Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Hu T et al. | Tacrolimus decreases proteinuria in patients with refractory IgA nephropathy. | 2018 | Medicine (Baltimore) | pmid:29718866 |
Mei S et al. | Simultaneous determination of cyclosporine and tacrolimus in human whole blood by ultra-high performance liquid chromatography tandem mass spectrometry and comparison with a chemiluminescence microparticle immunoassay. | 2018 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:29704799 |
Stanton BZ et al. | Chemically induced proximity in biology and medicine. | 2018 | Science | pmid:29590011 |
Wan Q et al. | Therapeutic Effect of 0.1% Tacrolimus Eye Drops in the Tarsal Form of Vernal Keratoconjunctivitis. | 2018 | Ophthalmic Res. | pmid:28803239 |
Takeuchi T et al. | Post-marketing surveillance study of the long-term use of mizoribine for the treatment of lupus nephritis: 2-Year results. | 2018 | Mod Rheumatol | pmid:28722500 |
Tsujimura K et al. | Effect of Influenza Vaccine in Patients With Kidney Transplant. | 2018 | Transplant. Proc. | pmid:30316375 |
Kanda J et al. | Effects of the calcineurin inhibitors cyclosporine and tacrolimus on bone metabolism in rats. | 2018 | Biomed. Res. | pmid:29899188 |
Pflugrad H et al. | Longterm calcineurin inhibitor therapy and brain function in patients after liver transplantation. | 2018 | Liver Transpl. | pmid:29156491 |
Loeschenberger B et al. | Calcineurin inhibitor-induced complement system activation via ERK1/2 signalling is inhibited by SOCS-3 in human renal tubule cells. | 2018 | Eur. J. Immunol. | pmid:29143318 |
Zhang Y and Zhang R | Recent advances in analytical methods for the therapeutic drug monitoring of immunosuppressive drugs. | 2018 | Drug Test Anal | pmid:28851030 |
Cheng CY et al. | Intervention of Online Percent Coefficient of Variation Reporting System Reduces the Variability of Tacrolimus Trough Concentration in Kidney Transplant Recipients. | 2018 | Transplant. Proc. | pmid:30316366 |
Liu Y et al. | Delayed Initiation of Tacrolimus Is Safe and Effective in Renal Transplant Recipients With Delayed and Slow Graft Function. | 2018 | Transplant. Proc. | pmid:30316359 |
Nordheim E et al. | Preserved insulin secretion and kidney function in recipients with functional pancreas grafts 1 year after transplantation: a single-center prospective observational study | 2018 | Eur. J. Endocrinol. | pmid:30299895 |
Kandula P et al. | Plantar ulcerative lichen planus: rapid improvement with a novel triple-therapy approach. | 2018 | Cutis | pmid:30235362 |
Jiang JW et al. | Optimal immunosuppressor induces stable gut microbiota after liver transplantation. | 2018 | World J. Gastroenterol. | pmid:30228781 |
Ohtsuki M et al. | Tacrolimus ointment for the treatment of adult and pediatric atopic dermatitis: Review on safety and benefits. | 2018 | J. Dermatol. | pmid:29927498 |
Shimoda-Komatsu Y et al. | Chronological observation of surgically-treated granuloma faciale implies the necessity of circumspect management for perinasal nodular subset. | 2018 | J. Dermatol. | pmid:29905388 |
Hou Y et al. | Management of hepatic vein occlusive disease after liver transplantation: A case report with literature review. | 2018 | Medicine (Baltimore) | pmid:29901618 |
Park S et al. | Reduced Tacrolimus Trough Level Is Reflected by Estimated Glomerular Filtration Rate (eGFR) Changes in Stable Renal Transplantation Recipients: Results of the OPTIMUM Phase 3 Randomized Controlled Study. | 2018 | Ann. Transplant. | pmid:29891834 |
Gu B et al. | Exploration of Fecal Microbiota Transplantation in the Treatment of Refractory Diarrhea After Renal Transplantation. | 2018 | Transplant. Proc. | pmid:29880353 |
Gmitterová K et al. | Tacrolimus-induced parkinsonism in a patient after liver transplantation - case report. | 2018 | BMC Neurol | pmid:29678162 |
Liu HY et al. | Ribavirin-induced anaemia reduced tacrolimus level in a hepatitis C patient receiving haemodialysis. | 2018 | BMJ Case Rep | pmid:29669765 |
Majeed A et al. | A 20-year experience with nocardiosis in solid organ transplant (SOT) recipients in the Southwestern United States: A single-center study. | 2018 | Transpl Infect Dis | pmid:29668074 |
Mah A et al. | Graft loss attributed to possible transfusion-transmitted ehrlichiosis following cord blood stem cell transplant. | 2018 | Transpl Infect Dis | pmid:29668040 |
Ma D et al. | Manipulating the expression of SARP family regulator BulZ and its target gene product to increase tacrolimus production. | 2018 | Appl. Microbiol. Biotechnol. | pmid:29666890 |
Ichinose K et al. | The efficacy of adjunct tacrolimus treatment in pregnancy outcomes in patients with systemic lupus erythematosus. | 2018 | Lupus | pmid:29665758 |
