Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Mehta RS et al. | Post-transplantation cyclophosphamide versus conventional graft-versus-host disease prophylaxis in mismatched unrelated donor haematopoietic cell transplantation. | 2016 | Br. J. Haematol. | pmid:26947769 |
Kiyohara H et al. | Up-to-date medical treatment for ulcerative colitis. | 2016 | Nihon Shokakibyo Gakkai Zasshi | pmid:26947041 |
Carcas-Sansuán AJ | Limited sampling strategies for once daily tacrolimus exposure monitoring. | 2016 | Eur. J. Clin. Pharmacol. | pmid:26939899 |
Herz S et al. | Checkpoint inhibitors in chronic kidney failure and an organ transplant recipient. | 2016 | Eur. J. Cancer | pmid:27614165 |
Hazama Y et al. | Effect of Physiological Changes in the Skin on Systemic Absorption of Tacrolimus Following Topical Application in Rats. | 2016 | Biol. Pharm. Bull. | pmid:26934927 |
Nakajima A et al. | Effectiveness of tacrolimus in comparison with methotrexate or biologics in propensity score-matched patients with rheumatoid arthritis. | 2016 | Mod Rheumatol | pmid:26934454 |
Iguchi A et al. | Graft-versus-host disease (GVHD) prophylaxis by using methotrexate decreases pre-engraftment syndrome and severe acute GVHD, and accelerates engraftment after cord blood transplantation. | 2016 | Pediatr Transplant | pmid:26526424 |
Pan GH et al. | Low-dose tacrolimus combined with donor-derived mesenchymal stem cells after renal transplantation: a prospective, non-randomized study. | 2016 | Oncotarget | pmid:26933811 |
Kloster-Jensen K et al. | Treatment with Tacrolimus and Sirolimus Reveals No Additional Adverse Effects on Human Islets In Vitro Compared to Each Drug Alone but They Are Reduced by Adding Glucocorticoids. | 2016 | J Diabetes Res | pmid:26885529 |
Shen X et al. | Calcineurin inhibitors cyclosporin A and tacrolimus protect against podocyte injury induced by puromycin aminonucleoside in rodent models. | 2016 | Sci Rep | pmid:27580845 |
Thölking G et al. | Influence of tacrolimus metabolism rate on BKV infection after kidney transplantation. | 2016 | Sci Rep | pmid:27573493 |
Tang J et al. | Cytokine Profile in Calcineurin Inhibitor-Induced Chronic Nephrotoxicity in Chinese Liver Transplant Recipients. | 2016 | Transplant. Proc. | pmid:27788813 |
Fukuta T et al. | Non-invasive evaluation of neuroprotective drug candidates for cerebral infarction by PET imaging of mitochondrial complex-I activity. | 2016 | Sci Rep | pmid:27440054 |
Dugast E et al. | Failure of Calcineurin Inhibitor (Tacrolimus) Weaning Randomized Trial in Long-Term Stable Kidney Transplant Recipients. | 2016 | Am. J. Transplant. | pmid:27367750 |
Lim SW et al. | Effect of Exendin-4 on Autophagy Clearance in Beta Cell of Rats with Tacrolimus-induced Diabetes Mellitus. | 2016 | Sci Rep | pmid:27436514 |
Knight SR | Intrapatient variability in tacrolimus exposure - a useful tool for clinical practice? | 2016 | Transpl. Int. | pmid:27283231 |
Shuker N et al. | A high intrapatient variability in tacrolimus exposure is associated with poor long-term outcome of kidney transplantation. | 2016 | Transpl. Int. | pmid:27188932 |
Kolb M et al. | Risk Factors for Subtherapeutic Tacrolimus Levels after Conversion from Continuous Intravenous Infusion to Oral in Children after Allogeneic Hematopoietic Cell Transplantation. | 2016 | Biol. Blood Marrow Transplant. | pmid:26880117 |
Arreola-Guerra JM et al. | Tacrolimus Trough Levels as a Risk Factor for Acute Rejection in Renal Transplant Patients. | 2016 | Ann. Transplant. | pmid:26879833 |
