tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Grinyó JM and Petruzzelli S | Once-daily LCP-Tacro MeltDose tacrolimus for the prophylaxis of organ rejection in kidney and liver transplantations. | 2014 | Expert Rev Clin Immunol | pmid:25407098 |
| Hattori Y et al. | Influence of cytochrome P450 3A5 polymorphisms on viral infection incidence in kidney transplant patients treated with tacrolimus. | 2014 | Transplant. Proc. | pmid:24656015 |
| Uchida J et al. | Effects of conversion from a twice-daily tacrolimus to a once-daily tacrolimus on glucose metabolism in stable kidney transplant recipients. | 2014 | Transplant. Proc. | pmid:24656005 |
| Zaltzman JS et al. | A randomized cross-over comparison of short-term exposure of once-daily extended release tacrolimus and twice-daily tacrolimus on renal function in healthy volunteers. | 2014 | Transpl. Int. | pmid:25160518 |
| Misra DP et al. | Pulmonary co-infection with Nocardia and Aspergillus in a patient with adult-onset Still's disease receiving steroids and tacrolimus. | 2014 | BMJ Case Rep | pmid:25398925 |
| Weng LC et al. | Association between use of FK506 and prevalence of post-transplantation diabetes mellitus in kidney transplant patients. | 2014 | Transplant. Proc. | pmid:24656004 |
| Takahashi K et al. | Safety and efficacy of once-daily modified-release tacrolimus in kidney transplant recipients: interim analysis of multicenter postmarketing surveillance in Japan. | 2014 | Transplant. Proc. | pmid:24655975 |
| Wu MJ et al. | Reduced variability of tacrolimus trough level in once-daily tacrolimus-based Taiwanese kidney transplant recipients with high-expressive genotype of cytochrome P450 3A5. | 2014 | Transplant. Proc. | pmid:24655974 |
| Cusinato DA et al. | Relationship of CYP3A5 genotype and ABCB1 diplotype to tacrolimus disposition in Brazilian kidney transplant patients. | 2014 | Br J Clin Pharmacol | pmid:24528196 |
| Gérard C et al. | Determination of the most influential sources of variability in tacrolimus trough blood concentrations in adult liver transplant recipients: a bottom-up approach. | 2014 | AAPS J | pmid:24526611 |
| Leung EK et al. | Clinical evaluation of the QMS® Tacrolimus immunoassay. | 2014 | Clin. Chim. Acta | pmid:24518359 |
| McCormack PL | Extended-release tacrolimus: a review of its use in de novo kidney transplantation. | 2014 | Drugs | pmid:25352392 |
| Qi R et al. | FK506 inhibits the mice glomerular mesangial cells proliferation by affecting the transforming growth factor-β and Smads signal pathways. | 2014 | Ren Fail | pmid:24512120 |
| Mocchegiani F et al. | Tacrolimus and Everolimus de novo versus minimization of standard dosage of Tacrolimus provides a similar renal function at one year after liver transplantation: a case-control matched-pairs analysis. | 2014 | Ann. Transplant. | pmid:25347718 |
| Klawitter J et al. | Mycophenolate mofetil enhances the negative effects of sirolimus and tacrolimus on rat kidney cell metabolism. | 2014 | PLoS ONE | pmid:24497939 |
| Filler G | Finding the optimal therapeutic window for tacrolimus. | 2014 | Pediatr Transplant | pmid:25345999 |
| Okada K et al. | [Single institution experience of HLA-haploidentical hematopoietic stem cell transplantation for children: current problems and perspective]. | 2014 | Rinsho Ketsueki | pmid:24492043 |
| Thölking G et al. | The tacrolimus metabolism rate influences renal function after kidney transplantation. | 2014 | PLoS ONE | pmid:25340655 |
| Méndez A et al. | Pharmacokinetic study of conversion from tacrolimus twice-daily to tacrolimus once-daily in stable lung transplantation. | 2014 | Transplantation | pmid:24492423 |
