tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Guy S et al. | Immunosuppression conversion for relief of side effects. | 1994 | Transplant. Proc. | pmid:7527956 |
| Knoop C et al. | FK 506 rescue therapy for irreversible airway rejection in heart-lung transplant recipients: report on five cases. | 1994 | Transplant. Proc. | pmid:7527957 |
| Candinas D et al. | Efficacy of leflunomide in combination with current immunosuppressive agents in rat cardiac allotransplantation. | 1994 | Transplant. Proc. | pmid:7527959 |
| Reduced incidence of acute, refractory acute, and chronic rejection after liver transplantation with FK506-based immunosuppression. European FK506 Multicentre Liver Study Group. | 1994 | Transplant. Proc. | pmid:7527960 | |
| Nomoto S et al. | Cardiotoxicity of long-term intravenous administration of FK506 in rabbits: dose relationship and recovery after discontinuance. | 1994 | Transplant. Proc. | pmid:7513477 |
| Kato H et al. | Spontaneous proliferation of peripheral blood mononuclear cells as an indicator for insufficient plasma levels of FK 506 in the early phase after liver transplantation. | 1994 | Transplant. Proc. | pmid:7513481 |
| Nishikawa K et al. | Experimental studies of vascularized joint allografts in rats. | 1994 | Transplant. Proc. | pmid:7513482 |
| Fukuzawa M and Okada A | Analysis of mouse xenogeneic T-cell responses and the effect of FK 506 on these responses and on xeno-skin graft rejection. | 1994 | Transplant. Proc. | pmid:7513483 |
| Kraus-Friedmann N and Feng L | Reduction of ryanodine binding and cytosolic Ca2+ levels in liver by the immunosuppressant FK506. | 1994 | Biochem. Pharmacol. | pmid:7529023 |
| Ohtsuka S et al. | Experimental rat pancreas transplant: surgical technique and immunological considerations. | 1994 | Surg. Today | pmid:7516209 |
| Cardenas ME et al. | Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands. | 1994 | EMBO J. | pmid:7529175 |
| Hisatomi K et al. | Limited effectiveness of FK506 administration for ongoing rejection in heterotopic rat heart transplantation. | 1994 | Surg. Today | pmid:7516210 |
| Burkhalter EL et al. | Severe neurological complications following orthotopic liver transplantation in patients receiving FK 506 and prednisone. | 1994 | J. Hepatol. | pmid:7529272 |
| Kawano K et al. | Evidence that FK506 alleviates ischemia/reperfusion injury to the rat liver: in vivo demonstration for suppression of TNF-a production in response to endotoxemia. | 1994 | Eur Surg Res | pmid:7516291 |
| Wolter K et al. | Interaction between FK 506 and clarithromycin in a renal transplant patient. | 1994 | Eur. J. Clin. Pharmacol. | pmid:7532134 |
| Hashimoto T et al. | Treatment with FK506 prevents rejection of rat colon allografts. | 1994 | Transplantation | pmid:7516586 |
| Konishi M et al. | Effects of FK506 on surface antigen expression by regenerating thymocytes after sublethal irradiation in the rat. | 1994 | Thymus | pmid:7532330 |
| Shapiro R et al. | A prospective, randomized trial of FK-506 in renal transplantation--a comparison between double- and triple-drug therapy. | 1994 | Clin Transplant | pmid:7532475 |
| Ohtsuka S et al. | Mechanism of antibody production in guinea pig to rat discordant xenotransplant: establishment of a simple model by intravenous injection of discordant splenocytes. | 1994 | Transplant. Proc. | pmid:7518130 |
| Todo S et al. | Intestinal transplantation at the University of Pittsburgh. | 1994 | Transplant. Proc. | pmid:7518136 |
| Reyes J et al. | Lymphoproliferative disease after intestinal transplantation under primary FK 506 immunosuppression. | 1994 | Transplant. Proc. | pmid:7518137 |
| Murase N et al. | Small bowel transplantation in sensitized recipients: comparison with heart, kidney, and liver grafts. | 1994 | Transplant. Proc. | pmid:7518139 |
| Fujisaki S et al. | Effects of preformed antibodies induced by whole blood transfusion on small bowel transplantation. | 1994 | Transplant. Proc. | pmid:7518140 |
| Pruschy MN et al. | Mechanistic studies of a signaling pathway activated by the organic dimerizer FK1012. | 1994 | Chem. Biol. | pmid:9383386 |
| Platz KP et al. | Nephrotoxicity following orthotopic liver transplantation. A comparison between cyclosporine and FK506. | 1994 | Transplantation | pmid:7518975 |
