Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Shirai T et al. | Successful treatment with tacrolimus in TAFRO syndrome: two case reports and literature review. | 2018 | Medicine (Baltimore) | pmid:29879072 |
Nakahara T et al. | Mechanistic insights into topical tacrolimus for the treatment of atopic dermatitis. | 2018 | Pediatr Allergy Immunol | pmid:29205511 |
Motta A et al. | Immunohistopathological characterization and the impact of topical immunomodulatory therapy in oral chronic graft-versus-host disease: A pilot study. | 2018 | Oral Dis | pmid:29197137 |
Bond MMK et al. | Cyclosporine Versus Tacrolimus: Which Calcineurin Inhibitor Has Influence on Cytomegalovirus Infection in Cardiac Transplantation? | 2018 | Transplant. Proc. | pmid:29661443 |
Ixtlapale-Carmona X et al. | Graft immunologic events in deceased donor kidney transplant recipients with preformed HLA-donor specific antibodies. | 2018 | Transpl. Immunol. | pmid:28974434 |
Li YM et al. | Impact of immunosuppressive drugs on circulating Tfh cells in kidney transplant recipients: A pilot study. | 2018 | Transpl. Immunol. | pmid:28974433 |
Shuker N et al. | Intrapatient Variability in Tacrolimus Exposure Does Not Predict The Development of Cardiac Allograft Vasculopathy After Heart Transplant. | 2018 | Exp Clin Transplant | pmid:28969528 |
Bae SC and Lee YH | Comparative efficacy and tolerability of monotherapy with leflunomide or tacrolimus for the treatment of rheumatoid arthritis: a Bayesian network meta-analysis of randomized controlled trials. | 2018 | Clin. Rheumatol. | pmid:28967035 |
Zhao J et al. | Comparison of different regimens of pimecrolimus 1% cream in the treatment of facial seborrheic dermatitis. | 2018 | J Cosmet Dermatol | pmid:28589618 |
Shank BR et al. | Interdisciplinary implementation of tacrolimus intravenous standard concentration in hematopoietic stem cell transplantation recipients. | 2018 | J Oncol Pharm Pract | pmid:28554241 |
González-VÃlchez F et al. | Efficacy and Safety of de Novo and Early Use of Extended-release Tacrolimus in Heart Transplantation. | 2018 | Rev Esp Cardiol (Engl Ed) | pmid:28545984 |
Koppelstaetter C et al. | Effect of cyclosporine, tacrolimus and sirolimus on cellular senescence in renal epithelial cells. | 2018 | Toxicol In Vitro | pmid:29309803 |
Tillmann FP et al. | Impact of low-dose steroids on HbA1c levels and development of pre-diabetes and NODAT in non-diabetic renal transplant recipients on long-term follow-up. | 2018 | Int Urol Nephrol | pmid:29197933 |
Harada N et al. | Serum Asunaprevir and Daclatasvir Concentrations and Outcomes in Patients with Recurrent Hepatitis C Who Have Undergone Living Donor Liver Transplantation. | 2018 | Anticancer Res. | pmid:30194210 |
Sahu S et al. | Active natural oil-based nanoemulsion containing tacrolimus for synergistic antipsoriatic efficacy. | 2018 | Nanomedicine (Lond) | pmid:30188761 |
Min S et al. | A randomized clinical trial of age and genotype-guided tacrolimus dosing after pediatric solid organ transplantation. | 2018 | Pediatr Transplant | pmid:30178515 |
Zegarska J et al. | Evaluation of the Relationship Between Concentrations of Tacrolimus Metabolites, 13-O-Demethyl Tacrolimus and 15-O-Demethyl Tacrolimus, and Clinical and Biochemical Parameters in Kidney Transplant Recipients. | 2018 | Transplant. Proc. | pmid:30177142 |
Lee H et al. | Thymoglobulin Versus Basiliximab Induction Therapy in Low-Risk Kidney Transplant Recipients: A Single-Center Experience. | 2018 | Transplant. Proc. | pmid:29880348 |
La Maestra S et al. | Brain microglia activation induced by intracranial administration of oligonucleotides and its pharmacological modulation. | 2018 | Drug Deliv Transl Res | pmid:29869293 |
Liang TT et al. | Modeling Analysis of Potential Target of Dolastatin 16 by Computational Virtual Screening. | 2018 | Chem. Pharm. Bull. | pmid:29863061 |
Ichinose K et al. | The efficacy of adjunct tacrolimus treatment in pregnancy outcomes in patients with systemic lupus erythematosus. | 2018 | Lupus | pmid:29665758 |
Ishikawa S et al. | Management of Juvenile Idiopathic Arthritis in ABO-incompatible Kidney Transplantation: A Case Report. | 2018 | Transplant. Proc. | pmid:29661455 |
Moura Neto A et al. | Frequency of Thyroid Dysfunction in Patients With Diabetes Mellitus Before and After Liver Transplantation. | 2018 | Transplant. Proc. | pmid:29661439 |
Moura Neto A et al. | Clinical Profile of Patients With Diabetes Mellitus and Liver Transplantation: Results After a Multidisciplinary Team Intervention. | 2018 | Transplant. Proc. | pmid:29661438 |
Crouse L et al. | Pyoderma gangrenosum in an infant: A case report and review of the literature. | 2018 | Pediatr Dermatol | pmid:29656404 |
