tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Swanson C et al. | FK 506-based immunosuppression in clinical pancreas transplantation. | 1995 | Transplant. Proc. | pmid:8539827 |
| Tesi RJ et al. | Conversion of pancreas transplants to FK 506 from CsA. | 1995 | Transplant. Proc. | pmid:8539828 |
| Wiederrecht GJ et al. | Mechanism of action of rapamycin: new insights into the regulation of G1-phase progression in eukaryotic cells. | 1995 | Prog Cell Cycle Res | pmid:9552353 |
| Burke GW et al. | Use of FK 506 in simultaneous pancreas/kidney transplantation: lack of impairment of glycemic or lipid metabolism. | 1995 | Transplant. Proc. | pmid:8539872 |
| Burke GW et al. | The use of FK506 in simultaneous pancreas/kidney transplantation: rescue, induction, and maintenance immunosuppression. | 1995 | Transplant. Proc. | pmid:8539874 |
| Wennberg L et al. | Immunosuppression with leflunomide and cyclosporine prevents pig-to-rat islet xenograft rejection. | 1995 | Transplant. Proc. | pmid:8539967 |
| Gruessner RW et al. | A prospective study of FK506 versus CsA and pig ATG in a porcine model of small bowel transplantation. | 1995 | Transplantation | pmid:7530871 |
| Todo S et al. | Abdominal multivisceral transplantation. | 1995 | Transplantation | pmid:7530873 |
| Fukuzaki T et al. | A protocol with FK 506 for inducing unresponsiveness to murine islet allografts. | 1995 | Surgery | pmid:7531371 |
| Lemster BH et al. | IL-8/IL-8 receptor expression in psoriasis and the response to systemic tacrolimus (FK506) therapy. | 1995 | Clin. Exp. Immunol. | pmid:7531627 |
| Coghlan VM et al. | Association of protein kinase A and protein phosphatase 2B with a common anchoring protein. | 1995 | Science | pmid:7528941 |
| Clardy J | The chemistry of signal transduction. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7529414 |
| Braun W et al. | Three-dimensional structure and actions of immunosuppressants and their immunophilins. | 1995 | FASEB J. | pmid:7529736 |
| McDiarmid SV et al. | FK506 (tacrolimus) compared with cyclosporine for primary immunosuppression after pediatric liver transplantation. Results from the U.S. Multicenter Trial. | 1995 | Transplantation | pmid:7533345 |
| Jain AB et al. | One thousand consecutive primary orthotopic liver transplants under FK 506: survival and adverse events. | 1995 | Transplant. Proc. | pmid:7533353 |
| Rucay P et al. | FK 506 as treatment of late acute rejection in liver transplant patients. | 1995 | Transplant. Proc. | pmid:7533354 |
| Schwartz M et al. | FK 506 in liver transplantation: correlation of whole blood levels with efficacy and toxicity. The US Multicenter FK 506 Dose Optimization. | 1995 | Transplant. Proc. | pmid:7533355 |
| Yasuhara M et al. | Pharmacokinetics and pharmacodynamics of FK 506 in pediatric patients receiving living-related donor liver transplantations. | 1995 | Transplant. Proc. | pmid:7533356 |
| Platz KP et al. | OKT3 vs FK 506 rescue management of acute steroid-resistant and chronic rejection. | 1995 | Transplant. Proc. | pmid:7533357 |
| Bierer BE | Mechanisms of action of immunosuppressive agents: cyclosporin A, FK506, and rapamycin. | 1995 | Proc. Assoc. Am. Physicians | pmid:8630742 |
| Porayko MK et al. | Comparing nephrotoxicity of FK 506 and cyclosporine regimens after liver transplantation: preliminary results from US Multicenter trial. U.S. Multicenter Liver Study Group. | 1995 | Transplant. Proc. | pmid:7533358 |
| Mueller AR et al. | The superior immunosuppressant according to diagnosis: FK 506 or cyclosporine A. | 1995 | Transplant. Proc. | pmid:7533359 |
| Abouljoud MS et al. | Hyperlipidemia after liver transplantation: long-term results of the FK506/cyclosporine A US Multicenter Trial. US Multicenter Study Group. | 1995 | Transplant. Proc. | pmid:7533360 |
| Grobecker HF et al. | Cyclosporine A-induced hypertension in SHR and WKY: role of the sympatho-adrenal system. | 1995 | Clin Exp Pharmacol Physiol Suppl | pmid:9072458 |
| Celli S et al. | Mechanisms of protection from humoral rejection by a xenografted liver. | 1995 | Transplant. Proc. | pmid:7533395 |
