Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Prytula A et al. | Tacrolimus Predose Concentration Is Associated With Hypertension in Pediatric Liver Transplant Recipients. | 2016 | J. Pediatr. Gastroenterol. Nutr. | pmid:26910645 |
Muduma G et al. | Indirect treatment comparison of belatacept versus tacrolimus from a systematic review of immunosuppressive therapies for kidney transplant patients. | 2016 | Curr Med Res Opin | pmid:26907083 |
Sato Y et al. | Acute encephalitis with refractory, repetitive partial seizures: Pathological findings and a new therapeutic approach using tacrolimus. | 2016 | Brain Dev. | pmid:26906012 |
Ghareeb M and Akhlaghi F | Development and validation of a sensitive and selective LC-MS/MS method for determination of tacrolimus in oral fluids. | 2016 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:27771258 |
Fu LF et al. | Improvement of FK506 production by synthetic biology approaches. | 2016 | Biotechnol. Lett. | pmid:27600954 |
Rodrigo E et al. | Within-Patient Variability in Tacrolimus Blood Levels Predicts Kidney Graft Loss and Donor-Specific Antibody Development. | 2016 | Transplantation | pmid:26703349 |
Coghill AE et al. | Immunosuppressive Medications and Squamous Cell Skin Carcinoma: Nested Case-Control Study Within the Skin Cancer after Organ Transplant (SCOT) Cohort. | 2016 | Am. J. Transplant. | pmid:26824445 |
Hellström VC et al. | Malignancies in transplanted patients: Multidisciplinary evaluation and switch to mTOR inhibitors after kidney transplantation - experiences from a prospective, clinical, observational study. | 2016 | Acta Oncol | pmid:26824275 |
Snell GI et al. | ABO incompatible renal transplantation following lung transplantation. | 2016 | Transpl. Immunol. | pmid:27663090 |
Juillerat A et al. | Design of chimeric antigen receptors with integrated controllable transient functions. | 2016 | Sci Rep | pmid:26750734 |
Prakash A et al. | Crystal structure of the FK506 binding domain of human FKBP25 in complex with FK506. | 2016 | Protein Sci. | pmid:26749369 |
Bae JM et al. | Repigmentation of poliosis in a patient with segmental vitiligo. | 2016 | J. Am. Acad. Dermatol. | pmid:27317537 |
Ganetsky A et al. | Higher tacrolimus concentrations early after transplant reduce the risk of acute GvHD in reduced-intensity allogeneic stem cell transplantation. | 2016 | Bone Marrow Transplant. | pmid:26691423 |
El-Asmar J et al. | Clotrimazole troches induce supratherapeutic blood levels of sirolimus and tacrolimus in an allogeneic hematopoietic cell-transplant recipient resulting in acute kidney injury. | 2016 | Hematol Oncol Stem Cell Ther | pmid:26684920 |
Wasiak D et al. | Delayed, Uncommon Recurrence of Hepatocellular Carcinoma After Liver Transplantation: A Case Report. | 2016 | Transplant. Proc. | pmid:27496507 |
Gojowy D et al. | High Frequency of Arterial Hypertension in Patients After Liver Transplantation. | 2016 | Transplant. Proc. | pmid:27496479 |
Wilusz M et al. | Effects of Immunosuppressive Drugs on Serum Fatty Acids of Phospholipids Fraction in Renal Transplant Recipients. | 2016 | Transplant. Proc. | pmid:27496457 |
Wu Q et al. | Repair of Neurological Function in Response to FK506 Through CaN/NFATc1 Pathway Following Traumatic Brain Injury in Rats. | 2016 | Neurochem. Res. | pmid:27386875 |
O'Donnell JC et al. | Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes. | 2016 | J. Neurosci. | pmid:27383588 |
Zarrinpar A et al. | Individualizing liver transplant immunosuppression using a phenotypic personalized medicine platform. | 2016 | Sci Transl Med | pmid:27053773 |
Oetting WS et al. | Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles. | 2016 | Am. J. Transplant. | pmid:26485092 |
Deininger KM et al. | CYP3A pharmacogenetics and tacrolimus disposition in adult heart transplant recipients. | 2016 | Clin Transplant | pmid:27314545 |
de Mesquita Coutinho PR et al. | Effects of tacrolimus and erythropoietin in experimental spinal cord lesion in rats: functional and histological evaluation. | 2016 | Spinal Cord | pmid:26481712 |
M Kotowski M et al. | The influence of the tumor necrosis factor-alpa-308G>A polymorphism on the efficacy of immunosuppressive therapy in patients after kidney transplantation. | 2016 | J. Physiol. Pharmacol. | pmid:28195062 |