| Moss MC et al. | Lithium use for bipolar disorder post renal transplant: is mood stabilization without toxicity possible? | 2014 | Transplantation | pmid:24492429 |
| Lipson EJ et al. | Successful administration of ipilimumab to two kidney transplantation patients with metastatic melanoma. | 2014 | J. Clin. Oncol. | pmid:24493726 |
| Hinchliffe E et al. | Therapeutic drug monitoring of ciclosporin A and tacrolimus in heart lung transplant patients using dried blood spots. | 2014 | Ann. Clin. Biochem. | pmid:23939194 |
| Pulsipher MA et al. | The addition of sirolimus to tacrolimus/methotrexate GVHD prophylaxis in children with ALL: a phase 3 Children's Oncology Group/Pediatric Blood and Marrow Transplant Consortium trial. | 2014 | Blood | pmid:24497539 |
| Torres IB et al. | The Interplay between inflammation and fibrosis in kidney transplantation. | 2014 | Biomed Res Int | pmid:24991565 |
| Isoda K et al. | The proton pump inhibitor lansoprazole, but not rabeprazole, the increased blood concentrations of calcineurin inhibitors in Japanese patients with connective tissue diseases. | 2014 | Intern. Med. | pmid:24990333 |
| Wada A et al. | Ribosome display and photo-cross-linking techniques for in vitro identification of target proteins of bioactive small molecules. | 2014 | Anal. Chem. | pmid:24380432 |
| Buendia JA et al. | Effects of combinational CYP3A5 6986A>G polymorphism in graft liver and native intestine on the pharmacokinetics of tacrolimus in liver transplant patients: a meta-analysis. | 2014 | Ther Drug Monit | pmid:24378577 |
| Eid L et al. | Late acute rejection: incidence, risk factors, and effect on graft survival and function. | 2014 | Pediatr Transplant | pmid:24372967 |
| Peng ZG and Tian J | Higher Serum Trough Levels of Tacrolimus Increase 5-Year Allograft Survival in Antibody Positive Renal Transplant Patients. | 2014 | Clin Transpl | pmid:26281147 |
| Filler G et al. | Similar MPA exposure on modified release and regular tacrolimus. | 2014 | Ther Drug Monit | pmid:24365986 |
| Jain A et al. | Delayed introduction of tacrolimus postliver transplant with intravenous mycophenolate mofetil preserves renal function without incurring rejection. | 2014 | Transplantation | pmid:25285953 |
| Gounden V and Soldin SJ | Tacrolimus measurement: building a better immunoassay. | 2014 | Clin. Chem. | pmid:24415738 |
| Basu B | Ofatumumab for rituximab-resistant nephrotic syndrome. | 2014 | N. Engl. J. Med. | pmid:24670185 |
| Takeuchi T et al. | Post-marketing surveillance of the safety and effectiveness of tacrolimus in 3,267 Japanese patients with rheumatoid arthritis. | 2014 | Mod Rheumatol | pmid:24261753 |
| Fukushima A et al. | Therapeutic effects of 0.1% tacrolimus eye drops for refractory allergic ocular diseases with proliferative lesion or corneal involvement. | 2014 | Br J Ophthalmol | pmid:24695688 |
| Cho A et al. | Calcineurin signaling regulates neural induction through antagonizing the BMP pathway. | 2014 | Neuron | pmid:24698271 |
| Czubkowski P et al. | Cardiovascular risk factors after conversion from cyclosporine to tacrolimus in children after liver transplantation. | 2014 | Ann. Transplant. | pmid:25409773 |
| Guitard J et al. | An unexpected diagnosis in a renal-transplant patient with proteinuria treated with everolimus: AL amyloidosis. | 2014 | Clin. Nephrol. | pmid:24040781 |
| Protic M et al. | The effectiveness and safety of rescue treatments in 108 patients with steroid-refractory ulcerative colitis with sequential rescue therapies in a subgroup of patients. | 2014 | J Crohns Colitis | pmid:24908178 |