| Kuroki H and Ikuta Y | Nerve regeneration of vascularized rat limb allograft and functional recovery of long-term graft survivals treated by short course of FK 506 or cyclosporine. | 1995 | Transplant. Proc. | pmid:7533405 |
| Ko S et al. | Significance of newly developed liposomal FK 506 in canine liver transplantation. | 1995 | Transplant. Proc. | pmid:7533406 |
| Fukuzaki T et al. | Induction of unresponsiveness to islet allografts with donor spleen cell inoculation followed by a single injection of FK 506. | 1995 | Transplant. Proc. | pmid:7533407 |
| Grochowicz PM et al. | Synergism of castanospermine and FK 506. | 1995 | Transplant. Proc. | pmid:7533408 |
| Itoh S and Navia MA | Structure comparison of native and mutant human recombinant FKBP12 complexes with the immunosuppressant drug FK506 (tacrolimus). | 1995 | Protein Sci. | pmid:8563622 |
| Tamura K et al. | Inhibition of insulin production by FK 506 is caused at the transcriptional level in pancreatic beta cell when FK BP-12 content is relatively high. | 1995 | Transplant. Proc. | pmid:7533409 |
| Kawano K et al. | Protective effect of FK 506 on hepatic injury following cold ischemic preservation and transplantation: influence on hepatic microcirculation. | 1995 | Transplant. Proc. | pmid:7533410 |
| Charters AR et al. | Developmental expression of FK506 binding proteins and calcineurin in rat brain. | 1995 | Biochem. Soc. Trans. | pmid:8566310 |
| Tanabe M et al. | Therapeutic synergism between low-dose FK 506 and antimetabolites in rat allogeneic heart transplantation. | 1995 | Transplant. Proc. | pmid:7533411 |
| Abu-Elmagd K et al. | The current status of hepatic transplantation at the University of Pittsburgh. | 1995 | Clin Transpl | pmid:8794262 |
| Masri MA | Comparative study of toxicity and efficacy of cyclosporine, cyclosporine G (OG37), FK 506, and rapamycin in BALB/c mice with fitted skin grafts. | 1995 | Transplant. Proc. | pmid:7533412 |
| Shapiro R et al. | The superiority of tacrolimus in renal transplant recipients -- the Pittsburgh experience. | 1995 | Clin Transpl | pmid:8794266 |
| Jiang H et al. | Immunosuppressive effects of FK 506 on rat renal allograft survival, in comparison with cyclosporine. | 1995 | Transplant. Proc. | pmid:7533413 |
| Swenson JM et al. | Immunosuppression switch in pediatric heart transplant recipients: cyclosporine to FK 506. | 1995 | J. Am. Coll. Cardiol. | pmid:7534779 |
| Hodgkiss JP and Kelly JS | Only 'de novo' long-term depression (LTD) in the rat hippocampus in vitro is blocked by the same low concentration of FK506 that blocks LTD in the visual cortex. | 1995 | Brain Res. | pmid:8821755 |
| Grimmond S et al. | Exclusion of the 13-kDa rapamycin binding protein gene (FKBP2) as a candidate gene for multiple endocrine neoplasia type 1. | 1995 | Hum. Genet. | pmid:7535744 |
| Jiang H et al. | Induction of anagen in telogen mouse skin by topical application of FK506, a potent immunosuppressant. | 1995 | J. Invest. Dermatol. | pmid:7535825 |
| Atkison P et al. | Hypertrophic cardiomyopathy associated with tacrolimus in paediatric transplant patients. | 1995 | Lancet | pmid:7535875 |
| Shaffer D et al. | Normal pancreas allograft function following simultaneous pancreas kidney transplantation after rescue therapy with tacrolimus (FK506). | 1995 | Transplantation | pmid:7535958 |
| Bronster DJ et al. | Demyelinating sensorimotor polyneuropathy after administration of FK506. | 1995 | Transplantation | pmid:7535959 |
| Iwasaki K et al. | Further metabolism of FK506 (tacrolimus). Identification and biological activities of the metabolites oxidized at multiple sites of FK506. | 1995 | Drug Metab. Dispos. | pmid:7536652 |
| Tumlin JA et al. | Expression of calcineurin activity and alpha-subunit isoforms in specific segments of the rat nephron. | 1995 | Am. J. Physiol. | pmid:7485542 |
| Winkler M and Christians U | A risk-benefit assessment of tacrolimus in transplantation. | 1995 | Drug Saf | pmid:7545405 |
| Marumo T et al. | Cyclosporin A inhibits nitric oxide synthase induction in vascular smooth muscle cells. | 1995 | Hypertension | pmid:7536714 |
