tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jordan ML et al. | FK 506 salvage of renal allografts with ongoing rejection failing cyclosporine immunosuppression. | 1993 | Transplant. Proc. | pmid:7679827 |
| Klintmalm GB et al. | Prognostic factors for successful conversion from cyclosporine to FK 506-based immunosuppressive therapy for refractory rejection after liver transplantation. US Multicenter FK 506 Liver Study Group. | 1993 | Transplant. Proc. | pmid:7679828 |
| Lane BC et al. | Evaluation of calcineurin's role in the immunosuppressive activity of FK 506, related macrolactams, and cyclosporine. | 1993 | Transplant. Proc. | pmid:7679829 |
| Celli S et al. | Long-term survival of heart and liver xenografts with splenectomy and FK 506. | 1993 | Transplant. Proc. | pmid:7679830 |
| Japanese study of FK 506 on kidney transplantation: results of late phase II study. | 1993 | Transplant. Proc. | pmid:7679831 | |
| Kobayashi M et al. | Production of monoclonal antibody against recombinant human FKBP-12 and subcellular localization of FKBP-12 in human mononuclear and polymorphonuclear cells. | 1993 | Transplant. Proc. | pmid:7679832 |
| Kuroki H et al. | Effect of FK 506 and donor-specific blood transfusion on the rat composite tissue limb allograft and the mechanism of long-term graft survival. | 1993 | Transplant. Proc. | pmid:7679833 |
| Azhderian EM et al. | Nucleus associated FK 506 binding proteins with potential relevance to FK 506 immunosuppression. | 1993 | Transplant. Proc. | pmid:7679834 |
| Hirao A et al. | Effects of immunosuppressants, FK506, deoxyspergualin, and cyclosporine A on immature human hematopoiesis. | 1993 | Blood | pmid:7680241 |
| Tamura K et al. | Suppression of autoimmune thyroid disease by FK 506: influence on thyroid-infiltrating cells, adhesion molecule expression and anti-thyroglobulin antibody production. | 1993 | Clin. Exp. Immunol. | pmid:7680293 |
| Armitage JM et al. | A decade (1982 to 1992) of pediatric cardiac transplantation and the impact of FK 506 immunosuppression. | 1993 | J. Thorac. Cardiovasc. Surg. | pmid:7680396 |
| Randhawa PS et al. | The histopathological changes associated with allograft rejection and drug toxicity in renal transplant recipients maintained on FK506. Clinical significance and comparison with cyclosporine. | 1993 | Am. J. Surg. Pathol. | pmid:7680544 |
| Xu RX et al. | Heteronuclear 3D NMR studies of water bound to an FK506 binding protein/immunosuppressant complex. | 1993 | Biochemistry | pmid:7680570 |
| Egan DA et al. | Equilibrium denaturation of recombinant human FK binding protein in urea. | 1993 | Biochemistry | pmid:7680574 |
| Lionetti P et al. | Activation of mucosal V beta 3+ T cells and tissue damage in human small intestine by the bacterial superantigen, Staphylococcus aureus enterotoxin B. | 1993 | Eur. J. Immunol. | pmid:7680613 |
| Nelson PA et al. | Immunosuppressive activity of [MeBm2t]1-, D-diaminobutyryl-8-, and D-diaminopropyl-8-cyclosporin analogues correlates with inhibition of calcineurin phosphatase activity. | 1993 | J. Immunol. | pmid:7680683 |
| Piekoszewski W and Jusko WJ | Plasma protein binding of tacrolimus in humans. | 1993 | J Pharm Sci | pmid:7680714 |
| Jindal RM et al. | Effect of deoxyspergualin on the endocrine function of the rat pancreas. | 1993 | Transplantation | pmid:7504347 |
| Kodama M et al. | FK506 therapy of experimental autoimmune myocarditis after onset of the disease. | 1993 | Am. Heart J. | pmid:7504393 |
| Yem AW et al. | An active FK506-binding domain of 17,000 daltons is isolated following limited proteolysis of chicken thymus hsp56. | 1993 | Biochemistry | pmid:7504525 |
| Manev H et al. | Macrolide antibiotics protect neurons in culture against the N-methyl-D-aspartate (NMDA) receptor-mediated toxicity of glutamate. | 1993 | Brain Res. | pmid:7504570 |
| Takahara S et al. | [Blood level monitoring of FK506 on kidney transplant recipients]. | 1993 | Nippon Hinyokika Gakkai Zasshi | pmid:7504758 |
| Lieberman I et al. | Synergy between tetrandrine and FK506 in prevention of diabetes in BB rats. | 1993 | Life Sci. | pmid:7504774 |
