tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ricordi C et al. | Donor bone marrow cell infusion without recipient cytoablation induces acceptance of rat islet allografts. | 1994 | Transplant. Proc. | pmid:7527967 |
| Tsugita M et al. | Hepatocytes or liver nonparenchymal cells plus FK 506 prolong liver xenograft survival. | 1994 | Transplant. Proc. | pmid:7527969 |
| Asselin I et al. | Polymerase chain reaction-based assay to assess the success of myoblast transplantation in mdx mice. | 1994 | Transplant. Proc. | pmid:7527970 |
| Kinoshita I et al. | Immunosuppression with FK 506 insures good success of myoblast transplantation in MDX mice. | 1994 | Transplant. Proc. | pmid:7527978 |
| Egawa H et al. | FK506 conversion therapy in pediatric liver transplantation. | 1994 | Transplantation | pmid:7513911 |
| Reggiani P et al. | Conversion to rescue therapy with FK 506: data from eight liver transplant patients. | 1994 | Transplant. Proc. | pmid:7527982 |
| Cvetkovic M et al. | The deleterious effects of long-term cyclosporine A, cyclosporine G, and FK506 on bone mineral metabolism in vivo. | 1994 | Transplantation | pmid:7513912 |
| Arakawa H et al. | Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7513996 |
| Langrehr JM et al. | Mucosal recipient-type mononuclear repopulation and low-grade chronic rejection occur simultaneously in indefinitely surviving recipients of small bowel allografts. | 1994 | Transpl. Int. | pmid:7513999 |
| Leach KL et al. | A soluble binding assay for measuring 3H-FK506 binding to the hsp56 immunophilin. | 1994 | J Immunoassay | pmid:7530727 |
| Genestier L et al. | Cyclosporin A and FK506 inhibit activation-induced cell death in the murine WEHI-231 B cell line. | 1994 | Cell. Immunol. | pmid:7514101 |
| Peattie DA et al. | Three distinct messenger RNAs can encode the human immunosuppressant-binding protein FKBP12. | 1994 | Gene | pmid:7529739 |
| Shipston MJ et al. | Glucocorticoid negative feedback in pituitary corticotropes. Pivotal role for calcineurin inhibition of adenylyl cyclase. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7529975 |
| Firdaous I et al. | Pediatric intravenous FK506--how much are we really infusing? | 1994 | Transplantation | pmid:7517079 |
| Manez R et al. | Rejection and hepatitis in liver transplants. | 1994 | Transplantation | pmid:7517080 |
| Dawson VL et al. | Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures. | 1994 | Neuropharmacology | pmid:7532825 |
| Igarashi T et al. | Central nervous system toxicity related to FK506 in patients with Behçet's disease. | 1994 | Ann. Rheum. Dis. | pmid:7517134 |
| Eng WK et al. | The yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growth. | 1994 | Gene | pmid:7530227 |
| Ellis D et al. | Comparison of FK-506 and cyclosporine regimens in pediatric renal transplantation. | 1994 | Pediatr. Nephrol. | pmid:7517171 |
| Klintmalm GB | FK 506: an update. | 1994 | Clin Transplant | pmid:7517226 |
| Morikawa K et al. | Immunomodulatory effects of three macrolides, midecamycin acetate, josamycin, and clarithromycin, on human T-lymphocyte function in vitro. | 1994 | Antimicrob. Agents Chemother. | pmid:7532933 |
| Orita T et al. | Effect of FK 506 in combination with prednisolone on the graft-vs-host reaction after small bowel transplantation in rats. | 1994 | Transplant. Proc. | pmid:7518147 |
| Alessiani M et al. | Total orthotopic small bowel transplantation in swine under FK 506. | 1994 | Transplant. Proc. | pmid:7518148 |
| Jain A et al. | FK 506 in small bowel transplant recipients: pharmacokinetics and dosing. | 1994 | Transplant. Proc. | pmid:7518149 |
| Takara T et al. | Intraportal donor-specific transfusion given 24 hours before small bowel transplantation with cyclosporine and FK 506. | 1994 | Transplant. Proc. | pmid:7518150 |
| Kusne S et al. | Infectious complications after small bowel transplantation in adults. | 1994 | Transplant. Proc. | pmid:7518153 |