| Nowaczyk M et al. | 2-Chlorodeoxyadenosine: lack of synergism with cyclosporine A and tacrolimus (FK 506). | 1995 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:8744655 |
| Schwaninger M et al. | Involvement of the Ca(2+)-dependent phosphatase calcineurin in gene transcription that is stimulated by cAMP through cAMP response elements. | 1995 | J. Biol. Chem. | pmid:7536740 |
| Min Z and Jones NF | Limb transplantation in rats: immunosuppression with FK-506. | 1995 | J Hand Surg Am | pmid:7536766 |
| Pockley AG et al. | Effect of cyclosporin A, FK506 and rapamycin on proliferation and soluble IL-2 receptor release from mitogenically stimulated rat spleen cells. | 1995 | Biochem. Soc. Trans. | pmid:8654800 |
| Kobayashi I et al. | Combination therapy with tacrolimus and betamethasone for a patient with X-linked auto-immune enteropathy. | 1995 | Eur. J. Pediatr. | pmid:7556338 |
| Adachi M et al. | IL-2-induced gene expression of protein-tyrosine phosphatase LC-PTP requires acidic and serine-rich regions within IL-2 receptor beta chain. | 1995 | FEBS Lett. | pmid:7556630 |
| David M et al. | [Occurrence of suspicious changes in cervix cytology in women after liver transplantation]. | 1995 | Geburtshilfe Frauenheilkd | pmid:7557217 |
| Mills RA et al. | Topical FK-506 prevents experimental corneal allograft rejection. | 1995 | Cornea | pmid:7538061 |
| [Experimental and clinical studies on the effectiveness of new immunosuppressive agents used in heart transplantation and transplantation-related complications]. | 1995 | Nihon Kyobu Geka Gakkai Zasshi | pmid:7561285 | |
| Yamamoto S et al. | Cross-species transplantation of photoreceptors with tacrolimus hydrate (FK506) treatment. | 1995 | Jpn. J. Ophthalmol. | pmid:8926639 |
| Lee TK et al. | Postoperative selective bowel decontamination prevents gram-negative bacterial translocation in small-bowel graft recipients. | 1995 | J. Surg. Res. | pmid:7538186 |
| Asano K et al. | Generation of effector T cells in Hymenolepis nana-infected, FK-506-treated BALB/c mice. | 1995 | Immunol. Lett. | pmid:7590919 |
| Lam E et al. | A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. | 1995 | J. Biol. Chem. | pmid:7592869 |
| Galat A and Metcalfe SM | Peptidylproline cis/trans isomerases. | 1995 | Prog. Biophys. Mol. Biol. | pmid:7538221 |
| Goldfeld AE et al. | Cyclosporin A and FK506 block induction of the Epstein-Barr virus lytic cycle by anti-immunoglobulin. | 1995 | Virology | pmid:7538254 |
| Kanda T et al. | Synergistic effects of tacrolimus and human interferon-alpha A/D in murine viral myocarditis. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7542339 |
| Jurim O et al. | Living-donor liver transplantation at UCLA. | 1995 | Am. J. Surg. | pmid:7538267 |
| Canzanello VJ et al. | Renal sodium handling with cyclosporin A and FK506 after orthotopic liver transplantation. | 1995 | J. Am. Soc. Nephrol. | pmid:7542491 |
| Conde M et al. | Inhibitory effect of cyclosporin A and FK506 on nitric oxide production by cultured macrophages. Evidence of a direct effect on nitric oxide synthase activity. | 1995 | Immunology | pmid:7538492 |
| Skeen MJ and Ziegler HK | Activation of gamma delta T cells for production of IFN-gamma is mediated by bacteria via macrophage-derived cytokines IL-1 and IL-12. | 1995 | J. Immunol. | pmid:7538532 |
| Columbo M et al. | Human skin mast cells express functional beta 1 integrins that mediate adhesion to extracellular matrix proteins. | 1995 | J. Immunol. | pmid:7538541 |
| Pearlman DA and Connelly PR | Determination of the differential effects of hydrogen bonding and water release on the binding of FK506 to native and Tyr82-->Phe82 FKBP-12 proteins using free energy simulations. | 1995 | J. Mol. Biol. | pmid:7538591 |
| Lochmüller H et al. | Immunosuppression by FK506 markedly prolongs expression of adenovirus-delivered transgene in skeletal muscles of adult dystrophic [mdx] mice. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7544122 |
| Deschler DG et al. | Posttransplantation lymphoproliferative disorder in patients under primary tacrolimus (FK 506) immunosuppression. | 1995 | Arch. Otolaryngol. Head Neck Surg. | pmid:7544136 |
