tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lee YH and Song GG | Relative efficacy and safety of tacrolimus, mycophenolate mofetil, and cyclophosphamide as induction therapy for lupus nephritis: a Bayesian network meta-analysis of randomized controlled trials. | 2015 | Lupus | pmid:26162684 |
| Obayashi N et al. | Management of tacrolimus-associated food allergy after liver transplantation. | 2015 | Pediatr Int | pmid:26541649 |
| Hu L et al. | Severe Tacrolimus-Induced Granulomatous Rosacea Recalcitrant to Oral Tetracyclines. | 2015 | J Drugs Dermatol | pmid:26091390 |
| Melilli E et al. | De novo use of a generic formulation of tacrolimus versus reference tacrolimus in kidney transplantation: evaluation of the clinical results, histology in protocol biopsies, and immunological monitoring. | 2015 | Transpl. Int. | pmid:26088437 |
| Traitanon O et al. | Differential Effects of Tacrolimus versus Sirolimus on the Proliferation, Activation and Differentiation of Human B Cells. | 2015 | PLoS ONE | pmid:26087255 |
| Boukoum H et al. | BK and JC polyomavirus infections in Tunisian renal transplant recipients. | 2015 | J. Med. Virol. | pmid:25952258 |
| Lee J et al. | A 12-month single arm pilot study to evaluate the efficacy and safety of sirolimus in combination with tacrolimus in kidney transplant recipients at high immunologic risk. | 2015 | J. Korean Med. Sci. | pmid:26028917 |
| Mabuchi M et al. | Improvement of solid material for affinity resins by application of long PEG spacers to capture the whole target complex of FK506. | 2015 | Bioorg. Med. Chem. Lett. | pmid:26025877 |
| Zhang D et al. | Multifunctional Poly(methyl vinyl ether-co-maleic anhydride)-graft-hydroxypropyl-β-cyclodextrin Amphiphilic Copolymer as an Oral High-Performance Delivery Carrier of Tacrolimus. | 2015 | Mol. Pharm. | pmid:26024817 |
| Huang G et al. | [Analysis on BK virus associated nephropathy related risk factors in renal transplant recipients]. | 2015 | Zhonghua Yi Xue Za Zhi | pmid:26814103 |
| Grammatikopoulos T et al. | Anti-CD20 Monoclonal Antibody Therapy in Functional Bile Salt Export Pump Deficiency After Liver Transplantation. | 2015 | J. Pediatr. Gastroenterol. Nutr. | pmid:24231640 |
| Lim EJ et al. | Effect of Immunosuppressive Agents on Hepatocyte Apoptosis Post-Liver Transplantation. | 2015 | PLoS ONE | pmid:26390404 |
| Baird K et al. | Imatinib mesylate for the treatment of steroid-refractory sclerotic-type cutaneous chronic graft-versus-host disease. | 2015 | Biol. Blood Marrow Transplant. | pmid:25771402 |
| Shuker N et al. | Conversion from twice-daily to once-daily tacrolimus does not reduce intrapatient variability in tacrolimus exposure. | 2015 | Ther Drug Monit | pmid:25265255 |
| Soto GAC et al. | Dose increase needed in most cystic fibrosis lung transplantation patients when changing from twice- to once-daily tacrolimus oral administration. | 2015 | Eur. J. Clin. Pharmacol. | pmid:25953736 |
| Leyking S et al. | Calcineurin inhibitors differentially alter the circadian rhythm of T-cell functionality in transplant recipients. | 2015 | J Transl Med | pmid:25885792 |
| Wang X et al. | Tacrolimus 0.03% ointment in labial discoid lupus erythematosus: A randomized, controlled clinical trial. | 2015 | J Clin Pharmacol | pmid:25951426 |
| Ding L et al. | Clinical Immunosuppressants Inhibit Inflammatory, Proliferative, and Reprogramming Potential, But Not Angiogenesis of Human Pancreatic Duct Cells. | 2015 | Cell Transplant | pmid:25198311 |
| Zhou X et al. | Effect of immunosuppression on the human mesangial cell cycle. | 2015 | Mol Med Rep | pmid:25370945 |
