tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:8615615 | ||||
| Mayba JN and Gooderham MJ | Review of Atopic Dermatitis and Topical Therapies. | J Cutan Med Surg | pmid:28300440 | |
| Elloudi S et al. | [Frontal fibrosing alopecia: A prospective study of 20Â cases]. | Ann Dermatol Venereol | pmid:28258757 | |
| Qu W et al. | Correlation Between Immunosuppressive Therapy and CD4(+) T-Cell Intracellular Adenosine Triphosphate Levels in Liver Transplant Recipients. | Transplant. Proc. | pmid:27569951 | |
| Mlinšek G et al. | The role of single nucleotide polymorphisms of CYP3A and ABCB1 on tacrolimus predose concentration in kidney transplant recipients. | Clin. Nephrol. | pmid:28655393 | |
| Bonatti HJR et al. | Clostridium difficile-Associated Colitis Post-Transplant Is Not Associated with Elevation of Tacrolimus Concentrations. | Surg Infect (Larchmt) | pmid:28650734 | |
| Liendo VL et al. | Topical tacrolimus for the treatment of severe allergic keratoconjunctivitis in children. | Arq Bras Oftalmol | pmid:28954018 | |
| Johnson JL et al. | Pyoderma gangrenosum associated with an aseptic splenic abscess in a patient with neurofibromatosis. | Pediatr Dermatol | pmid:23535023 | |
| Errichetti E et al. | Annular elastolytic giant cell granuloma treated with topical pimecrolimus. | Indian J Dermatol Venereol Leprol | pmid:25201861 | |
| Sathyan S et al. | Prevention of recurrent episodes of rhabdomyolysis with tacrolimus in a transplant recipient with myopathy. | Am J Ther | pmid:23429166 | |
| Moreno Gonzales M et al. | Sublingual Tacrolimus in Liver Transplantation: A Valid Option? | Transplant. Proc. | pmid:27569953 | |
| Ciancio G et al. | Pilot Randomized Trial of Tacrolimus/Everolimus vs Tacrolimus/Enteric-Coated Mycophenolate Sodium in Adult, Primary Kidney Transplant Recipients at a Single Center. | Transplant. Proc. | pmid:27569936 | |
| Huang CT et al. | Higher Variability of Tacrolimus Trough Level Increases Risk of Acute Rejection in Kidney Transplant Recipients. | Transplant. Proc. | pmid:27569931 | |
| Ge J et al. | Impact of FOXP3 Polymorphisms on the Blood Level of Tacrolimus in Renal Transplant Recipients. | Transplant. Proc. | pmid:27569929 | |
| Cakici O et al. | Periorbital discoid lupus: a rare localization in a patient with systemic lupus erythematosus. | An Bras Dermatol | pmid:28300917 | |
| Ming M et al. | Effect of immunosuppressants tacrolimus and mycophenolate mofetil on the keratinocyte UVB response. | Photochem. Photobiol. | pmid:25039758 | |
| Park JS et al. | Combinatory treatment using tacrolimus and a STAT3 inhibitor regulate Treg cells and plasma cells. | Int J Immunopathol Pharmacol | pmid:29873267 | |
| pmid: | ||||
| pmid:28951508 | ||||
| pmid:28761977 | ||||
| Torres A et al. | Mineral metabolism disorders, vertebral fractures and aortic calcifications in stable kidney transplant recipients: The role of gender (EMITRAL study). | Nefrologia | pmid:27133898 | |
| Malik S et al. | Disseminated infection in a kidney-pancreas transplant recipient: A case report and review of the literature. | Saudi J Kidney Dis Transpl | pmid:27900974 | |
| Tan GF et al. | Anogenital epidermolytic acanthomas: effective treatment of pruritus with 0.1% tacrolimus ointment. | Dermatol Ther | pmid:24703270 | |
| Collier DS et al. | FK-506 in experimental renal allografts. | 1987 | Transplant. Proc. | pmid:2445063 |
| First International Workshop on FK-506. A potential breakthrough in immunosuppression. Proceedings. | 1987 | Transplant. Proc. | pmid:2445066 | |
| Tanaka H et al. | Physicochemical properties of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis. | 1987 | Transplant. Proc. | pmid:2445067 |
