tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Takahashi K et al. | Safety and efficacy of once-daily modified-release tacrolimus in kidney transplant recipients: interim analysis of multicenter postmarketing surveillance in Japan. | 2014 | Transplant. Proc. | pmid:24655975 |
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| Murase N et al. | Induction of liver, heart, and multivisceral graft acceptance with a short course of FK 506. | 1990 | Transplant. Proc. | pmid:1689906 |
| Ericzon BG et al. | Pharmacokinetics of FK 506 during maintenance therapy in liver transplant patients. | 1991 | Transplant. Proc. | pmid:1721273 |
| Tanaka M et al. | Tacrolimus (FK 506)-dependent tolerance after liver and heart xenotransplantation: inhibition of humoral response and acceptance of donor organs. | 1996 | Transplant. Proc. | pmid:8623341 |
| Platz KP et al. | FK506 for primary and rescue therapy following liver transplantation. | 1998 | Transplant. Proc. | pmid:9636570 |
| Hoffman AL et al. | The effect of FK 506 on small intestine allotransplantation in the rat. | 1990 | Transplant. Proc. | pmid:1689907 |
| Ye Q et al. | Functional analysis of hamster kidney xenografts in the rat: possible functional incompatibility and adaptation of hamster kidney grafts in a xenogenic rat environment. | 1996 | Transplant. Proc. | pmid:8623350 |
| Taibi A et al. | Rescue FK506 therapy for acute rejection and early chronic rejection after liver transplantation: report of 14 cases. | 1998 | Transplant. Proc. | pmid:9636571 |
| Shimada H et al. | Existence of serum p53 antibodies in cyclosporine A-treated transplant patients: possible detection of p53 protein over-expression. | 2000 | Transplant. Proc. | pmid:11119931 |
| Vela CG et al. | Prospective study of lipid disorders in FK506-versus cyclosporine-treated renal transplant patients. | 2000 | Transplant. Proc. | pmid:10715453 |
| Rodrigo E et al. | High initial blood levels of tacrolimus in overweight renal transplant recipients. | 2005 | Transplant. Proc. | pmid:15866635 |
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| Armenta Bautista A et al. | Renal Transplantation in Second-Level Private Hospitals in the State of Mexico. | 2018 | Transplant. Proc. | pmid:29579825 |
| Connelly PR | Thermodynamics of interaction of FK 506-binding protein and its ligands. | 1991 | Transplant. Proc. | pmid:1721304 |
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| Goulet O et al. | Small bowel transplantation alone or with the liver in children: changes by using FK506. | 1998 | Transplant. Proc. | pmid:9636636 |
| Hampel G et al. | Different effects of cyclosporine and tacrolimus on the activation of mesangial metalloproteinases and their inhibitors. | 1999 | Transplant. Proc. | pmid:10578279 |
| Ishibashi M et al. | Elimination of the adverse effects of tacrolimus-based induction therapy by a 5-day exposure of optimal steady-state blood concentration in renal transplant patients in the early postoperative period. | 1999 | Transplant. Proc. | pmid:10578281 |
| Yang S et al. | Characteristics of long-term immunosuppressive therapy in Chinese pediatric renal transplant patients: a single-center experience. | 2009 | Transplant. Proc. | pmid:20005361 |
| Hohage H et al. | Cyclosporine and tacrolimus: influence on cardiovascular risk factors. | 2005 | Transplant. Proc. | pmid:15848615 |
| Seymen P et al. | Effects of cyclosporine-tacrolimus switching in posttransplantation hyperlipidemia on high-density lipoprotein 2/3, lipoprotein a1/b, and other lipid parameters. | 2009 | Transplant. Proc. | pmid:20005364 |
| Schuller S et al. | Daclizumab induction therapy associated with tacrolimus-MMF has better outcome compared with tacrolimus-MMF alone in pediatric living donor liver transplantation. | 2005 | Transplant. Proc. | pmid:15848653 |
