| MeSH term | MeSH ID | Detail |
|---|---|---|
| Scorpion Stings | D065008 | 1 associated lipids |
| Drug-Related Side Effects and Adverse Reactions | D064420 | 3 associated lipids |
| Retrognathia | D063173 | 1 associated lipids |
| End Stage Liver Disease | D058625 | 1 associated lipids |
| Candidiasis, Invasive | D058365 | 2 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
| Thrombotic Microangiopathies | D057049 | 1 associated lipids |
| Central Serous Chorioretinopathy | D056833 | 1 associated lipids |
| Leukoencephalopathies | D056784 | 3 associated lipids |
| Netherton Syndrome | D056770 | 1 associated lipids |
| Latent Tuberculosis | D055985 | 1 associated lipids |
| Invasive Pulmonary Aspergillosis | D055744 | 1 associated lipids |
| Keratosis, Actinic | D055623 | 3 associated lipids |
| Multiple Pulmonary Nodules | D055613 | 2 associated lipids |
| Pancreatitis, Graft | D055589 | 1 associated lipids |
| Failed Back Surgery Syndrome | D055111 | 3 associated lipids |
| Primary Graft Dysfunction | D055031 | 1 associated lipids |
| Idiopathic Interstitial Pneumonias | D054988 | 1 associated lipids |
| Dendritic Cell Sarcoma, Interdigitating | D054739 | 1 associated lipids |
| Precursor Cell Lymphoblastic Leukemia-Lymphoma | D054198 | 10 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sheiner PA et al. | Acute renal failure associated with the use of ibuprofen in two liver transplant recipients on FK506. | 1994 | Transplantation | pmid:7513099 |
| Tanabe M et al. | The influence of donor and recipient strains in isolated small bowel transplantation in rats. | 1994 | Transplant. Proc. | pmid:7527986 |
| Yamamoto S and Kato R | Hair growth-stimulating effects of cyclosporin A and FK506, potent immunosuppressants. | 1994 | J. Dermatol. Sci. | pmid:7528050 |
| Hossain M et al. | Eosinophil viability-enhancing activity in mite-sensitive bronchial asthma. | 1994 | Intern. Med. | pmid:7528071 |
| Suzuki S | FK506 and deoxyspergualin: experimental studies and clinical applications. | 1994 | Transpl. Immunol. | pmid:7528087 |
| Burdmann EA et al. | Urinary enzymes as biomarkers of renal injury in experimental nephrotoxicity of immunosuppressive drugs. | 1994 | Ren Fail | pmid:7514309 |
| Yli-Kauhaluoma J and Janda KD | Twisted alpha-keto amides as transition-state analogues for acyl-transfer reactions: synthesis of the immunoconjugates. | 1994 | Bioorg. Med. Chem. | pmid:7528089 |
| Jindal RM et al. | Serum lipid changes in liver transplant recipients in a prospective trial of cyclosporine versus FK506. | 1994 | Transplantation | pmid:7514317 |
| Stan R et al. | Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue. | 1994 | J. Biol. Chem. | pmid:7528205 |
| Haddy A and Rusnak F | Overexpression and characterization of a recombinant form of rat calcineurin A. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7514397 |
| Woerly G et al. | Demonstration of ternary immunophilin-calcineurin complexes with the immunosuppressants cyclosporin and macrolide FK506. | 1994 | Biochem. Pharmacol. | pmid:7514409 |
| Lauerma AI and Maibach HI | Topical FK506--clinical potential or laboratory curiosity? | 1994 | Dermatology (Basel) | pmid:7514460 |
| Chen TS et al. | Microbial transformation of immunosuppressive compounds. IV. Hydroxylation and hemiketal formation of ascomycin (immunomycin) by Streptomyces sp. MA 6970 (ATCC No. 55281). | 1994 | J. Antibiot. | pmid:7531195 |
| Brillantes AB et al. | Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein. | 1994 | Cell | pmid:7514503 |
| Bennett WM et al. | Nephrotoxicity of immunosuppressive drugs. | 1994 | Miner Electrolyte Metab | pmid:7531274 |
| Sekigawa I et al. | FK506 can inhibit apoptotic cell death induced by the HIV-1 envelope glycoprotein gp120. | 1994 | AIDS | pmid:7531458 |
| Tanaka K et al. | Living related liver transplantation in children. | 1994 | Am. J. Surg. | pmid:7517649 |
| Yu L et al. | NMR studies of the FK506 binding protein bound to a spin-labeled ascomycin analog. | 1994 | J Magn Reson B | pmid:7517786 |
| Aagaard-Tillery KM and Jelinek DF | Inhibition of human B lymphocyte cell cycle progression and differentiation by rapamycin. | 1994 | Cell. Immunol. | pmid:7517796 |
| Furue M et al. | Immunosuppressive effects of azelastine hydrochloride on contact hypersensitivity and T-cell proliferative response: a comparative study with FK-506. | 1994 | J. Invest. Dermatol. | pmid:7517981 |