Nie F et al. | [Post-transplant kidney from C-III donation after cardiac death of children: a clinicopathologic study of 20 cases]. | 2016 | Zhonghua Bing Li Xue Za Zhi | pmid:26879429 |
Song JL et al. | Minimizing tacrolimus decreases the risk of new-onset diabetes mellitus after liver transplantation. | 2016 | World J. Gastroenterol. | pmid:26877618 |
Than NN et al. | Long-term follow-up of patients with difficult to treat type 1 autoimmune hepatitis on Tacrolimus therapy. | 2016 | Scand. J. Gastroenterol. | pmid:26458216 |
Žilinská Z et al. | Impact of Trough Levels of Tacrolimus on Kidney Function and Graft Survival in Short and Longer Periods After Renal Transplantation. | 2016 | Transplant. Proc. | pmid:27788794 |
Dharnidharka VR et al. | Differential risks for adverse outcomes 3 years after kidney transplantation based on initial immunosuppression regimen: a national study. | 2016 | Transpl. Int. | pmid:27564782 |
Wang X et al. | Ureaplasma urealyticum Causes Hyperammonemia in an Experimental Immunocompromised Murine Model. | 2016 | PLoS ONE | pmid:27537683 |
Rostaing L et al. | Successful Transplantation in ABO- and HLA-Incompatible Living Kidney Transplant Patients: A Report on 12 Cases. | 2016 | Ther Apher Dial | pmid:27073167 |
Pirojsakul K et al. | Management of sensitized pediatric patients prior to renal transplantation. | 2016 | Pediatr. Nephrol. | pmid:26801944 |
Malik N et al. | A simple office-based procedure for patients with extensive vitiligo. | 2016 | J. Am. Acad. Dermatol. | pmid:27745651 |
Lee JH et al. | Stability of tacrolimus solutions in polyolefin containers. | 2016 | Am J Health Syst Pharm | pmid:26796907 |
Guo YW et al. | Successful treatment of ileal ulcers caused by immunosuppressants in two organ transplant recipients. | 2016 | World J. Gastroenterol. | pmid:27350740 |
Ward I et al. | Digital Pulp Ulcerations and Inverse Gottron Papules in Melanoma Differentiation-Associated Gene 5-Related Dermatomyositis. | 2016 | J Clin Rheumatol | pmid:27464773 |
EriÅŸ E et al. | Evaluation of Effect of Topical Tacrolimus Treatment on Herpetic Stromal Keratitis in a Rat Model. | 2016 | Eye Contact Lens | pmid:25996419 |
Yingfang F et al. | Pimecrolimus micelle exhibits excellent therapeutic effect for Keratoconjunctivitis Sicca. | 2016 | Colloids Surf B Biointerfaces | pmid:26731192 |
Nekkanti V et al. | Design, Characterization, and In Vivo Pharmacokinetics of Tacrolimus Proliposomes. | 2016 | AAPS PharmSciTech | pmid:26729532 |
Armand P et al. | The addition of sirolimus to the graft-versus-host disease prophylaxis regimen in reduced intensity allogeneic stem cell transplantation for lymphoma: a multicentre randomized trial. | 2016 | Br. J. Haematol. | pmid:26729448 |
Choi WJ et al. | Oral administration of Lactococcus chungangensis inhibits 2,4-dinitrochlorobenzene-induced atopic-like dermatitis in NC/Nga mice. | 2016 | J. Dairy Sci. | pmid:27289147 |
Bapur Erduran F and Adışen E | Comparison of the efficacy of 308-nm excimer lamp monotherapy with topical tacrolimus or clobetasol 17-propionate combination therapies in localized vitiligo. | 2016 | Photodermatol Photoimmunol Photomed | pmid:27552312 |
Badr R et al. | Assessment of global ischemic/reperfusion and Tacrolimus administration on CA1 region of hippocampus: gene expression profiles of BAX and BCL2 genes. | 2016 | Bratisl Lek Listy | pmid:27546370 |
Hanaoka K et al. | A chronic renal rejection model with a fully MHC-mismatched rat strain combination under immunosuppressive therapy. | 2016 | Transpl. Immunol. | pmid:27545900 |
