tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sewing KF | Pharmacokinetics, dosing principles, and blood level monitoring of FK506. | 1994 | Transplant. Proc. | pmid:7527962 |
| Klintmalm GB et al. | Prognostic factors for successful conversion from cyclosporine to FK 506-based immunosuppressive therapy for refractory rejection after liver transplantation. US Multicenter FK 506 Liver Study Group. | 1993 | Transplant. Proc. | pmid:7679828 |
| Tang J et al. | Cytokine Profile in Calcineurin Inhibitor-Induced Chronic Nephrotoxicity in Chinese Liver Transplant Recipients. | 2016 | Transplant. Proc. | pmid:27788813 |
| Wachtman GS et al. | Biologics and donor bone marrow cells for targeted immunomodulation in vascularized composite allotransplantation: a translational trial in swine. | 2011 | Transplant. Proc. | pmid:22099837 |
| Venkataramanan R et al. | Pharmacokinetics of FK 506 in transplant patients. | 1991 | Transplant. Proc. | pmid:1721261 |
| Washburn WK et al. | Tacrolimus rescue therapy for renal allograft rejection refractory to cyclosporine-based immunosuppression. | 1996 | Transplant. Proc. | pmid:8623214 |
| Fitzsimmons WE et al. | Demographic considerations in tacrolimus pharmacokinetics. | 1998 | Transplant. Proc. | pmid:9636552 |
| Jang HJ et al. | Conversion from cyclosporine to tacrolimus in renal allograft recipients with delayed graft function from severe acute tubular necrosis. | 2000 | Transplant. Proc. | pmid:11119904 |
| Chakkera HA et al. | Genetic differences in Native Americans and tacrolimus dosing after kidney transplantation. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375287 |
| Burke GW et al. | Tacrolimus-related microangiopathy in kidney and simultaneous pancreas-kidney recipients: evidence of endothelin and cytokine involvement. | 1998 | Transplant. Proc. | pmid:9532223 |
| Tian Ch et al. | B- and T-lymphocyte attenuator/herpes virus entry mediator as early indicators for acute rejection following kidney transplantation. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375291 |
| Sahar G et al. | Glucose metabolism in heart transplant recipients treated with FK506 or cyclosporine. | 2003 | Transplant. Proc. | pmid:12644092 |
| Vilalta R et al. | Delayed graft function is reduced with antithymocyte globulin induction in pediatric kidney transplantation. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715923 |
| Sgrosso JL et al. | Tacrolimus pharmacokinetics in heart transplant. | 2002 | Transplant. Proc. | pmid:11959225 |
| Ueda Y et al. | Induction of graft acceptance after dog kidney or liver transplantation. | 1990 | Transplant. Proc. | pmid:1689909 |
| Žilinská Z et al. | Impact of Trough Levels of Tacrolimus on Kidney Function and Graft Survival in Short and Longer Periods After Renal Transplantation. | 2016 | Transplant. Proc. | pmid:27788794 |
| Akselband Y et al. | Rapamycin inhibits spontaneous and fibroblast growth factor beta-stimulated proliferation of endothelial cells and fibroblasts. | 1991 | Transplant. Proc. | pmid:1721292 |
| Schreiber SL et al. | Immunophilin-ligand complexes as probes of intracellular signaling pathways. | 1991 | Transplant. Proc. | pmid:1721293 |
| Klintmalm GB | Clinical use of FK 506 in liver transplantation. | 1996 | Transplant. Proc. | pmid:8623484 |
| Maggard M et al. | Incidence of acute rejection in African-American liver transplant recipients. | 1998 | Transplant. Proc. | pmid:9636607 |
| Yamaguchi M et al. | FK 506 significantly improves transferred insulin gene expression in total pancreatectomized dogs. | 2000 | Transplant. Proc. | pmid:11120255 |
| Butt TR et al. | Molecular basis of immunosuppressive drug action: regulation of steroid receptor-mediated transcription by FK 506. | 1996 | Transplant. Proc. | pmid:8623486 |
| Mueller AR et al. | Influence of immunosuppression on patient outcome after liver transplantation. | 1998 | Transplant. Proc. | pmid:9636608 |
| Yoshida S et al. | Combination therapy with FK 506 and RS61443 for rejection following allogeneic small bowel transplantation in rats. | 2000 | Transplant. Proc. | pmid:11120262 |
| Morales JM et al. | Tacrolimus, mycophenolate mofetil and corticosteroids as primary immunosuppression after renal transplantation at the Hospital 12 de Octubre, Madrid. | 1999 | Transplant. Proc. | pmid:10576051 |
| Jordan ML et al. | Outcome of tacrolimus conversion therapy for renal allograft rejection: 5-year follow-up. | 1999 | Transplant. Proc. | pmid:10576052 |