| Suzuki S and Toledo-Pereyra LH | Interleukin 1 and tumor necrosis factor production as the initial stimulants of liver ischemia and reperfusion injury. | 1994 | J. Surg. Res. | pmid:7518017 |
| Pruschy MN et al. | Mechanistic studies of a signaling pathway activated by the organic dimerizer FK1012. | 1994 | Chem. Biol. | pmid:9383386 |
| D'Ambrosio R et al. | Improved procedures for enzyme immunoassay of tacrolimus (FK506) in whole blood. | 1994 | Clin. Chem. | pmid:7507007 |
| Bäckman L et al. | Chronic nephrotoxicity of FK 506 after liver transplantation. | 1994 | Transplant. Proc. | pmid:7518159 |
| Bäckman L et al. | Whole blood and plasma levels of FK 506 after liver transplantation: correlation with toxicity. | 1994 | Transplant. Proc. | pmid:7518160 |
| Duncan JI | Differential inhibition of cutaneous T-cell-mediated reactions and epidermal cell proliferation by cyclosporin A, FK-506, and rapamycin. | 1994 | J. Invest. Dermatol. | pmid:7507155 |
| Engelbrecht ME et al. | The effect of immunosuppressants on human leukocyte NADPH oxidase. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7518204 |
| Reding R et al. | Conversion from cyclosporine to FK506 for salvage of immunocompromised pediatric liver allografts. Efficacy, toxicity, and dose regimen in 23 children. | 1994 | Transplantation | pmid:7507272 |
| Zuany-Amorim C et al. | Modulation by rm interferon-gamma and CD4+ T-lymphocytes of allergic eosinophil accumulation in the mice peritoneal cavity. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7518212 |
| Sabatini DM et al. | RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. | 1994 | Cell | pmid:7518356 |
| Scantlebury VP et al. | Pediatric kidney transplantation at the University of Pittsburgh. | 1994 | Transplant. Proc. | pmid:7509095 |
| Oyanagui Y | Nitric oxide- and hydrogen peroxide-mediated gene expression by glucocorticoids and FK506 in histamine paw edema of mice. | 1994 | Life Sci. | pmid:7520521 |
| Hayakawa K et al. | Involvement of clonal deletion in immunotolerance induction: tests of Tacrolimus administration in rat renal transplantation. | 1994 | Transplant. Proc. | pmid:7520608 |
| Yoshimura R et al. | Study of the effect of immunosuppressive agents on renal cytochrome P-450 system in the rat. | 1994 | Transplant. Proc. | pmid:7520610 |
| Kitamura M et al. | Clinical experience of FK 506 for renal allograft transplantation. | 1994 | Transplant. Proc. | pmid:7520611 |
| Chen CL et al. | FK 506 used as rescue therapy for refractory liver allograft rejection. | 1994 | Transplant. Proc. | pmid:7520612 |
| Pai SY et al. | Cross-linking CD28 leads to activation of 70-kDa S6 kinase. | 1994 | Eur. J. Immunol. | pmid:7523138 |
| Schmidt B et al. | A homodimer represents an active species of the peptidyl-prolyl cis/trans isomerase FKBP25mem from Legionella pneumophila. | 1994 | FEBS Lett. | pmid:7523184 |
| Hakamata Y et al. | Involvement of the brain type of ryanodine receptor in T-cell proliferation. | 1994 | FEBS Lett. | pmid:7523185 |
| Ahern GP et al. | Single channel activity of the ryanodine receptor calcium release channel is modulated by FK-506. | 1994 | FEBS Lett. | pmid:7523191 |
| Clipstone NA et al. | Molecular analysis of the interaction of calcineurin with drug-immunophilin complexes. | 1994 | J. Biol. Chem. | pmid:7523407 |
| Lemster B et al. | Influence of FK 506 (tacrolimus) on circulating CD4+ T cells expressing CD25 and CD45RA antigens in 19 patients with chronic progressive multiple sclerosis participating in an open label drug safety trial. | 1994 | Autoimmunity | pmid:7539635 |
| Wakabayashi H et al. | The effect of FK506 on warm ischemia and reperfusion injury in the rat liver. | 1994 | Surg. Today | pmid:7539646 |
| Lepre CA et al. | Solution structure of FK506 bound to the R42K, H87V double mutant of FKBP-12. | 1994 | Biochemistry | pmid:7524662 |
| Yu L and Fesik SW | pH titration of the histidine residues of cyclophilin and FK506 binding protein in the absence and presence of immunosuppressant ligands. | 1994 | Biochim. Biophys. Acta | pmid:7524680 |
| Papaccio G et al. | The immunosuppressant FK506 inhibits the damage to mouse pancreatic islets induced by low dose streptozocin. | 1994 | Cell Tissue Res. | pmid:7525068 |
