MeSH term | MeSH ID | Detail |
---|---|---|
Ileus | D045823 | 3 associated lipids |
Rectal Diseases | D012002 | 1 associated lipids |
Angiolymphoid Hyperplasia with Eosinophilia | D000796 | 1 associated lipids |
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Sheiner PA et al. | Acute renal failure associated with the use of ibuprofen in two liver transplant recipients on FK506. | 1994 | Transplantation | pmid:7513099 |
Kinoshita I et al. | Immunosuppression with FK 506 insures good success of myoblast transplantation in MDX mice. | 1994 | Transplant. Proc. | pmid:7527978 |
Reggiani P et al. | Conversion to rescue therapy with FK 506: data from eight liver transplant patients. | 1994 | Transplant. Proc. | pmid:7527982 |
Lemmens HP et al. | Outcome following orthotopic liver transplantation in HBsAg-positive patients using short- or long-term immunoprophylaxis. | 1994 | Transplant. Proc. | pmid:7527983 |
Mueller AR et al. | Increased rejection after liver transplantation in FK 506-treated patients is associated with viral hepatitis C disease. | 1994 | Transplant. Proc. | pmid:7527984 |
Langrehr JM et al. | Mucosal recipient-type mononuclear repopulation and low-grade chronic rejection occur simultaneously in indefinitely surviving recipients of small bowel allografts. | 1994 | Transpl. Int. | pmid:7513999 |
Tanabe M et al. | The influence of donor and recipient strains in isolated small bowel transplantation in rats. | 1994 | Transplant. Proc. | pmid:7527986 |
Leach KL et al. | A soluble binding assay for measuring 3H-FK506 binding to the hsp56 immunophilin. | 1994 | J Immunoassay | pmid:7530727 |
Genestier L et al. | Cyclosporin A and FK506 inhibit activation-induced cell death in the murine WEHI-231 B cell line. | 1994 | Cell. Immunol. | pmid:7514101 |
Yamamoto S and Kato R | Hair growth-stimulating effects of cyclosporin A and FK506, potent immunosuppressants. | 1994 | J. Dermatol. Sci. | pmid:7528050 |
Rao US and Scarborough GA | Direct demonstration of high affinity interactions of immunosuppressant drugs with the drug binding site of the human P-glycoprotein. | 1994 | Mol. Pharmacol. | pmid:7514263 |
Hossain M et al. | Eosinophil viability-enhancing activity in mite-sensitive bronchial asthma. | 1994 | Intern. Med. | pmid:7528071 |
Lieberman DN and Mody I | Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphatase. | 1994 | Nature | pmid:7514273 |
Suzuki S | FK506 and deoxyspergualin: experimental studies and clinical applications. | 1994 | Transpl. Immunol. | pmid:7528087 |
Burdmann EA et al. | Urinary enzymes as biomarkers of renal injury in experimental nephrotoxicity of immunosuppressive drugs. | 1994 | Ren Fail | pmid:7514309 |
Yli-Kauhaluoma J and Janda KD | Twisted alpha-keto amides as transition-state analogues for acyl-transfer reactions: synthesis of the immunoconjugates. | 1994 | Bioorg. Med. Chem. | pmid:7528089 |
Jindal RM et al. | Serum lipid changes in liver transplant recipients in a prospective trial of cyclosporine versus FK506. | 1994 | Transplantation | pmid:7514317 |
Haddy A and Rusnak F | Overexpression and characterization of a recombinant form of rat calcineurin A. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7514397 |
Borel JF and Baumann G | Molecular mechanisms of immunosuppressive agents. | 1994 | Bull. Mem. Acad. R. Med. Belg. | pmid:7531051 |
Woerly G et al. | Demonstration of ternary immunophilin-calcineurin complexes with the immunosuppressants cyclosporin and macrolide FK506. | 1994 | Biochem. Pharmacol. | pmid:7514409 |
Whiting PH | Acute and chronic nephrotoxicity associated with immunosuppressive drugs. | 1994 | Curr. Opin. Nephrol. Hypertens. | pmid:7531104 |
Lauerma AI and Maibach HI | Topical FK506--clinical potential or laboratory curiosity? | 1994 | Dermatology (Basel) | pmid:7514460 |
Eng WK et al. | The yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growth. | 1994 | Gene | pmid:7530227 |
