tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gjertson DW et al. | The relative effects of FK506 and cyclosporine on short- and long-term kidney graft survival. | 1995 | Transplantation | pmid:8545861 |
| Shirakata Y et al. | Inhibitory effect of plasma FKBP12 on immunosuppressive activity of FK506. | 1995 | Transplantation | pmid:8545894 |
| Aoyama H et al. | Successful treatment of resistant facial lesions of atopic dermatitis with 0.1% FK506 ointment. | 1995 | Br. J. Dermatol. | pmid:8547017 |
| Gharpure VS et al. | Thrombotic thrombocytopenic purpura associated with FK506 following bone marrow transplantation. | 1995 | Bone Marrow Transplant. | pmid:8547871 |
| Kawai M et al. | Pyrrolidine dithiocarbamate inhibits intercellular adhesion molecule-1 biosynthesis induced by cytokines in human fibroblasts. | 1995 | J. Immunol. | pmid:7532665 |
| Venkataraman L et al. | FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells. | 1995 | J. Exp. Med. | pmid:7532676 |
| Martinez OM et al. | Molecular markers of Epstein-Barr virus infection in the circulation of transplant recipients. | 1995 | Transplant. Proc. | pmid:7533372 |
| Fung JJ and Starzl TE | FK506 in solid organ transplantation. | 1995 | Ther Drug Monit | pmid:8588226 |
| Langrehr JM et al. | Liver transplantation in hepatitis B surface antigen positive patients with postoperative long-term immunoprophylaxis. | 1995 | Transplant. Proc. | pmid:7533373 |
| Jusko WJ | Analysis of tacrolimus (FK 506) in relation to therapeutic drug monitoring. | 1995 | Ther Drug Monit | pmid:8588227 |
| Vargas V et al. | Alpha-interferon for acute hepatitis C in liver transplant patients. | 1995 | Transplant. Proc. | pmid:7533374 |
| McMaster P et al. | Therapeutic drug monitoring of tacrolimus in clinical transplantation. | 1995 | Ther Drug Monit | pmid:8588228 |
| Barkholt LM et al. | New criteria for diagnosing cytomegalovirus hepatitis in liver transplant patients. | 1995 | Transplant. Proc. | pmid:7533375 |
| Jusko WJ et al. | Consensus document: therapeutic monitoring of tacrolimus (FK-506). | 1995 | Ther Drug Monit | pmid:8588229 |
| Chakraborty TK et al. | Design and synthesis of a rapamycin-based high affinity binding FKBP12 ligand. | 1995 | Chem. Biol. | pmid:9383417 |
| Laskow DA et al. | Phase II FK 506 multicenter concentration control study: one-year follow-up. | 1995 | Transplant. Proc. | pmid:7533431 |
| Shapiro R et al. | A prospective, randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone in renal transplant patients. | 1995 | Transplant. Proc. | pmid:7533432 |
| Winkler M et al. | Comparison of plasma vs whole blood as matrix for FK 506 drug level monitoring. | 1995 | Transplant. Proc. | pmid:7533433 |
| Sakamoto K et al. | Sodium-losing nephropathy and distal tubular damage of transplant kidneys with FK506 administration. | 1995 | Transplant. Proc. | pmid:7533434 |
| Ochiai T et al. | Phase III study of FK 506 in kidney transplantation. Japanese FK 506 Study Group. | 1995 | Transplant. Proc. | pmid:7533435 |
| Sen J et al. | Expression and induction of nuclear factor-kappa B-related proteins in thymocytes. | 1995 | J. Immunol. | pmid:7534792 |
| Komori T | [The change of lymphocyte subset and effect of FK506 in experimental small bowel transplantation of rats]. | 1995 | Nihon Geka Gakkai Zasshi | pmid:7534867 |
| Miranker A and Karplus M | An automated method for dynamic ligand design. | 1995 | Proteins | pmid:8749844 |
| Furuke K et al. | Suppression of adult T cell leukemia-derived factor/human thioredoxin induction by FK506 and cyclosporin A: a new mechanism of immune modulation via redox control. | 1995 | Int. Immunol. | pmid:7577807 |
| Mehta BA et al. | Two pathways of exocytosis of cytoplasmic granule contents and target cell killing by cytokine-induced CD3+ CD56+ killer cells. | 1995 | Blood | pmid:7579455 |
| Coss MC et al. | Molecular cloning, DNA sequence analysis, and biochemical characterization of a novel 65-kDa FK506-binding protein (FKBP65). | 1995 | J. Biol. Chem. | pmid:7493967 |
