Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Morello RJ et al. | Remote ischemic preconditioning and tacrolimus in the fetal small bowel transplant in mice. | 2016 | Acta Cir Bras | pmid:27828601 |
Vohra S et al. | Clinical and serological efficacy of topical calcineurin inhibitors in oral lichen planus: a prospective randomized controlled trial. | 2016 | Int. J. Dermatol. | pmid:26147635 |
Anderson K et al. | A retrospective analysis of pediatric patients with lichen sclerosus treated with a standard protocol of class I topical corticosteroid and topical calcineurin inhibitor. | 2016 | J Dermatolog Treat | pmid:26138407 |
Pan GH et al. | Low-dose tacrolimus combined with donor-derived mesenchymal stem cells after renal transplantation: a prospective, non-randomized study. | 2016 | Oncotarget | pmid:26933811 |
Moes DJ et al. | Response: Limited sampling strategies for once daily tacrolimus exposure monitoring. | 2016 | Eur. J. Clin. Pharmacol. | pmid:26931555 |
Merino D et al. | Different in vitro proliferation and cytokine-production inhibition of memory T-cell subsets after calcineurin and mammalian target of rapamycin inhibitors treatment. | 2016 | Immunology | pmid:26931075 |
Lee SG et al. | Enhanced topical delivery of tacrolimus by a carbomer hydrogel formulation with transcutol P. | 2016 | Drug Dev Ind Pharm | pmid:26925849 |
Doke T et al. | Post-Transplant Membranous Nephropathy Associated with Chronic Active Antibody-Mediated Rejection and Hepatitis C Infection after Deceased Donor Renal Transplantation. | 2016 | Intern. Med. | pmid:26875963 |
Shuker N et al. | A high intrapatient variability in tacrolimus exposure is associated with poor long-term outcome of kidney transplantation. | 2016 | Transpl. Int. | pmid:27188932 |
Wen X et al. | Comparison of Utilization and Clinical Outcomes for Belatacept- and Tacrolimus-Based Immunosuppression in Renal Transplant Recipients. | 2016 | Am. J. Transplant. | pmid:27137884 |
Koura-Nishiura A et al. | Clearance of atypical facial necrobiosis lipoidica with tacrolimus ointment. | 2016 | J Eur Acad Dermatol Venereol | pmid:25353715 |
Lee SH et al. | Low-dose mycophenolate mofetil in tablet form or capsule form combined with tacrolimus in the early period after kidney transplantation: a prospective randomized trial
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Cortes M et al. | The use of temporary portocaval shunt as a technical aid in auxiliary orthotopic liver transplantation. | 2016 | Liver Transpl. | pmid:27357622 |
Siponen M et al. | Cathepsin K expression is increased in oral lichen planus. | 2016 | J. Oral Pathol. Med. | pmid:27152719 |
Viesselmann CW et al. | Clinically Significant Drug Interaction Between Clotrimazole and Tacrolimus in Pancreas Transplant Recipients and Associated Risk of Allograft Rejection. | 2016 | Pharmacotherapy | pmid:26877191 |
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Chitvanich S et al. | Combination of non-ablative fractional photothermolysis and 0.1% tacrolimus ointment is efficacious for treating idiopathic guttate hypomelanosis. | 2016 | J Dermatolog Treat | pmid:26864301 |
Wang X et al. | Ureaplasma urealyticum Causes Hyperammonemia in an Experimental Immunocompromised Murine Model. | 2016 | PLoS ONE | pmid:27537683 |
Ueno KI et al. | Advantage of administering tacrolimus for improving prognosis of patients with polymyositis and dermatomyositis. | 2016 | Int J Rheum Dis | pmid:27457756 |
Chatterjee S and Agrawal D | Tacrolimus in Corticosteroid-Refractory Vernal Keratoconjunctivitis. | 2016 | Cornea | pmid:27310883 |