| Cakaloglu Y et al. | Importance of cytochrome P-450IIIA activity in determining dosage and blood levels of FK 506 and cyclosporine in liver transplant recipients. | 1994 | Hepatology | pmid:7519161 |
| Luan S et al. | Light-regulated, tissue-specific immunophilins in a higher plant. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7508125 |
| Blazar BR et al. | FK506 inhibits graft-versus-host disease and bone marrow graft rejection in murine recipients of MHC disparate donor grafts by interfering with mature peripheral T cell expansion post-transplantation. | 1994 | J. Immunol. | pmid:7519216 |
| Laifer SA et al. | Pregnancy after cardiac transplantation. | 1994 | Am J Perinatol | pmid:7519426 |
| Tze WJ et al. | Successful islet allotransplantation in diabetic rats immunosuppressed with FK506: a functional and immunological study. | 1994 | Metab. Clin. Exp. | pmid:7510012 |
| Yamauchi T | [Multiple abdominal organ transplantation in swine using FK-506]. | 1994 | Nihon Geka Gakkai Zasshi | pmid:7510015 |
| Hara Y et al. | Heterotopic rat heart transplantation to the iliac vessels. | 1994 | Transplant. Proc. | pmid:7520632 |
| Nozaki S et al. | Effect of brequinar sodium on accelerated cardiac allograft rejection in presensitized recipients. | 1994 | Transplant. Proc. | pmid:7520633 |
| Masaoka T | Problems of bone marrow transplantation in Japan. | 1994 | Transplant. Proc. | pmid:7520634 |
| Okano K et al. | Ameliorative effect of FK 506 on cold ischemia reperfusion injury of the rat liver. | 1994 | Transplant. Proc. | pmid:7520635 |
| Surdacka E et al. | [New immunosuppressive drugs in transplantation]. | 1994 | Prz. Lek. | pmid:7532870 |
| D'Ambrosio R et al. | Multicenter comparison of tacrolimus (FK 506) whole blood concentrations as measured by the Abbott IMX analyzer and enzyme immunoassay with methylene chloride extraction. | 1994 | Ther Drug Monit | pmid:7521979 |
| Metcalfe S et al. | FK506 and cyclosporin A each inhibit antigen-specific signaling in the T cell line 171 in the absence of a calcium signal. | 1994 | Cell. Immunol. | pmid:7522130 |
| Nichols RA et al. | Calcineurin-mediated protein dephosphorylation in brain nerve terminals regulates the release of glutamate. | 1994 | J. Biol. Chem. | pmid:7522234 |
| Calne RY | Immunosuppression in liver transplantation. | 1994 | N. Engl. J. Med. | pmid:7523947 |
| Schleuning M et al. | Inhibition of cyclosporin A/FK506 resistant, lymphokine-induced T-cell activation by phenothiazine derivatives. | 1994 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:7523957 |
| Perotti BY et al. | HPLC assay for FK 506 and two metabolites in isolated rat hepatocytes and rat liver microsomes. | 1994 | Pharm. Res. | pmid:7524055 |
| FDA approved new drug bulletin: aprotinin injection (trasylol), tacrolimus (prograf). | 1994 | RN | pmid:7524131 | |
| Cullen BR and Heitman J | Human immunodeficiency virus. Chaperoning a pathogen. | 1994 | Nature | pmid:7526224 |
| Connolly JO et al. | Renal arteriopathy associated with FK 506 therapy following liver transplantation. | 1994 | Nephrol. Dial. Transplant. | pmid:7526278 |
| Pham SM et al. | Cardiac transplantation at the University of Pittsburgh: 1994 update. | 1994 | Clin Transpl | pmid:7547531 |
| Radanyi C et al. | The ability of the immunophilin FKBP59-HBI to interact with the 90-kDa heat shock protein is encoded by its tetratricopeptide repeat domain. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7526392 |
| Abu-Elmagd K et al. | Hepatic transplantation at the University of Pittsburgh: new horizons and paradigms after 30 years of experience. | 1994 | Clin Transpl | pmid:7547533 |
| Ericzon B et al. | Glucose metabolism in liver transplant recipients treated with FK 506 or cyclosporin in the European multicentre study. | 1994 | Transpl. Int. | pmid:11271178 |
| Ko S et al. | The pharmacokinetic benefits of newly developed liposome-incorporated FK506. | 1994 | Transplantation | pmid:7526494 |
| Shapiro R et al. | Renal transplantation at the University of Pittsburgh: the impact of FK506. | 1994 | Clin Transpl | pmid:7547544 |
| Undre N and Möller A | Pharmacokinetic interpretation of FK 506 levels in blood and in plasma during a European randomised study in primary liver transplant patients. The FK 506 European Study Group. | 1994 | Transpl. Int. | pmid:11271189 |