Petros AM and Fesik SW | Nuclear magnetic resonance methods for studying protein-ligand complexes. | 1994 | Meth. Enzymol. | pmid:7530321 |
Klintmalm GB | FK 506: an update. | 1994 | Clin Transplant | pmid:7517226 |
Dawson TM et al. | The immunophilins, FK506 binding protein and cyclophilin, are discretely localized in the brain: relationship to calcineurin. | 1994 | Neuroscience | pmid:7530348 |
Curley RW et al. | Stereospecific assignments of glycine in proteins by stereospecific deuteration and 15N labeling. | 1994 | J. Biomol. NMR | pmid:7517241 |
Nagase K et al. | Distribution and protein binding of FK506, a potent immunosuppressive macrolide lactone, in human blood and its uptake by erythrocytes. | 1994 | J. Pharm. Pharmacol. | pmid:7517447 |
Glaum SR and Miller RJ | Inhibition of phosphoprotein phosphatases blocks metabotropic glutamate receptor effects in the rat nucleus tractus solitarii. | 1994 | Mol. Pharmacol. | pmid:7517497 |
Tanaka K et al. | Living related liver transplantation in children. | 1994 | Am. J. Surg. | pmid:7517649 |
Yu L et al. | NMR studies of the FK506 binding protein bound to a spin-labeled ascomycin analog. | 1994 | J Magn Reson B | pmid:7517786 |
Aagaard-Tillery KM and Jelinek DF | Inhibition of human B lymphocyte cell cycle progression and differentiation by rapamycin. | 1994 | Cell. Immunol. | pmid:7517796 |
Furue M et al. | Immunosuppressive effects of azelastine hydrochloride on contact hypersensitivity and T-cell proliferative response: a comparative study with FK-506. | 1994 | J. Invest. Dermatol. | pmid:7517981 |
Suzuki S and Toledo-Pereyra LH | Interleukin 1 and tumor necrosis factor production as the initial stimulants of liver ischemia and reperfusion injury. | 1994 | J. Surg. Res. | pmid:7518017 |
Singh N et al. | Decreased incidence of viral infections in liver transplant recipients. Possible effects of FK506? | 1994 | Dig. Dis. Sci. | pmid:7506641 |
Kusne S et al. | Infectious complications after small bowel transplantation in adults. | 1994 | Transplant. Proc. | pmid:7518153 |
Lee TK et al. | Bacterial translocation and the role of postoperative selective bowel decontamination in small intestinal transplantation. | 1994 | Transplant. Proc. | pmid:7518154 |
Pruschy MN et al. | Mechanistic studies of a signaling pathway activated by the organic dimerizer FK1012. | 1994 | Chem. Biol. | pmid:9383386 |
Grossi P et al. | Infectious complications in experimental small bowel transplantation. | 1994 | Transplant. Proc. | pmid:7518155 |
D'Ambrosio R et al. | Improved procedures for enzyme immunoassay of tacrolimus (FK506) in whole blood. | 1994 | Clin. Chem. | pmid:7507007 |
Bäckman L et al. | Chronic nephrotoxicity of FK 506 after liver transplantation. | 1994 | Transplant. Proc. | pmid:7518159 |
Bäckman L et al. | Whole blood and plasma levels of FK 506 after liver transplantation: correlation with toxicity. | 1994 | Transplant. Proc. | pmid:7518160 |
Duncan JI | Differential inhibition of cutaneous T-cell-mediated reactions and epidermal cell proliferation by cyclosporin A, FK-506, and rapamycin. | 1994 | J. Invest. Dermatol. | pmid:7507155 |
Engelbrecht ME et al. | The effect of immunosuppressants on human leukocyte NADPH oxidase. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7518204 |
Reding R et al. | Conversion from cyclosporine to FK506 for salvage of immunocompromised pediatric liver allografts. Efficacy, toxicity, and dose regimen in 23 children. | 1994 | Transplantation | pmid:7507272 |
Zuany-Amorim C et al. | Modulation by rm interferon-gamma and CD4+ T-lymphocytes of allergic eosinophil accumulation in the mice peritoneal cavity. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7518212 |
Dilling MB et al. | Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin-like growth factor receptor. | 1994 | Cancer Res. | pmid:7508822 |
Yamamoto S et al. | Stimulation of hair growth by topical application of FK506, a potent immunosuppressive agent. | 1994 | J. Invest. Dermatol. | pmid:7508960 |