| Nassar CA et al. | Effects of long-term FK 506 therapy on the alveolar bone and cementum of rats. | 2009 | Transplant. Proc. | pmid:19545747 |
| Karabulut AB and Ara C | Melatonin ameliorates tacrolimus (FK-506)'s induced immunosupressive effect in rat liver. | 2009 | Transplant. Proc. | pmid:19545748 |
| Demirbas A et al. | FK 506 in simultaneous pancreas/kidney transplantation: the University of Miami experience. | 1997 | Transplant. Proc. | pmid:9365608 |
| Kliem V et al. | Long-term results after primary successful FK 506 treatment of steroid- and OKT3-resistant rejection in renal transplant recipients. | 1997 | Transplant. Proc. | pmid:9365627 |
| Hryniewiecka E et al. | Arterial hypertension in liver transplant recipients. | 2011 | Transplant. Proc. | pmid:21996217 |
| Mayer AD | Chronic rejection and graft half-life: five-year follow-up of the European Tacrolimus Multicenter Renal Study. | 2002 | Transplant. Proc. | pmid:12176452 |
| Bäckman L et al. | Whole blood and plasma levels of FK 506 after liver transplantation: correlation with toxicity. | 1994 | Transplant. Proc. | pmid:7518160 |
| Abu-Elmagd K et al. | Management of intestinal transplantation in humans. | 1992 | Transplant. Proc. | pmid:1376523 |
| Celli S et al. | Mechanisms of protection from humoral rejection by a xenografted liver. | 1995 | Transplant. Proc. | pmid:7533395 |
| Woodle ES et al. | FK 506: reversal of humorally mediated rejection following ABO-incompatible liver transplantation. | 1991 | Transplant. Proc. | pmid:1721337 |
| Weimer R et al. | sCD30 and neopterin as risk factors of chronic renal transplant rejection: impact of cyclosporine A, tacrolimus, and mycophenolate mofetil. | 2005 | Transplant. Proc. | pmid:15919463 |
| Allers C et al. | Tacrolimus, daclizumab, sirolimus, and budesonide after small bowel transplantation in order to reduce nephrotoxicity. | 2002 | Transplant. Proc. | pmid:12034251 |
| Rosh JR et al. | Therapy with FK 506 in pediatric liver recipients. | 1994 | Transplant. Proc. | pmid:7509091 |
| Scantlebury VP et al. | Pediatric kidney transplantation at the University of Pittsburgh. | 1994 | Transplant. Proc. | pmid:7509095 |
| Souza ER et al. | Acute effects of FK 506 on glomerular hemodynamics. | 1992 | Transplant. Proc. | pmid:1281585 |
| Takayama J et al. | Living related liver transplantation in patients with ABO incompatibility. | 1998 | Transplant. Proc. | pmid:9838537 |
| Hamano I et al. | Condyloma Acuminata of the Urethra in a Male Renal Transplant Recipient: A Case Report. | 2018 | Transplant. Proc. | pmid:30316397 |
| Darras FS et al. | Transplantation of pediatric en bloc kidneys under FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721368 |
| Wu MS et al. | Cyclosporine, but not FK 506 and rapamycin, enhances cell proliferation in mouse medullary thick ascending cultured cells. | 1998 | Transplant. Proc. | pmid:9838561 |
| Shapiro R et al. | Kidney transplantation under FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1703352 |
| Todo S et al. | Clinical small bowel or small bowel plus liver transplantation under FK 506. | 1991 | Transplant. Proc. | pmid:1721369 |
| Scott JS et al. | Tacrolimus: a cause of hypertrophic cardiomyopathy in pediatric heart transplant recipients? | 1999 Feb-Mar | Transplant. Proc. | pmid:10083017 |
| Tzakis AG et al. | Use of FK 506 in pediatric patients. | 1991 | Transplant. Proc. | pmid:1703353 |
| Meiser BM et al. | The efficacy of the combination of tacrolimus and mycophenolate mofetil for prevention of acute myocardial rejection is dependent on routine monitoring of mycophenolic acid trough acid levels. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083018 |
