Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Garcia C et al. | Collaborative Brazilian Pediatric Renal Transplant Registry (CoBrazPed-RTx): A Report From 2004 to 2013. | 2015 | Transplant. Proc. | pmid:26036492 |
Melo MJ et al. | Impact of conversion from Advagraf to twice-daily generic tacrolimus in kidney transplant recipients: a single-center study. | 2015 | Transplant. Proc. | pmid:26036484 |
Miyata H et al. | Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive. | 2015 | Science | pmid:26429887 |
Meyer C et al. | Impact of irradiation and immunosuppressive agents on immune system homeostasis in rhesus macaques. | 2015 | Clin. Exp. Immunol. | pmid:25902927 |
Sassi MB et al. | Involvement of CYP 3A5 In the Interaction Between Tacrolimus and Nicardipine: A Case Report. | 2015 | Curr Drug Saf | pmid:25968921 |
Wang CY et al. | Analysis of tacrolimus blood concentrations in renal transplant patients. | 2015 | Genet. Mol. Res. | pmid:25966149 |
Caro J et al. | Predictors of response and relapse in patients with idiopathic membranous nephropathy treated with tacrolimus. | 2015 | Nephrol. Dial. Transplant. | pmid:25274748 |
Wang L et al. | Benefits of minimizing immunosuppressive dosage according to cytochrome P450 3A5 genotype in liver transplant patients: findings from a single-center study. | 2015 | Genet. Mol. Res. | pmid:25966085 |
Bedi M and Taylor AL | Recalcitrant Hailey-Hailey disease responds to oral tacrolimus and botulinum toxin type A. | 2015 | Cutis | pmid:26761940 |
Colak H et al. | Relationship of Interleukin-10 and Transforming Growth Factor-β Levels With Short-Term Graft Function After Kidney Transplantation. | 2015 | Transplant. Proc. | pmid:25964218 |
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Chen KH et al. | De novo cancer avoidance after renal transplantation: A case-control study on low-dose sirolimus combined with a calcineurin inhibitor. | 2015 | J. Formos. Med. Assoc. | pmid:25843527 |
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Gajzlerska W et al. | Use of three-carbon chain compounds as biosynthesis precursors to enhance tacrolimus production in Streptomyces tsukubaensis. | 2015 | N Biotechnol | pmid:25152525 |
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Yu Z et al. | IL-15 is decreased upon CsA and FK506 treatment of acute rejection following heart transplantation in mice. | 2015 | Mol Med Rep | pmid:25333459 |
Tajdaran K et al. | A novel polymeric drug delivery system for localized and sustained release of tacrolimus (FK506). | 2015 | Biotechnol. Bioeng. | pmid:25850693 |
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Jia N et al. | Collapsing focal segmental glomerulosclerosis following long-term treatment with oral ibandronate: case report and review of literature. | 2015 | BMC Cancer | pmid:26197890 |
Duong SQ et al. | Transition from brand to generic tacrolimus is associated with a decrease in trough blood concentration in pediatric heart transplant recipients. | 2015 | Pediatr Transplant | pmid:26497983 |
Pucci N et al. | Tacrolimus vs. cyclosporine eyedrops in severe cyclosporine-resistant vernal keratoconjunctivitis: A randomized, comparative, double-blind, crossover study. | 2015 | Pediatr Allergy Immunol | pmid:25712437 |
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Van der Perren A et al. | FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease. | 2015 | Neurobiol. Aging | pmid:25660193 |
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Kallscheuer N et al. | Single-Domain Peptidyl-Prolyl cis/trans Isomerase FkpA from Corynebacterium glutamicum Improves the Biomass Yield at Increased Growth Temperatures. | 2015 | Appl. Environ. Microbiol. | pmid:26341203 |
Rojas-Vega L et al. | Increased phosphorylation of the renal Na+-Cl- cotransporter in male kidney transplant recipient patients with hypertension: a prospective cohort. | 2015 | Am. J. Physiol. Renal Physiol. | pmid:26336164 |
Sánchez-Lázaro I et al. | Association of SNPs with the efficacy and safety of immunosuppressant therapy after heart transplantation. | 2015 | Pharmacogenomics | pmid:26107754 |
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Urquhart BL and Knauer MJ | Dried blood spots for therapeutic drug monitoring of tacrolimus and sirolimus in pediatric patients. | 2015 | Pediatr Transplant | pmid:25546506 |
Minami-Hori M et al. | Periorbital lupus profundus successfully treated with oral tacrolimus plus low-dose prednisolone. | 2015 | J. Dermatol. | pmid:25544984 |
Pagliarello C et al. | Calcipotriol/betamethasone dipropionate ointment compared with tacrolimus ointment for the treatment of erosive pustular dermatosis of the scalp: a split-lesion comparison. | 2015 | Eur J Dermatol | pmid:25786341 |
Xing J et al. | Association between interleukin-18 promoter variants and tacrolimus pharmacokinetics in Chinese renal transplant patients. | 2015 | Eur. J. Clin. Pharmacol. | pmid:25487141 |
Muduma G et al. | Evaluating the economic implications of non-adherence and antibody-mediated rejection in renal transplant recipients: the role of once-daily tacrolimus in the UK. | 2015 | J Med Econ | pmid:26201252 |
Mizuno K et al. | Dexamethasone but not tacrolimus suppresses TNF-α-induced thymic stromal lymphopoietin expression in lesional keratinocytes of atopic dermatitis model. | 2015 | J. Dermatol. Sci. | pmid:26198442 |
Niioka T et al. | Effects of CYP3A5 polymorphism and the tacrolimus 12 h concentration on tacrolimus-induced acute renal dysfunction in patients with lupus nephritis. | 2015 | Xenobiotica | pmid:26189776 |
Rathi M et al. | Conversion from tacrolimus to cyclosporine in patients with new-onset diabetes after renal transplant: an open-label randomized prospective pilot study. | 2015 | Transplant. Proc. | pmid:26036543 |
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