Speckmann T et al. | Npas4 Transcription Factor Expression Is Regulated by Calcium Signaling Pathways and Prevents Tacrolimus-induced Cytotoxicity in Pancreatic Beta Cells. | 2016 | J. Biol. Chem. | pmid:26663079 |
Matsa E et al. | Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro. | 2016 | Cell Stem Cell | pmid:27545504 |
Fang YP et al. | What is the discrepancy between drug permeation into/across intact and diseased skins? Atopic dermatitis as a model. | 2016 | Int J Pharm | pmid:26657274 |
Lee B et al. | Appropriate timing of tacrolimus concentration measurements in the emergency department. | 2016 | Am J Health Syst Pharm | pmid:27543574 |
Thao le Q et al. | Pharmaceutical potential of tacrolimus-loaded albumin nanoparticles having targetability to rheumatoid arthritis tissues. | 2016 | Int J Pharm | pmid:26657273 |
Mokuda S and Oiwa H | Successful treatment of FKBP51-expressed multicentric reticulohistiocytosis using combination therapy with low-dose denosumab and tacrolimus. | 2016 | Scand. J. Rheumatol. | pmid:26652057 |
Komaki Y et al. | Efficacy and Safety of Tacrolimus Therapy for Active Ulcerative Colitis; A Systematic Review and Meta-analysis. | 2016 | J Crohns Colitis | pmid:26645641 |
Vadcharavivad S et al. | Population pharmacokinetics of tacrolimus in Thai kidney transplant patients: comparison with similar data from other populations. | 2016 | J Clin Pharm Ther | pmid:27191538 |
Albeiroti S et al. | Evaluation of 2 Batched Pretreatment Systems for the Measurement of Whole Blood Tacrolimus on the ARCHITECT Immunoassay Analyzer. | 2016 | Lab Med | pmid:27474776 |
Yu H et al. | Risk factors for new-onset diabetes mellitus after living donor kidney transplantation in Korea - a retrospective single center study. | 2016 | BMC Nephrol | pmid:27473469 |
Filler G et al. | Minimum mycophenolic acid levels are associated with donor-specific antibody formation. | 2016 | Pediatr Transplant | pmid:26589470 |
Scalea JR et al. | Tacrolimus for the prevention and treatment of rejection of solid organ transplants. | 2016 | Expert Rev Clin Immunol | pmid:26588770 |
Dabrowska-Zamojcin E et al. | CCL2 gene polymorphism is associated with post-transplant diabetes mellitus. | 2016 | Int. Immunopharmacol. | pmid:26802601 |
Ikeya K et al. | The Ulcerative Colitis Endoscopic Index of Severity More Accurately Reflects Clinical Outcomes and Long-term Prognosis than the Mayo Endoscopic Score. | 2016 | J Crohns Colitis | pmid:26581895 |
Gala-Lopez BL et al. | Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice. | 2016 | Diabetes | pmid:26581595 |
Sakai R et al. | A comparison of tacrolimus and cyclosporine combined with methotrexate for graft-versus-host disease prophylaxis, stratified by stem cell source: a retrospective nationwide survey. | 2016 | Int. J. Hematol. | pmid:26800676 |
Milgrom SA et al. | Graft-versus-host disease after radiation therapy in patients who have undergone allogeneic stem cell transplantation: two case reports. | 2016 | J Med Case Rep | pmid:27465468 |
Pouché L et al. | New challenges and promises in solid organ transplantation pharmacogenetics: the genetic variability of proteins involved in the pharmacodynamics of immunosuppressive drugs. | 2016 | Pharmacogenomics | pmid:26799749 |
Wu SY et al. | Comprehensive risk assessment for early neurologic complications after liver transplantation. | 2016 | World J. Gastroenterol. | pmid:27350733 |
Constantinescu AA et al. | Differential influence of tacrolimus and sirolimus on mitochondrial-dependent signaling for apoptosis in pancreatic cells. | 2016 | Mol. Cell. Biochem. | pmid:27344165 |