| Nishikawa S et al. | Extended mycophenolate mofetil administration beyond day 30 in allogeneic hematopoietic stem cell transplantation as preemptive therapy for severe graft-versus-host disease. | 2009 | Transplant. Proc. | pmid:19917404 |
| Pérez-Flores I et al. | Incidence and risk factors for the metabolic syndrome and posttransplant diabetes in renal transplant recipients taking tacrolimus. | 2010 | Transplant. Proc. | pmid:20970565 |
| Marzorati S et al. | Effects of systemic immunosuppression on islet engraftment and function into a subcutaneous biocompatible device. | 2009 Jan-Feb | Transplant. Proc. | pmid:19249555 |
| Metcalfe S et al. | FK 506 and cyclosporine A: early effects on activation and gene induction in mouse spleen cells. | 1990 | Transplant. Proc. | pmid:1697107 |
| Morris RE et al. | A study of the contrasting effects of cyclosporine, FK 506, and rapamycin on the suppression of allograft rejection. | 1990 | Transplant. Proc. | pmid:1697111 |
| Spada M et al. | Morphology of acute rejection and observation of lymphoproliferative hyperplastic reaction in FK 506 treated pigs after small bowel transplantation. | 1994 | Transplant. Proc. | pmid:7518142 |
| Kai N et al. | A study on the timing of immunologic priming in autoimmune insulitis in NOD mice. | 1992 | Transplant. Proc. | pmid:1376511 |
| Langrehr JM et al. | Liver transplantation in hepatitis B surface antigen positive patients with postoperative long-term immunoprophylaxis. | 1995 | Transplant. Proc. | pmid:7533373 |
| Nakata S et al. | Immunosuppressive effect of FK 506 on cytotoxic T lymphocytes and delayed-type hypersensitivity in rats. | 1991 | Transplant. Proc. | pmid:1721325 |
| Liu B et al. | Single-center experience: tacrolimus and mycophenolate mofetil in early stage of kidney transplantation with liver dysfunction. | 2003 | Transplant. Proc. | pmid:12591396 |
| Nakamura K et al. | Renal transplant recipient experiencing pneumatosis cystoides intestinalis: a case report. | 2003 | Transplant. Proc. | pmid:12591410 |
| Koefoed-Nielsen PB et al. | Comparison of the temporal profile of calcineurin inhibition by cyclosporine and tacrolimus in renal transplant patients. | 2005 | Transplant. Proc. | pmid:15919449 |
| Iwahori T et al. | Pharmacokinetic differences between morning and evening administration of cyclosporine and tacrolimus therapy. | 2005 | Transplant. Proc. | pmid:15919450 |
| Varo E et al. | Cardiovascular risk factors in liver allograft recipients: relationship with immunosuppressive therapy. | 2002 | Transplant. Proc. | pmid:12176481 |
| Winkler M et al. | Comparison of plasma vs whole blood as matrix for FK 506 drug level monitoring. | 1995 | Transplant. Proc. | pmid:7533433 |
| Odoul F et al. | Massive ingestion of tacrolimus in a young liver transplant patient. | 1998 | Transplant. Proc. | pmid:9865375 |
| Van Thiel DH et al. | Interferon therapy of hepatitis following liver transplantation under FK 506 or cyclosporine. | 1991 | Transplant. Proc. | pmid:1721357 |
| Weber M et al. | Decreased rejection episodes in African-American renal transplant recipients receiving mycophenolate mofetil/tacrolimus therapy. | 1997 | Transplant. Proc. | pmid:9414883 |
| Deniz H et al. | Inhibition of the renin angiotensin system decreases fibrogenic cytokine expression in tacrolimus nephrotoxicity in rats. | 2006 | Transplant. Proc. | pmid:16549154 |
| Fisniku O et al. | Protective effects of PG490-88 on chronic allograft rejection by changing intragraft gene expression profiles. | 2005 | Transplant. Proc. | pmid:15919518 |
| Jiménez O et al. | Defining the initial doses of sirolimus and tacrolimus in the period immediately after renal transplantation. | 2003 | Transplant. Proc. | pmid:12962758 |
| Cotovio P et al. | New-onset diabetes after transplantation: assessment of risk factors and clinical outcomes. | 2013 | Transplant. Proc. | pmid:23622631 |
| Cronin DC et al. | Tacrolimus therapy for refractory renal allograft rejection: experience with steroid withdrawal. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123010 |
| Teebken OE et al. | Primary immunosuppression with tacrolimus and mycophenolate mofetil versus cyclosporine and azathioprine in heart transplant recipients. | 2002 | Transplant. Proc. | pmid:12072335 |