Mei S et al. | Simultaneous determination of cyclosporine and tacrolimus in human whole blood by ultra-high performance liquid chromatography tandem mass spectrometry and comparison with a chemiluminescence microparticle immunoassay. | 2018 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:29704799 |
Stanton BZ et al. | Chemically induced proximity in biology and medicine. | 2018 | Science | pmid:29590011 |
Foroutan A et al. | Successful treatment of allergic conjunctival granuloma by topical tacrolimus: A clinicopathologic case report. | 2018 | Indian J Ophthalmol | pmid:29582827 |
Efe C et al. | Tacrolimus and Mycophenolate Mofetil as Second-Line Therapies for Pediatric Patients with Autoimmune Hepatitis. | 2018 | Dig. Dis. Sci. | pmid:29569003 |
Bittersohl H et al. | A simple and highly sensitive on-line column extraction liquid chromatography-tandem mass spectrometry method for the determination of protein-unbound tacrolimus in human plasma samples. | 2018 | J Chromatogr A | pmid:29544893 |
Solomentsev G et al. | Conformational Entropy of FK506 Binding to FKBP12 Determined by Nuclear Magnetic Resonance Relaxation and Molecular Dynamics Simulations. | 2018 | Biochemistry | pmid:29412644 |
Sano H et al. | T-cell-replete haploidentical stem cell transplantation using low-dose antithymocyte globulin in children with relapsed or refractory acute leukemia. | 2018 | Int. J. Hematol. | pmid:29508228 |
Kociszewska-Najman B et al. | Low Transfer of Tacrolimus and Its Metabolites into Colostrum of Graft Recipient Mothers. | 2018 | Nutrients | pmid:29495430 |
Ghadimi M et al. | Tacrolimus interaction with oral oestrogen in kidney transplant recipients: A case-control study. | 2018 | J Clin Pharm Ther | pmid:29492991 |
Li X et al. | Association of the PPARγ/PI3K/Akt pathway with the cardioprotective effects of tacrolimus in myocardial ischemic/reperfusion injury. | 2018 | Mol Med Rep | pmid:29488613 |
Yeh CT et al. | Seroclearance of hepatitis B surface antigen following hepatitis E exacerbation on chronic hepatitis E and B dual infection in a renal transplant recipient: a case report. | 2018 | J Med Case Rep | pmid:29486803 |
Takeuchi T et al. | Post-marketing surveillance study of the long-term use of mizoribine for the treatment of lupus nephritis: 2-Year results. | 2018 | Mod Rheumatol | pmid:28722500 |
Takeuchi T et al. | Safety and effectiveness of tacrolimus add-on therapy for rheumatoid arthritis patients without an adequate response to biological disease-modifying anti-rheumatic drugs (DMARDs): Post-marketing surveillance in Japan. | 2018 | Mod Rheumatol | pmid:28649878 |
Oetting WS et al. | Attempted validation of 44 reported SNPs associated with tacrolimus troughs in a cohort of kidney allograft recipients. | 2018 | Pharmacogenomics | pmid:29318894 |
Rayar M et al. | High Intrapatient Variability of Tacrolimus Exposure in the Early Period After Liver Transplantation Is Associated With Poorer Outcomes. | 2018 | Transplantation | pmid:29315140 |
Naniwa T et al. | Long-term efficacy and safety of add-on tacrolimus for persistent, active rheumatoid arthritis despite treatment with methotrexate and tumor necrosis factor inhibitors. | 2018 | Int J Rheum Dis | pmid:29314738 |
Li YM et al. | Soluble Tim-3 and Gal-9 are associated with renal allograft dysfunction in kidney transplant recipients: A cross-sectional study. | 2018 | Int. Immunopharmacol. | pmid:29310109 |
Lim SW et al. | Ginseng extract reduces tacrolimus-induced oxidative stress by modulating autophagy in pancreatic beta cells. | 2017 | Lab. Invest. | pmid:28759009 |
Saliba F et al. | Efficacy and Safety of Everolimus and Mycophenolic Acid With Early Tacrolimus Withdrawal After Liver Transplantation: A Multicenter Randomized Trial. | 2017 | Am. J. Transplant. | pmid:28133906 |
Willerth SM | Localized Tacrolimus Delivery Repairs the Damaged Central Nervous System. | 2017 | EBioMedicine | pmid:29195745 |
Gu K et al. | Atypical pneumonia due to human bocavirus in an immunocompromised patient. | 2017 | CMAJ | pmid:28507089 |
Smolders EJ et al. | Decreased tacrolimus plasma concentrations during HCV therapy: a drug-drug interaction or is there an alternative explanation? | 2017 | Int. J. Antimicrob. Agents | pmid:28185946 |
Wungwattana M and Savic M | Tacrolimus interaction with nafcillin resulting in significant decreases in tacrolimus concentrations: A case report. | 2017 | Transpl Infect Dis | pmid:28067989 |
Nakamura K et al. | AS2553627, a novel JAK inhibitor, prevents chronic rejection in rat cardiac allografts. | 2017 | Eur. J. Pharmacol. | pmid:27993641 |
Gelens MACJ et al. | No evidence for progressive deterioration in stimulated insulin secretion in renal transplant recipients after 12years tacrolimus exposure. | 2017 | J. Diabetes Complicat. | pmid:28720321 |