| Ã…berg F et al. | Asymptomatic De Novo Inflammatory Bowel Disease Late After Liver Transplantation for Primary Sclerosing Cholangitis: A Case Report. | 2015 | Transplant. Proc. | pmid:26680092 |
| Rojanathammanee L et al. | Attenuation of microglial activation in a mouse model of Alzheimer's disease via NFAT inhibition. | 2015 | J Neuroinflammation | pmid:25889879 |
| Peccerillo F et al. | Eosinophilic cellulitis. | 2015 | G Ital Dermatol Venereol | pmid:25946678 |
| Størset E et al. | Improved Tacrolimus Target Concentration Achievement Using Computerized Dosing in Renal Transplant Recipients--A Prospective, Randomized Study. | 2015 | Transplantation | pmid:25886918 |
| Montero N and Pascual J | Immunosuppression and Post-transplant Hyperglycemia. | 2015 | Curr Diabetes Rev | pmid:25824238 |
| Reig Mezquida JP et al. | Thrombotic microangiopathy associated with tacrolimus in lung transplantation. | 2015 | Arch. Bronconeumol. | pmid:25138798 |
| Yasuda S et al. | Comment on: The efficacy of tacrolimus in patients with interstitial lung diseases complicated with polymyositis or dermatomyositis: reply. | 2015 | Rheumatology (Oxford) | pmid:25832614 |
| Eichenfield DZ and Eichenfield LF | Pimecrolimus is safe and effective in treating atopic dermatitis. | 2015 | J. Pediatr. | pmid:26603713 |
| Calabrese B and Halpain S | Differential targeting of dynamin-1 and dynamin-3 to nerve terminals during chronic suppression of neuronal activity. | 2015 | Mol. Cell. Neurosci. | pmid:25827095 |
| Li Z et al. | Tacrolimus Induces Insulin Resistance and Increases the Glucose Absorption in the Jejunum: A Potential Mechanism of the Diabetogenic Effects. | 2015 | PLoS ONE | pmid:26599323 |
| Madariaga ML et al. | Kidney-induced cardiac allograft tolerance in miniature swine is dependent on MHC-matching of donor cardiac and renal parenchyma. | 2015 | Am. J. Transplant. | pmid:25824550 |
| Wang YY et al. | Biochemical characterization of a malonyl-specific acyltransferase domain of FK506 biosynthetic polyketide synthase. | 2015 | Protein Pept. Lett. | pmid:25267255 |
| Chhatrala R et al. | Evolution of serum atherogenic risk in liver transplant recipients: Role of lipoproteins and metabolic and inflammatory markers. | 2015 | Liver Transpl. | pmid:25762084 |
| Cendales L et al. | Tacrolimus to Belatacept Conversion Following Hand Transplantation: A Case Report. | 2015 | Am. J. Transplant. | pmid:25773260 |
| Soylu H et al. | Survival of renal transplant patients: data from a tertiary care center in Turkey. | 2015 | Transplant. Proc. | pmid:25769571 |
| Singh N et al. | Extended release once a day tacrolimus. | 2015 | Curr Opin Organ Transplant | pmid:26536429 |
| Ohe M and Bohgaki T | A Case of Adult-Onset Still's Disease Treated with Monitoring of Serum Tacrolimus Levels. | 2015 | Bull Hosp Jt Dis (2013) | pmid:26535602 |
| Xiao A et al. | H2S, a novel gasotransmitter, involves in gastric accommodation. | 2015 | Sci Rep | pmid:26531221 |
| Abdel-Azim H et al. | Unrelated donor hematopoietic stem cell transplantation for the treatment of non-malignant genetic diseases: An alemtuzumab based regimen is associated with cure of clinical disease; earlier clearance of alemtuzumab may be associated with graft rejection. | 2015 | Am. J. Hematol. | pmid:26242764 |
| Liu X et al. | Associations of HSD11B1 polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients with prednisone combined therapy. | 2015 | Drug Metab. Dispos. | pmid:25587129 |
| Zitelli K et al. | Eosinophilic folliculitis occurring after stem cell transplant for acute lymphoblastic leukemia: a case report and review. | 2015 | Int. J. Dermatol. | pmid:25039354 |