| Rossi G et al. | Results of orthotopic liver-small bowel transplantation in the pig using different immunosuppressive regimens. | 1996 | Transplant. Proc. | pmid:8907932 |
| Burke GW et al. | Randomized trial of three different immunosuppressive regimens to prevent chronic renal allograft rejection. | 2002 | Transplant. Proc. | pmid:12176505 |
| Meçule A et al. | Tacrolimus trough levels and level-to-dose ratio in stable renal transplant patients converted to a once-daily regimen. | 2011 | Transplant. Proc. | pmid:21620042 |
| Humar A et al. | Surgical complications requiring early relaparotomy after pancreas transplantation: comparison of the cyclosporine and FK 506 eras. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083256 |
| Kaufman DB et al. | Single-center experience of 60 consecutive simultaneous pancreas-kidney transplants using mycophenolate mofetil and tacrolimus as primary maintenance immunotherapy. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083261 |
| Sanghvi A et al. | Increased cyclosporine uptake by cells pretreated with FK506 and evidence for binding of both drugs to a common intracellular protein. | 1989 | Transplant. Proc. | pmid:2468204 |
| Winkler M et al. | Association of elevated FK 506 plasma levels with nephrotoxicity in liver-grafted patients. | 1991 | Transplant. Proc. | pmid:1721389 |
| Takagishi K et al. | Effects of FK-506 on collagen arthritis in mice. | 1989 | Transplant. Proc. | pmid:2468205 |
| Schmidt RJ et al. | Hemolytic-uremic syndrome in a renal transplant recipient on FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721390 |
| Personett HA et al. | Impact of molecular adsorbent recirculating system therapy on tacrolimus elimination: a case report. | 2014 | Transplant. Proc. | pmid:25017243 |
| Grochowicz PM et al. | Synergistic interaction between castanospermine and tacrolimus in a rat heart allograft model. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123296 |
| Guo Z et al. | Leflunomide, a potential immunosuppressant for pancreatic islet transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123314 |
| Gerbase MW et al. | Low doses of mycophenolate mofetil with low doses of tacrolimus prevent acute rejection and long-term function loss after lung transplantation. | 2001 | Transplant. Proc. | pmid:11377481 |
| Yussim A et al. | Conversion from cyclosporine to tacrolimus in hepatic and renal transplantation. | 1996 | Transplant. Proc. | pmid:8962233 |
| Sifontis NM et al. | Clinically significant drug interaction between basiliximab and tacrolimus in renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176554 |
| Gerhardt U et al. | High QT dispersion in tacrolimus-treated kidney transplant recipients. | 2001 | Transplant. Proc. | pmid:11377482 |
| Golling M et al. | Tacrolimus reduction improves glucose metabolism and insulin secretion after liver transplantation. | 1996 | Transplant. Proc. | pmid:8962234 |
| Toda F et al. | Tacrolimus trough level adjustment after administration of fluconazole to kidney recipients. | 2002 | Transplant. Proc. | pmid:12176555 |
| Ju MK et al. | A 6-month, open-label, multicenter clinical study in Korean de novo renal transplant patients evaluating the efficacy, safety, and tolerance of myfortic concomitantly used with tacrolimus. | 2012 | Transplant. Proc. | pmid:22310600 |
| Ciancio G et al. | Daclizumab induction for primary kidney transplant recipients using tacrolimus, mycophenolate mofetil, and steroids as maintenance immunosuppression. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267169 |
| Boggs S et al. | FK 506 has no short-term effects on endogenous or exogenous myeloid reconstitution in irradiated mice. | 1991 | Transplant. Proc. | pmid:1721420 |
| Ogawa N et al. | Suppressive effects of combination therapy with mizoribine and FK 506 on the development of accelerated coronary artery disease and myocardial rejection after heart transplantation. | 1996 | Transplant. Proc. | pmid:8658710 |
| Pan D et al. | Tacrolimus-associated Diffuse Gastrointestinal Ulcerations and Pathergy: A Case Report. | Transplant. Proc. | pmid:28104141 | |
| Dick TB et al. | Fludrocortisone is effective in the management of tacrolimus-induced hyperkalemia in liver transplant recipients. | 2011 | Transplant. Proc. | pmid:21911143 |
| Zhou S et al. | Tacrolimus enhances the invasion potential of hepatocellular carcinoma cells and promotes lymphatic metastasis in a rat model of hepatocellular carcinoma: involvement of vascular endothelial growth factor-C. | 2011 | Transplant. Proc. | pmid:21911157 |