| Rouvière-Fourmy N et al. | 1H and 15N assignment of NMR spectrum, secondary structure and global folding of the immunophilin-like domain of the 59-kDa FK506-binding protein. | 1995 | Eur. J. Biochem. | pmid:7544285 |
| Sakamoto K et al. | A new assay method for immunosuppressants with a tacrolimus (FK506)-like mode of action. | 1995 | J. Antibiot. | pmid:7544337 |
| Natazuka T et al. | Immunosuppressive drugs and hypertrophic cardiomyopathy. | 1995 | Lancet | pmid:7540241 |
| Lee MJ et al. | Combined inhibition effects of tacrolimus and methylprednisolone on in vitro human lymphocyte proliferation. | 1995 | Immunopharmacol Immunotoxicol | pmid:7544367 |
| Dhawan A et al. | Immunosuppressive drugs and hypertrophic cardiomyopathy. | 1995 | Lancet | pmid:7540242 |
| Sauer P et al. | In patients with orthotopic liver transplantation, serum markers of cholestasis are unreliable indicators of biliary secretion. | 1995 | J. Hepatol. | pmid:7544368 |
| Nielsen FT et al. | Nephrotoxicity of FK-506 in the rat. Studies on glomerular and tubular function, and on the relationship between efficacy and toxicity. | 1995 | Nephrol. Dial. Transplant. | pmid:7540737 |
| Chang HY et al. | Asymmetric retraction of growth cone filopodia following focal inactivation of calcineurin. | 1995 | Nature | pmid:7544441 |
| Reichenspurner H et al. | First experience with FK 506 for treatment of chronic pulmonary rejection. | 1995 | Transplant. Proc. | pmid:7540775 |
| Murio JE et al. | Compassionate use of FK 506 in liver transplantation. | 1995 | Transplant. Proc. | pmid:7544501 |
| Yumiba T et al. | Immunosuppressive and diabetogenic effect of FK 506 on pancreatic islet xenotransplantation. | 1995 | Transplant. Proc. | pmid:7540780 |
| Llull R et al. | Multilineage amplification of graft-vs-host disease-resistant chimerism following rat vascularized bone marrow allotransplantation. | 1995 | Transplant. Proc. | pmid:7544504 |
| Horne SM and Young KD | Escherichia coli and other species of the Enterobacteriaceae encode a protein similar to the family of Mip-like FK506-binding proteins. | 1995 | Arch. Microbiol. | pmid:7540828 |
| Teutsch M et al. | Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK-520 and rapamycin. | 1995 | Int. Immunol. | pmid:7540861 |
| Mori A et al. | IL-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A. | 1995 | Int. Immunol. | pmid:7540862 |
| Tashiro H et al. | Monitoring for engraftment following rat orthotopic liver transplantation by in vitro amplification of Y-chromosome gene using polymerase chain reaction. | 1995 | Cell Transplant | pmid:7540919 |
| Hikita N et al. | Effects of topical FK506 on endotoxin-induced uveitis (EIU) in the Lewis rat. | 1995 | Curr. Eye Res. | pmid:7540967 |
| Okamoto M et al. | In situ proliferating status of mononuclear cells in rat small bowel grafts. | 1995 | Int J Exp Pathol | pmid:7547442 |
| Platz KP et al. | Toxicity versus rejection--or why conversions between cyclosporine A and FK506 were performed after liver transplantation. | 1995 | Clin Transplant | pmid:7549052 |
| Mueller AR et al. | The optimal immunosuppressant after liver transplantation according to diagnosis: cyclosporine A or FK506? | 1995 | Clin Transplant | pmid:7549057 |
| Nagai H et al. | Effect of some immunosuppressors on allergic bronchial inflammation and airway hyperresponsiveness in mice. | 1995 | Int. Arch. Allergy Immunol. | pmid:7549508 |
| Jung-Testas I et al. | Cyclosporin A promotes nuclear transfer of a cytoplasmic progesterone receptor mutant. | 1995 | C. R. Acad. Sci. III, Sci. Vie | pmid:7583777 |
| Faerman CH and Karplus PA | Consensus preferred hydration sites in six FKBP12-drug complexes. | 1995 | Proteins | pmid:8539241 |
| Groth CG | Immunosuppressive regimens of tomorrow. | 1995 | Transplant. Proc. | pmid:8539797 |
| Hariharan S et al. | Conversion from cyclosporine to tacrolimus after pancreas transplantation. | 1995 | Transplant. Proc. | pmid:8539799 |
| Henley SE et al. | Lipids following pancreas transplantation in recipients receiving FK 506. | 1995 | Transplant. Proc. | pmid:8539809 |
| Stratta RJ et al. | Preliminary experience with FK 506 in pancreas transplant recipients. | 1995 | Transplant. Proc. | pmid:8539823 |