Logan TM et al. | Structural characterization of the FK506 binding protein unfolded in urea and guanidine hydrochloride. | 1994 | J. Mol. Biol. | pmid:7508991 |
Ito T et al. | Protective effects of gabexate mesilate on acute pancreatitis induced by tacrolimus (FK-506) in rats in which the pancreas was stimulated by caerulein. | 1994 | J. Gastroenterol. | pmid:7520321 |
Cooper MH et al. | Rapamycin but not FK506 inhibits the proliferation of mononuclear phagocytes induced by colony-stimulating factors. | 1994 | Transplantation | pmid:7509089 |
Zeniya A et al. | Anti-ulcer effect of FK 506, immunosuppressive agent, in rats. | 1994 | J. Gastroenterol. | pmid:7520322 |
Rosh JR et al. | Therapy with FK 506 in pediatric liver recipients. | 1994 | Transplant. Proc. | pmid:7509091 |
Yamamoto S et al. | Inhibition of anthralin-caused skin tumor promotion and interleukin-1 alpha production by potent immunosuppressant FK506. | 1994 | Cancer Lett. | pmid:7520353 |
Scantlebury VP et al. | Pediatric kidney transplantation at the University of Pittsburgh. | 1994 | Transplant. Proc. | pmid:7509095 |
Dawson TM et al. | Nitric oxide: cellular regulation and neuronal injury. | 1994 | Prog. Brain Res. | pmid:7533914 |
Enslen H and Soderling TR | Roles of calmodulin-dependent protein kinases and phosphatase in calcium-dependent transcription of immediate early genes. | 1994 | J. Biol. Chem. | pmid:7520433 |
Sewell TJ et al. | Inhibition of calcineurin by a novel FK-506-binding protein. | 1994 | J. Biol. Chem. | pmid:7520438 |
Oyanagui Y | Nitric oxide- and hydrogen peroxide-mediated gene expression by glucocorticoids and FK506 in histamine paw edema of mice. | 1994 | Life Sci. | pmid:7520521 |
Gonschior AK et al. | Measurement of blood concentrations of FK506 (tacrolimus) and its metabolites in seven liver graft patients after the first dose by h.p.l.c.-MS and microparticle enzyme immunoassay (MEIA). | 1994 | Br J Clin Pharmacol | pmid:7534100 |
Hayakawa K et al. | Involvement of clonal deletion in immunotolerance induction: tests of Tacrolimus administration in rat renal transplantation. | 1994 | Transplant. Proc. | pmid:7520608 |
Yoshimura R et al. | Study of the effect of immunosuppressive agents on renal cytochrome P-450 system in the rat. | 1994 | Transplant. Proc. | pmid:7520610 |
Kitamura M et al. | Clinical experience of FK 506 for renal allograft transplantation. | 1994 | Transplant. Proc. | pmid:7520611 |
Malyszko J et al. | FK 506 affects platelet aggregation in vitro. | 1994 | Thromb. Res. | pmid:7521072 |
Schreier MH | Immunophilins and immunosuppression by cyclosporins and macrolide structures. | 1994 | Acta Derm Venereol Suppl (Stockh) | pmid:7521103 |
Chen Y et al. | A putative sirolimus (rapamycin) effector protein. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7521160 |
Abu-Elmagd K et al. | Three years clinical experience with intestinal transplantation. | 1994 | J. Am. Coll. Surg. | pmid:7522850 |
Shapiro R et al. | Improving results of pediatric renal transplantation. | 1994 | J. Am. Coll. Surg. | pmid:7522851 |
Moia LJ et al. | Immunosuppressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat. | 1994 | Brain Res. | pmid:7522929 |
Pai SY et al. | Cross-linking CD28 leads to activation of 70-kDa S6 kinase. | 1994 | Eur. J. Immunol. | pmid:7523138 |
Schmidt B et al. | A homodimer represents an active species of the peptidyl-prolyl cis/trans isomerase FKBP25mem from Legionella pneumophila. | 1994 | FEBS Lett. | pmid:7523184 |
Hakamata Y et al. | Involvement of the brain type of ryanodine receptor in T-cell proliferation. | 1994 | FEBS Lett. | pmid:7523185 |
Ahern GP et al. | Single channel activity of the ryanodine receptor calcium release channel is modulated by FK-506. | 1994 | FEBS Lett. | pmid:7523191 |
Lemster B et al. | Influence of FK 506 (tacrolimus) on circulating CD4+ T cells expressing CD25 and CD45RA antigens in 19 patients with chronic progressive multiple sclerosis participating in an open label drug safety trial. | 1994 | Autoimmunity | pmid:7539635 |
