Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Epperla N et al. | Impact of treatment and outcomes for patients with posttransplant drug-associated thrombotic microangiopathy. | 2017 | Transfusion | pmid:28836275 |
Müller EG et al. | Tacrolimus eye drops as monotherapy for vernal keratoconjunctivitis: a randomized controlled trial. | 2017 | Arq Bras Oftalmol | pmid:28832739 |
Charlton M et al. | Everolimus Is Associated With Less Weight Gain Than Tacrolimus 2 Years After Liver Transplantation: Results of a Randomized Multicenter Study. | 2017 | Transplantation | pmid:28817434 |
Ghaffari R et al. | Tacrolimus Eye Drops as Adjunct Therapy in Severe Corneal Endothelial Rejection Refractory to Corticosteroids. | 2017 | Cornea | pmid:28817391 |
van der Merwe Y et al. | An Elastomeric Polymer Matrix, PEUU-Tac, Delivers Bioactive Tacrolimus Transdurally to the CNS in Rat. | 2017 | EBioMedicine | pmid:29208469 |
Kumai Y et al. | Reversible Cerebral Vasoconstriction Syndrome After Heart Transplantation: A Case Report. | 2017 | Transplant. Proc. | pmid:29198694 |
Nazmul MN et al. | Severe Hyperkalemia Complicating Voriconazole Treatment in a Kidney Transplant Recipient With Histoplasmosis: A Case Report. | 2017 | Transplant. Proc. | pmid:29198681 |
Tolkachjov SN et al. | Frontal fibrosing alopecia among men: AÂ clinicopathologic study of 7 cases. | 2017 | J. Am. Acad. Dermatol. | pmid:28716436 |
Ahn SW et al. | A multicenter prospective observational study on the safety and efficacy of tacrolimus in patients with myasthenia gravis. | 2017 | J. Neurol. Sci. | pmid:28716258 |
Savić V et al. | Tacrolimus loaded biocompatible lecithin-based microemulsions with improved skin penetration: Structure characterization and in vitro/in vivo performances. | 2017 | Int J Pharm | pmid:28711641 |
Montenovo MI et al. | Superior Patient and Graft Survival in Adult Liver Transplant with Rabbit Antithymocyte Globulin Induction: Experience with 595 Patients. | 2017 | Exp Clin Transplant | pmid:27309029 |
Berisa Prado S et al. | Topical Tacrolimus for Corneal Subepithelial Infiltrates Secondary to Adenoviral Keratoconjunctivitis. | 2017 | Cornea | pmid:28704319 |
Groll AH et al. | Pharmacokinetic Assessment of Drug-Drug Interactions of Isavuconazole With the Immunosuppressants Cyclosporine, Mycophenolic Acid, Prednisolone, Sirolimus, and Tacrolimus in Healthy Adults. | 2017 | Clin Pharmacol Drug Dev | pmid:27273343 |
Hirai T et al. | The effectiveness of new triple combination therapy using synthetic disease-modifying anti-rheumatic drugs with different pharmacological function against rheumatoid arthritis: the verification by an in vitro and clinical study. | 2017 | Clin. Rheumatol. | pmid:27783236 |
Das B et al. | Alemtuzumab (Campath-1H) therapy for refractory rejections in pediatric heart transplant recipients. | 2017 | Pediatr Transplant | pmid:27862703 |
Tamashiro EY et al. | Influence of CYP3A4 and CYP3A5 polymorphisms on tacrolimus and sirolimus exposure in stable kidney transplant recipients. | 2017 | Drug Metab Pers Ther | pmid:28593920 |
Srinivas NR | Letter: sublingual dosing of tacrolimus in transplant patients-interesting concept to overcome first pass effects. | 2017 | Aliment. Pharmacol. Ther. | pmid:28589592 |
BenÃtez C et al. | Letter: sublingual dosing of tacrolimus in transplant patients-interesting concept to overcome first pass effects. Authors' reply. | 2017 | Aliment. Pharmacol. Ther. | pmid:28589580 |
Gerlach UA et al. | Intragraft and Systemic Immune Parameters Discriminating Between Rejection and Long-Term Graft Function in a Preclinical Model of Intestinal Transplantation. | 2017 | Transplantation | pmid:27607529 |
Efe C et al. | Efficacy and Safety of Mycophenolate Mofetil and Tacrolimus as Second-line Therapy for Patients With Autoimmune Hepatitis. | 2017 | Clin. Gastroenterol. Hepatol. | pmid:28603052 |
Aguiar D et al. | Real-World Multicenter Experience of Immunosuppression Minimization Among 661 Liver Transplant Recipients. | 2017 | Ann. Transplant. | pmid:28461684 |
Justice JA et al. | Disruption of K2.1 somato-dendritic clusters prevents the apoptogenic increase of potassium currents. | 2017 | Neuroscience | pmid:28461216 |
Lu XF et al. | Use of a semi-physiological pharmacokinetic model to investigate the influence of itraconazole on tacrolimus absorption, distribution and metabolism in mice. | 2017 | Xenobiotica | pmid:27533047 |
Zheng X et al. | Effect of FK-506 (tacrolimus) therapy on bone healing of titanium implants: a histometric and biomechanical study in mice. | 2017 | Eur. J. Oral Sci. | pmid:27935130 |
Song K et al. | Engineering of the LysR family transcriptional regulator FkbR1 and its target gene to improve ascomycin production. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28349163 |