| Robertus J | Structure-based drug design ten years on. | 1994 | Nat. Struct. Biol. | pmid:7545074 |
| Milan D et al. | The latch region of calcineurin B is involved in both immunosuppressant-immunophilin complex docking and phosphatase activation. | 1994 | Cell | pmid:7525078 |
| Ericzon B et al. | Glucose metabolism in liver transplant recipients treated with FK 506 or cyclosporin in the European multicentre study. | 1994 | Transpl. Int. | pmid:11271178 |
| Undre N and Möller A | Pharmacokinetic interpretation of FK 506 levels in blood and in plasma during a European randomised study in primary liver transplant patients. The FK 506 European Study Group. | 1994 | Transpl. Int. | pmid:11271189 |
| Yano K et al. | Effects of intrahepatic arterial and intraportal administration of FK 506 on liver allograft survival in rats. | 1994 | Transpl. Int. | pmid:11271200 |
| Jiang H et al. | The superior effect of the combination of FK 506 and deoxyspergualin on rat cardiac allograft survival. | 1994 | Transpl. Int. | pmid:7527637 |
| Winkler M et al. | The use of plasma levels for FK 506 dosing in liver-grafted patients. | 1994 | Transpl. Int. | pmid:7527638 |
| Stark JH et al. | Sensitivity of baboon lymphocytes to cyclosporin A and FK 506: relative resistance of alloactivated cells to CyA. | 1994 | Transpl. Int. | pmid:7527639 |
| Abdalla AH et al. | FK 506 as an alternative in cyclosporin-induced hemolytic uremic syndrome in a kidney transplant recipient. | 1994 | Transpl. Int. | pmid:7527640 |
| Cooper MH et al. | Short-term myeloid reconstitution following TBI is not adversely affected by doses of FK506 that abrogate lethal GVHD. | 1994 | Bone Marrow Transplant. | pmid:7527689 |
| Yasunami Y and Ikeda S | Induction of donor specific unresponsiveness in rat islet allografts by intraportal grafting and FK506. | 1994 | Cell Transplant | pmid:7512877 |
| Mor E et al. | Reversal of gastrointestinal toxicity associated with long-term FK506 immunosuppression by conversion to cyclosporine in liver transplant recipients. | 1994 | Transplantation | pmid:7513098 |
| Lhoëst G et al. | Isolation and identification of a novel isomerized epoxide metabolite of FK-506 from erythromycin-induced rabbit liver microsomes. | 1993 Sep-Oct | Drug Metab. Dispos. | pmid:7694828 |
| Iwasaki K et al. | Isolation, identification, and biological activities of oxidative metabolites of FK506, a potent immunosuppressive macrolide lactone. | 1993 Nov-Dec | Drug Metab. Dispos. | pmid:7507815 |
| Fukuse T et al. | Combined therapy with FK-506 and cyclosporine for canine lung allotransplantation: immunosuppressive effects and blood trough levels. | 1993 Nov-Dec | J. Heart Lung Transplant. | pmid:7508750 |
| Morris RE | New small molecule immunosuppressants for transplantation: review of essential concepts. | 1993 Nov-Dec | J. Heart Lung Transplant. | pmid:7508752 |
| Schreier MH | Immunophilins and immunosuppression. | 1993 Mar-Apr | Clin. Exp. Rheumatol. | pmid:7686830 |
| Piekoszewski W et al. | Disposition of tacrolimus (FK 506) in rabbits. Role of red blood cell binding in hepatic clearance. | 1993 Jul-Aug | Drug Metab. Dispos. | pmid:7690698 |
| Kobayashi J et al. | A new rat infection-heart transplant model: effect of infection on graft survival studies. | 1993 Jul-Aug | J. Heart Lung Transplant. | pmid:7690253 |
| Murase N et al. | Effect of FK 506 and antiproliferative agents for heart and liver xenotransplantation from hamster to rat. | 1993 | Transplant. Proc. | pmid:7679817 |
| Schreier MH et al. | Inhibition of T-cell signaling pathways by immunophilin drug complexes: are side effects inherent to immunosuppressive properties? | 1993 | Transplant. Proc. | pmid:7679818 |
| Kahan BD | Cyclosporine: the base for immunosuppressive therapy--present and future. | 1993 | Transplant. Proc. | pmid:7679819 |
| Starzl TE | FK 506 versus cyclosporine. | 1993 | Transplant. Proc. | pmid:7679820 |
| Todo S et al. | Intestinal transplantation in humans under FK 506. | 1993 | Transplant. Proc. | pmid:7680148 |
| Reyes J et al. | Nutritional management of intestinal transplant recipients. | 1993 | Transplant. Proc. | pmid:7680149 |
| Abu-Elmagd KM et al. | Monitoring and treatment of intestinal allograft rejection in humans. | 1993 | Transplant. Proc. | pmid:7680150 |