Yan L et al. | Donor ABCB1 3435 C>T genetic polymorphisms influence early renal function in kidney transplant recipients treated with tacrolimus. | 2016 | Pharmacogenomics | pmid:26784512 |
Barreto P et al. | Conversion From Twice-Daily to Once-Daily Tacrolimus in Stable Kidney Graft Recipients. | 2016 | Transplant. Proc. | pmid:27742278 |
Wu YJ et al. | Safe One-to-One Dosage Conversion From Twice-Daily to Once-Daily Tacrolimus in Long-Term Stable Recipients After Liver Transplantation. | 2016 | Ann. Transplant. | pmid:26782179 |
Robinson CL et al. | Posaconazole in lung transplant recipients: use, tolerability, and efficacy. | 2016 | Transpl Infect Dis | pmid:26781986 |
Ishida H et al. | A Prospective Randomized, Comparative Trial of High-Dose Mizoribine Versus Mycophenolate Mofetil in Combination With Tacrolimus and Basiliximab for Living Donor Renal Transplant: A Multicenter Trial. | 2016 | Exp Clin Transplant | pmid:27733107 |
Tsunashima D et al. | Preparation of extended release solid dispersion formulations of tacrolimus using ethylcellulose and hydroxypropylmethylcellulose by solvent evaporation method. | 2016 | J. Pharm. Pharmacol. | pmid:26773717 |
Mok MM et al. | Acute Phosphate Nephropathy: An Under-Recognized Complication Leading to Impaired Allograft Function After Renal Transplant. | 2016 | Nephrology (Carlton) | pmid:27730726 |
Bogossian H et al. | Expression of NO Synthase Under Medication with Cyclosporine A, Mycophenolate Mofetil, and Tacrolimus during Development of Transplant Vasculopathy on Rat Cardiac Allograft. | 2016 | Cardiovasc Ther | pmid:26924260 |
EriÅŸ E et al. | Evaluation of Effect of Topical Tacrolimus Treatment on Herpetic Stromal Keratitis in a Rat Model. | 2016 | Eye Contact Lens | pmid:25996419 |
First MR et al. | Use of low-dose tacrolimus and associated hypomagnesemia in the prevention of erectile dysfunction following prostatectomy for prostate cancer. | 2016 | Pharmacol Rep | pmid:27607363 |
RodrÃguez-Lago I et al. | Previous exposure to biologics and C-reactive protein are associated with the response to tacrolimus in inflammatory bowel disease. | 2016 | Rev Esp Enferm Dig | pmid:27604685 |
Pereira M et al. | Hyperacute Rejection in a Kidney Transplant With Negative Crossmatch: A Case Report. | 2016 | Transplant. Proc. | pmid:27742303 |
Rostaing L et al. | Novel Once-Daily Extended-Release Tacrolimus Versus Twice-Daily Tacrolimus in De Novo Kidney Transplant Recipients: Two-Year Results of Phase 3, Double-Blind, Randomized Trial. | 2016 | Am. J. Kidney Dis. | pmid:26717860 |
Shuker N et al. | A Randomized Controlled Trial Comparing the Efficacy of Cyp3a5 Genotype-Based With Body-Weight-Based Tacrolimus Dosing After Living Donor Kidney Transplantation. | 2016 | Am. J. Transplant. | pmid:26714287 |
Spain L et al. | Management of toxicities of immune checkpoint inhibitors. | 2016 | Cancer Treat. Rev. | pmid:26874776 |
Kronbichler A et al. | Moderator's view: The use of calcineurin inhibitors in the treatment of lupus nephritis. | 2016 | Nephrol. Dial. Transplant. | pmid:27591329 |
Juvvadi PR et al. | Novel motif in calcineurin catalytic subunit is required for septal localization of calcineurin in Aspergillus fumigatus. | 2016 | FEBS Lett. | pmid:26864964 |
Wang L et al. | Therapeutic advances for primary biliary cholangitis: the old and the new. | 2016 | Eur J Gastroenterol Hepatol | pmid:26862931 |
Ocampo-Garza J et al. | Acquired Hyperpigmentation and Cicatricial Alopecia. | 2016 | Am. J. Med. Sci. | pmid:27524226 |
Solomon A | Allergic manifestations of contact lens wearing. | 2016 | Curr Opin Allergy Clin Immunol | pmid:27518840 |