| Dilling MB et al. | Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin-like growth factor receptor. | 1994 | Cancer Res. | pmid:7508822 |
| Randomised trial comparing tacrolimus (FK506) and cyclosporin in prevention of liver allograft rejection. European FK506 Multicentre Liver Study Group. | 1994 | Lancet | pmid:7520105 | |
| Yamamoto S et al. | Stimulation of hair growth by topical application of FK506, a potent immunosuppressive agent. | 1994 | J. Invest. Dermatol. | pmid:7508960 |
| Funauchi M et al. | Effects of an inhibitor for calcium/calmodulin-dependent protein phosphatase, calcineurin, on induction of long-term potentiation in rat visual cortex. | 1994 | Neurosci. Res. | pmid:7520143 |
| Ito T et al. | Protective effects of gabexate mesilate on acute pancreatitis induced by tacrolimus (FK-506) in rats in which the pancreas was stimulated by caerulein. | 1994 | J. Gastroenterol. | pmid:7520321 |
| Zeniya A et al. | Anti-ulcer effect of FK 506, immunosuppressive agent, in rats. | 1994 | J. Gastroenterol. | pmid:7520322 |
| Dawson TM et al. | Nitric oxide: cellular regulation and neuronal injury. | 1994 | Prog. Brain Res. | pmid:7533914 |
| Gailliot FP et al. | Isolation and characterization of the major equilibrium product of FK-520. | 1994 | J. Antibiot. | pmid:7520900 |
| Stancato LF et al. | The native v-Raf.hsp90.p50 heterocomplex contains a novel immunophilin of the FK506 binding class. | 1994 | J. Biol. Chem. | pmid:7520912 |
| Hirano Y et al. | Mechanism of FK506-induced glucose intolerance in rats. | 1994 | J Toxicol Sci | pmid:7520947 |
| Tacrolimus (FK506) for organ transplants. | 1994 | Med Lett Drugs Ther | pmid:7520968 | |
| Bierer BE | Biology of cyclosporin A and FK506. | 1994 | Prog. Clin. Biol. Res. | pmid:7536944 |
| Malyszko J et al. | FK 506 affects platelet aggregation in vitro. | 1994 | Thromb. Res. | pmid:7521072 |
| Todo S et al. | Single-center experience with primary orthotopic liver transplantation with FK 506 immunosuppression. | 1994 | Ann. Surg. | pmid:7522431 |
| Lebeau MC et al. | Rabbit FKBP-59/HBI does not inhibit calcineurin activity in vitro. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7522447 |
| Mouzaki A and Rungger D | Properties of transcription factors regulating interleukin-2 gene transcription through the NFAT binding site in untreated or drug-treated naive and memory T-helper cells. | 1994 | Blood | pmid:7522636 |
| Abu-Elmagd K et al. | Three years clinical experience with intestinal transplantation. | 1994 | J. Am. Coll. Surg. | pmid:7522850 |
| Yoshimura R et al. | Effect of immunosuppressive drugs (CsA, FK 506, rapamycin) on the kidney microsomal cytochrome P-450 system in the rat. | 1994 | Transplant. Proc. | pmid:7524223 |
| Kupferman JC et al. | Activation of the renal renin-angiotensin system by cyclosporine A and FK 506 in the rat. | 1994 | Transplant. Proc. | pmid:7524224 |
| Kattner A et al. | Conversion from CyA to CyA-NOF in a cholestatic liver grafted patient with CyA malabsorption. | 1994 | Transplant. Proc. | pmid:7524225 |
| Fung JJ and Starzl TE | FK 506 in solid organ transplantation. | 1994 | Transplant. Proc. | pmid:7524226 |
| Tacrolimus introduced for use in liver transplantation. | 1994 | Am J Hosp Pharm | pmid:7524317 | |
| Lemoine A et al. | FK 506 renal toxicity and lack of detectable cytochrome P-450 3A in the liver graft of a patient undergoing liver transplantation. | 1994 | Hepatology | pmid:7527003 |
| Alnemri ES et al. | FKBP46, a novel Sf9 insect cell nuclear immunophilin that forms a protein-kinase complex. | 1994 | J. Biol. Chem. | pmid:7527037 |
| Rosenwirth B et al. | Inhibition of human immunodeficiency virus type 1 replication by SDZ NIM 811, a nonimmunosuppressive cyclosporine analog. | 1994 | Antimicrob. Agents Chemother. | pmid:7527198 |
| Shaw LM and Brayman KL | FK-506 therapeutic drug monitoring. | 1994 | Clin. Chem. | pmid:7527305 |
| Jordan ML et al. | FK506 "rescue" for resistant rejection of renal allografts under primary cyclosporine immunosuppression. | 1994 | Transplantation | pmid:7512293 |