| Holländer GA et al. | Disruption of T cell development and repertoire selection by calcineurin inhibition in vivo. | 1994 | Transplantation | pmid:7526495 |
| Yano K et al. | Effects of intrahepatic arterial and intraportal administration of FK 506 on liver allograft survival in rats. | 1994 | Transpl. Int. | pmid:11271200 |
| Chavin KD et al. | Anti-CD2 monoclonal antibodies synergize with FK506 but not with cyclosporine or rapamycin to induce tolerance. | 1994 | Transplantation | pmid:7511258 |
| Yano S et al. | Cyclosporin A enhances susceptibility of multi-drug resistant human cancer cells to anti-P-glycoprotein antibody-dependent cytotoxicity of monocytes, but not of lymphocytes. | 1994 | Jpn. J. Cancer Res. | pmid:7511575 |
| Iwata H et al. | Suppression of allograft responses by combining alloantigen-specific i.v. pre-sensitization with suboptimal doses of rapamycin. | 1994 | Int. Immunol. | pmid:7511931 |
| Mayrleitner M et al. | The calcium release channel of sarcoplasmic reticulum is modulated by FK-506 binding protein: effect of FKBP-12 on single channel activity of the skeletal muscle ryanodine receptor. | 1994 | Cell Calcium | pmid:7511990 |
| Lhoëst G et al. | Isolation and identification of a novel isomerized epoxide metabolite of FK-506 from erythromycin-induced rabbit liver microsomes. | 1993 Sep-Oct | Drug Metab. Dispos. | pmid:7694828 |
| Iwasaki K et al. | Isolation, identification, and biological activities of oxidative metabolites of FK506, a potent immunosuppressive macrolide lactone. | 1993 Nov-Dec | Drug Metab. Dispos. | pmid:7507815 |
| Fukuse T et al. | Combined therapy with FK-506 and cyclosporine for canine lung allotransplantation: immunosuppressive effects and blood trough levels. | 1993 Nov-Dec | J. Heart Lung Transplant. | pmid:7508750 |
| Morris RE | New small molecule immunosuppressants for transplantation: review of essential concepts. | 1993 Nov-Dec | J. Heart Lung Transplant. | pmid:7508752 |
| Schreier MH | Immunophilins and immunosuppression. | 1993 Mar-Apr | Clin. Exp. Rheumatol. | pmid:7686830 |
| Piekoszewski W et al. | Disposition of tacrolimus (FK 506) in rabbits. Role of red blood cell binding in hepatic clearance. | 1993 Jul-Aug | Drug Metab. Dispos. | pmid:7690698 |
| Kobayashi J et al. | A new rat infection-heart transplant model: effect of infection on graft survival studies. | 1993 Jul-Aug | J. Heart Lung Transplant. | pmid:7690253 |
| Jordan ML et al. | FK 506 salvage of renal allografts with ongoing rejection failing cyclosporine immunosuppression. | 1993 | Transplant. Proc. | pmid:7679827 |
| Klintmalm GB et al. | Prognostic factors for successful conversion from cyclosporine to FK 506-based immunosuppressive therapy for refractory rejection after liver transplantation. US Multicenter FK 506 Liver Study Group. | 1993 | Transplant. Proc. | pmid:7679828 |
| Lane BC et al. | Evaluation of calcineurin's role in the immunosuppressive activity of FK 506, related macrolactams, and cyclosporine. | 1993 | Transplant. Proc. | pmid:7679829 |
| Celli S et al. | Long-term survival of heart and liver xenografts with splenectomy and FK 506. | 1993 | Transplant. Proc. | pmid:7679830 |
| Tamura K et al. | Suppression of autoimmune thyroid disease by FK 506: influence on thyroid-infiltrating cells, adhesion molecule expression and anti-thyroglobulin antibody production. | 1993 | Clin. Exp. Immunol. | pmid:7680293 |
| Armitage JM et al. | A decade (1982 to 1992) of pediatric cardiac transplantation and the impact of FK 506 immunosuppression. | 1993 | J. Thorac. Cardiovasc. Surg. | pmid:7680396 |
| Randhawa PS et al. | The histopathological changes associated with allograft rejection and drug toxicity in renal transplant recipients maintained on FK506. Clinical significance and comparison with cyclosporine. | 1993 | Am. J. Surg. Pathol. | pmid:7680544 |
| Xu RX et al. | Heteronuclear 3D NMR studies of water bound to an FK506 binding protein/immunosuppressant complex. | 1993 | Biochemistry | pmid:7680570 |
| López-Gil JA and GarcÃa Sáiz M | [FK506: an immunosuppressor for the '90's?]. | 1993 | Med Clin (Barc) | pmid:7505871 |