Navarro-Villarán E et al. | Differential Antitumoral Properties and Renal-Associated Tissue Damage Induced by Tacrolimus and Mammalian Target of Rapamycin Inhibitors in Hepatocarcinoma: In Vitro and In Vivo Studies. | 2016 | PLoS ONE | pmid:27518575 |
Ben Fredj N et al. | Modeling of Tacrolimus Exposure in Kidney Transplant According to Posttransplant Time Based on Routine Trough Concentration Data. | 2016 | Exp Clin Transplant | pmid:27506258 |
Jung HJ et al. | Improved oral absorption of tacrolimus by a solid dispersion with hypromellose and sodium lauryl sulfate. | 2016 | Int. J. Biol. Macromol. | pmid:26642839 |
Hirsch HH et al. | BK Polyomavirus Replication in Renal Tubular Epithelial Cells Is Inhibited by Sirolimus, but Activated by Tacrolimus Through a Pathway Involving FKBP-12. | 2016 | Am. J. Transplant. | pmid:26639422 |
Imai Y et al. | Histone deacetylase inhibitor panobinostat induces calcineurin degradation in multiple myeloma. | 2016 | JCI Insight | pmid:27699258 |
Cassuto E et al. | Adherence to and Acceptance of Once-Daily Tacrolimus After Kidney and Liver Transplant: Results From OSIRIS, a French Observational Study. | 2016 | Transplantation | pmid:27653227 |
Elshatory YM et al. | Diagnostic and Therapeutic Challenges. | 2016 | Retina (Philadelphia, Pa.) | pmid:26225484 |
Griffin SP and Nelson JE | Impact of a Clinical Solid Organ Transplant Pharmacist on Tacrolimus Nephrotoxicity, Therapeutic Drug Monitoring, and Institutional Revenue Generation in Adult Kidney Transplant Recipients. | 2016 | Prog Transplant | pmid:27628498 |
Li X and Sun S | Targeting the fungal calcium-calcineurin signaling network in overcoming drug resistance. | 2016 | Future Med Chem | pmid:27463738 |
Saliba F et al. | Corticosteroid-Sparing and Optimization of Mycophenolic Acid Exposure in Liver Transplant Recipients Receiving Mycophenolate Mofetil and Tacrolimus: A Randomized, Multicenter Study. | 2016 | Transplantation | pmid:27454919 |
Liu XX et al. | Limited Sampling Strategy for the Estimation of Tacrolimus Area Under the Concentration-Time Curve in Chinese Adult Liver Transplant Patients. | 2016 | Pharmacology | pmid:27449772 |
Gala-Lopez BL et al. | Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice. | 2016 | Diabetes | pmid:26581595 |
Butts AR et al. | Factors associated with optimized tacrolimus dosing in hematopoietic stem cell transplantation. | 2016 | J Oncol Pharm Pract | pmid:25802301 |
Chan SW et al. | Associations of the CYP3A5*3 and CYP3A4*1G polymorphisms with the pharmacokinetics of oral midazolam and the urinary 6β-hydroxycortisol/cortisol ratio as markers of CYP3A activity in healthy male Chinese. | 2016 | J Clin Pharm Ther | pmid:27511886 |
Jung H et al. | FK506 regulates pigmentation by maturing the melanosome and facilitating their transfer to keratinocytes. | 2016 | Pigment Cell Melanoma Res | pmid:26581186 |
Belliere J et al. | Pilot conversion trial from mycophenolic acid to everolimus in ABO-incompatible kidney-transplant recipients with BK viruria and/or viremia. | 2016 | Transpl. Int. | pmid:26575959 |
Zhao CY et al. | External evaluation of published population pharmacokinetic models of tacrolimus in adult renal transplant recipients. | 2016 | Br J Clin Pharmacol | pmid:26574188 |
Zhang X et al. | The effect of calcineurin inhibitors in the induction and maintenance treatment of lupus nephritis: a systematic review and meta-analysis. | 2016 | Int Urol Nephrol | pmid:26781720 |
Moes DJ et al. | Population pharmacokinetics and pharmacogenetics of once daily tacrolimus formulation in stable liver transplant recipients. | 2016 | Eur. J. Clin. Pharmacol. | pmid:26521259 |
Yeo L and Ormerod AD | Oral tacrolimus: a treatment option for recalcitrant erosive lichen planus. | 2016 | Clin. Exp. Dermatol. | pmid:27339859 |