| Crespo-Leiro MG | Tacrolimus in heart transplantation. | 2003 | Transplant. Proc. | pmid:12962869 |
| Rayes N et al. | Distribution of lymphocyte subtypes in liver transplant recipients. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123103 |
| Platz KP et al. | Impact of immunosuppression and acute rejection on hepatitis B recurrence. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123107 |
| Asfar S et al. | Small bowel transplantation. | 1996 | Transplant. Proc. | pmid:8908039 |
| Reyes J et al. | Intestinal transplantation in children: five-year experience. | 1996 | Transplant. Proc. | pmid:8908042 |
| Dietl KH | Oral dosing of tacrolimus and cyclosporine microemulsion--results from a large multicenter study in renal transplantation. | 2002 | Transplant. Proc. | pmid:12176524 |
| San Miguel C et al. | Immunosuppression Strategies in the Treatment of Hepatocellular Carcinoma in Virgen de las Nieves University Hospital. | 2015 | Transplant. Proc. | pmid:26518930 |
| Miura K et al. | Development of the Intestinal Transplantation Model With Major Histocompatibility Complex Inbred CLAWN Miniature Swine. | 2016 | Transplant. Proc. | pmid:27320612 |
| Lee HK et al. | Expression of Endoplasmic Reticulum-Mediated Stress Proteins in FK506-Treated T-Lymphocytes. | 2016 | Transplant. Proc. | pmid:27320607 |
| Ito A et al. | Induction of tolerance in rat cardiac allograft model by intrathymic injection of donor bone marrow cells. | 1995 | Transplant. Proc. | pmid:7536974 |
| Park JW et al. | Invasive pulmonary aspergillosis after living donor liver transplantation should be eradicated or not? A case report. | 2011 Jul-Aug | Transplant. Proc. | pmid:21839284 |
| DiMartini A et al. | Psychiatric morbidity in liver transplant patients. | 1991 | Transplant. Proc. | pmid:1721399 |
| Steinmueller T et al. | The effect of cyclosporine vs FK 506 on glucose metabolism. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083504 |
| Moutabarrik A et al. | Effect of FK 506 and cyclosporine on the expression of IL-6 and its receptor on stimulated monocytes. | 1993 | Transplant. Proc. | pmid:7685949 |
| Ochiai T et al. | Comparative studies on the immunosuppressive activity of FK506, 15-deoxyspergualin, and cyclosporine. | 1989 | Transplant. Proc. | pmid:2468228 |
| Bhaloo S and Prasad GV | Severe reduction in tacrolimus levels with rifampin despite multiple cytochrome P450 inhibitors: a case report. | 2003 | Transplant. Proc. | pmid:14611983 |
| Iacona I et al. | Mycophenolic acid in combination with FK 506: a pharmacokinetic study in piglets after small-bowel transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123489 |
| Migita K and Eguchi K | FK 506-mediated T-cell apoptosis induction. | 2001 | Transplant. Proc. | pmid:11377532 |
| Omoto K et al. | Adverse events in renal transplantation under tacrolimus/mycophnolate mofetil immunosuppression: a single-center experience. | 2002 | Transplant. Proc. | pmid:12176591 |
| Nakache R et al. | Management of massive proteinuria following renal transplantation with mycophenolate mofetil and blood pressure normalization. | 2001 | Transplant. Proc. | pmid:11377533 |
| Baran DA et al. | A novel tacrolimus dosing strategy in cardiac transplantation: drug levels, renal function, and biopsy results. | 2002 | Transplant. Proc. | pmid:12176595 |
| Canivet C et al. | T-cell function in maintenance renal transplant patients receiving mycophenolate mofetil and steroids with or without tacrolimus. | 2008 | Transplant. Proc. | pmid:19100403 |
| Maass E et al. | Decrease in serum tacrolimus level and rise in serum creatinine under late addition of cinacalcet in a renal transplant recipient with hyperparathyroidism: a case report. | 2007 | Transplant. Proc. | pmid:18089410 |
