C. | 1991 | Cell | pmid:1706222 |
| de Paulis A et al. | FK-506, a potent novel inhibitor of the release of proinflammatory mediators from human Fc epsilon RI+ cells. | 1991 | J. Immunol. | pmid:1706398 |
| Abu-Elmagd K et al. | Efficacy of FK 506 in the treatment of recalcitrant pyoderma gangrenosum. | 1991 | Transplant. Proc. | pmid:1721451 |
| Thomson AW et al. | Influence of FK 506 on T lymphocytes, Langerhans' cells and the expression of cytokine receptors and adhesion molecules in psoriatic skin lesions: a preliminary study. | 1991 | Transplant. Proc. | pmid:1721452 |
| Hultsch T et al. | Immunophilin ligands demonstrate common features of signal transduction leading to exocytosis or transcription. | 1991 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1712484 |
| Miyahara H et al. | Comparative studies of the effects of FK506 and cyclosporin A on passively transferred collagen-induced arthritis in rats. | 1991 | Clin. Immunol. Immunopathol. | pmid:1712688 |
| Fung JJ et al. | Conversion of liver allograft recipients from cyclosporine to FK 506-based immunosuppression: benefits and pitfalls. | 1991 | Transplant. Proc. | pmid:1703682 |
| Wu J et al. | Comparative immunoregulatory effects of rapamycin, FK 506 and cyclosporine on mitogen-induced cytokine production and lymphoproliferation. | 1991 | Transplant. Proc. | pmid:1703683 |
| Sakai K et al. | [The effect of a new immunosuppressive agent, FK-506, on xenogeneic neural transplantation in rodents--comparison with cyclosporin A]. | 1991 | No To Shinkei | pmid:1716937 |
| Yoshimura R et al. | A comparative study between cyclosporine and FK 506 effects on renal microsomal P-450. | 1991 | Transplant. Proc. | pmid:1703686 |
| McWhinnie DL and Morris PJ | Combination drug therapies for immunosuppression in transplantation. | 1991 | Ann. Acad. Med. Singap. | pmid:1724724 |
| Pourtier-Manzanedo A et al. | FK-506 (fujimycin) reverses the multidrug resistance of tumor cells in vitro. | 1991 | Anticancer Drugs | pmid:1724925 |
| Jordan ML et al. | Initial studies with FK506 in renal transplantation. | 1991 Sep-Oct | Cleve Clin J Med | pmid:1718631 |
| Kuo CJ et al. | Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. | 1992 | Nature | pmid:1614535 |
| Takaya S et al. | The adverse impact on liver transplantation of using positive cytotoxic crossmatch donors. | 1992 | Transplantation | pmid:1371195 |
| Francavilla A et al. | Inhibition of liver, kidney, and intestine regeneration by rapamycin. | 1992 | Transplantation | pmid:1371198 |
| Matsukawa W et al. | Effects of a new immunosuppressive agent, FK506, in rats with active Heymann nephritis. | 1992 | J. Lab. Clin. Med. | pmid:1371298 |
| Sampson BA and Gotschlich EC | Neisseria meningitidis encodes an FK506-inhibitable rotamase. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1371354 |
| Andersson J et al. | Effects of FK506 and cyclosporin A on cytokine production studied in vitro at a single-cell level. | 1992 | Immunology | pmid:1371491 |
| Strasser S et al. | Effect of FK506 on insulin secretion in normal dogs. | 1992 | Metab. Clin. Exp. | pmid:1371575 |
| Andersson J et al. | FK 506 and cyclosporine inhibit antigen- or mitogen-induced monokine and lymphokine production in vitro. | 1992 | Transplant. Proc. | pmid:1371621 |
| Matsuura T et al. | Blockade of interleukin-2 production from cloned T cells by cyclosporine and FK 506 assessed by proliferation assays in vitro. | 1992 | Transplant. Proc. | pmid:1371623 |
| Okamura N et al. | Enhanced liver regeneration by FK 506 can be blocked by interleukin-1 alpha and interleukin-2. | 1992 | Transplant. Proc. | pmid:1371624 |
| Metcalfe S et al. | FK506 and rapamycin: differential sensitivity of human, baboon, cynomolgus monkey, dog and pig lymphocytes. | 1992 | Transpl. Int. | pmid:14621863 |
| Japanese study of kidney transplantation: 1. Results of early phase II study. | 1992 | Transpl. Int. | pmid:14621866 | |
| Japanese study of FK 506 on kidney transplantation: 2. Follow-up study of FK 506-treated patients. | 1992 | Transpl. Int. | pmid:14621874 | |
| Walpoth B et al. | Prevention of cardiac allograft rejection by FK506 and rapamycin: assessment by histology and nuclear magnetic resonance. | 1992 | Transpl. Int. | pmid:14621877 |
| Asako H et al. | Reduction of leukocyte adherence and emigration by cyclosporine and L683,590 (FK506) in postcapillary venules. | 1992 | Transplantation | pmid:1384191 |