| Müller MK et al. | [Pathophysiologic concepts and protective possibilities in experimental pancreatic lesions]. | 1993 | Z Gastroenterol | pmid:7504856 |
| Panis Y and Valleur P | [Small intestine transplantation. Experimental and clinical results]. | 1993 | Ann Chir | pmid:7504899 |
| Hutchison KA et al. | FK506 binding to the 56-kilodalton immunophilin (Hsp56) in the glucocorticoid receptor heterocomplex has no effect on receptor folding or function. | 1993 | Biochemistry | pmid:7682438 |
| Shorrock C and Neuberger J | The changing face of liver transplantation. | 1993 | Gut | pmid:7682532 |
| Nakajima J | [The immunosuppressive effects of FK506 on single lung allotransplantation in Japanese monkey (Macaca fuscata)]. | 1993 | Nihon Kyobu Geka Gakkai Zasshi | pmid:7690829 |
| Wenzel-Seifert K and Seifert R | Partial inhibition of human neutrophil activation by FK-506 at supratherapeutic concentrations. | 1993 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:7690907 |
| Liu J | FK506 and cyclosporin, molecular probes for studying intracellular signal transduction. | 1993 | Immunol. Today | pmid:7691065 |
| Mori T et al. | FK-506: a new immunosuppressive agent, failed to reduce cerebral vasospasm after experimental subarachnoid hemorrhage. | 1993 | J. Vet. Med. Sci. | pmid:7691190 |
| Distant DA and Gonwa TA | The kidney in liver transplantation. | 1993 | J. Am. Soc. Nephrol. | pmid:7691205 |
| Muthukkumar S et al. | Elevation of cytosolic calcium is sufficient to induce growth inhibition in a B cell lymphoma. | 1993 | Eur. J. Immunol. | pmid:7691606 |
| Quesniaux VF | Immunosuppressants: tools to investigate the physiological role of cytokines. | 1993 | Bioessays | pmid:7507316 |
| Fernandes JB et al. | Comparative investigation of the effects of the immunosuppressants cyclosporine A, cyclosporine G, and FK-506 on platelet activation. | 1993 | Cell. Mol. Biol. Res. | pmid:7507391 |
| McDiarmid SV et al. | FK506 conversion for intractable rejection of the liver allograft. | 1993 | Transpl. Int. | pmid:7507675 |
| Thomson AW et al. | Comparative effects of rapamycin, FK 506 and cyclosporine on antibody production, lymphocyte populations and immunoglobulin isotype switching in the rat. | 1993 | Immunopharmacol Immunotoxicol | pmid:7693791 |
| Tzakis AG et al. | Intestinal transplantation in children under FK 506 immunosuppression. | 1993 | J. Pediatr. Surg. | pmid:7693907 |
| Kawauchi M et al. | Prolonged survival of orthotopically transplanted heart xenograft in infant baboons. | 1993 | J. Thorac. Cardiovasc. Surg. | pmid:7693999 |
| Shutter LA et al. | Cortical blindness and white matter lesions in a patient receiving FK506 after liver transplantation. | 1993 | Neurology | pmid:7694189 |
| Dawson TM et al. | Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7694293 |
| Spencer DM et al. | Controlling signal transduction with synthetic ligands. | 1993 | Science | pmid:7694365 |
| Travis J | Making molecular matches in the cell. | 1993 | Science | pmid:7694368 |
| Jusko WJ and Kobayashi M | Therapeutic monitoring of tacrolimus (FK 506) | 1993 | Ther Drug Monit | pmid:7694395 |
| Takahara S | Efficacy of FK506 in renal transplantation. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509132 |
| Thomson AW et al. | Incidence of CD4+ IL-2R alpha+ and CD4+ CD45RA+ T-cells in progressive multiple sclerosis and the influence of short-term (3 months) FK 506 therapy. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509133 |
| Lemster B et al. | FK 506 inhibits cytokine gene and adhesion molecule expression in psoriatic skin lesions. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509134 |
| Tamura K et al. | Inhibitory effect of FK 506 on autoimmune thyroid disease in the PVG rat. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509135 |
| Ochiai T et al. | Combination of immunosuppressive drugs for organ transplantation. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509136 |
| Wiederrecht G et al. | The mechanism of action of FK-506 and cyclosporin A. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7509138 |