| Kagayama A et al. | Oral absorption of FK506 in rats. | 1993 | Pharm. Res. | pmid:7505939 |
| Kim YI et al. | Augmentation of hepatocyte proliferation by immunosuppressant pretherapy is associated with up-regulation of malondialdehyde production. | 1993 | Res Exp Med (Berl) | pmid:7506444 |
| Hutchison KA et al. | FK506 binding to the 56-kilodalton immunophilin (Hsp56) in the glucocorticoid receptor heterocomplex has no effect on receptor folding or function. | 1993 | Biochemistry | pmid:7682438 |
| Shorrock C and Neuberger J | The changing face of liver transplantation. | 1993 | Gut | pmid:7682532 |
| Nakajima J | [The immunosuppressive effects of FK506 on single lung allotransplantation in Japanese monkey (Macaca fuscata)]. | 1993 | Nihon Kyobu Geka Gakkai Zasshi | pmid:7690829 |
| Takada K et al. | Distribution characteristics of immunosuppressants FK506 and cyclosporin A in the blood compartment. | 1993 | Biopharm Drug Dispos | pmid:7508273 |
| Thomson AW et al. | Comparative effects of rapamycin, FK 506 and cyclosporine on antibody production, lymphocyte populations and immunoglobulin isotype switching in the rat. | 1993 | Immunopharmacol Immunotoxicol | pmid:7693791 |
| Tzakis AG et al. | Intestinal transplantation in children under FK 506 immunosuppression. | 1993 | J. Pediatr. Surg. | pmid:7693907 |
| Kawauchi M et al. | Prolonged survival of orthotopically transplanted heart xenograft in infant baboons. | 1993 | J. Thorac. Cardiovasc. Surg. | pmid:7693999 |
| Shutter LA et al. | Cortical blindness and white matter lesions in a patient receiving FK506 after liver transplantation. | 1993 | Neurology | pmid:7694189 |
| Lemster B et al. | Blood lymphocytes of autoimmune disease patients receiving FK506 exhibit normal ex vivo cytokine gene expression and proliferative responses. | 1993 | Immunol. Lett. | pmid:7510265 |
| Parent SA et al. | Calcineurin-dependent growth of an FK506- and CsA-hypersensitive mutant of Saccharomyces cerevisiae. | 1993 | J. Gen. Microbiol. | pmid:7510323 |
| Metcalfe S et al. | Prodigiosin 25C: effect in in vitro models for T cell activation and T cell cycling and in vivo for rat heart allografts. | 1993 | Int. Arch. Allergy Immunol. | pmid:7685216 |
| Bumgardner GL and Roberts JP | New immunosuppressive agents. | 1993 | Gastroenterol. Clin. North Am. | pmid:7685324 |
| Ahmed SS et al. | Adrenochrome reaction implicates oxygen radicals in metabolism of cyclosporine A and FK-506 in rat and human liver microsomes. | 1993 | J. Pharmacol. Exp. Ther. | pmid:7685382 |
| Sewell KL | Immunotherapy and other novel therapies, including biologic response modifiers, apheresis, and dietary modifications. | 1993 | Curr Opin Rheumatol | pmid:7685614 |
| Altmeyer A and Dumont FJ | Rapamycin inhibits IL-1-mediated interferon-gamma production in the YAC-1 T cell lymphoma. | 1993 | Cytokine | pmid:7687472 |
| Przepiorka D et al. | Bronchiolitis obliterans organizing pneumonia in a BMT patient receiving FK506. | 1993 | Bone Marrow Transplant. | pmid:7687503 |
| Bram RJ et al. | Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. | 1993 | Mol. Cell. Biol. | pmid:7687744 |
| Fesik SW | NMR structure-based drug design. | 1993 | J. Biomol. NMR | pmid:7689377 |
| McManus BM et al. | Direct myocardial injury by enterovirus: a central role in the evolution of murine myocarditis. | 1993 | Clin. Immunol. Immunopathol. | pmid:7689428 |
| Namiki Y et al. | Tautomeric phenomenon of a novel potent immunosuppressant (FK506) in solution. I. Isolation and structure determination of tautomeric compounds. | 1993 | J. Antibiot. | pmid:7689551 |
| Kondo T et al. | [Antitumor sensitivity test, subrenal capsule assay using FK-506: preliminary report]. | 1993 | Nihon Geka Gakkai Zasshi | pmid:7689693 |
| Ibarra F et al. | Bidirectional regulation of Na+,K(+)-ATPase activity by dopamine and an alpha-adrenergic agonist. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7678337 |
| Murase N et al. | Graft-versus-host disease after brown Norway-to-Lewis and Lewis-to-Brown Norway rat intestinal transplantation under FK506. | 1993 | Transplantation | pmid:7678353 |
| Herold KC et al. | Inhibition of glucose-stimulated insulin release from beta TC3 cells and rodent islets by an analog of FK506. | 1993 | Transplantation | pmid:7678356 |