| Kawano K et al. | FK 506 ameliorates normothermic liver ischemia in rats by suppressing production of tumor necrosis factor. | 1992 | Transpl. Int. | pmid:14621904 |
| Fruman DA et al. | Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1373887 |
| Lake JR et al. | Maintenance immunosuppression after liver transplantation. | 1992 | Semin. Liver Dis. | pmid:1373916 |
| Taormina D et al. | Stability and sorption of FK 506 in 5% dextrose injection and 0.9% sodium chloride injection in glass, polyvinyl chloride, and polyolefin containers. | 1992 | Am J Hosp Pharm | pmid:1373936 |
| Ochiai T | [Advances in the fundamentals and therapeutic use of immunosuppressive agents]. | 1992 | Arerugi | pmid:1374229 |
| Yamada K et al. | New morphological changes induced by FK506 in a short period in the rat kidney and the effect of superoxide dismutase and OKY-046 on THEM: the relationship of FK506 nephrotoxicity to lipid peroxidation and change in production of thromboxane A2 in the kidney. | 1992 | Transpl. Int. | pmid:14621878 |
| Hung DT and Schreiber SL | cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1374240 |
| Jayaraman T et al. | FK506 binding protein associated with the calcium release channel (ryanodine receptor). | 1992 | J. Biol. Chem. | pmid:1374404 |
| Höllsberg P et al. | Characterization of HTLV-I in vivo infected T cell clones. IL-2-independent growth of nontransformed T cells. | 1992 | J. Immunol. | pmid:1374452 |
| Schreiber SL and Crabtree GR | The mechanism of action of cyclosporin A and FK506. | 1992 | Immunol. Today | pmid:1374612 |
| Demetris AJ et al. | Conversion of liver allograft recipients from cyclosporine to FK506 immunosuppressive therapy--a clinicopathologic study of 96 patients. | 1992 | Transplantation | pmid:1374944 |
| Ricordi C et al. | Effect of FK 506 on human pancreatic islets following renal subcapsular transplantation in diabetic nude mice. | 1992 | Transplant. Proc. | pmid:1376512 |
| Hisanaga M et al. | Successful combination therapy with FK 506 and 15-deoxyspergualin in pancreatic islet xenografting. | 1992 | Transplant. Proc. | pmid:1376513 |
| Ogasa N et al. | Successful transplantation of newborn rat intestine as a free graft. | 1992 | Transplant. Proc. | pmid:1376514 |
| Graeb C et al. | Cytoimmunologic monitoring of small bowel allograft recipients. | 1992 | Transplant. Proc. | pmid:1376515 |
| Date K et al. | Effect of FK 506 on graft survival in rat small intestinal allografts. | 1992 | Transplant. Proc. | pmid:1376516 |
| Hatazawa C et al. | Effect of FK 506 on bowel transplantation in rats. | 1992 | Transplant. Proc. | pmid:1376517 |
| Jain A et al. | Intravenous, oral pharmacokinetics, and oral dosing of FK 506 in small bowel transplant patients. | 1992 | Transplant. Proc. | pmid:1376518 |
| Masutani H et al. | Suppression of the histologic changes of GVHD by FK 506 in rat small bowel transplantation. | 1992 | Transplant. Proc. | pmid:1376519 |
| Santiago SF et al. | Effect of short-term immunosuppressive therapy with FK 506 or CyA on the donor in small intestine allotransplantation in rats. | 1992 | Transplant. Proc. | pmid:1376520 |
| Utsunomiya H et al. | Effect of FK 506 on orthotopic small bowel transplantation in rats. | 1992 | Transplant. Proc. | pmid:1376521 |
| Foor F et al. | Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from alpha-factor arrest in yeast. | 1992 | Nature | pmid:1281518 |
| Goldfeld AE et al. | Transcription of the tumor necrosis factor alpha gene is rapidly induced by anti-immunoglobulin and blocked by cyclosporin A and FK506 in human B cells. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1281550 |
| Morikawa K et al. | The distinct effects of FK506 on the activation, proliferation, and differentiation of human B lymphocytes. | 1992 | Transplantation | pmid:1281561 |
| Moutabarrik A et al. | FK506-induced kidney tubular cell injury. | 1992 | Transplantation | pmid:1281562 |
| Yagihashi A et al. | HLA matching effect in liver transplantation. | 1992 | Transplant. Proc. | pmid:1281569 |
| Kobayashi M et al. | Posttransplant donor-specific T-lymphocytotoxic antibody in liver transplant patients with a positive crossmatch. | 1992 | Transplant. Proc. | pmid:1281570 |
| Lemster B et al. | Cytokine gene expression in murine lymphocytes activated in the presence of FK 506, bredinin, mycophenolic acid, or brequinar sodium. | 1992 | Transplant. Proc. | pmid:1281576 |
| Tze WJ et al. | FK 506: an effective immunosuppressant for islet xenotransplantation. | 1992 | Transplant. Proc. | pmid:1281577 |