Kyaw TH et al. | A 45-Year-Old Woman With 3 Weeks of Cough and Night Sweats. | 2016 | Chest | pmid:26965979 |
Golubovic B et al. | Population Pharmacokinetic Approach of Immunosuppressive Therapy in Kidney Transplant Patients. | 2016 | Curr. Med. Chem. | pmid:26687831 |
Hošková L et al. | Comparison of Cystatin C and NGAL in Early Diagnosis of Acute Kidney Injury After Heart Transplantation. | 2016 | Ann. Transplant. | pmid:27226081 |
Yousef AM et al. | Effects of Genetic Polymorphism in CYP3A4 and CYP3A5 Genes on Tacrolimus Dose Among Kidney Transplant Recipients. | 2016 | Iran J Kidney Dis | pmid:27225724 |
Fields JA et al. | Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity. | 2016 | J Neuroinflammation | pmid:27220536 |
Jia W et al. | The calcineruin inhibitor cyclosporine a synergistically enhances the susceptibility of Candida albicans biofilms to fluconazole by multiple mechanisms. | 2016 | BMC Microbiol. | pmid:27316338 |
Azzi J et al. | Targeted Delivery of Immunomodulators to Lymph Nodes. | 2016 | Cell Rep | pmid:27134176 |
SelimoÄŸlu MA et al. | Evaluation of renal functions in pediatric liver transplantation. | 2016 | Pediatr Transplant | pmid:26607307 |
Giussani A et al. | Posterior reversible encephalopathy syndrome after kidney transplantation in pediatric recipients: Two cases. | 2016 | Pediatr Transplant | pmid:26607205 |
Adler M et al. | A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. | 2016 | J. Am. Soc. Nephrol. | pmid:26260164 |
Jung H and Oh ES | FK506 positively regulates the migratory potential of melanocyte-derived cells by enhancing syndecan-2 expression. | 2016 | Pigment Cell Melanoma Res | pmid:27060922 |
Labroo P et al. | Controlled Delivery of FK506 to Improve Nerve Regeneration. | 2016 | Shock | pmid:27058050 |
Kawahara T et al. | Cyclosporine A and tacrolimus inhibit urothelial tumorigenesis. | 2016 | Mol. Carcinog. | pmid:25594762 |
Sinangil A et al. | New-Onset Diabetes After Kidney Transplantation and Pretransplant Hypomagnesemia. | 2016 | Prog Transplant | pmid:27136250 |
Moiseev IS et al. | Graft-versus-Host Disease Prophylaxis in Unrelated Peripheral Blood Stem Cell Transplantation with Post-Transplantation Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil. | 2016 | Biol. Blood Marrow Transplant. | pmid:26970381 |
Dury S et al. | Bronchiectasis diagnosed after renal transplantation: a retrospective multicenter study. | 2015 | BMC Pulm Med | pmid:26545860 |
Obayashi N et al. | Management of tacrolimus-associated food allergy after liver transplantation. | 2015 | Pediatr Int | pmid:26541649 |
Kwon M et al. | Bioequivalence of tacrolimus formulations with different dynamic solubility and in-vitro dissolution profiles. | 2015 | Arch. Pharm. Res. | pmid:24627339 |
Tang T et al. | Roles of the tacrolimus-dependent transcription factor IRF4 in acute rejection after liver transplantation. | 2015 | Int. Immunopharmacol. | pmid:26093273 |
Hu L et al. | Severe Tacrolimus-Induced Granulomatous Rosacea Recalcitrant to Oral Tetracyclines. | 2015 | J Drugs Dermatol | pmid:26091390 |
Boukoum H et al. | BK and JC polyomavirus infections in Tunisian renal transplant recipients. | 2015 | J. Med. Virol. | pmid:25952258 |
Miura M et al. | Tacrolimus reduction with everolimus addition for calcineurin inhibitor-induced arteriolopathy in kidney allografts. | 2015 | Nephrology (Carlton) | pmid:26031588 |
Yagisawa T et al. | Arteriosclerosis in zero-time biopsy is a risk factor for tacrolimus-induced chronic nephrotoxicity. | 2015 | Nephrology (Carlton) | pmid:26031587 |
Lee J et al. | A 12-month single arm pilot study to evaluate the efficacy and safety of sirolimus in combination with tacrolimus in kidney transplant recipients at high immunologic risk. | 2015 | J. Korean Med. Sci. | pmid:26028917 |
Kaieda S et al. | Successful treatment of macrophage activation syndrome in a patient with dermatomyositis by combination with immunosuppressive therapy and plasmapheresis. | 2015 | Mod Rheumatol | pmid:24252010 |
Ichimaru N et al. | Risk factors and incidence for lipid abnormalities in kidney transplant patients. | 2015 | Transplant. Proc. | pmid:25891708 |