| Pensi D et al. | An UPLC-MS/MS method coupled with automated on-line SPE for quantification of tacrolimus in peripheral blood mononuclear cells. | 2015 | J Pharm Biomed Anal | pmid:25698619 |
| Roche NA et al. | Long-Term Multifunctional Outcome and Risks of Face Vascularized Composite Allotransplantation. | 2015 | J Craniofac Surg | pmid:26468783 |
| Wang JY and Fan H | P70S6 kinase phosphorylation: a new site to assess pharmacodynamy of sirolimus. | 2015 | Chin. Med. J. | pmid:25698201 |
| Ishida K et al. | Evaluation of the Safety and Effectiveness of Add-On Tacrolimus in Patients with Rheumatoid Arthritis Who Failed to Show an Adequate Response to Biological DMARDs: The Interim Results of a Specific Drug Use-Results Survey of Tacrolimus. | 2015 | Drugs R D | pmid:26386566 |
| Chow SP et al. | Long-Term Outcomes of High-Risk Keratoplasty in Patients Receiving Systemic Immunosuppression. | 2015 | Cornea | pmid:26382894 |
| Lin NC et al. | Minimization or withdrawal of immunosuppressants in pediatric liver transplant recipients. | 2015 | J. Pediatr. Surg. | pmid:26377868 |
| Ogul H et al. | Severe toxic leukoencephalopathy associated with tacrolimus after living donor liver transplantation. | 2015 | Acta Neurol Belg | pmid:24854146 |
| Tsujiwaki M et al. | Warty intralymphatic histiocytosis successfully treated with topical tacrolimus. | 2015 | J Eur Acad Dermatol Venereol | pmid:24851952 |
| Pallet N et al. | Kidney transplant recipients carrying the CYP3A4*22 allelic variant have reduced tacrolimus clearance and often reach supratherapeutic tacrolimus concentrations. | 2015 | Am. J. Transplant. | pmid:25588704 |
| Elbadri A et al. | Factors affecting eGFR 5-year post-deceased donor renal transplant: analysis and predictive model. | 2015 | Ren Fail | pmid:25585951 |
| Krystel-Whittemore M et al. | Polyomavirus nephropathy of the native kidney in a patient with rheumatoid arthritis and pulmonary fibrosis. | 2015 | BMJ Case Rep | pmid:26318171 |
| Saint-Marcoux F et al. | How to handle missed or delayed doses of tacrolimus in renal transplant recipients? A pharmacokinetic investigation. | 2015 | Pharmacol. Res. | pmid:26316426 |
| Karam S and Wali RK | Current State of Immunosuppression: Past, Present, and Future. | 2015 | Crit. Rev. Eukaryot. Gene Expr. | pmid:26080606 |
| Ramachandran R et al. | Role of Tacrolimus only therapy in modified Ponticelli regimen resistant idiopathic membranous glomerulonephritis. | 2015 | Nephrology (Carlton) | pmid:25535867 |
| Aikawa Y et al. | Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells. | 2015 | Cancer Sci. | pmid:25529853 |
| Ãœnal CM and Steinert M | FKBPs in bacterial infections. | 2015 | Biochim. Biophys. Acta | pmid:25529296 |
| Higa M et al. | Spatial control of calcineurin in response to heat shock in fission yeast. | 2015 | Genes Cells | pmid:25529221 |
| Joshi S et al. | Phosphatase inhibition prevents the activity-dependent trafficking of GABAA receptors during status epilepticus in the young animal. | 2015 | Epilepsia | pmid:26248944 |
| Duvoux C et al. | Sustained virological response to antiviral therapy in a randomized trial of cyclosporine versus tacrolimus in liver transplant patients with recurrent hepatitis C infection. | 2015 | Ann. Transplant. | pmid:25588713 |
| Hoerning A et al. | Pharmacodynamic monitoring of mammalian target of rapamycin inhibition by phosphoflow cytometric determination of p70S6 kinase activity. | 2015 | Transplantation | pmid:25099702 |