| Hemenway C | FK506 in bone marrow transplantation. | 1995 | Blood | pmid:7579473 |
| Lee MJ et al. | Physicochemical, pharmacokinetic and pharmacodynamic evaluation of liposomal tacrolimus (FK 506) in rats. | 1995 | Pharm. Res. | pmid:7494802 |
| Yamamoto M et al. | Cyclosporin A and FK506 reverse anthracycline resistance by altering the cell cycle. | 1995 | Anticancer Drugs | pmid:7579561 |
| Arita S et al. | Effect of FK 506 in experimental pancreas transplantation. | 1995 | Transplant. Proc. | pmid:7536980 |
| Zhao Y and Iwata M | Cross-linking of the TCR-CD3 complex with CD4, CD8 or LFA-1 induces an anti-apoptotic signal in thymocytes: the signal is canceled by FK506. | 1995 | Int. Immunol. | pmid:7495746 |
| Aono T et al. | Minimal threshold of FK 506 for enhancing liver regeneration in thymectomized rats. | 1995 | Transplant. Proc. | pmid:7536981 |
| Saito T et al. | In situ dephosphorylation of tau by protein phosphatase 2A and 2B in fetal rat primary cultured neurons. | 1995 | FEBS Lett. | pmid:7498550 |
| Iwabuchi T et al. | Effects of immunosuppressive peptidyl-prolyl cis-trans isomerase (PPIase) inhibitors, cyclosporin A, FK506, ascomycin and rapamycin, on hair growth initiation in mouse: immunosuppression is not required for new hair growth. | 1995 | J. Dermatol. Sci. | pmid:7537082 |
| Antoni FA et al. | Calcineurin feedback inhibition of agonist-evoked cAMP formation. | 1995 | J. Biol. Chem. | pmid:7499291 |
| Griffith JP et al. | X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex. | 1995 | Cell | pmid:7543369 |
| Prud'homme GJ et al. | Effects of cyclosporin A, rapamycin, and FK520 on peripheral T-cell deletion and anergy. | 1995 | Cell. Immunol. | pmid:7543371 |
| Migita K et al. | FK506 augments activation-induced programmed cell death of T lymphocytes in vivo. | 1995 | J. Clin. Invest. | pmid:7543492 |
| Lhoëst G et al. | The in vitro immunosuppressive activity of the C15-demethylated metabolite of FK-506 is governed by ring- and open-chain tautomerism effects. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7543569 |
| Schleibner S et al. | FK 506 versus cyclosporin in the prevention of renal allograft rejection--European pilot study: six-week results. | 1995 | Transpl. Int. | pmid:7539270 |
| Textor SC et al. | Urinary endothelin and renal vasoconstriction with cyclosporine or FK506 after liver transplantation. | 1995 | Kidney Int. | pmid:7543625 |
| Ko S et al. | The enhanced immunosuppressive efficacy of newly developed liposomal FK506 in canine liver transplantation. | 1995 | Transplantation | pmid:7539553 |
| Fealy MJ et al. | Association of down-regulation of cytokine activity with rat hind limb allograft survival. | 1995 | Transplantation | pmid:7539555 |
| Varela E | [Small bowel transplantation]. | 1995 | Acta Gastroenterol. Latinoam. | pmid:7544939 |
| Taler SJ et al. | Loss of nocturnal blood pressure fall after liver transplantation during immunosuppressive therapy. | 1995 | Am. J. Hypertens. | pmid:7544983 |
| Teague S | Lessons from molecular matchmakers. | 1995 | Nat. Struct. Biol. | pmid:7545076 |
| Milad M et al. | Interaction of the progesterone receptor with binding proteins for FK506 and cyclosporin A. | 1995 | Mol. Endocrinol. | pmid:7476967 |
| Zhang J and Steiner JP | Nitric oxide synthase, immunophilins and poly(ADP-ribose) synthetase: novel targets for the development of neuroprotective drugs. | 1995 | Neurol. Res. | pmid:7477744 |
| Jindal RM and Popescu I | Renal dysfunction associated with liver transplantation. | 1995 | Postgrad Med J | pmid:7479462 |
| Yeh WC et al. | Identification and characterization of an immunophilin expressed during the clonal expansion phase of adipocyte differentiation. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7479941 |
| Kissinger CR et al. | Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. | 1995 | Nature | pmid:8524402 |
| Cardenas ME et al. | Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin. | 1995 | Curr. Opin. Nephrol. Hypertens. | pmid:8591053 |