Lim EJ et al. | Effect of Immunosuppressive Agents on Hepatocyte Apoptosis Post-Liver Transplantation. | 2015 | PLoS ONE | pmid:26390404 |
Shu WY et al. | Pharmacogenomics and personalized medicine: a review focused on their application in the Chinese population. | 2015 | Acta Pharmacol. Sin. | pmid:25891088 |
Baird K et al. | Imatinib mesylate for the treatment of steroid-refractory sclerotic-type cutaneous chronic graft-versus-host disease. | 2015 | Biol. Blood Marrow Transplant. | pmid:25771402 |
Soto GAC et al. | Dose increase needed in most cystic fibrosis lung transplantation patients when changing from twice- to once-daily tacrolimus oral administration. | 2015 | Eur. J. Clin. Pharmacol. | pmid:25953736 |
Rojas L et al. | Effect of CYP3A5*3 on kidney transplant recipients treated with tacrolimus: a systematic review and meta-analysis of observational studies. | 2015 | Pharmacogenomics J. | pmid:25201288 |
Daunton A et al. | A cutaneous presentation of a common condition. | 2015 | BMJ | pmid:26681202 |
Yang SS et al. | A single center, open-label, randomized pilot study to evaluate the safety and efficacy of tacrolimus modified release, Advagraf, versus tacrolimus twice daily, Prograf, in stable renal recipients (single). | 2015 | Transplant. Proc. | pmid:25891697 |
Ã…berg F et al. | Asymptomatic De Novo Inflammatory Bowel Disease Late After Liver Transplantation for Primary Sclerosing Cholangitis: A Case Report. | 2015 | Transplant. Proc. | pmid:26680092 |
Hempen CM et al. | Hematocrit-independent recovery of immunosuppressants from DBS using heated flow-through desorption. | 2015 | Bioanalysis | pmid:26327182 |
Reig Mezquida JP et al. | Thrombotic microangiopathy associated with tacrolimus in lung transplantation. | 2015 | Arch. Bronconeumol. | pmid:25138798 |
Rajaganapathy BR et al. | Intravesical Liposomal Tacrolimus Protects against Radiation Cystitis Induced by 3-Beam Targeted Bladder Radiation. | 2015 | J. Urol. | pmid:25839382 |
Furlan SN et al. | Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention. | 2015 | Sci Transl Med | pmid:26606970 |
Nagashima T and Minota S | Comment on: The efficacy of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis. | 2015 | Rheumatology (Oxford) | pmid:25832615 |
Vollmar J et al. | Efficacy and safety of a conversion from the original tacrolimus and mycophenolate mofetil to the generics Tacpan and Mowel after liver transplantation. | 2015 | Drug Des Devel Ther | pmid:26604701 |
Yasuda S et al. | Comment on: The efficacy of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis: reply. | 2015 | Rheumatology (Oxford) | pmid:25832614 |
Eichenfield DZ and Eichenfield LF | Pimecrolimus is safe and effective in treating atopic dermatitis. | 2015 | J. Pediatr. | pmid:26603713 |
Calabrese B and Halpain S | Differential targeting of dynamin-1 and dynamin-3 to nerve terminals during chronic suppression of neuronal activity. | 2015 | Mol. Cell. Neurosci. | pmid:25827095 |
Wang YY et al. | Biochemical characterization of a malonyl-specific acyltransferase domain of FK506 biosynthetic polyketide synthase. | 2015 | Protein Pept. Lett. | pmid:25267255 |
Adotama P et al. | Patient satisfaction with different treatment modalities for vitiligo. | 2015 | J. Am. Acad. Dermatol. | pmid:25773415 |
Cendales L et al. | Tacrolimus to Belatacept Conversion Following Hand Transplantation: A Case Report. | 2015 | Am. J. Transplant. | pmid:25773260 |
Singh N et al. | Extended release once a day tacrolimus. | 2015 | Curr Opin Organ Transplant | pmid:26536429 |
Mahajan R et al. | Co-localization of agminated congenital melanocytic nevi with vitiligo vulgaris: an unusual presentation. | 2015 | Int. J. Dermatol. | pmid:25039486 |
Zitelli K et al. | Eosinophilic folliculitis occurring after stem cell transplant for acute lymphoblastic leukemia: a case report and review. | 2015 | Int. J. Dermatol. | pmid:25039354 |
Yokoyama Y et al. | Corticosteroid-sparing effect of tacrolimus in the initial treatment of dermatomyositis and polymyositis. | 2015 | Mod Rheumatol | pmid:25775144 |
Asrani SK and O'Leary JG | Can one pill a day keep rejection away? | 2015 | Am. J. Transplant. | pmid:25703394 |
Guethoff S et al. | De novo sirolimus with low-dose tacrolimus versus full-dose tacrolimus with mycophenolate mofetil after heart transplantation--8-year results. | 2015 | J. Heart Lung Transplant. | pmid:25701373 |