| Hayashi K et al. | Delayed false elevation of circulating tacrolimus concentrations after cord blood transplantation in a patient with myelodysplastic syndrome. | 2014 | Intern. Med. | pmid:25400189 |
| Sugiyama K et al. | Immune monitoring with a lymphocyte adenosine triphosphate assay in kidney transplant recipients treated with a calcineurin inhibitor. | 2014 | Exp Clin Transplant | pmid:24907718 |
| Lankarani KB et al. | New onset diabetes and impaired fasting glucose after liver transplant: risk analysis and the impact of tacrolimus dose. | 2014 | Exp Clin Transplant | pmid:23902591 |
| Spagnoletti G et al. | Conversion from Prograf to Advagraf in stable kidney transplant recipients: better renal function after 3-year follow-up. | 2014 | Transplant. Proc. | pmid:25242756 |
| Schellekens J et al. | The Maastricht Transplant Center: clinical setting and epitope searches in HLA class II molecules: does the structural localization of a polymorphic site contribute to its immunogenicity? | 2014 | Transpl. Immunol. | pmid:25240735 |
| Liu FL et al. | FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines. | 2014 | J. Biosci. | pmid:24499793 |
| Parks AC et al. | Long-term clearance of linear porokeratosis with tacrolimus, 0.1%, ointment. | 2014 | JAMA Dermatol | pmid:24553841 |
| Xu C et al. | Tacrolimus reversibly reduces insulin secretion, induces insulin resistance, and causes islet cell damage in rats. | 2014 | Int J Clin Pharmacol Ther | pmid:24755137 |
| Ichinose K et al. | [Rare case of systemic lupus erythematosus with encapsulating peritoneal sclerosis during hemodialysis]. | 2014 | Nihon Jinzo Gakkai Shi | pmid:24730352 |
| Schmid S et al. | Volatility of serum creatinine relative to tacrolimus levels predicts kidney transplant rejection. | 2014 | Ann. Transplant. | pmid:25123847 |
| Caraveo G et al. | Calcineurin determines toxic versus beneficial responses to α-synuclein. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25122673 |
| Gajanayake T et al. | A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft. | 2014 | Sci Transl Med | pmid:25122638 |
| Thorat A et al. | Effects of converting tacrolimus formulation from twice-daily to once-daily in liver transplantation recipients. | 2014 | Biomed Res Int | pmid:25121091 |
| Griffith RD et al. | Cells to surgery quiz: September 2014. | 2014 | J. Invest. Dermatol. | pmid:25120152 |
| GarcÃa-GarcÃa B et al. | Frosch' surface microscopy score for the assessment of steroid-induced atrophy. | 2014 | Arch. Dermatol. Res. | pmid:24402286 |
| Gionchetti P and Rizzello F | IBD. Sequential rescue therapy in steroid-refractory ulcerative colitis. | 2014 | Nat Rev Gastroenterol Hepatol | pmid:25023033 |
| Van der Hauwaert C et al. | Expression profiles of genes involved in xenobiotic metabolism and disposition in human renal tissues and renal cell models. | 2014 | Toxicol. Appl. Pharmacol. | pmid:25036895 |
| Helenius-Hietala J et al. | Oral mucosal health in liver transplant recipients and controls. | 2014 | Liver Transpl. | pmid:24142471 |
| Tsuchida T et al. | The development of humanized liver with Rag1 knockout rats. | 2014 | Transplant. Proc. | pmid:24815157 |
| Farkas K et al. | Ability of different rescue therapies to save the bowel in acute, severe, steroid-refractory ulcerative colitis. | 2014 | Expert Rev Gastroenterol Hepatol | pmid:24738535 |
| Hamilton BK and Kalaycio M | Maximizing the benefits of mycophenolate mofetil as graft-versus-host disease prophylaxis. | 2014 | Biol. Blood Marrow Transplant. | pmid:25065905 |