| Wu B et al. | Triple immunosuppressive therapy in steroid-resistant nephrotic syndrome children with tacrolimus resistance or tacrolimus sensitivity but frequently relapsing. | 2015 | Nephrology (Carlton) | pmid:25312783 |
| Valke LL et al. | Soluble CD30 does not predict late acute rejection or safe tapering of immunosuppression in renal transplantation. | 2015 | Transpl. Immunol. | pmid:25446808 |
| Huang G et al. | Monitoring of polyomavirus BK replication and impact of preemptive immunosuppression reduction in renal-transplant recipients in China: a 5-year single-center analysis. | 2015 | Diagn. Microbiol. Infect. Dis. | pmid:25445121 |
| Mandelbrot DA et al. | Effect of Ramipril on Urinary Protein Excretion in Maintenance Renal Transplant Patients Converted to Sirolimus. | 2015 | Am. J. Transplant. | pmid:26176342 |
| Guo CL et al. | Efficacy of Topical Tacrolimus for Erosive Oral Lichen Planus: A Meta-analysis. | 2015 | Chin. Med. Sci. J. | pmid:26960301 |
| Apalla Z et al. | Psoriatic cheilitis: a report of 2 cases treated successfully with topical tacrolimus and a review of the literature. | 2015 | Actas Dermosifiliogr | pmid:26164836 |
| Vives R et al. | Safety and Activity of UR-1505 in Atopic Dermatitis: A Randomized, Double-blind Phase II Exploratory Trial. | 2015 | Clin Ther | pmid:26163200 |
| Kabrine M and Laraba-Djebari F | Immunomodulatory and protective properties of tacrolimus in experimental scorpion envenomation. | 2014 Jan-Mar | Int J Immunopathol Pharmacol | pmid:24674680 |
| Wang C and Lin A | Efficacy of topical calcineurin inhibitors in psoriasis. | 2014 Jan-Feb | J Cutan Med Surg | pmid:24377467 |
| Feito-RodrÃguez M et al. | Bacterial vaginosis in the context of lichen sclerosus in a prepubertal girl. | 2014 Jan-Feb | Pediatr Dermatol | pmid:24125016 |
| Veisa G et al. | The importance of renal biopsy in the management of renal transplantation. | 2014 Apr-Jun | Rev Med Chir Soc Med Nat Iasi | pmid:25076703 |
| Shin BH et al. | Regulation of anti-HLA antibody-dependent natural killer cell activation by immunosuppressive agents. | 2014 | Transplantation | pmid:24342979 |
| Siddiqui A et al. | Chemometric methods for the quantification of crystalline tacrolimus in solid dispersion by powder X-ray diffractrometry. | 2014 | J Pharm Sci | pmid:24585357 |
| Shivaswamy V et al. | Tacrolimus and sirolimus have distinct effects on insulin signaling in male and female rats. | 2014 | Transl Res | pmid:24361102 |
| Uesugi S et al. | Calcineurin inhibitors suppress the high-temperature stress sensitivity of the yeast ubiquitin ligase Rsp5 mutant: a new method of screening for calcineurin inhibitors. | 2014 | FEMS Yeast Res. | pmid:25035868 |
| Goldberg NR et al. | Success with single-agent immunosuppression for multifocal choroidopathies. | 2014 | Am. J. Ophthalmol. | pmid:25194229 |
| Suarez-Kurtz G et al. | Pharmacogenomic implications of population admixture: Brazil as a model case. | 2014 | Pharmacogenomics | pmid:24444410 |
| Ducroux E et al. | Hidradenitis suppurativa after renal transplantation: complete remission after switching from oral cyclosporine to oral tacrolimus. | 2014 | J. Am. Acad. Dermatol. | pmid:25437996 |
| Hancock WW | Effects of histone deacetylase inhibitors on alloresponses. | 2014 | Lancet Oncol. | pmid:24295573 |
| Taguchi K et al. | False tacrolimus concentrations measured by antibody-conjugated magnetic immunoassay in liver transplant patient: 2 case reports and literature review. | 2014 | Exp Clin Transplant | pmid:24206050 |
| Trotter JF and Lizardo-Sanchez L | Everolimus in liver transplantation. | 2014 | Curr Opin Organ Transplant | pmid:25254569 |