| Morikawa K et al. | Immunosuppressive activity of fosfomycin on human T-lymphocyte function in vitro. | 1993 | Antimicrob. Agents Chemother. | pmid:7509146 |
| Schwaninger M et al. | The immunosuppressive drugs cyclosporin A and FK506 inhibit calcineurin phosphatase activity and gene transcription mediated through the cAMP-responsive element in a nonimmune cell line. | 1993 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:7509460 |
| Asami M et al. | Detection of the FK506-FKBP-calcineurin complex by a simple binding assay. | 1993 | Biochem. Biophys. Res. Commun. | pmid:7685169 |
| Metcalfe S et al. | Prodigiosin 25C: effect in in vitro models for T cell activation and T cell cycling and in vivo for rat heart allografts. | 1993 | Int. Arch. Allergy Immunol. | pmid:7685216 |
| Bumgardner GL and Roberts JP | New immunosuppressive agents. | 1993 | Gastroenterol. Clin. North Am. | pmid:7685324 |
| Ahmed SS et al. | Adrenochrome reaction implicates oxygen radicals in metabolism of cyclosporine A and FK-506 in rat and human liver microsomes. | 1993 | J. Pharmacol. Exp. Ther. | pmid:7685382 |
| Sewell KL | Immunotherapy and other novel therapies, including biologic response modifiers, apheresis, and dietary modifications. | 1993 | Curr Opin Rheumatol | pmid:7685614 |
| Wagner JA et al. | Failure of FK 506 to suppress the T cell-mediated immunity of mice to Listeria monocytogenes. | 1993 | Clin. Exp. Immunol. | pmid:7685672 |
| Pilot-Matias TJ et al. | High-level synthesis of the 12-kDa human FK506-binding protein in Escherichia coli using translational coupling. | 1993 | Gene | pmid:7685727 |
| Akamine S et al. | [Effect of FK-506 on bronchial healing of canine lung allografts]. | 1993 | Nihon Kyobu Geka Gakkai Zasshi | pmid:7685803 |
| Partaledis JA and Berlin V | The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7685904 |
| Hibbins M et al. | Inhibition of PHA induced mononuclear cell proliferation by FK506 in combination with cyclosporine, methylprednisolone, 6-mercaptopurine and mycophenolic acid. | 1993 | Transpl. Immunol. | pmid:7521736 |
| Thomson AW et al. | Effects of combined administration of FK 506 and the purine biosynthesis inhibitors mizoribine or mycophenolic acid on lymphocyte DNA synthesis and T cell activation molecule expression in human mixed lymphocyte cultures. | 1993 | Transpl. Immunol. | pmid:7521738 |
| Matsuura T et al. | Organ-specific unresponsiveness induced by intrathymic injection of donor bone marrow cells and a short course of immunosuppression in the rat heart transplantation model. | 1993 | Transpl. Immunol. | pmid:7521742 |
| Altmeyer A and Dumont FJ | Rapamycin inhibits IL-1-mediated interferon-gamma production in the YAC-1 T cell lymphoma. | 1993 | Cytokine | pmid:7687472 |
| Przepiorka D et al. | Bronchiolitis obliterans organizing pneumonia in a BMT patient receiving FK506. | 1993 | Bone Marrow Transplant. | pmid:7687503 |
| Bram RJ et al. | Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. | 1993 | Mol. Cell. Biol. | pmid:7687744 |
| Heitman J et al. | The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae. | 1993 | Mol. Cell. Biol. | pmid:7687745 |
| Hirakawa K et al. | [The effect of perioperative portal venous inoculation with donor lymphocytes in combination with immunosuppressive agents on rat cardiac allograft survivals]. | 1993 | Nihon Geka Gakkai Zasshi | pmid:7688065 |
| Entani C et al. | Effect of a novel immunosuppressant, FK506, on spontaneous lupus nephritis in MRL/MpJ-lpr/lpr mice. | 1993 | Nephron | pmid:7688103 |
| Ueki M et al. | Diabetogenic effects of FK506 on renal subcapsular islet isografts in rat. | 1993 | Diabetes Res. Clin. Pract. | pmid:7688276 |
| Pleyer U et al. | Ocular absorption of topically applied FK506 from liposomal and oil formulations in the rabbit eye. | 1993 | Invest. Ophthalmol. Vis. Sci. | pmid:7688360 |
| Fesik SW | NMR structure-based drug design. | 1993 | J. Biomol. NMR | pmid:7689377 |
| McManus BM et al. | Direct myocardial injury by enterovirus: a central role in the evolution of murine myocarditis. | 1993 | Clin. Immunol. Immunopathol. | pmid:7689428 |