| Shimizu M et al. | Treatment of refractory polyarticular juvenile idiopathic arthritis with tacrolimus. | 2014 | Rheumatology (Oxford) | pmid:25065006 |
| Dai YJ et al. | Effect of pharmacological intervention on MIP-1α, MIP-1β and MCP-1 expression in patients with psoriasis vulgaris. | 2014 | Asian Pac J Trop Med | pmid:25063291 |
| Garriga-Companys S and Labrador-Horrillo M | [Chronic spontaneous urticaria]. | 2014 | Med Clin (Barc) | pmid:24120109 |
| Kurzawski M et al. | Impact of PPARA and POR polymorphisms on tacrolimus pharmacokinetics and new-onset diabetes in kidney transplant recipients. | 2014 | Pharmacogenet. Genomics | pmid:24921414 |
| Marits P et al. | Evaluation of T and B lymphocyte function in clinical practice using a flow cytometry based proliferation assay. | 2014 | Clin. Immunol. | pmid:24909732 |
| Uesugi M et al. | Impact of cytochrome P450 3A5 polymorphism in graft livers on the frequency of acute cellular rejection in living-donor liver transplantation. | 2014 | Pharmacogenet. Genomics | pmid:24911663 |
| Di Stasio D et al. | Oral lichen planus: a narrative review. | 2014 | Front Biosci (Elite Ed) | pmid:24896212 |
| Levinger E et al. | Topical 0.03% tacrolimus for subepithelial infiltrates secondary to adenoviral keratoconjunctivitis. | 2014 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:24696044 |
| Al-Harbi NO et al. | Olmesartan attenuates tacrolimus-induced biochemical and ultrastructural changes in rat kidney tissue. | 2014 | Biomed Res Int | pmid:24987695 |
| Nikitin AV | [Mechanisms of nephrotoxic action of immunodepressants, calcineurine inhibitors]. | 2014 | Antibiot. Khimioter. | pmid:25051716 |
| Sun J et al. | [A preliminary study on the biological characteristics and function of tolerogenic dendritic cells induced by tacrolimus]. | 2014 | Zhonghua Xue Ye Xue Za Zhi | pmid:24985179 |
| GoriaÄnov VA et al. | [Effect of tacrolimus on the results of living related kidney donor transplantation]. | 2014 | Ter. Arkh. | pmid:25095659 |
| Carbajal R et al. | Case report: boldo (Peumus boldus) and tacrolimus interaction in a renal transplant patient. | 2014 | Transplant. Proc. | pmid:24981811 |
| Saracino A et al. | Multidrug-resistance 1 gene single-nucleotide polymorphisms do not influence long-term graft survival after kidney transplantation. | 2014 | Transplant. Proc. | pmid:25242754 |
| Lan X et al. | Efficacy of immunosuppression monotherapy after liver transplantation: a meta-analysis. | 2014 | World J. Gastroenterol. | pmid:25232269 |
| Ji SM et al. | Retrospective evaluation of the effect of mycophenolate mofetil dosage on survival of kidney grafts based on biopsy results. | 2014 | Transplant. Proc. | pmid:25498056 |
| Zhu H et al. | Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF‑1α expression in vivo. | 2014 | Mol Med Rep | pmid:24912495 |
| Van Laecke S et al. | The effect of magnesium supplements on early post-transplantation glucose metabolism: a randomized controlled trial. | 2014 | Transpl. Int. | pmid:24909487 |
| Hosohata K et al. | Association between CYP3A5 genotypes in graft liver and increase in tacrolimus biotransformation from steroid treatment in living-donor liver transplant patients. | 2014 | Drug Metab. Pharmacokinet. | pmid:23955548 |
| Trkulja V et al. | Effect of cyclosporine on steady-state pharmacokinetics of MPA in renal transplant recipients is not affected by the MPA formulation: analysis based on therapeutic drug monitoring data. | 2014 | Ther Drug Monit | pmid:24518562 |