| RodrÃguez-Serrano M et al. | Does the calcineurin inhibitor have influence on cytomegalovirus infection in heart transplantation? | 2014 | Clin Transplant | pmid:24325305 |
| Sæves I et al. | Tacrolimus exposure and mycophenolate pharmacokinetics and pharmacodynamics early after liver transplantation. | 2014 | Ther Drug Monit | pmid:24081206 |
| Ghanem RC et al. | Tacrolimus for the treatment of subepithelial infiltrates resistant to topical steroids after adenoviral keratoconjunctivitis. | 2014 | Cornea | pmid:25188789 |
| Kim JS et al. | Effects of FK-506 and CTLA4--Ig on nerve allografts in mice. | 2014 | J Plast Reconstr Aesthet Surg | pmid:24120418 |
| Purani JM and Purani HJ | Treatment of geographic tongue with topical tacrolimus. | 2014 | BMJ Case Rep | pmid:25085945 |
| Kornblit B et al. | A randomized phase II trial of tacrolimus, mycophenolate mofetil and sirolimus after non-myeloablative unrelated donor transplantation. | 2014 | Haematologica | pmid:25085357 |
| Thapa RK and Yoo BK | Evaluation of the effect of tacrolimus-loaded liquid crystalline nanoparticles on psoriasis-like skin inflammation. | 2014 | J Dermatolog Treat | pmid:23210668 |
| Yamazoe K et al. | Efficacy and safety of systemic tacrolimus in high-risk penetrating keratoplasty after graft failure with systemic cyclosporine. | 2014 | Cornea | pmid:25255133 |
| John K et al. | Role of dendritic cells in the context of acute cellular rejection: comparison between tacrolimus- or cyclosporine A-treated heart transplanted recipients. | 2014 | Cytometry B Clin Cytom | pmid:24668729 |
| Okamoto T et al. | Clinically mild encephalitis/encephalopathy with a reversible splenial lesion associated with febrile urinary tract infection. | 2014 | Eur. J. Pediatr. | pmid:24221606 |
| Rahman Z et al. | Near-infrared and fourier transform infrared chemometric methods for the quantification of crystalline tacrolimus from sustained-release amorphous solid dispersion. | 2014 | J Pharm Sci | pmid:24931728 |
| Kim SH et al. | Expression, purification and characterization of soluble recombinant peptidyl-prolyl cis/trans isomerase from Vibrio anguillarum. | 2014 | Protein Expr. Purif. | pmid:24931498 |
| Cutler C et al. | Tacrolimus/sirolimus vs tacrolimus/methotrexate as GVHD prophylaxis after matched, related donor allogeneic HCT. | 2014 | Blood | pmid:24982504 |
| Tran D et al. | Conversion from twice-daily to once-daily extended-release tacrolimus in renal transplant recipients: 2-year results and review of the literature. | 2014 | Exp Clin Transplant | pmid:24844288 |
| Kahvecioglu S et al. | Effects of calcineurin inhibitors on paraoxonase and arylesterase activity after a kidney transplant. | 2014 | Exp Clin Transplant | pmid:24447269 |
| Kalkan G et al. | An alternative treatment model: the combination therapy of narrow band ultraviolet B phototherapy and tacrolimus ointment 0.1% in biphasic amyloidosis. | 2014 | J Pak Med Assoc | pmid:25272550 |
| Hashi S et al. | Assessment of four methodologies (microparticle enzyme immunoassay, chemiluminescent enzyme immunoassay, affinity column-mediated immunoassay, and flow injection assay-tandem mass spectrometry) for measuring tacrolimus blood concentration in Japanese liver transplant recipients. | 2014 | Transplant. Proc. | pmid:24767342 |
| Uemoto S et al. | Safety and efficacy of once-daily modified-release tacrolimus in liver transplant recipients: a multicenter postmarketing surveillance in Japan. | 2014 | Transplant. Proc. | pmid:24767340 |
| Borda B et al. | Side effects of the calcineurin inhibitor, such as new-onset diabetes after kidney transplantation. | 2014 | Acta Physiol Hung | pmid:25183511 |