| Winkler M et al. | Plasma vs whole blood for therapeutic drug monitoring of patients receiving FK 506 for immunosuppression. | 1994 | Clin. Chem. | pmid:7527306 |
| Wijdicks EF et al. | FK506-induced neurotoxicity in liver transplantation. | 1994 | Ann. Neurol. | pmid:7512320 |
| Cheng JW et al. | 15N NMR relaxation studies of the FK506 binding protein: dynamic effects of ligand binding and implications for calcineurin recognition. | 1994 | Biochemistry | pmid:7512379 |
| Mori A et al. | Regulation of interleukin-5 production by peripheral blood mononuclear cells from atopic patients with FK506, cyclosporin A and glucocorticoid. | 1994 | Int. Arch. Allergy Immunol. | pmid:7512393 |
| Okubo Y et al. | Cytokine production in patients with mite-sensitive bronchial asthma. | 1994 | Int. Arch. Allergy Immunol. | pmid:7512395 |
| Lhoëst G et al. | Isolation and identification of a novel isomerized epoxide metabolite of FK-506 from erythromycin-induced rabbit liver microsomes. | 1993 Sep-Oct | Drug Metab. Dispos. | pmid:7694828 |
| Iwasaki K et al. | Isolation, identification, and biological activities of oxidative metabolites of FK506, a potent immunosuppressive macrolide lactone. | 1993 Nov-Dec | Drug Metab. Dispos. | pmid:7507815 |
| Fukuse T et al. | Combined therapy with FK-506 and cyclosporine for canine lung allotransplantation: immunosuppressive effects and blood trough levels. | 1993 Nov-Dec | J. Heart Lung Transplant. | pmid:7508750 |
| Morris RE | New small molecule immunosuppressants for transplantation: review of essential concepts. | 1993 Nov-Dec | J. Heart Lung Transplant. | pmid:7508752 |
| Schreier MH | Immunophilins and immunosuppression. | 1993 Mar-Apr | Clin. Exp. Rheumatol. | pmid:7686830 |
| Piekoszewski W et al. | Disposition of tacrolimus (FK 506) in rabbits. Role of red blood cell binding in hepatic clearance. | 1993 Jul-Aug | Drug Metab. Dispos. | pmid:7690698 |
| Kobayashi J et al. | A new rat infection-heart transplant model: effect of infection on graft survival studies. | 1993 Jul-Aug | J. Heart Lung Transplant. | pmid:7690253 |
| Propper DJ et al. | Effects of the immunosuppressive macrolides rapamycin and FK 506 in high responder rats presensitized to major histocompatibility complex antigens. | 1993 | Transplant. Proc. | pmid:7679837 |
| Stock PG et al. | Standard sequential immunosuppression with Minnesota antilymphoblast globulin and cyclosporine vs FK 506: a comparison of early nephrotoxicity. | 1993 | Transplant. Proc. | pmid:7679838 |
| Tabasco-Minguillan J et al. | Long-term insulin requirement after liver transplantation with FK 506 in American veterans. | 1993 | Transplant. Proc. | pmid:7679839 |
| Klintmalm GB et al. | Use of Prograf (FK 506) as rescue therapy for refractory rejection after liver transplantation. US Multicenter FK 506 Liver Study Group. | 1993 | Transplant. Proc. | pmid:7679840 |
| Jayaraman T and Marks AR | Rapamycin-FKBP12 blocks proliferation, induces differentiation, and inhibits cdc2 kinase activity in a myogenic cell line. | 1993 | J. Biol. Chem. | pmid:7503980 |
| D'Ambrosio R et al. | Validation and quality assurance program for monitoring tacrolimus (FK 506) concentrations in plasma and whole blood. | 1993 | Ther Drug Monit | pmid:7504339 |
| Dutz JP et al. | A role for calcineurin in degranulation of murine cytotoxic T lymphocytes. | 1993 | J. Immunol. | pmid:7681074 |
| Takeguchi N et al. | Inhibition of the multidrug efflux pump in isolated hepatocyte couplets by immunosuppressants FK506 and cyclosporine. | 1993 | Transplantation | pmid:7681229 |
| Valdivia LA et al. | Successful hamster-to-rat liver xenotransplantation under FK506 immunosuppression induces unresponsiveness to hamster heart and skin. | 1993 | Transplantation | pmid:7681230 |
| Peters DH et al. | Tacrolimus. A review of its pharmacology, and therapeutic potential in hepatic and renal transplantation. | 1993 | Drugs | pmid:7506654 |
