Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Piekoszewski W et al. | Pharmacokinetic and pharmacodynamic effects of coadministration of methylprednisolone and tacrolimus in rabbits. | 1994 | J. Pharmacol. Exp. Ther. | pmid:7513355 |
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Yasunami Y et al. | Acceptance of donor-specific islet allografts in rat by intraportal preimmunization with islets and FK 506. | 1994 | Transplant. Proc. | pmid:7513467 |
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Foster CA et al. | Pharmacological modulation of endothelial cell-associated adhesion molecule expression: implications for future treatment of dermatological diseases. | 1994 | J. Dermatol. | pmid:7531725 |
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Breuder T et al. | Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7515500 |
Kawauchi M et al. | Cardiac xenotransplantation from pig to Japanese monkey with splenectomy, tacrolims, filtration plasmapheresis, and nafamstat mesilate. | 1994 | Transplant. Proc. | pmid:7518105 |
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Yasutomi M et al. | Mechanism of antibody production in hamster-to-rat concordant xenotransplantation: establishment of a simple model using intravenous injection of concordant splenocytes. | 1994 | Transplant. Proc. | pmid:7518110 |
Miyazawa H et al. | Mechanisms of hamster kidney graft rejection in the rat. | 1994 | Transplant. Proc. | pmid:7518111 |
Nardo B et al. | Pretransplant xenogeneic blood transfusion combined with FK 506 prolongs hamster-to-rat liver xenograft survival. | 1994 | Transplant. Proc. | pmid:7518112 |
Pan F et al. | FK 506 prolongs survival of liver but not heart mouse-to-rat vascularized xenografts. | 1994 | Transplant. Proc. | pmid:7518113 |
Raymond M et al. | Functional expression of P-glycoprotein in Saccharomyces cerevisiae confers cellular resistance to the immunosuppressive and antifungal agent FK520. | 1994 | Mol. Cell. Biol. | pmid:7505392 |
Valdivia LA et al. | Complement and target cells belong to the same species after liver xenografting: protection from hyperacute rejection. | 1994 | Transplant. Proc. | pmid:7518123 |
Hayashi S et al. | Synergistic effect of donor pretreatment using FK 506 in hamster-to-rat cardiac xenotransplantation. | 1994 | Transplant. Proc. | pmid:7518126 |
Ohtsuka S et al. | Mechanism of antibody production in guinea pig to rat discordant xenotransplant: establishment of a simple model by intravenous injection of discordant splenocytes. | 1994 | Transplant. Proc. | pmid:7518130 |
Cunningham KW and Fink GR | Calcineurin-dependent growth control in Saccharomyces cerevisiae mutants lacking PMC1, a homolog of plasma membrane Ca2+ ATPases. | 1994 | J. Cell Biol. | pmid:7507493 |
Wang T et al. | Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12. | 1994 | Science | pmid:7518616 |
Fealy MJ et al. | Efficacy of rapamycin and FK 506 in prolonging rat hind limb allograft survival. | 1994 | Ann. Surg. | pmid:7507657 |
Tanabe M et al. | Combined immunosuppressive therapy with low dose FK506 and antimetabolites in rat allogeneic heart transplantation. | 1994 | Transplantation | pmid:7518619 |
Bossard MJ et al. | Catalytic and ligand binding properties of the FK506 binding protein FKBP12: effects of the single amino acid substitution of Tyr82 to Leu. | 1994 | Biochem. J. | pmid:7507662 |
Tamura K et al. | Interaction of tacrolimus(FK506) and its metabolites with FKBP and calcineurin. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7518678 |
Hooks MA | Tacrolimus, a new immunosuppressant--a review of the literature. | 1994 | Ann Pharmacother | pmid:7518710 |
Frizell E et al. | FK506 enhances fibrogenesis in in vitro and in vivo models of liver fibrosis in rats. | 1994 | Gastroenterology | pmid:7518783 |