| Zucker MJ et al. | De novo immunosuppression with sirolimus and tacrolimus in heart transplant recipients compared with cyclosporine and mycophenolate mofetil: a one-year follow-up analysis. | 2005 | Transplant. Proc. | pmid:15964386 |
| Gridelli B et al. | Frequency of switch from cyclosporine to FK 506 before and after Neoral use in pediatric liver transplantation. | 1998 | Transplant. Proc. | pmid:9723311 |
| Kiberd BA et al. | Impact of mycophenolate mofetil loading on drug exposure in the early posttransplant period. | 2005 | Transplant. Proc. | pmid:15964408 |
| Hummel AD et al. | Application of artificial neural networks in renal transplantation: classification of nephrotoxicity and acute cellular rejection episodes. | 2010 | Transplant. Proc. | pmid:20304167 |
| Wiseman AC et al. | Fixed-dose sirolimus with reduced dose calcineurin inhibitor: the University of Colorado experience. | 2003 | Transplant. Proc. | pmid:12742482 |
| Holt DW et al. | Therapeutic monitoring of sirolimus: its contribution to optimal prescription. | 2003 | Transplant. Proc. | pmid:12742490 |
| Webb NJ et al. | Pharmacokinetics of tacrolimus in paediatric renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176639 |
| Collin C et al. | Sublingual tacrolimus as an alternative to intravenous route in patients with thoracic transplant: a retrospective study. | 2010 | Transplant. Proc. | pmid:21168693 |
| Sundberg AK et al. | Conversion from cyclosporine to tacrolimus is preferred by pediatric renal transplant recipients: a focus on opinions and outcomes. | 2002 | Transplant. Proc. | pmid:12176640 |
| Li ZY et al. | Analytical performance of the Abbott Architect i2000 tacrolimus assay in Chinese patients after renal transplantation. | 2010 | Transplant. Proc. | pmid:21168731 |
| Mohamed MA et al. | TGF-beta expression in protocol transplant liver biopsies: a comparative study between cyclosporine-A (CyA) and tacrolimus (FK 506) immunosuppression. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267336 |
| Shokouh-Amiri MH et al. | The importance of early prevention of renal dysfunction in liver transplant recipients. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267345 |
| Alvarez-ElÃas AC et al. | CYP3A5 Genotype and Time to Reach Tacrolimus Therapeutic Levels in Renal Transplant Children. | 2016 | Transplant. Proc. | pmid:27110018 |
| Abu-Elmagd K et al. | Efficacy of FK 506 in the treatment of recalcitrant pyoderma gangrenosum. | 1991 | Transplant. Proc. | pmid:1721451 |
| Cofan F et al. | Oxidation of low-density lipoproteins in renal transplant recipients. | 1999 | Transplant. Proc. | pmid:10500604 |
| Reiner J et al. | After Intestinal Transplantation Kidney Function Is Impaired by Downregulation of Epithelial Ion Transporters in the Ileum. | 2016 | Transplant. Proc. | pmid:27109987 |
| Thomson AW et al. | Influence of FK 506 on T lymphocytes, Langerhans' cells and the expression of cytokine receptors and adhesion molecules in psoriatic skin lesions: a preliminary study. | 1991 | Transplant. Proc. | pmid:1721452 |
| GarcÃa González M et al. | Reversal of QT interval electrocardiographic alterations in cirrhotic patients undergoing liver transplantation. | 1999 | Transplant. Proc. | pmid:10500620 |
| Immunosuppression: FK506. | 1988 | Transplant. Proc. | pmid:2450415 | |
| Todo S et al. | Effect of FK506 in experimental organ transplantation. | 1988 | Transplant. Proc. | pmid:2450416 |
| Yoshimura R et al. | A comparative study between cyclosporine and FK 506 effects on renal microsomal P-450. | 1991 | Transplant. Proc. | pmid:1703686 |
| Miyagawa S et al. | Mechanism of unresponsiveness in rats induced by a short course of FK 506 or CyA. | 1991 | Transplant. Proc. | pmid:1703687 |
| Kinukawa T et al. | Long-term comparison of tacrolimus and cyclosporine-based immunosuppression in kidney recipients with grafts from non-heart-beating cadaver donor. | 1998 | Transplant. Proc. | pmid:9636498 |
| Morris-Stiff G et al. | Preoperative induction with tacrolimus does not have a detrimental effect on primary graft function in adult cadaveric renal transplantation. | 1998 | Transplant. Proc. | pmid:9636499 |
| Alak AM and Moy S | Biological activity of tacrolimus (FK506) and its metabolites from whole blood of kidney transplant patients. | 1997 | Transplant. Proc. | pmid:9270821 |