Kim M et al. | Nail lichen striatus: report of seven cases and review of the literature. | 2015 | Int. J. Dermatol. | pmid:26474189 |
Cen J et al. | The new immunosuppressant, isogarcinol, binds directly to its target enzyme calcineurin, unlike cyclosporin A and tacrolimus. | 2015 | Biochimie | pmid:25701551 |
Mizokami D et al. | Tacrolimus prevents laryngotracheal stenosis in an acute-injury rat model. | 2015 | Laryngoscope | pmid:25647147 |
Ferjani H et al. | Tacrolimus and mycophenolate mofetil associations: Induction of oxidative stress or antioxidant effect? | 2015 | Hum Exp Toxicol | pmid:25645822 |
RodrÃguez-Perálvarez M et al. | Everolimus is safe within the first month after liver transplantation. | 2015 | Transpl. Immunol. | pmid:26392195 |
Ishida K et al. | Evaluation of the Safety and Effectiveness of Add-On Tacrolimus in Patients with Rheumatoid Arthritis Who Failed to Show an Adequate Response to Biological DMARDs: The Interim Results of a Specific Drug Use-Results Survey of Tacrolimus. | 2015 | Drugs R D | pmid:26386566 |
Knops N et al. | The functional implications of common genetic variation in CYP3A5 and ABCB1 in human proximal tubule cells. | 2015 | Mol. Pharm. | pmid:25590378 |
Ge Y et al. | The efficacy of tacrolimus in patients with refractory dermatomyositis/polymyositis: a systematic review. | 2015 | Clin. Rheumatol. | pmid:26328518 |
Demir T et al. | Cancer Screening of Renal Transplant Patients Undergoing Long-Term Immunosuppressive Therapy. | 2015 | Transplant. Proc. | pmid:26093731 |
Schaap MM et al. | A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens. | 2015 | Arch. Toxicol. | pmid:25270620 |
Yoo MC et al. | Steroid-free Liver Transplantation Using Rabbit Antithymocyte Globulin Induction in 500 Consecutive Patients. | 2015 | Transplantation | pmid:25539464 |
Offer K et al. | Efficacy of tacrolimus/mycophenolate mofetil as acute graft-versus-host disease prophylaxis and the impact of subtherapeutic tacrolimus levels in children after matched sibling donor allogeneic hematopoietic cell transplantation. | 2015 | Biol. Blood Marrow Transplant. | pmid:25536217 |
Ramachandran R et al. | Role of Tacrolimus only therapy in modified Ponticelli regimen resistant idiopathic membranous glomerulonephritis. | 2015 | Nephrology (Carlton) | pmid:25535867 |
Aikawa Y et al. | Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells. | 2015 | Cancer Sci. | pmid:25529853 |
Kim SH et al. | Conversion of twice-daily to once-daily tacrolimus is safe in stable adult living donor liver transplant recipients. | 2015 | HBPD INT | pmid:26256081 |
Clift DE et al. | Effects of embryonic cyclosporine exposures on brain development and behavior. | 2015 | Behav. Brain Res. | pmid:25591474 |
Duvoux C et al. | Sustained virological response to antiviral therapy in a randomized trial of cyclosporine versus tacrolimus in liver transplant patients with recurrent hepatitis C infection. | 2015 | Ann. Transplant. | pmid:25588713 |
Valke LL et al. | Soluble CD30 does not predict late acute rejection or safe tapering of immunosuppression in renal transplantation. | 2015 | Transpl. Immunol. | pmid:25446808 |
Huang G et al. | Monitoring of polyomavirus BK replication and impact of preemptive immunosuppression reduction in renal-transplant recipients in China: a 5-year single-center analysis. | 2015 | Diagn. Microbiol. Infect. Dis. | pmid:25445121 |
Spiekerkoetter E et al. | Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension. | 2015 | Am. J. Respir. Crit. Care Med. | pmid:26177174 |
Mandelbrot DA et al. | Effect of Ramipril on Urinary Protein Excretion in Maintenance Renal Transplant Patients Converted to Sirolimus. | 2015 | Am. J. Transplant. | pmid:26176342 |
Regelmann MO et al. | New-onset diabetes mellitus after pediatric liver transplantation. | 2015 | Pediatr Transplant | pmid:26032592 |
Guo CL et al. | Efficacy of Topical Tacrolimus for Erosive Oral Lichen Planus: A Meta-analysis. | 2015 | Chin. Med. Sci. J. | pmid:26960301 |
Apalla Z et al. | Psoriatic cheilitis: a report of 2 cases treated successfully with topical tacrolimus and a review of the literature. | 2015 | Actas Dermosifiliogr | pmid:26164836 |