| Foroncewicz B et al. | Cyclosporine is superior to tacrolimus in liver transplant recipients with recurrent psoriasis. | 2014 | Ann. Transplant. | pmid:25163829 |
| Hayashi T and Harada N | Post-translational dual regulation of cytochrome P450 aromatase at the catalytic and protein levels by phosphorylation/dephosphorylation. | 2014 | FEBS J. | pmid:25158681 |
| Savikko J et al. | Different effects of tacrolimus and cyclosporine on PDGF induction and chronic allograft injury: evidence for improved kidney graft outcome. | 2014 | Transpl. Immunol. | pmid:25158212 |
| Kern G et al. | Tacrolimus increases Nox4 expression in human renal fibroblasts and induces fibrosis-related genes by aberrant TGF-beta receptor signalling. | 2014 | PLoS ONE | pmid:24816588 |
| Lebel MJ et al. | Increase in de novo food allergies after pediatric liver transplantation: tacrolimus vs. cyclosporine immunosuppression. | 2014 | Pediatr Transplant | pmid:25156571 |
| Sánchez L et al. | Topical tacrolimus for recurrent penile Crohn's disease. | 2014 | J Crohns Colitis | pmid:24815787 |
| Reynolds BC et al. | Use of belatacept to maintain adequate early immunosuppression in calcineurin-mediated microangiopathic hemolysis post-renal transplant. | 2014 | Pediatr Transplant | pmid:24815506 |
| Kim YE and Eun SC | Effect of FK506 ointment (Protopic) on rat skin allograft model. | 2014 | Transplant. Proc. | pmid:24815165 |
| Lee KM and Eun SC | Experimental canine facial transplantation. | 2014 | Transplant. Proc. | pmid:24815162 |
| Wang J and Fan H | [Assessment of P70S6 kinase phosphorylation after liver transplantation by phospho-flow cytometry]. | 2014 | Zhonghua Yi Xue Za Zhi | pmid:25623311 |
| Osmola-Mańkowska A et al. | Topical tacrolimus vs medium-dose ultraviolet A1 phototherapy in the treatment of atopic dermatitis - a preliminary study in relation to parameters of the epidermal barrier function and high-frequency ultrasonography. | 2014 | Eur Rev Med Pharmacol Sci | pmid:25555886 |
| Ishikawa Y and Bächinger HP | A substrate preference for the rough endoplasmic reticulum resident protein FKBP22 during collagen biosynthesis. | 2014 | J. Biol. Chem. | pmid:24821723 |
| Upadhyay V et al. | Rapid and sensitive UPLC-MS-MS determination of tacrolimus in Wistar rats and human blood. | 2014 | J Chromatogr Sci | pmid:23264321 |
| Hilgers M and Megahed M | [Oral lichen planus. Insight into the pathogenesis and therapeutic options]. | 2014 | Hautarzt | pmid:24722910 |
| Shipkova M et al. | Multi-center analytical evaluation of a novel automated tacrolimus immunoassay. | 2014 | Clin. Biochem. | pmid:24721684 |
| Lin BW et al. | Effect of 0.025% FK-506 eyedrops on botulinum toxin B-induced mouse dry eye. | 2014 | Invest. Ophthalmol. Vis. Sci. | pmid:25491293 |
| Lee SJ et al. | Functional interpretation of metabolomics data as a new method for predicting long-term side effects: treatment of atopic dermatitis in infants. | 2014 | Sci Rep | pmid:25491116 |
| Hsiao FY and Hsu WW | Epidemiology of post-transplant malignancy in Asian renal transplant recipients: a population-based study. | 2014 | Int Urol Nephrol | pmid:24009082 |
| Földes G et al. | Immunosuppressive agents modulate function, growth, and survival of cardiomyocytes and endothelial cells derived from human embryonic stem cells. | 2014 | Stem Cells Dev. | pmid:24192059 |
| Kharfan-Dabaja M et al. | Mycophenolate mofetil versus methotrexate for prevention of graft-versus-host disease in people receiving allogeneic hematopoietic stem cell transplantation. | 2014 | Cochrane Database Syst Rev | pmid:25061777 |