| Mühl H et al. | Cyclosporin derivatives inhibit interleukin 1 beta induction of nitric oxide synthase in renal mesangial cells. | 1993 | Eur. J. Pharmacol. | pmid:7506668 |
| Nagata K et al. | Failure of FK-506, a new immunosuppressant, to prevent cerebral vasospasm in a canine two-hemorrhage model. | 1993 | J. Neurosurg. | pmid:7692019 |
| Lhoëst G et al. | Isolation and identification by FAB mass spectrometry and NMR spectroscopy of a demethylated metabolite of FK506 from erythromycin-induced rabbit liver microsomes. | 1993 | Pharm Acta Helv | pmid:7692454 |
| Izumi S and Okuhara M | [FK506 and kifunensine, new immunomodulators of microbial origin]. | 1993 | Tanpakushitsu Kakusan Koso | pmid:7692469 |
| Wakugami T et al. | Effect of FK506 on the development of diabetes in BB rats in comparison with that of cyclosporin. | 1993 | Tohoku J. Exp. Med. | pmid:7692621 |
| White DJ | Immunosuppression for heart transplantation. | 1993 | Br. J. Biomed. Sci. | pmid:7694717 |
| Blaehr H et al. | Acute effects of FK506 and cyclosporine A on cultured human proximal tubular cells. | 1993 | Eur. J. Pharmacol. | pmid:7683267 |
| Kadmon M et al. | Inhibition by cyclosporin A of adenosine triphosphate-dependent transport from the hepatocyte into bile. | 1993 | Gastroenterology | pmid:7683296 |
| McDiarmid SV et al. | Differences in oral FK506 dose requirements between adult and pediatric liver transplant patients. | 1993 | Transplantation | pmid:7685933 |
| Moutabarrik A et al. | Use of FK 506 in kidney transplantation. | 1993 | Transplant. Proc. | pmid:7685946 |
| Moutabarrik A et al. | Effect of FK 506 and cyclosporine on the expression of IL-6 and its receptor on stimulated monocytes. | 1993 | Transplant. Proc. | pmid:7685949 |
| Takaya S et al. | Use of prostaglandin E1 in crossmatch-negative liver transplant recipients treated with FK 506. | 1993 | Transplant. Proc. | pmid:7685953 |
| Lyson T et al. | Cyclosporine- and FK506-induced sympathetic activation correlates with calcineurin-mediated inhibition of T-cell signaling. | 1993 | Circ. Res. | pmid:7688670 |
| Morkawa K et al. | Immunosuppressive property of bromocriptine on human B lymphocyte function in vitro. | 1993 | Clin. Exp. Immunol. | pmid:7688676 |
| Yamaoka K et al. | Cyclosporin A and FK506 block the negative signaling mediated by surface IgM cross-linking in normal human mature B cells. | 1993 | Immunol. Lett. | pmid:7688712 |
| Smith DF et al. | Two FKBP-related proteins are associated with progesterone receptor complexes. | 1993 | J. Biol. Chem. | pmid:7688746 |
| Starzl TE et al. | Allograft and xenograft acceptance under FK-506 and other immunosuppressant treatment. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689809 |
| Reem GH et al. | FK-506 inhibits the IL-2-independent induction of the activation antigen CD 69. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689811 |
| Mollison KW et al. | Comparison of FK-506, rapamycin, ascomycin, and cyclosporine in mouse models of host-versus-graft disease and heterotopic heart transplantation. | 1993 | Ann. N. Y. Acad. Sci. | pmid:7689812 |
| Tai PK et al. | P59 (FK506 binding protein 59) interaction with heat shock proteins is highly conserved and may involve proteins other than steroid receptors. | 1993 | Biochemistry | pmid:7689858 |
| Fingar DC et al. | Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes. | 1993 | J. Biol. Chem. | pmid:7679106 |
| Griffiths EJ and Halestrap AP | Protection by Cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts. | 1993 | J. Mol. Cell. Cardiol. | pmid:7512654 |
| McCaffrey PG et al. | NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs. | 1993 | J. Biol. Chem. | pmid:7679116 |
| Armitage JM et al. | Pediatric lung transplantation. The years 1985 to 1992 and the clinical trial of FK 506. | 1993 | J. Thorac. Cardiovasc. Surg. | pmid:7679172 |
| Ito K and Komatsu Y | [Drug induced hemolytic uremic syndrome]. | 1993 | Nippon Rinsho | pmid:7679450 |