Fujimura A and Ebihara A | Administration time-dependent toxicity of a new immunosuppressive agent, tacrolimus (FK 506). | 1994 | Life Sci. | pmid:7518886 |
Gottschalk AR et al. | Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7518929 |
Prasad TN et al. | FK 506 (Tacrolimus) metabolism by rat liver microsomes and its inhibition by other drugs. | 1994 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:7518966 |
Morphopathological findings of renal allografts under FK 506 therapy. Japanese FK 506 Study Group. | 1994 | Transplant. Proc. | pmid:7520614 | |
Imanishi M et al. | Induction of tolerance by intrathymic injection of donor bone marrow cells in the rat: simultaneous heart and skin allograft model. | 1994 | Transplant. Proc. | pmid:7520615 |
Charters AR et al. | Immunochemical analysis of FK506 binding proteins in neuronal cell lines and rat brain. | 1994 | Biochem. Soc. Trans. | pmid:7535258 |
Matsuura T et al. | Organ-specific tolerance induced by intrathymic injection of donor bone marrow cells and FK 506 or antilymphocyte serum in rat heart transplantation. | 1994 | Transplant. Proc. | pmid:7520616 |
Andoh TF et al. | Enhancement of FK506 nephrotoxicity by sodium depletion in an experimental rat model. | 1994 | Transplantation | pmid:7509514 |
Charters AR et al. | The subcellular distribution of FK506 binding proteins in rat brain. | 1994 | Biochem. Soc. Trans. | pmid:7535259 |
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Bäckman L et al. | FK506 trough levels in whole blood and plasma in liver transplant recipients. Correlation with clinical events and side effects. | 1994 | Transplantation | pmid:7509516 |
Hirose M and Kuroda Y | Reinforcement of cyclosporin A-induced red cell destruction by superoxide. | 1994 | Tokushima J. Exp. Med. | pmid:7535479 |
Takahara S et al. | Monitoring of FK 506 blood levels in kidney transplant recipients. | 1994 | Transplant. Proc. | pmid:7520623 |
Kitamura Y et al. | Suppressive effect of FK-506, a novel immunosuppressant, against MPTP-induced dopamine depletion in the striatum of young C57BL/6 mice. | 1994 | J. Neuroimmunol. | pmid:7509816 |
Sun CK et al. | Intensive care after orthotopic liver transplantation. | 1994 | Transplant. Proc. | pmid:7520627 |
Sato K et al. | Effectiveness of triple regimen immunosuppression in canine pancreatic allotransplantation. | 1994 | Transplant. Proc. | pmid:7520628 |
Thomson AW | Immunosuppressive drugs and the induction of transplantation tolerance. | 1994 | Transpl. Immunol. | pmid:7535641 |
Oishi M et al. | Successful swine small bowel transplantation using FK506: effect on endotoxin translocation. | 1994 | Transplant. Proc. | pmid:7520629 |
Tai PK et al. | Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506. | 1994 | Biochemistry | pmid:7521210 |
Akita K et al. | Suppression of nitric oxide production by cyclosporin A and FK506A in rat vascular smooth muscle cells. | 1994 | Clin. Exp. Pharmacol. Physiol. | pmid:7521274 |
Weaver JL et al. | The interaction of immunosuppressive compounds in tandem stimulated peripheral human lymphocytes. | 1994 | Immunopharmacol Immunotoxicol | pmid:7521360 |
Woo J et al. | FK506 inhibits the differentiation of developing thymocytes but not negative selection of T cell receptor V beta 5+ and V beta 11+ T lymphocytes in vivo. | 1994 | Transpl. Immunol. | pmid:7521743 |
Kasiske BL | The effects of immunosuppressive agents on plasma lipoproteins after organ transplantation. | 1994 | J. Lab. Clin. Med. | pmid:7521894 |
Krentz AJ et al. | Serum lipids and apolipoproteins in liver transplant recipients: a comparative study of cyclosporin A and FK 506. | 1994 | J. Lab. Clin. Med. | pmid:7521895 |