Hashimoto K et al. | Pure red cell aplasia induced by anti-erythropoietin antibodies, well-controlled with tacrolimus. | 2016 | Int. J. Hematol. | pmid:27338269 |
Grönhagen CM and Tey HL | Meralgia paresthetica successfully treated with topical 0.1% tacrolimus: a case report. | 2016 | Int. J. Dermatol. | pmid:26518996 |
Korobko IV and Lomonosov KM | A pilot comparative study of topical latanoprost and tacrolimus in combination with narrow-band ultraviolet B phototherapy and microneedling for the treatment of nonsegmental vitiligo. | 2016 | Dermatol Ther | pmid:27329330 |
Vadcharavivad S et al. | Validation of a 2-Point Limited Sampling Strategy to Predict the Tacrolimus Area-Under-the-12-Hour-Curve in Kidney Transplant Recipients. | 2016 | Ther Drug Monit | pmid:27328329 |
Ayyala RS et al. | Imaging findings in a child with calcineurin inhibitor-induced pain syndrome after bone marrow transplant for beta thalassemia major. | 2016 | Pediatr Radiol | pmid:27324395 |
Wu H et al. | Developmental Neurotoxic Effects of Percutaneous Drug Delivery: Behavior and Neurochemical Studies in C57BL/6 Mice. | 2016 | PLoS ONE | pmid:27606422 |
Luo X et al. | Prediction of tacrolimus metabolism and dosage requirements based on CYP3A4 phenotype and CYP3A5(*)3 genotype in Chinese renal transplant recipients. | 2016 | Acta Pharmacol. Sin. | pmid:26924289 |
Grześk E et al. | Cyclosporine-A, but not tacrolimus significantly increases reactivity of vascular smooth muscle cells. | 2016 | Pharmacol Rep | pmid:26721374 |
McShane AJ et al. | Therapeutic drug monitoring of immunosuppressants by liquid chromatography-mass spectrometry. | 2016 | Clin. Chim. Acta | pmid:26721314 |
Lien YH | Top 10 Things Primary Care Physicians Should Know About Maintenance Immunosuppression for Transplant Recipients. | 2016 | Am. J. Med. | pmid:26714210 |
Kostereva NV et al. | IGF-1 and Chondroitinase ABC Augment Nerve Regeneration after Vascularized Composite Limb Allotransplantation. | 2016 | PLoS ONE | pmid:27272754 |
Raja R et al. | A prospective study of collapsing focal segmental glomerulosclerosis. | 2016 | Ren Fail | pmid:27266801 |
De Meyer M et al. | Pharmacogenetic-based strategy using de novo tacrolimus once daily after kidney transplantation: prospective pilot study. | 2016 | Pharmacogenomics | pmid:27266721 |
Wilkes SR et al. | How Clinically Relevant Are Treatment Comparisons of Topical Calcineurin Inhibitor Trials for Atopic Eczema? | 2016 | J. Invest. Dermatol. | pmid:27265005 |
Miura M et al. | Inter-laboratory Variability of Current Immunoassay Methods for Tacrolimus among Japanese Hospitals. | 2016 | Biol. Pharm. Bull. | pmid:27263473 |
Weiner SM | [Combination of tacrolimus and MMF for treatment of proliferative lupus nephritis]. | 2016 | Z Rheumatol | pmid:27259912 |
Bagherani N | Comparison of pimecrolimus with clobetasol propionate in the treatment of localized vitiligo. | 2016 | Dermatol Ther | pmid:26445411 |
Gaynor JJ et al. | Lower tacrolimus trough levels are associated with subsequently higher acute rejection risk during the first 12 months after kidney transplantation. | 2016 | Transpl. Int. | pmid:26442829 |
Ahmad M et al. | Effectiveness of minocycline and FK506 alone and in combination on enhanced behavioral and biochemical recovery from spinal cord injury in rats. | 2016 | Pharmacol. Biochem. Behav. | pmid:27106204 |
Ramachandran R et al. | Cyclical cyclophosphamide and steroids is effective in resistant or relapsing nephrotic syndrome due to M-type phospholipase A2 receptor-related membranous nephropathy after tacrolimus therapy. | 2016 | Kidney Int. | pmid:27181781 |