| Honbo T et al. | The oral dosage form of FK-506. | 1987 | Transplant. Proc. | pmid:2445068 |
| Tamura K et al. | A highly sensitive method to assay FK-506 levels in plasma. | 1987 | Transplant. Proc. | pmid:2445069 |
| Venkataramanan R et al. | Biopharmaceutical aspects of FK-506. | 1987 | Transplant. Proc. | pmid:2445070 |
| Kino T et al. | Effect of FK-506 on human mixed lymphocyte reaction in vitro. | 1987 | Transplant. Proc. | pmid:2445071 |
| Goto T et al. | Discovery of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis. | 1987 | Transplant. Proc. | pmid:2445072 |
| Zeevi A et al. | Immunosuppressive effect of FK-506 on in vitro lymphocyte alloactivation: synergism with cyclosporine A. | 1987 | Transplant. Proc. | pmid:2445073 |
| Sanghvi A et al. | FK-506 enhances cyclosporine uptake by peripheral blood lymphocytes. | 1987 | Transplant. Proc. | pmid:2445074 |
| Ochiai T et al. | Prolongation of canine renal allograft survival by treatment with FK-506. | 1987 | Transplant. Proc. | pmid:2445075 |
| Todo S et al. | Canine kidney transplantation with FK-506 alone or in combination with cyclosporine and steroids. | 1987 | Transplant. Proc. | pmid:2445076 |
| Collier DS et al. | Kidney transplantation in the dog receiving FK-506. | 1987 | Transplant. Proc. | pmid:2445077 |
| Calne R et al. | Observations about FK-506 in primates. | 1987 | Transplant. Proc. | pmid:2445078 |
| Todo S et al. | Orthotopic liver transplantation in dogs receiving FK-506. | 1987 | Transplant. Proc. | pmid:2445079 |
| Lim SM et al. | Heterotopic heart transplantation in the rat receiving FK-506. | 1987 | Transplant. Proc. | pmid:2445080 |
| Murase N et al. | Heterotopic heart transplantation in the rat receiving FK-506 alone or with cyclosporine. | 1987 | Transplant. Proc. | pmid:2445081 |
| Makowka L et al. | The effect of FK-506 on hyperacute rejection in presensitized rats. | 1987 | Transplant. Proc. | pmid:2445082 |
| Ochiai T et al. | Effects of FK-506 on xenotransplantation of the heart and skin in a mouse-rat combination. | 1987 | Transplant. Proc. | pmid:2445083 |
| Nalesnik MA et al. | Toxicology of FK-506 in the Lewis rat. | 1987 | Transplant. Proc. | pmid:2445084 |
| Ochiai T et al. | Histopathologic studies in renal transplant recipient dogs receiving treatment with FK-506. | 1987 | Transplant. Proc. | pmid:2445085 |
| Thiru S et al. | Pathological studies in canine and baboon renal allograft recipients immunosuppressed with FK-506. | 1987 | Transplant. Proc. | pmid:2445086 |
| Kino T et al. | FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics. | 1987 | J. Antibiot. | pmid:2445721 |
| Kino T et al. | FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro. | 1987 | J. Antibiot. | pmid:2445722 |
| Ochiai T et al. | Studies of the effects of FK506 on renal allografting in the beagle dog. | 1987 | Transplantation | pmid:2447688 |
| Ochiai T et al. | Studies of the induction and maintenance of long-term graft acceptance by treatment with FK506 in heterotopic cardiac allotransplantation in rats. | 1987 | Transplantation | pmid:2447689 |
| Ochiai T et al. | Effect of a new immunosuppressive agent, FK 506, on heterotopic cardiac allotransplantation in the rat. | 1987 | Transplant. Proc. | pmid:2484094 |
| Sawada S et al. | Novel immunosuppressive agent, FK506. In vitro effects on the cloned T cell activation. | 1987 | J. Immunol. | pmid:2442255 |
| Inamura N et al. | Immunosuppressive effect of FK506 on collagen-induced arthritis in rats. | 1988 | Clin. Immunol. Immunopathol. | pmid:2446810 |