| Namiki Y et al. | Tautomeric phenomenon of a novel potent immunosuppressant (FK506) in solution. I. Isolation and structure determination of tautomeric compounds. | 1993 | J. Antibiot. | pmid:7689551 |
| Kondo T et al. | [Antitumor sensitivity test, subrenal capsule assay using FK-506: preliminary report]. | 1993 | Nihon Geka Gakkai Zasshi | pmid:7689693 |
| Abu-Elmagd K et al. | Resolution of severe pyoderma gangrenosum in a patient with streaking leukocyte factor disease after treatment with tacrolimus (FK 506). | 1993 | Ann. Intern. Med. | pmid:7689802 |
| Christensen BG | FK-506: its role in immunosuppression. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689803 |
| Kino T and Goto T | Discovery of FK-506 and update. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689804 |
| Parsons WH et al. | FK-506--a novel immunosuppressant. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689805 |
| Ibarra F et al. | Bidirectional regulation of Na+,K(+)-ATPase activity by dopamine and an alpha-adrenergic agonist. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7678337 |
| Murase N et al. | Graft-versus-host disease after brown Norway-to-Lewis and Lewis-to-Brown Norway rat intestinal transplantation under FK506. | 1993 | Transplantation | pmid:7678353 |
| Herold KC et al. | Inhibition of glucose-stimulated insulin release from beta TC3 cells and rodent islets by an analog of FK506. | 1993 | Transplantation | pmid:7678356 |
| Holman MJ et al. | FK506-associated thrombotic thrombocytopenic purpura. | 1993 | Transplantation | pmid:7678357 |
| Kawai M et al. | Structure-activity profiles of macrolactam immunosuppressant FK-506 analogues. | 1993 | FEBS Lett. | pmid:7678400 |
| Van Duyne GD et al. | Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin. | 1993 | J. Mol. Biol. | pmid:7678431 |
| Meadows RP et al. | Three-dimensional structure of the FK506 binding protein/ascomycin complex in solution by heteronuclear three- and four-dimensional NMR. | 1993 | Biochemistry | pmid:7678499 |
| Jiang H et al. | Anti-tumor-promoting action of FK506, a potent immunosuppressive agent. | 1993 | Carcinogenesis | pmid:7678785 |
| Sattler M et al. | Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat. | 1992 Sep-Oct | Drug Metab. Dispos. | pmid:1385058 |
| Bowman H and Lennard TW | Immunosuppressive drugs. | 1992 Nov 4-17 | Br J Hosp Med | pmid:1282440 |
| Nazer H et al. | FK 506 associated disorders in liver transplantation. | 1992 May-Jun | J. Gastroenterol. Hepatol. | pmid:1377038 |
| Arai S et al. | The impact of FK506 on graft coronary disease of rat cardiac allograft--a comparison with cyclosporine. | 1992 Jul-Aug | J. Heart Lung Transplant. | pmid:1379829 |
| Fagiuoli S et al. | FK 506: a new immunosuppressive agent for organ transplantation. Pharmacology, mechanism of action and clinical applications. | 1992 Jul-Aug | Ital J Gastroenterol | pmid:1381245 |
| Tong J et al. | Effect of FK-506 and cyclosporin A on in vitro CFU-GM growth in severe aplastic anemia patients. | 1992 Jul-Aug | Haematologica | pmid:1385279 |
| Mizuno K et al. | Modulation of multidrug resistance by immunosuppressive agents: cyclosporin analogues, FK506 and mizoribine. | 1992 Jan-Feb | Anticancer Res. | pmid:1373592 |
| Andersson J et al. | FK 506 and cyclosporine inhibit antigen- or mitogen-induced monokine and lymphokine production in vitro. | 1992 | Transplant. Proc. | pmid:1371621 |
| Jain A et al. | Intravenous, oral pharmacokinetics, and oral dosing of FK 506 in small bowel transplant patients. | 1992 | Transplant. Proc. | pmid:1376518 |
| Lemster B et al. | Cytokine gene expression in murine lymphocytes activated in the presence of FK 506, bredinin, mycophenolic acid, or brequinar sodium. | 1992 | Transplant. Proc. | pmid:1281576 |
| Rondeau E | [Mechanism of action of the new immunosuppressants: cyclosporin A, FK 506 and rapamycin]. | 1992 | Nephrologie | pmid:1379348 |
| Petros AM et al. | Conformation of two non-immunosuppressive FK506 analogs when bound to FKBP by isotope-filtered NMR. | 1992 | FEBS Lett. | pmid:1380470 |