Ikeguchi R et al. | Recipient bone marrow-derived stromal cells prolong graft survival in a rat hind limb allotransplantation model. | 2017 | Microsurgery | pmid:27859595 |
Kodama S et al. | Tacrolimus-Induced Reversible Cerebral Vasoconstriction Syndrome with Delayed Multi-Segmental Vasoconstriction. | 2017 | J Stroke Cerebrovasc Dis | pmid:28342655 |
Lichtenberg S et al. | The incidence of post-transplant cancer among kidney transplant recipients is associated with the level of tacrolimus exposure during the first year after transplantation. | 2017 | Eur. J. Clin. Pharmacol. | pmid:28342067 |
Salgüero Fernández I et al. | Rapidly progressive infiltrated plaques in a transplant recipient. | 2017 | Actas Dermosifiliogr | pmid:27677210 |
Zhu J et al. | Granzyme B producing B-cells in renal transplant patients. | 2017 | Clin. Immunol. | pmid:28461110 |
Moes AD et al. | Chlorthalidone Versus Amlodipine for Hypertension in Kidney Transplant Recipients Treated With Tacrolimus: A Randomized Crossover Trial. | 2017 | Am. J. Kidney Dis. | pmid:28259499 |
Terada Y et al. | Tacrolimus Triggers Transient Receptor Potential Vanilloid-1-Dependent Relapse of Pancreatitis-Related Pain in Mice. | 2017 | Pharmacology | pmid:28253495 |
Basu B et al. | Long-term efficacy and safety of common steroid-sparing agents in idiopathic nephrotic children. | 2017 | Clin. Exp. Nephrol. | pmid:27108294 |
Moiseev IS et al. | Pharmacokinetic comparison of cyclosporin A and tacrolimus in graft-versus-host disease prophylaxis. | 2017 | Ann. Hematol. | pmid:28343273 |
Dobbels F et al. | Efficacy of a medication adherence enhancing intervention in transplantation: The MAESTRO-Tx trial. | 2017 | J. Heart Lung Transplant. | pmid:28162931 |
Grant CR et al. | Immunosuppressive drugs affect interferon (IFN)-γ and programmed cell death 1 (PD-1) kinetics in patients with newly diagnosed autoimmune hepatitis. | 2017 | Clin. Exp. Immunol. | pmid:28257599 |
Kaneshiro S et al. | The efficacy and safety of additional administration of tacrolimus in patients with rheumatoid arthritis who showed an inadequate response to tocilizumab. | 2017 | Mod Rheumatol | pmid:27181115 |
Kim D et al. | FK506, an Immunosuppressive Drug, Induces Autophagy by Binding to the V-ATPase Catalytic Subunit A in Neuronal Cells. | 2017 | J. Proteome Res. | pmid:28056508 |
Noda K et al. | Tacrolimus-induced hypertrophic cardiomyopathy in a patient with dermatomyositis. | 2017 | Rheumatology (Oxford) | pmid:28977571 |
Wang J et al. | Metabolic network model guided engineering ethylmalonyl-CoA pathway to improve ascomycin production in Streptomyces hygroscopicus var. ascomyceticus. | 2017 | Microb. Cell Fact. | pmid:28974216 |
Ordóñez-Robles M et al. | Analysis of the Pho regulon in Streptomyces tsukubaensis. | 2017 | Microbiol. Res. | pmid:28942849 |
Jia Y et al. | Estimation of Mycophenolic Acid Area Under the Curve With Limited-Sampling Strategy in Chinese Renal Transplant Recipients Receiving Enteric-Coated Mycophenolate Sodium. | 2017 | Ther Drug Monit | pmid:27941535 |
Cohen JB et al. | Belatacept Compared With Tacrolimus for Kidney Transplantation: A Propensity Score Matched Cohort Study. | 2017 | Transplantation | pmid:27941427 |
Reese PP et al. | Automated Reminders and Physician Notification to Promote Immunosuppression Adherence Among Kidney Transplant Recipients: A Randomized Trial. | 2017 | Am. J. Kidney Dis. | pmid:27940063 |
Kaneko T et al. | Effectiveness of Measuring Genetic Polymorphisms in Metabolizing Enzymes of Tacrolimus within One Medical Facility. | 2017 | J Nippon Med Sch | pmid:29279557 |
Terakura S et al. | Exploratory research for optimal GvHD prophylaxis after single unit CBT in adults: short-term methotrexate reduced the incidence of severe GvHD more than mycophenolate mofetil. | 2017 | Bone Marrow Transplant. | pmid:27941766 |
Andrade LM et al. | Improved tacrolimus skin permeation by co-encapsulation with clobetasol in lipid nanoparticles: Study of drug effects in lipid matrix by electron paramagnetic resonance. | 2017 | Eur J Pharm Biopharm | pmid:28627400 |
Baas M et al. | Unique clinical conditions associated with different acinar regions of fibrosis in long-term surviving pediatric liver grafts. | 2017 | Pediatr Transplant | pmid:28627016 |
Božina N et al. | Steady-state pharmacokinetics of mycophenolic acid in renal transplant patients: exploratory analysis of the effects of cyclosporine, recipients' and donors' ABCC2 gene variants, and their interactions. | 2017 | Eur. J. Clin. Pharmacol. | pmid:28624888 |
Vanhove T et al. | Effect of the Direct Oral Anticoagulants Rivaroxaban and Apixaban on the Disposition of Calcineurin Inhibitors in Transplant Recipients. | 2017 | Ther Drug Monit | pmid:27861314 |