| Inamura N et al. | Prolongation of skin allograft survival in rats by a novel immunosuppressive agent, FK506. | 1988 | Transplantation | pmid:2447690 |
| Ochiai T et al. | Studies on FK506 in experimental organ transplantation. | 1988 | Transplant. Proc. | pmid:2450414 |
| Immunosuppression: FK506. | 1988 | Transplant. Proc. | pmid:2450415 | |
| Todo S et al. | Effect of FK506 in experimental organ transplantation. | 1988 | Transplant. Proc. | pmid:2450416 |
| Tsuchimoto S et al. | [Orthotopic liver transplantation in the rat--immunosuppressive effect of FR100906 on the survival of liver allografts]. | 1988 | Nihon Geka Gakkai Zasshi | pmid:2452341 |
| Nakajima K et al. | Prolongation of cardiac xenograft survival in rats treated with 15-deoxyspergualin alone and in combination with FK506. | 1988 | Transplantation | pmid:2454521 |
| Todo S et al. | Immunosuppression of canine, monkey, and baboon allografts by FK 506: with special reference to synergism with other drugs and to tolerance induction. | 1988 | Surgery | pmid:2456627 |
| Kawashima H et al. | Effects of a new immunosuppressive agent, FK506, on experimental autoimmune uveoretinitis in rats. | 1988 | Invest. Ophthalmol. Vis. Sci. | pmid:2458329 |
| Warty V et al. | FK506: a novel immunosuppressive agent. Characteristics of binding and uptake by human lymphocytes. | 1988 | Transplantation | pmid:2458643 |
| Hewitt CW and Black KS | Comparative studies of FK506 with cyclosporine. | 1988 | Transplantation | pmid:2458644 |
| Woo J et al. | Spleen lymphocyte populations and expression of activation markers in rats treated with the potent new immunosuppressive agent FK-506. | 1988 | Immunology | pmid:2460401 |
| Hatanaka H et al. | FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics. | 1988 | J. Antibiot. | pmid:2461926 |
| Inamura N et al. | Immunosuppressive effect of FK506 on experimental allergic encephalomyelitis in rats. | 1988 | Int. J. Immunopharmacol. | pmid:2463974 |
| Hatanaka H et al. | FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. I. Taxonomy of the producing strain. | 1988 | J. Antibiot. | pmid:3198493 |
| Yoshimura N et al. | Effect of a new immunosuppressive agent, FK506, on human lymphocyte responses in vitro. I. Inhibition of expression of alloantigen-activated suppressor cells, as well as induction of alloreactivity. | 1989 | Transplantation | pmid:2465592 |
| Yoshimura N et al. | Effect of a new immunosuppressive agent, FK506, on human lymphocyte responses in vitro. II. Inhibition of the production of IL-2 and gamma-IFN, but not B cell-stimulating factor 2. | 1989 | Transplantation | pmid:2465593 |
| Takabayashi K et al. | Effect of FK-506, a novel immunosuppressive drug on murine systemic lupus erythematosus. | 1989 | Clin. Immunol. Immunopathol. | pmid:2466594 |
| Morris RE et al. | Immunopharmacology of FK-506. | 1989 | Transplant. Proc. | pmid:2468201 |
| Yoshimura N et al. | A new immunosuppressive agent, FK506, inhibits the expression of alloantigen-activated suppressor cells as well as the induction of alloreactivity. | 1989 | Transplant. Proc. | pmid:2468202 |
| Thomson AW et al. | Immunosuppressive activity, T-cell subset analysis, and acute toxicity of FK-506 in rats. | 1989 | Transplant. Proc. | pmid:2468203 |
| Sanghvi A et al. | Increased cyclosporine uptake by cells pretreated with FK506 and evidence for binding of both drugs to a common intracellular protein. | 1989 | Transplant. Proc. | pmid:2468204 |
| Takagishi K et al. | Effects of FK-506 on collagen arthritis in mice. | 1989 | Transplant. Proc. | pmid:2468205 |
| Arita C et al. | Effect of FK 506 (FR 900506) on collagen arthritis in rats: a preliminary report. | 1989 | Transplant. Proc. | pmid:2468206 |