| Yem AW et al. | An active FK506-binding domain of 17,000 daltons is isolated following limited proteolysis of chicken thymus hsp56. | 1993 | Biochemistry | pmid:7504525 |
| Manev H et al. | Macrolide antibiotics protect neurons in culture against the N-methyl-D-aspartate (NMDA) receptor-mediated toxicity of glutamate. | 1993 | Brain Res. | pmid:7504570 |
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| Lieberman I et al. | Synergy between tetrandrine and FK506 in prevention of diabetes in BB rats. | 1993 | Life Sci. | pmid:7504774 |
| Lundemose AG et al. | Chlamydia trachomatis Mip-like protein has peptidyl-prolyl cis/trans isomerase activity that is inhibited by FK506 and rapamycin and is implicated in initiation of chlamydial infection. | 1993 | Mol. Microbiol. | pmid:7682281 |
| Wiesner RH et al. | Early cellular rejection treated with high-dose intravenous corticosteroid therapy is associated with a decrease in the incidence of steroid-resistant rejection and graft failure from rejection. | 1993 | Transplant. Proc. | pmid:7682352 |
| Frank B et al. | Neurotoxicity of FK 506 in liver transplant recipients. | 1993 | Transplant. Proc. | pmid:7682355 |
| Klintmalm GB et al. | Rejection: FK 506 for rescue or maintenance. | 1993 | Transplant. Proc. | pmid:7682356 |
| Fernandes JB et al. | Comparative investigation of the effects of the immunosuppressants cyclosporine A, cyclosporine G, and FK-506 on platelet activation. | 1993 | Cell. Mol. Biol. Res. | pmid:7507391 |
| David M et al. | [Changes in cervix cytology in women with liver transplants treated with immunosuppressive therapy]. | 1993 | Zentralbl Gynakol | pmid:7692689 |
| Wallemacq PE and Reding R | FK506 (tacrolimus), a novel immunosuppressant in organ transplantation: clinical, biomedical, and analytical aspects. | 1993 | Clin. Chem. | pmid:7693372 |
| Nakamura T et al. | Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions. | 1993 | EMBO J. | pmid:7693452 |
| Lemster B et al. | FK 506 inhibits cytokine gene and adhesion molecule expression in psoriatic skin lesions. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509134 |
| Tamura K et al. | Inhibitory effect of FK 506 on autoimmune thyroid disease in the PVG rat. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509135 |
| Ochiai T et al. | Combination of immunosuppressive drugs for organ transplantation. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509136 |
| Wiederrecht G et al. | The mechanism of action of FK-506 and cyclosporin A. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509138 |
| Becker JW et al. | FK-506-binding protein: three-dimensional structure of the complex with the antagonist L-685,818. | 1993 | J. Biol. Chem. | pmid:7684380 |
| Dickey JB et al. | Periocular FK-506 delays allograft rejection in rat penetrating keratoplasty. | 1993 | Cornea | pmid:7684663 |
| Francavilla A et al. | Hepatic regeneration and growth factors. | 1993 | J Surg Oncol Suppl | pmid:7684910 |
| Hibbins M et al. | Inhibition of PHA induced mononuclear cell proliferation by FK506 in combination with cyclosporine, methylprednisolone, 6-mercaptopurine and mycophenolic acid. | 1993 | Transpl. Immunol. | pmid:7521736 |
| Thomson AW et al. | Effects of combined administration of FK 506 and the purine biosynthesis inhibitors mizoribine or mycophenolic acid on lymphocyte DNA synthesis and T cell activation molecule expression in human mixed lymphocyte cultures. | 1993 | Transpl. Immunol. | pmid:7521738 |
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| Koga T et al. | Pulmonary infiltrates recovered by FK506 in a patient with Behçet's disease. | 1993 | Chest | pmid:7686837 |
| Nishi M et al. | Effects of the immunosuppressant FK506 on a penetrating keratoplasty rejection model in the rat. | 1993 | Invest. Ophthalmol. Vis. Sci. | pmid:7686893 |
| Odocha O et al. | Serum cholesterol levels in African Americans after renal transplantation under FK 506 immunosuppression. | 1993 | Transplant. Proc. | pmid:7689269 |
| McCauley J et al. | Renal transplantation under FK 506 in African-Americans: early experience. | 1993 | Transplant. Proc. | pmid:7689270 |
| Groth CG et al. | New immunosuppressive drugs in transplantation. | 1993 | Transplant. Proc. | pmid:7689274 |
| Whitington PF et al. | Orthotopic auxiliary liver transplantation for Crigler-Najjar syndrome type 1. | 1993 | Lancet | pmid:7690444 |