Ha DH et al. | Effects of tacrolimus on morphology, proliferation and differentiation of mesenchymal stem cells derived from gingiva tissue. | 2016 | Mol Med Rep | pmid:27177273 |
Jin J et al. | Klotho Deficiency Aggravates Tacrolimus-Induced Renal Injury via the Phosphatidylinositol 3-Kinase-Akt-Forkhead Box Protein O Pathway. | 2016 | Am. J. Nephrol. | pmid:27174564 |
Kim JM et al. | Conversion of once-daily extended-release tacrolimus is safe in stable liver transplant recipients: A randomized prospective study. | 2016 | Liver Transpl. | pmid:26360125 |
Bican Demir A et al. | Two Cases With Developing Neurologic Complications After Liver Transplant. | 2016 | Exp Clin Transplant | pmid:26643318 |
Bruns K et al. | Quantitative determination of four immunosuppressants by high resolution mass spectrometry (HRMS). | 2016 | Clin. Chem. Lab. Med. | pmid:26641969 |
Al-Maawali AK et al. | Modern Treatments and Stem Cell Therapies for Perianal Crohn's Fistulas. | 2016 | Can J Gastroenterol Hepatol | pmid:28053967 |
Pretagostini R et al. | Delayed Introduction of Everolimus in De Novo Renal Transplanted Patients: A Single-Center Experience. | 2016 | Transplant. Proc. | pmid:27109947 |
Zamorano-Leon JJ et al. | New strategy of tacrolimus administration in animal model based on tacrolimus-loaded microspheres. | 2016 | Transpl. Immunol. | pmid:27102446 |
Park OJ et al. | A combination of excimer laser treatment and topical tacrolimus is more effective in treating vitiligo than either therapy alone for the initial 6 months, but not thereafter. | 2016 | Clin. Exp. Dermatol. | pmid:26299799 |
Dasgupta A et al. | Analytical Performance Evaluation of a New Cobas Tacrolimus Assay on Cobas e411 Analyzer: Comparison of Values Obtained by the CMIA Tacrolimus Assay and a Liquid Chromatography Combined with Tandem Mass Spectrometric Method. | 2016 | Ann. Clin. Lab. Sci. | pmid:27098629 |
Watanabe H et al. | The efficacy of add-on tacrolimus for minor flare in patients with systemic lupus erythematosus: a retrospective study. | 2016 | Lupus | pmid:26296361 |
Gomes RM et al. | Ten-year kidney transplant survival of cyclosporine- or tacrolimus-treated patients in Brazil. | 2016 | Expert Rev Clin Pharmacol | pmid:27181131 |
Krejci K et al. | Clinical experience of conversion from cyclosporine to tacrolimus prolonged-release in stabilized kidney transplant patients. | 2016 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | pmid:27174195 |
Alagoz S et al. | Gangliocytoma Presenting With Tacrolimus Neurotoxicity in a Renal Transplant Recipient: Case Report. | 2016 | Transplant. Proc. | pmid:27932167 |
Shipley CA and Spivakovsky S | Tacrolimus or clobetasol for treatment of oral lichen planus. | 2016 | Evid Based Dent | pmid:27012570 |
Ko DH et al. | Performance Evaluation of a Restored Dimension TACR Assay: An Automated Platform for Measuring the Whole Blood Tacrolimus Concentration. | 2016 | Clin. Lab. | pmid:27012028 |
Tang JT et al. | Pharmacogenetic aspects of the use of tacrolimus in renal transplantation: recent developments and ethnic considerations. | 2016 | Expert Opin Drug Metab Toxicol | pmid:27010623 |
Wakamatsu A et al. | Role of calcineurin (CN) in kidney glomerular podocyte: CN inhibitor ameliorated proteinuria by inhibiting the redistribution of CN at the slit diaphragm. | 2016 | Physiol Rep | pmid:27009276 |
Oddis CV | Update on the pharmacological treatment of adult myositis. | 2016 | J. Intern. Med. | pmid:27098592 |
Tron C et al. | A high performance liquid chromatography tandem mass spectrometry for the quantification of tacrolimus in human bile in liver transplant recipients. | 2016 | J Chromatogr A | pmid:27837999 |