Fung JJ and Starzl TE | FK 506 in solid organ transplantation. | 1994 | Transplant. Proc. | pmid:7524226 |
Tacrolimus introduced for use in liver transplantation. | 1994 | Am J Hosp Pharm | pmid:7524317 | |
Przepiorka D et al. | Blood tacrolimus concentration unchanged by plasmapheresis. | 1994 | Am J Hosp Pharm | pmid:7524318 |
Burnett D et al. | Inhibition by FK506 of formyl peptide-induced neutrophil activation and associated protein synthesis. | 1994 | Biochem. Pharmacol. | pmid:7524504 |
Bierer BE | Cyclosporin A, FK506, and rapamycin: binding to immunophilins and biological action. | 1994 | Chem. Immunol. | pmid:7524531 |
Lepre CA et al. | Solution structure of FK506 bound to the R42K, H87V double mutant of FKBP-12. | 1994 | Biochemistry | pmid:7524662 |
Yu L and Fesik SW | pH titration of the histidine residues of cyclophilin and FK506 binding protein in the absence and presence of immunosuppressant ligands. | 1994 | Biochim. Biophys. Acta | pmid:7524680 |
Papaccio G et al. | The immunosuppressant FK506 inhibits the damage to mouse pancreatic islets induced by low dose streptozocin. | 1994 | Cell Tissue Res. | pmid:7525068 |
Robertus J | Structure-based drug design ten years on. | 1994 | Nat. Struct. Biol. | pmid:7545074 |
Milan D et al. | The latch region of calcineurin B is involved in both immunosuppressant-immunophilin complex docking and phosphatase activation. | 1994 | Cell | pmid:7525078 |
Ericzon B et al. | Glucose metabolism in liver transplant recipients treated with FK 506 or cyclosporin in the European multicentre study. | 1994 | Transpl. Int. | pmid:11271178 |
Undre N and Möller A | Pharmacokinetic interpretation of FK 506 levels in blood and in plasma during a European randomised study in primary liver transplant patients. The FK 506 European Study Group. | 1994 | Transpl. Int. | pmid:11271189 |
Winkler M et al. | Plasma vs whole blood for therapeutic drug monitoring of patients receiving FK 506 for immunosuppression. | 1994 | Clin. Chem. | pmid:7527306 |
Lewis HM | Therapeutic progress. II: Treatment of psoriasis. | 1994 | J Clin Pharm Ther | pmid:7527403 |
Chen SR et al. | Asymmetrical blockade of the Ca2+ release channel (ryanodine receptor) by 12-kDa FK506 binding protein. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7527548 |
Calmus Y | [Rejection of a liver allograft. Diagnosis and treatment]. | 1994 | Ann Radiol (Paris) | pmid:7527621 |
Okubo Y et al. | Cytokine production in patients with mite-sensitive bronchial asthma. | 1994 | Int. Arch. Allergy Immunol. | pmid:7512395 |
Jiang H et al. | The superior effect of the combination of FK 506 and deoxyspergualin on rat cardiac allograft survival. | 1994 | Transpl. Int. | pmid:7527637 |
Winkler M et al. | The use of plasma levels for FK 506 dosing in liver-grafted patients. | 1994 | Transpl. Int. | pmid:7527638 |
Wilson JR et al. | Sensorimotor neuropathy resembling CIDP in patients receiving FK506. | 1994 | Muscle Nerve | pmid:7512691 |
Stark JH et al. | Sensitivity of baboon lymphocytes to cyclosporin A and FK 506: relative resistance of alloactivated cells to CyA. | 1994 | Transpl. Int. | pmid:7527639 |
Lyons WE et al. | Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7512727 |
Abdalla AH et al. | FK 506 as an alternative in cyclosporin-induced hemolytic uremic syndrome in a kidney transplant recipient. | 1994 | Transpl. Int. | pmid:7527640 |
Cooper MH et al. | Short-term myeloid reconstitution following TBI is not adversely affected by doses of FK506 that abrogate lethal GVHD. | 1994 | Bone Marrow Transplant. | pmid:7527689 |
Yasunami Y and Ikeda S | Induction of donor specific unresponsiveness in rat islet allografts by intraportal grafting and FK506. | 1994 | Cell Transplant | pmid:7512877 |
Mor E et al. | Reversal of gastrointestinal toxicity associated with long-term FK506 immunosuppression by conversion to cyclosporine in liver transplant recipients. | 1994 | Transplantation | pmid:7513098 |