Shao K et al. | Different Effects of Tacrolimus on Innate and Adaptive Immune Cells in the Allograft Transplantation. | 2016 | Scand. J. Immunol. | pmid:26524694 |
Cena T et al. | De novo noncutaneous malignancies after kidney transplantation are associated with an increased risk of graft failure: results from a time-dependent analysis on 672 patients. | 2016 | Transpl. Int. | pmid:27343849 |
Moes DJ et al. | Population pharmacokinetics and pharmacogenetics of once daily tacrolimus formulation in stable liver transplant recipients. | 2016 | Eur. J. Clin. Pharmacol. | pmid:26521259 |
Yeo L and Ormerod AD | Oral tacrolimus: a treatment option for recalcitrant erosive lichen planus. | 2016 | Clin. Exp. Dermatol. | pmid:27339859 |
Binkhathlan Z et al. | Reutilization of Tacrolimus Extracted from Expired Prograf® Capsules: Physical, Chemical, and Pharmacological Assessment. | 2016 | AAPS PharmSciTech | pmid:26729529 |
Gardiner KM et al. | Multinational Evaluation of Mycophenolic Acid, Tacrolimus, Cyclosporin, Sirolimus, and Everolimus Utilization. | 2016 | Ann. Transplant. | pmid:26729299 |
Chacon A and Mercer J | Successful management of angiolymphoid hyperplasia with eosinophilia in a split-face trial of topical tacrolimus and timolol solution. | 2016 | G Ital Dermatol Venereol | pmid:25014586 |
Grześk E et al. | Cyclosporine-A, but not tacrolimus significantly increases reactivity of vascular smooth muscle cells. | 2016 | Pharmacol Rep | pmid:26721374 |
Riegersperger M et al. | The Effect of ABCB1 Polymorphisms on Serial Tacrolimus Concentrations in Stable Austrian Long-Term Kidney Transplant Recipients. | 2016 | Clin. Lab. | pmid:28164520 |
Pizzo HP et al. | Sirolimus and tacrolimus coefficient of variation is associated with rejection, donor-specific antibodies, and nonadherence. | 2016 | Pediatr. Nephrol. | pmid:27286686 |
Fernández de Castillo Torras L et al. | Treatment with ulipristal acetate (Esmya(®)) and plasma levels of tacrolimus: a case report. | 2016 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:27282803 |
Levitsky J et al. | Immunoregulatory Effects of Everolimus on In Vitro Alloimmune Responses. | 2016 | PLoS ONE | pmid:27275747 |
Youssef M et al. | Asymptomatic papulonodular lesions in zosteriform distribution in an immunocompromised patient. | 2016 | Int. J. Dermatol. | pmid:26463835 |
Ferjani H et al. | The evaluate and compare the effects of the Tacrolimus and Sirolimus on the intestinal system using an intestinal cell culture model. | 2016 | Toxicol. Mech. Methods | pmid:26460985 |
Jebabli N et al. | Consequences of erroneous phone transmission of tacrolimus blood concentration: A case report. | 2016 | Therapie | pmid:27203160 |
Sasaki T et al. | Characteristic features of tacrolimus-induced lung disease in rheumatoid arthritis patients. | 2016 | Clin. Rheumatol. | pmid:25644583 |
Serrano-Mollar A et al. | Safety and Tolerability of Alveolar Type II Cell Transplantation in Idiopathic Pulmonary Fibrosis. | 2016 | Chest | pmid:27020420 |
Nerattini F et al. | II. Dissociation free energies in drug-receptor systems via nonequilibrium alchemical simulations: application to the FK506-related immunophilin ligands. | 2016 | Phys Chem Chem Phys | pmid:27193181 |
O'Regan JA et al. | Tacrolimus trough-level variability predicts long-term allograft survival following kidney transplantation. | 2016 | J. Nephrol. | pmid:26374111 |
Seok J et al. | Recalcitrant steroid-induced rosacea successfully treated with 0.03% tacrolimus and 595-nm pulsed dye laser. | 2016 | Eur J Dermatol | pmid:27193042 |