| Shishido S et al. | Pharmacokinetics of tacrolimus in pediatric renal transplant recipients. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267193 |
| Valdivia LA et al. | Differential survival of hamster-to-rat liver and cardiac xenografts under FK 506 immunosuppression. | 1991 | Transplant. Proc. | pmid:1721432 |
| Kawano K et al. | FK506 reduces oxidative hepatic injury following cold ischemic preservation and transplantation. | 1996 | Transplant. Proc. | pmid:8658938 |
| Ochiai T et al. | Prolongation of canine renal allograft survival by treatment with FK-506. | 1987 | Transplant. Proc. | pmid:2445075 |
| Atillasoy E et al. | Cholesterol levels long-term after liver transplant. | 1998 | Transplant. Proc. | pmid:9723387 |
| Quijano Y et al. | Tolerance: a study in long-term surviving animals after small bowel transplantation. | 1998 | Transplant. Proc. | pmid:9745494 |
| Ito T et al. | Therapeutic Effect of Sirolimus for Lymphangioleiomyomatosis Remaining in the Abdominopelvic Region After Lung Transplantation: A Case Report. | Transplant. Proc. | pmid:26915883 | |
| Lee KM and Eun SC | Experimental canine facial transplantation. | 2014 | Transplant. Proc. | pmid:24815162 |
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| Mehra MR et al. | A randomized comparison of an immunosuppressive strategy using tacrolimus and cyclosporine in black heart transplant recipients. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267438 |
| McManus BM et al. | Impact of FK 506 on myocarditis in the enteroviral murine model. | 1991 | Transplant. Proc. | pmid:1721463 |
| Nossal GJ | Summary of the First International FK 506 Congress: perspectives and prospects. | 1991 | Transplant. Proc. | pmid:1721464 |
| Fujimura T et al. | Cellular surface molecular and cytokine gene expression in rat heart allografts under optimal doses of cyclosporine and FK 506. | 1998 | Transplant. Proc. | pmid:9636413 |
| Yoshimura N et al. | Development of a macromolecular prodrug of FK 506: III: In vivo disposition of FK 506-dextran conjugate. | 1998 | Transplant. Proc. | pmid:9636415 |
| Tariciotti L et al. | Everolimus and Advagraf Ab Initio in Combined Liver and Kidney Transplant With Donor-Specific Antibodies: A Case Report. | 2016 | Transplant. Proc. | pmid:27932158 |
| Sevmis S et al. | Tacrolimus-related seizure in the early postoperative period after liver transplantation. | 2007 | Transplant. Proc. | pmid:17524935 |
| Ott R et al. | Conversion from tacrolimus to Neoral in liver and kidney transplant recipients. | 2001 Nov-Dec | Transplant. Proc. | pmid:11750359 |
| Badiou S et al. | Small dense low-density lipoprotein in renal transplant recipients: a potential target for prevention of cardiovascular complications? | 2006 | Transplant. Proc. | pmid:16980076 |
| Pillet A et al. | Monitoring HCMV infection with quantitative real-time PCR in HCMV-positive orthotopic liver transplant recipients, and predictive factors for treatment of the first episode of HCMV viremia. | 2006 | Transplant. Proc. | pmid:16980083 |
| Goto S et al. | Effect of FK 506 and cyclosporine on heart allograft survival in rats. | 1991 | Transplant. Proc. | pmid:1703700 |
| White SA et al. | Influence of delayed graft function in renal transplants from cadaveric or non-heart-beating donors. | 2000 | Transplant. Proc. | pmid:10701018 |
| Sens YA et al. | Posttransplant diabetes mellitus in renal transplant patients with hepatitis C virus. | 2004 | Transplant. Proc. | pmid:15194304 |
| Kliem V et al. | Tacrolimus for steroid- and OKT3-resistant rejection in kidney recipients. | 1998 | Transplant. Proc. | pmid:9636509 |