Jensen C et al. | Interaction between tacrolimus and erythromycin. | 1994 | Lancet | pmid:7521928 |
Winkler M et al. | Comparison of different assays for the quantitation of FK 506 levels in blood or plasma. | 1994 | Ther Drug Monit | pmid:7521978 |
Holländer GA et al. | Molecular and biological actions of cyclosporin A and FK506 on T cell development and function. | 1994 | Transfus Sci | pmid:10155542 |
Hiromura K et al. | FK506 inhibits renal glomerular thrombosis induced in rats by nephrotoxic serum and lipopolysaccharide. | 1994 | Kidney Int. | pmid:7523750 |
Ohtomo Y et al. | Coexisting NPY and NE synergistically regulate renal tubular Na+, K(+)-ATPase activity. | 1994 | Kidney Int. | pmid:7523751 |
Siekierka JJ | Probing T-cell signal transduction pathways with the immunosuppressive drugs, FK-506 and rapamycin. | 1994 | Immunol. Res. | pmid:7539823 |
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Gruber SA et al. | Pharmacokinetics of FK506 after intravenous and oral administration in patients awaiting renal transplantation. | 1994 | J Clin Pharmacol | pmid:7525661 |
Funk JO and Maibach HI | Horizons in pharmacologic intervention in allergic contact dermatitis. | 1994 | J. Am. Acad. Dermatol. | pmid:7525668 |
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Hiromatsu Y et al. | Inhibitory effect of FK506 on intercellular adhesion molecule-1 (ICAM-1) expression on cultured thyroid cells. | 1994 | Kurume Med J | pmid:7526029 |
Kinoshita I et al. | Very efficient myoblast allotransplantation in mice under FK506 immunosuppression. | 1994 | Muscle Nerve | pmid:7526208 |
Matsunami H et al. | New technique for measuring tacrolimus concentrations in blood. | 1994 | Am J Hosp Pharm | pmid:7510929 |
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Renoir JM et al. | Effects of immunosuppressants FK506 and rapamycin on the heterooligomeric form of the progesterone receptor. | 1994 | J. Steroid Biochem. Mol. Biol. | pmid:7510997 |
Ayres RC et al. | Peripheral neurotoxicity with tacrolimus. | 1994 | Lancet | pmid:7511197 |
Two-year follow-up study of the efficacy and safety of FK 506 in kidney transplant patients. Japanese FK 506 Study Group. | 1994 | Transpl. Int. | pmid:11271216 | |
Neuhaus P et al. | Neurological complications in the European multicentre study of FK 506 and cyclosporin in primary liver transplantation. | 1994 | Transpl. Int. | pmid:11271222 |
Bismuth H et al. | Focus on intractable rejection: 6-month results of the European multicentre liver study of FK 506 and cyclosporin A. | 1994 | Transpl. Int. | pmid:11271231 |
McMaster P | Patient and graft survival in the European Multicentre Liver Study--FK 506 vs cyclosporin A. | 1994 | Transpl. Int. | pmid:11271239 |
Mueller AR et al. | Neurotoxicity after orthotopic liver transplantation in cyclosporin A- and FK 506-treated patients. | 1994 | Transpl. Int. | pmid:11271254 |
D'Silva M et al. | The immunomodulatory effects of a novel agent, leflunomide, in rat cardiac allotransplantation. | 1994 | Transpl. Int. | pmid:11271257 |
Trocha K et al. | Neurological examinations after liver transplantation concerning patients under corticosteroid immunosuppression and either FK 506 or cyclosporin. | 1994 | Transpl. Int. | pmid:11271273 |
Ishii T et al. | Immunodepressants ameliorate normothermic ischemia injury to the rat liver by down-regulating tumor necrosis factor, not by alleviation of lipid peroxidative injury. | 1994 | Transpl. Int. | pmid:11271294 |
Nielsen FT et al. | Nephrotoxity of FK 506: a preliminary study on comparative aspects of FK 506 and cyclosporine nephrotoxicity. | 1994 | Transplant. Proc. | pmid:7527946 |
Fisher A et al. | Gastrointestinal toxicity associated with FK 506 in liver transplant recipients. | 1994 | Transplant. Proc. | pmid:7527947 |