Caillard S et al. | Advagraf(®) , a once-daily prolonged release tacrolimus formulation, in kidney transplantation: literature review and guidelines from a panel of experts. | 2016 | Transpl. Int. | pmid:26373896 |
Sisti A et al. | Effectiveness and safety of topical tacrolimus monotherapy for repigmentation in vitiligo: a comprehensive literature review. | 2016 | An Bras Dermatol | pmid:27192518 |
Ramachandran R et al. | Cyclical cyclophosphamide and steroids is effective in resistant or relapsing nephrotic syndrome due to M-type phospholipase A2 receptor-related membranous nephropathy after tacrolimus therapy. | 2016 | Kidney Int. | pmid:27181781 |
Alvarez-ElÃas AC et al. | CYP3A5 Genotype and Time to Reach Tacrolimus Therapeutic Levels in Renal Transplant Children. | 2016 | Transplant. Proc. | pmid:27110018 |
Reiner J et al. | After Intestinal Transplantation Kidney Function Is Impaired by Downregulation of Epithelial Ion Transporters in the Ileum. | 2016 | Transplant. Proc. | pmid:27109987 |
Rao B et al. | Use of Everolimus After Multivisceral Transplantation: A Report of Two Cases. | 2016 | Transplant. Proc. | pmid:27109983 |
Chang HK et al. | Ten-Year Experience With Bowel Transplantation at Seoul St. Mary's Hospital. | 2016 | Transplant. Proc. | pmid:27109981 |
Baraldo M | Meltdose Tacrolimus Pharmacokinetics. | 2016 | Transplant. Proc. | pmid:27109969 |
Pretagostini R et al. | Delayed Introduction of Everolimus in De Novo Renal Transplanted Patients: A Single-Center Experience. | 2016 | Transplant. Proc. | pmid:27109947 |
Felix MJ et al. | Time-Dependent and Immunosuppressive Drug-Associated Adverse Event Profiles in De Novo Kidney Transplant Recipients Converted from Tacrolimus to Sirolimus Regimens. | 2016 | Pharmacotherapy | pmid:26799522 |
Kishida N et al. | Increased Incidence of Thrombotic Microangiopathy After ABO-Incompatible Living Donor Liver Transplantation. | 2016 | Ann. Transplant. | pmid:27956735 |
Lonowski S et al. | Vitiligo: a potential autoimmune sequela of DRESS syndrome. | 2016 | Br. J. Dermatol. | pmid:27038429 |
Wang Y et al. | Preparation, characterization and in vivo evaluation of amorphous tacrolimus nanosuspensions produced using CO2-assisted in situ nanoamorphization method. | 2016 | Int J Pharm | pmid:27034003 |
Jimbo H et al. | Telangiectatic lichen sclerosus on the cheek successfully treated with topical tacrolimus. | 2016 | Eur J Dermatol | pmid:27033557 |
Shimizu K et al. | Specific delivery of an immunosuppressive drug to splenic B cells by antigen-modified liposomes and its antiallergic effect. | 2016 | J Drug Target | pmid:27030163 |
Vanhove T et al. | High Intrapatient Variability of Tacrolimus Concentrations Predicts Accelerated Progression of Chronic Histologic Lesions in Renal Recipients. | 2016 | Am. J. Transplant. | pmid:27013142 |
Yan Y et al. | Robust Axonal Regeneration in a Mouse Vascularized Composite Allotransplant Model Undergoing Delayed Tissue Rejection. | 2016 | Hand (N Y) | pmid:28149214 |
Ha DH et al. | Potential differentiation ability of gingiva originated human mesenchymal stem cell in the presence of tacrolimus. | 2016 | Sci Rep | pmid:27721434 |
Taşoğlu Ö et al. | Pregabalin: A New Adjunct in Calcineurin Inhibitor Pain Syndrome Treatment. | 2016 | Prog Transplant | pmid:27312682 |
Carrillo-Ibarra S et al. | The Oxidative and Inflammatory State in Patients with Acute Renal Graft Dysfunction Treated with Tacrolimus. | 2016 | Oxid Med Cell Longev | pmid:27872679 |
Thomusch O et al. | Rabbit-ATG or basiliximab induction for rapid steroid withdrawal after renal transplantation (Harmony): an open-label, multicentre, randomised controlled trial. | 2016 | Lancet | pmid:27871759 |