| Morimoto T et al. | Blood levels of FK506 after intramuscular and intravenous administration in dogs. | 1989 | Transplant. Proc. | pmid:2468207 |
| Tsuchimoto S et al. | Orthotopic liver transplantation in rats receiving FK506. | 1989 | Transplant. Proc. | pmid:2468208 |
| Yokota K et al. | Comparative studies of FK506 and cyclosporine in canine orthotopic hepatic allograft survival. | 1989 | Transplant. Proc. | pmid:2468209 |
| Inagaki K et al. | Effects of FK506 and 15-deoxyspergualin in rat orthotopic liver transplantation. | 1989 | Transplant. Proc. | pmid:2468210 |
| Gudas VM et al. | Comparison of the immunosuppressive and toxic effects of FK506 and cyclosporine in xenograft recipients. | 1989 | Transplant. Proc. | pmid:2468211 |
| Sato K et al. | Pancreaticoduodenal allotransplantation with cyclosporine and FK506. | 1989 | Transplant. Proc. | pmid:2468212 |
| Gschwendt M et al. | The immunosuppressant FK-506, like cyclosporins and didemnin B, inhibits calmodulin-dependent phosphorylation of the elongation factor 2 in vitro and biological effects of the phorbol ester TPA on mouse skin in vivo. | 1989 | Immunobiology | pmid:2471685 |
| Fujii Y et al. | Effect of a novel immunosuppressive agent, FK506, on mitogen-induced inositol phospholipid degradation in rat thymocytes. | 1989 | Transplantation | pmid:2472025 |
| Tocci MJ et al. | The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes. | 1989 | J. Immunol. | pmid:2472451 |
| Beck Y and Akiyama N | Effect of FK-506 and cyclosporine on human lymphocyte responses in vitro. | 1989 | Transplant. Proc. | pmid:2472695 |
| Thomson AW | FK-506--how much potential? | 1989 | Immunol. Today | pmid:2473767 |
| Ochiai T et al. | Optimal serum trough levels of FK506 in renal allotransplantation of the beagle dog. | 1989 | Transplantation | pmid:2474208 |
| Ochiai T et al. | Effects of combination treatment with FK506 and cyclosporine on survival time and vascular changes in renal-allograft-recipient dogs. | 1989 | Transplantation | pmid:2474209 |
| Siekierka JJ et al. | FK-506, a potent novel immunosuppressive agent, binds to a cytosolic protein which is distinct from the cyclosporin A-binding protein, cyclophilin. | 1989 | J. Immunol. | pmid:2474605 |
| Thomson AW and Woo J | Immunosuppressive properties of FK-506 and rapamycin. | 1989 | Lancet | pmid:2474733 |
| Todo S et al. | Renal transplantation in baboons under FK 506. | 1989 | Surgery | pmid:2474865 |
| Kay JE et al. | Inhibition of T-lymphocyte activation by the immunosuppressive drug FK-506. | 1989 | Immunology | pmid:2475433 |
| Moriyama S | [Experimental tracheal reconstruction by allotransplantation]. | 1989 | Nihon Kyobu Geka Gakkai Zasshi | pmid:2475555 |
| Freedman RB | Immunosuppression. Convergence of drug action. | 1989 | Nature | pmid:2477712 |
| Siekierka JJ et al. | A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin. | 1989 | Nature | pmid:2477714 |
| Harding MW et al. | A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase. | 1989 | Nature | pmid:2477715 |
| Kay JE et al. | The mechanism of action of the immunosuppressive drug FK-506. | 1989 | Cell. Immunol. | pmid:2478301 |
| Starzl TE et al. | FK 506 for liver, kidney, and pancreas transplantation. | 1989 | Lancet | pmid:2478846 |
| Leonard DK et al. | Toxicity of FK-506 in human fetal pancreas. | 1989 | Diabetes | pmid:2463195 |
| Stephen M et al. | Immunosuppressive activity, lymphocyte subset analysis, and acute toxicity of FK-506 in the rat. A comparative and combination study with cyclosporine. | 1989 | Transplantation | pmid:2463701 |