| Lake KD and Canafax DM | Important interactions of drugs with immunosuppressive agents used in transplant recipients. | 1995 | J. Antimicrob. Chemother. | pmid:8601538 |
| Holsinger LJ et al. | Signal transduction in T lymphocytes using a conditional allele of Sos. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7568223 |
| Karanam BV et al. | FK 506 metabolism in human liver microsomes: investigation of the involvement of cytochrome P450 isozymes other than CYP3A4. | 1994 Sep-Oct | Drug Metab. Dispos. | pmid:7530623 |
| Cacciarelli TV et al. | Influence of the timing of FK 506 (Tacrolimus) administration on recovery of renal function from warm ischemic injury in rats. | 1994 Oct-Dec | ASAIO J. | pmid:7532042 |
| Ryffel B et al. | Nephrotoxicity of immunosuppressants in rats: comparison of macrolides with cyclosporin. | 1994 Nov-Dec | Exp. Nephrol. | pmid:7532090 |
| Kay AB | Immunosuppressive agents in chronic severe asthma. | 1994 May-Jun | Allergy Proc | pmid:7523242 |
| von Asmuth EJ et al. | IL-6, IL-8 and TNF production by cytokine and lipopolysaccharide-stimulated human renal cortical epithelial cells in vitro. | 1994 May-Jun | Eur. Cytokine Netw. | pmid:7524716 |
| Yoshida Y et al. | Comparison of cardiac rejection in heart and heart-lung concordant xenotransplantation. | 1994 Mar-Apr | J. Heart Lung Transplant. | pmid:7518252 |
| Assan R et al. | FK 506/fluconazole interaction enhances FK 506 nephrotoxicity. | 1994 Jan-Feb | Diabete Metab | pmid:7520007 |
| Perotti BY et al. | FK 506 metabolism in male and female rat liver microsomes. | 1994 Jan-Feb | Drug Metab. Dispos. | pmid:7512020 |
| Akita K et al. | Effect of FK506 and anti-CD4 therapy on fetal pig pancreas xenografts and host lymphoid cells in nod/Lt, CBA, and BALB/c mice. | 1994 Jan-Feb | Cell Transplant | pmid:7512875 |
| Yasunami Y et al. | Donor-specific unresponsiveness induced by intraportal grafting and FK506 in rat islet allografts: importance of low temperature culture and transplant site on induction and maintenance. | 1994 Jan-Feb | Cell Transplant | pmid:7512876 |
| Fruman DA et al. | Immunophilins in protein folding and immunosuppression. | 1994 | FASEB J. | pmid:7513288 |
| Piekoszewski W et al. | Pharmacokinetic and pharmacodynamic effects of coadministration of methylprednisolone and tacrolimus in rabbits. | 1994 | J. Pharmacol. Exp. Ther. | pmid:7513355 |
| Ueki M et al. | Peritoneal-omental pouch as a site for islet allotransplantation. | 1994 | Transplant. Proc. | pmid:7513462 |
| Hachida M et al. | [The rescue effect of FK506 in refractory rejection after cardiac transplantation]. | 1994 | Nihon Kyobu Geka Gakkai Zasshi | pmid:7528255 |
| Sugiyama E et al. | FK506, an immunosuppressant, partially inhibits interleukin 6 production by adherent rheumatoid synovial cells. | 1994 | J. Rheumatol. | pmid:7528280 |
| Bennett WM et al. | Nephrotoxicity of immunosuppressive drugs. | 1994 | Nephrol. Dial. Transplant. | pmid:7528363 |
| McCashland TM et al. | Bile acid metabolism and biliary secretion in patients receiving orthotopic liver transplants: differing effects of cyclosporine and FK 506. | 1994 | Hepatology | pmid:7514561 |
| Husi H et al. | Mapping of the immunophilin-immunosuppressant site of interaction on calcineurin. | 1994 | J. Biol. Chem. | pmid:7514602 |
| Dawson VL et al. | Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures. | 1994 | Neuropharmacology | pmid:7532825 |
| Nishimori H et al. | Combination therapy with FK 506 and splenectomy may induce tolerance in cardiac xenografts. | 1994 | Transplant. Proc. | pmid:7518102 |
| Kawauchi M et al. | Cardiac xenotransplantation from pig to Japanese monkey with splenectomy, tacrolims, filtration plasmapheresis, and nafamstat mesilate. | 1994 | Transplant. Proc. | pmid:7518105 |
| Ohtsuka S et al. | Effect of splenectomy on hamster-to-rat pancreas xenotransplantation. | 1994 | Transplant. Proc. | pmid:7518109 |
