tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
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| Bush WW | Overview of transplantation immunology and the pharmacotherapy of adult solid organ transplant recipients: focus on immunosuppression. | 1999 | AACN Clin Issues | pmid:10578712 |
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| Sy SK et al. | A Markov chain model to evaluate the effect of CYP3A5 and ABCB1 polymorphisms on adverse events associated with tacrolimus in pediatric renal transplantation. | 2013 | AAPS J | pmid:23990505 |
| Herskovitz J et al. | Immune Suppression During Preclinical Drug Development Mitigates Immunogenicity-Mediated Impact on Therapeutic Exposure. | 2017 | AAPS J | pmid:28070711 |
| Tremblay S and Alloway RR | Clinical Evaluation of Modified Release and Immediate Release Tacrolimus Formulations. | 2017 | AAPS J | pmid:28717926 |
| Colombo M et al. | Influence of Drug Brittleness, Nanomilling Time, and Freeze-Drying on the Crystallinity of Poorly Water-Soluble Drugs and Its Implications for Solubility Enhancement. | 2017 | AAPS PharmSciTech | pmid:28168626 |
| Pawar SK and Vavia PR | Rice germ oil as multifunctional excipient in preparation of self-microemulsifying drug delivery system (SMEDDS) of tacrolimus. | 2012 | AAPS PharmSciTech | pmid:22232022 |
| Borhade V et al. | Design and evaluation of self-microemulsifying drug delivery system (SMEDDS) of tacrolimus. | 2008 | AAPS PharmSciTech | pmid:18446456 |
| Zeng K et al. | Dissolution Test of Tacrolimus Capsule: Effects of Filtration and Glass Adsorption. | 2018 | AAPS PharmSciTech | pmid:28828626 |
| Nekkanti V et al. | Design, Characterization, and In Vivo Pharmacokinetics of Tacrolimus Proliposomes. | 2016 | AAPS PharmSciTech | pmid:26729532 |
| Binkhathlan Z et al. | Reutilization of Tacrolimus Extracted from Expired Prograf® Capsules: Physical, Chemical, and Pharmacological Assessment. | 2016 | AAPS PharmSciTech | pmid:26729529 |
| Wang YB et al. | In vitro and in vivo performance of dry powder inhalation formulations: comparison of particles prepared by thin film freezing and micronization. | 2014 | AAPS PharmSciTech | pmid:24824172 |
| Obaidat RM et al. | Using Supercritical Fluid Technology (SFT) in Preparation of Tacrolimus Solid Dispersions. | 2017 | AAPS PharmSciTech | pmid:27116202 |
| Wang N et al. | Paclitaxel and Tacrolimus Coencapsulated Polymeric Micelles That Enhance the Therapeutic Effect of Drug-Resistant Ovarian Cancer. | 2016 | ACS Appl Mater Interfaces | pmid:26809267 |
| Harikishore A et al. | Adamantyl derivative as a potent inhibitor of Plasmodium FK506 binding protein 35. | 2013 | ACS Med Chem Lett | pmid:24900611 |
| Lechner A et al. | Designed biosynthesis of 36-methyl-FK506 by polyketide precursor pathway engineering. | 2013 | ACS Synth Biol | pmid:23654255 |
| Butler KV et al. | Targeted Gene Repression Using Novel Bifunctional Molecules to Harness Endogenous Histone Deacetylation Activity. | 2018 | ACS Synth Biol | pmid:29073761 |
| Frantzeskaki F et al. | Posterior reversible encephalopathy syndrome in an intensive care unit patient receiving tacrolimus. | 2008 | Acta Anaesthesiol Scand | pmid:18840131 |
| Ricciardi S et al. | Infections and immunosuppression as specific problems in a HIV + patient transplanted for end-stage alcoholic cirrhosis. | 2007 Mar-Apr | Acta Chir. Belg. | pmid:17515275 |
| Vermeulen T et al. | Severe stomatitis complicating immune-suppressive switch after cardiac transplantation. | 2010 May-Jun | Acta Chir. Belg. | pmid:20690519 |
| Morello RJ et al. | Remote ischemic preconditioning and tacrolimus in the fetal small bowel transplant in mice. | 2016 | Acta Cir Bras | pmid:27828601 |
| Cavalli RC et al. | Analysis of the histology of the scar bladder and biochemical parameters of rats with a solitary kidney undergoing immunosuppression with tacrolimus. | 2014 | Acta Cir Bras | pmid:25140592 |
| Inácio CM et al. | Action of tacrolimus on Wistar rat kidneys implanted with Walker 256 carcinosarcoma. | 2010 | Acta Cir Bras | pmid:20126896 |
| Dias PH et al. | Effects of immunosuppression with tacrolimus and mycophenolate mofetil on renal histology and function in single kidney rats submitted to ischemia and reperfusion. | 2015 | Acta Cir Bras | pmid:25714692 |
| Waer M | New immunosuppressive agents for organ transplantation. | 1997 | Acta Clin Belg | pmid:9351290 |
| Liang J et al. | Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution. | 1999 | Acta Crystallogr. D Biol. Crystallogr. | pmid:10089303 |
| Bracher A et al. | Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90. | 2011 | Acta Crystallogr. D Biol. Crystallogr. | pmid:21636895 |
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| Schreier MH | Immunophilins and immunosuppression by cyclosporins and macrolide structures. | 1994 | Acta Derm Venereol Suppl (Stockh) | pmid:7521103 |
| de la Rosa Carrillo D and Christensen OB | Treatment of chronic discoid lupus erythematosus with topical tacrolimus. | 2004 | Acta Derm. Venereol. | pmid:15202845 |
| Reitamo S et al. | Long-term treatment with 0.1% tacrolimus ointment in adults with atopic dermatitis: results of a two-year, multicentre, non-comparative study. | 2007 | Acta Derm. Venereol. | pmid:17721647 |
| Benedix F et al. | Response of ulcerated necrobiosis lipoidica to clofazimine. | 2009 | Acta Derm. Venereol. | pmid:19997705 |
| Honda Y et al. | Disseminated Mycobacterium mantenii infection with multiple purulent cutaneous lesions. | 2015 | Acta Derm. Venereol. | pmid:25881714 |
| Lee HY et al. | Oral mucous membrane pemphigoid: complete response to topical tacrolimus. | 2011 | Acta Derm. Venereol. | pmid:21597668 |