Ishikawa S et al. | Management of Juvenile Idiopathic Arthritis in ABO-incompatible Kidney Transplantation: A Case Report. | 2018 | Transplant. Proc. | pmid:29661455 |
Kagaya H et al. | Prediction of Tacrolimus Exposure by CYP3A5 Genotype and Exposure of Co-Administered Everolimus in Japanese Renal Transplant Recipients. | 2018 | Int J Mol Sci | pmid:29547545 |
Yamada R et al. | A case of duodenal malignant lymphoma presenting as acute pancreatitis: systemic lupus erythematosus and immunosuppressive therapy as risk factors. | 2018 | Clin J Gastroenterol | pmid:29546569 |
Shi D et al. | CYP3A4 and GCK genetic polymorphisms are the risk factors of tacrolimus-induced new-onset diabetes after transplantation in renal transplant recipients. | 2018 | Eur. J. Clin. Pharmacol. | pmid:29546446 |
Mina M et al. | Comparison between the efficacy of microneedling combined with 5-fluorouracil vs microneedling with tacrolimus in the treatment of vitiligo. | 2018 | J Cosmet Dermatol | pmid:29532621 |
Zhong J et al. | Tacrolimus interacts with voriconazole to reduce the severity of fungal keratitis by suppressing IFN-related inflammatory responses and concomitant FK506 and voriconazole treatment suppresses fungal keratitis. | 2018 | Mol. Vis. | pmid:29527115 |
Okada K et al. | EBV-positive PEL-like lymphoma that developed in the course of antisynthetase syndrome treated with tacrolimus. | 2018 | Int. J. Hematol. | pmid:29516290 |
Song JL et al. | Higher tacrolimus blood concentration is related to increased risk of post-transplantation diabetes mellitus after living donor liver transplantation. | 2018 | Int J Surg | pmid:29360611 |
Charnaya O et al. | Results of early treatment for de novo donor-specific antibodies in pediatric kidney transplant recipients in a cross-sectional and longitudinal cohort. | 2018 | Pediatr Transplant | pmid:29356221 |
Yamada K et al. | Correlation between disease activity and serum ferritin in clinically amyopathic dermatomyositis with rapidly-progressive interstitial lung disease: a case report. | 2018 | BMC Res Notes | pmid:29338781 |
Jin L et al. | Effect of Conversion to CTLA4Ig on Tacrolimus-Induced Diabetic Rats. | 2018 | Transplantation | pmid:29319618 |
Oetting WS et al. | Attempted validation of 44 reported SNPs associated with tacrolimus troughs in a cohort of kidney allograft recipients. | 2018 | Pharmacogenomics | pmid:29318894 |
Rayar M et al. | High Intrapatient Variability of Tacrolimus Exposure in the Early Period After Liver Transplantation Is Associated With Poorer Outcomes. | 2018 | Transplantation | pmid:29315140 |
Cho EJ et al. | Performance of the Dimension TAC assay and comparison of multiple platforms for the measurement of tacrolimus. | 2018 | J. Clin. Lab. Anal. | pmid:29148096 |
Sir G et al. | Antagonistic Effect of Oxytocin and Tacrolimus Combination on Adipose Tissue - Derived Mesenchymal Stem Cells: Antagonistic effect of oxytocin and tacrolimus. | 2018 | Biomed. Pharmacother. | pmid:29136956 |
Liu L et al. | New insights of subfertility among transplanted women: Immunosuppressive drug FK506 leads to calcium leak and oocyte activation before fertilization. | 2018 | J. Cell. Biochem. | pmid:29131377 |
Kojima CA et al. | Sirolimus Associated with Tacrolimus at Low Doses in Elderly Kidney Transplant Patients: A Prospective Randomized Controlled Trial. | 2018 | Exp Clin Transplant | pmid:28836934 |
Lee WS et al. | Tacrolimus regulates endoplasmic reticulum stress-mediated osteoclastogenesis and inflammation: In vitro and collagen-induced arthritis mouse model. | 2018 | Cell Biol. Int. | pmid:28833755 |
Mithani Z et al. | De Novo Donor-Specific Antibody Formation in Tacrolimus-Based, Mycophenolate Versus Mammalian Target of Rapamycin Immunosuppressive Regimens. | 2018 | Exp Clin Transplant | pmid:28332959 |
Özçakar ZB et al. | Transplantation within the era of anti-IL-1 therapy: case series of five patients with familial Mediterranean fever-related amyloidosis. | 2018 | Transpl. Int. | pmid:29957882 |
Chao YH et al. | Tolerogenic β2-glycoprotein I DNA vaccine and FK506 as an adjuvant attenuates experimental obstetric antiphospholipid syndrome. | 2018 | PLoS ONE | pmid:29894515 |
Krogstad V et al. | Determination of Tacrolimus Concentration and Protein Expression of P-Glycoprotein in Single Human Renal Core Biopsies. | 2018 | Ther Drug Monit | pmid:29578937 |
Marquet P et al. | Pharmacokinetic Therapeutic Drug Monitoring of Advagraf in More Than 500 Adult Renal Transplant Patients, Using an Expert System Online. | 2018 | Ther Drug Monit | pmid:29505493 |
Chen J et al. | Controlled dimerization of insulin-like growth factor-1 and insulin receptors reveals shared and distinct activities of holo and hybrid receptors. | 2018 | J. Biol. Chem. | pmid:29330302 |