| Helekar SA et al. | Prolyl isomerase requirement for the expression of functional homo-oligomeric ligand-gated ion channels. | 1994 | Neuron | pmid:7507339 |
| Parsons JN et al. | Regulation of calcineurin phosphatase activity and interaction with the FK-506.FK-506 binding protein complex. | 1994 | J. Biol. Chem. | pmid:7518461 |
| Cunningham KW and Fink GR | Calcineurin-dependent growth control in Saccharomyces cerevisiae mutants lacking PMC1, a homolog of plasma membrane Ca2+ ATPases. | 1994 | J. Cell Biol. | pmid:7507493 |
| Wang T et al. | Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12. | 1994 | Science | pmid:7518616 |
| Tanabe M et al. | Combined immunosuppressive therapy with low dose FK506 and antimetabolites in rat allogeneic heart transplantation. | 1994 | Transplantation | pmid:7518619 |
| Nakata S et al. | Immunosuppressive mechanisms of deoxymethylspergualin and FK 506 on in vitro cytotoxic T lymphocytes. | 1994 | Transplant. Proc. | pmid:7520613 |
| Morphopathological findings of renal allografts under FK 506 therapy. Japanese FK 506 Study Group. | 1994 | Transplant. Proc. | pmid:7520614 | |
| Imanishi M et al. | Induction of tolerance by intrathymic injection of donor bone marrow cells in the rat: simultaneous heart and skin allograft model. | 1994 | Transplant. Proc. | pmid:7520615 |
| Charters AR et al. | Immunochemical analysis of FK506 binding proteins in neuronal cell lines and rat brain. | 1994 | Biochem. Soc. Trans. | pmid:7535258 |
| Matsuura T et al. | Organ-specific tolerance induced by intrathymic injection of donor bone marrow cells and FK 506 or antilymphocyte serum in rat heart transplantation. | 1994 | Transplant. Proc. | pmid:7520616 |
| Charters AR et al. | The subcellular distribution of FK506 binding proteins in rat brain. | 1994 | Biochem. Soc. Trans. | pmid:7535259 |
| Karmann K et al. | Endothelial cell-induced resistance to cyclosporin A in human peripheral blood T cells requires contact-dependent interactions involving CD2 but not CD28. | 1994 | J. Immunol. | pmid:7523510 |
| Hiromura K et al. | FK506 inhibits renal glomerular thrombosis induced in rats by nephrotoxic serum and lipopolysaccharide. | 1994 | Kidney Int. | pmid:7523750 |
| Ohtomo Y et al. | Coexisting NPY and NE synergistically regulate renal tubular Na+, K(+)-ATPase activity. | 1994 | Kidney Int. | pmid:7523751 |
| Siekierka JJ | Probing T-cell signal transduction pathways with the immunosuppressive drugs, FK-506 and rapamycin. | 1994 | Immunol. Res. | pmid:7539823 |
| Tamir H et al. | Secretogogue-induced gating of chloride channels in the secretory vesicles of parafollicular cells. | 1994 | Endocrinology | pmid:7525261 |
| Shafiee A et al. | Enzymology of FK-506 biosynthesis. Purification and characterization of 31-O-desmethylFK-506 O:methyltransferase from Streptomyces sp. MA6858. | 1994 | Eur. J. Biochem. | pmid:7525282 |
| Benton BM et al. | A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus. | 1994 | J. Cell Biol. | pmid:7525596 |
| Devlin J et al. | Renal complications and development of hypertension in the European study of FK 506 and cyclosporin in primary liver transplant recipients. | 1994 | Transpl. Int. | pmid:11271207 |
| Two-year follow-up study of the efficacy and safety of FK 506 in kidney transplant patients. Japanese FK 506 Study Group. | 1994 | Transpl. Int. | pmid:11271216 | |
| Neuhaus P et al. | Neurological complications in the European multicentre study of FK 506 and cyclosporin in primary liver transplantation. | 1994 | Transpl. Int. | pmid:11271222 |
| Lea JP et al. | Evidence that the inhibition of Na+/K(+)-ATPase activity by FK506 involves calcineurin. | 1994 | Kidney Int. | pmid:7527873 |
| Nielsen FT et al. | Nephrotoxity of FK 506: a preliminary study on comparative aspects of FK 506 and cyclosporine nephrotoxicity. | 1994 | Transplant. Proc. | pmid:7527946 |
| Fisher A et al. | Gastrointestinal toxicity associated with FK 506 in liver transplant recipients. | 1994 | Transplant. Proc. | pmid:7527947 |