| Kamei T et al. | Established intraportal islet allograft is rejected despite the acceptance of donor-specific second cardiac allograft. | 1992 | Transplant. Proc. | pmid:1281579 |
| Kenmochi T et al. | [The effect of FK506 on segmental pancreas allograft in mongrel dogs]. | 1992 | Nihon Geka Gakkai Zasshi | pmid:1378526 |
| Mouzaki A et al. | Cyclosporin A and FK506 prevent the derepression of the IL-2 gene in mitogen-induced primary T lymphocytes. | 1992 | Cytokine | pmid:1378764 |
| Ramamoorthy S et al. | Selective impairment of taurine transport by cyclosporin A in a human placental cell line. | 1992 | Pediatr. Res. | pmid:1378960 |
| Armitage JM et al. | Clinical trial of FK 506 immunosuppression in adult cardiac transplantation. | 1992 | Ann. Thorac. Surg. | pmid:1379032 |
| Thomson AW | The spectrum of action of new immunosuppressive drugs. | 1992 | Clin. Exp. Immunol. | pmid:1379130 |
| Fischer G et al. | Mip protein of Legionella pneumophila exhibits peptidyl-prolyl-cis/trans isomerase (PPlase) activity. | 1992 | Mol. Microbiol. | pmid:1379319 |
| Rondeau E | [Mechanism of action of the new immunosuppressants: cyclosporin A, FK 506 and rapamycin]. | 1992 | Nephrologie | pmid:1379348 |
| Schreiber SL | Immunophilin-sensitive protein phosphatase action in cell signaling pathways. | 1992 | Cell | pmid:1379518 |
| Aldape RA et al. | Charged surface residues of FKBP12 participate in formation of the FKBP12-FK506-calcineurin complex. | 1992 | J. Biol. Chem. | pmid:1379588 |
| Price DJ et al. | Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. | 1992 | Science | pmid:1380182 |
| Granelli-Piperno A | SRC-related proto-oncogenes and transcription factors in primary human T cells: modulation by cyclosporin A and FK506. | 1992 | J. Autoimmun. | pmid:1380242 |
| Reem GH | Molecular mode of action of cyclosporin and FK506 in human thymocytes. | 1992 | J. Autoimmun. | pmid:1380243 |
| Bach JF | Immunointervention in autoimmune diseases from cellular selectivity to autoantigen specificity. | 1992 | J. Autoimmun. | pmid:1380245 |
| Baumann G et al. | Molecular mechanisms of immunosuppression. | 1992 | J. Autoimmun. | pmid:1380246 |
| Walpoth B et al. | Assessment of new immunosuppressive drugs in a rat cardiac allograft heterotopic model. | 1992 | Eur Surg Res | pmid:1380460 |
| Petros AM et al. | Conformation of two non-immunosuppressive FK506 analogs when bound to FKBP by isotope-filtered NMR. | 1992 | FEBS Lett. | pmid:1380470 |
| Van Thiel DH et al. | FK 506 reduces the injury experienced following renal ischemia and reperfusion. | 1992 | Ren Fail | pmid:1380720 |
| Bolton C | The efficacy of cyclosporin A, FK-506 and prednisolone to modify the adoptive transfer of experimental allergic encephalomyelitis (EAE). | 1992 | Agents Actions | pmid:1380765 |
| Langrehr JM et al. | Evidence that indefinite survival of small bowel allografts achieved by a brief course of cyclosporine or FK506 is not due to systemic hyporesponsiveness. | 1992 | Transplantation | pmid:1384185 |
| McCarthy SA et al. | The effects of immunosuppressive drugs on the regulation of activation-induced apoptotic cell death in thymocytes. | 1992 | Transplantation | pmid:1384186 |
| Dhar DK et al. | The salutary effect of FK506 in ischemia-reperfusion injury of the canine liver. | 1992 | Transplantation | pmid:1384188 |
| Ericzon BG et al. | FK506-induced impairment of glucose metabolism in the primate--studies in pancreatic transplant recipients and in nontransplanted animals. | 1992 | Transplantation | pmid:1384189 |
| Meiser BM et al. | Continuous infusion of angiopeptin significantly reduces accelerated graft vessel disease induced by FK 506 in a rat heart allograft model. | 1992 | Transplant. Proc. | pmid:1384201 |
| Wakabayashi H et al. | Effect of FK 506 and cyclosporine A on hepatic energy status in the rat after warm ischemia, as monitored by 31P nuclear magnetic resonance spectroscopy in vivo. | 1992 | Transplant. Proc. | pmid:1384205 |
| Griffin AD et al. | FK 506 in canine renal transplantation. | 1992 | Transplant. Proc. | pmid:1384209 |
| Griffiths RJ et al. | Characterisation of passively transferred antigen arthritis induced by methylated bovine serum albumin in the rat: effect of FK 506 on arthritis development. | 1992 | Agents Actions | pmid:1384284 |
| Todo S et al. | Intestinal transplantation in composite visceral grafts or alone. | 1992 | Ann. Surg. | pmid:1384443 |