Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with tacrolimus
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Epperla N et al. | Impact of treatment and outcomes for patients with posttransplant drug-associated thrombotic microangiopathy. | 2017 | Transfusion | pmid:28836275 |
Müller EG et al. | Tacrolimus eye drops as monotherapy for vernal keratoconjunctivitis: a randomized controlled trial. | 2017 | Arq Bras Oftalmol | pmid:28832739 |
Charlton M et al. | Everolimus Is Associated With Less Weight Gain Than Tacrolimus 2 Years After Liver Transplantation: Results of a Randomized Multicenter Study. | 2017 | Transplantation | pmid:28817434 |
van der Merwe Y et al. | An Elastomeric Polymer Matrix, PEUU-Tac, Delivers Bioactive Tacrolimus Transdurally to the CNS in Rat. | 2017 | EBioMedicine | pmid:29208469 |
Kumai Y et al. | Reversible Cerebral Vasoconstriction Syndrome After Heart Transplantation: A Case Report. | 2017 | Transplant. Proc. | pmid:29198694 |
Tolkachjov SN et al. | Frontal fibrosing alopecia among men: AÂ clinicopathologic study of 7 cases. | 2017 | J. Am. Acad. Dermatol. | pmid:28716436 |
Ahn SW et al. | A multicenter prospective observational study on the safety and efficacy of tacrolimus in patients with myasthenia gravis. | 2017 | J. Neurol. Sci. | pmid:28716258 |
Savić V et al. | Tacrolimus loaded biocompatible lecithin-based microemulsions with improved skin penetration: Structure characterization and in vitro/in vivo performances. | 2017 | Int J Pharm | pmid:28711641 |
Montenovo MI et al. | Superior Patient and Graft Survival in Adult Liver Transplant with Rabbit Antithymocyte Globulin Induction: Experience with 595 Patients. | 2017 | Exp Clin Transplant | pmid:27309029 |
Groll AH et al. | Pharmacokinetic Assessment of Drug-Drug Interactions of Isavuconazole With the Immunosuppressants Cyclosporine, Mycophenolic Acid, Prednisolone, Sirolimus, and Tacrolimus in Healthy Adults. | 2017 | Clin Pharmacol Drug Dev | pmid:27273343 |
Hirai T et al. | The effectiveness of new triple combination therapy using synthetic disease-modifying anti-rheumatic drugs with different pharmacological function against rheumatoid arthritis: the verification by an in vitro and clinical study. | 2017 | Clin. Rheumatol. | pmid:27783236 |
Das B et al. | Alemtuzumab (Campath-1H) therapy for refractory rejections in pediatric heart transplant recipients. | 2017 | Pediatr Transplant | pmid:27862703 |
Tamashiro EY et al. | Influence of CYP3A4 and CYP3A5 polymorphisms on tacrolimus and sirolimus exposure in stable kidney transplant recipients. | 2017 | Drug Metab Pers Ther | pmid:28593920 |
Srinivas NR | Letter: sublingual dosing of tacrolimus in transplant patients-interesting concept to overcome first pass effects. | 2017 | Aliment. Pharmacol. Ther. | pmid:28589592 |
BenÃtez C et al. | Letter: sublingual dosing of tacrolimus in transplant patients-interesting concept to overcome first pass effects. Authors' reply. | 2017 | Aliment. Pharmacol. Ther. | pmid:28589580 |
Gerlach UA et al. | Intragraft and Systemic Immune Parameters Discriminating Between Rejection and Long-Term Graft Function in a Preclinical Model of Intestinal Transplantation. | 2017 | Transplantation | pmid:27607529 |
Fai D et al. | Duration of response in vitiligo lesions after narrowband UVB phototherapy combined with tacrolimus ointment. | 2017 | G Ital Dermatol Venereol | pmid:28621124 |
Efe C et al. | Efficacy and Safety of Mycophenolate Mofetil and Tacrolimus as Second-line Therapy for Patients With Autoimmune Hepatitis. | 2017 | Clin. Gastroenterol. Hepatol. | pmid:28603052 |
Nakagawa K et al. | Immunosuppressive treatment using tacrolimus promotes pregnancy outcome in infertile women with repeated implantation failures. | 2017 | Am. J. Reprod. Immunol. | pmid:28466977 |
Ramirez R et al. | Posterior Reversible Encephalopathy Syndrome After Orthotopic Heart Transplantation: A Case Report. | 2017 | Am J Case Rep | pmid:28465499 |
Aguiar D et al. | Real-World Multicenter Experience of Immunosuppression Minimization Among 661 Liver Transplant Recipients. | 2017 | Ann. Transplant. | pmid:28461684 |
Justice JA et al. | Disruption of K2.1 somato-dendritic clusters prevents the apoptogenic increase of potassium currents. | 2017 | Neuroscience | pmid:28461216 |
Lu XF et al. | Use of a semi-physiological pharmacokinetic model to investigate the influence of itraconazole on tacrolimus absorption, distribution and metabolism in mice. | 2017 | Xenobiotica | pmid:27533047 |
Zheng X et al. | Effect of FK-506 (tacrolimus) therapy on bone healing of titanium implants: a histometric and biomechanical study in mice. | 2017 | Eur. J. Oral Sci. | pmid:27935130 |
Song K et al. | Engineering of the LysR family transcriptional regulator FkbR1 and its target gene to improve ascomycin production. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28349163 |
Ikeguchi R et al. | Recipient bone marrow-derived stromal cells prolong graft survival in a rat hind limb allotransplantation model. | 2017 | Microsurgery | pmid:27859595 |
Kodama S et al. | Tacrolimus-Induced Reversible Cerebral Vasoconstriction Syndrome with Delayed Multi-Segmental Vasoconstriction. | 2017 | J Stroke Cerebrovasc Dis | pmid:28342655 |
Wan T et al. | Effects of nanoparticles with hydrotropic nicotinamide on tacrolimus: permeability through psoriatic skin and antipsoriatic and antiproliferative activities. | 2017 | Int J Nanomedicine | pmid:28260894 |
Zhu J et al. | Granzyme B producing B-cells in renal transplant patients. | 2017 | Clin. Immunol. | pmid:28461110 |
Solari S et al. | Sublingual tacrolimus administration provides similar drug exposure to per-oral route employing lower doses in liver transplantation: a pilot study. | 2017 | Aliment. Pharmacol. Ther. | pmid:28261844 |
Moes AD et al. | Chlorthalidone Versus Amlodipine for Hypertension in Kidney Transplant Recipients Treated With Tacrolimus: A Randomized Crossover Trial. | 2017 | Am. J. Kidney Dis. | pmid:28259499 |
Basu B et al. | Long-term efficacy and safety of common steroid-sparing agents in idiopathic nephrotic children. | 2017 | Clin. Exp. Nephrol. | pmid:27108294 |
Moiseev IS et al. | Pharmacokinetic comparison of cyclosporin A and tacrolimus in graft-versus-host disease prophylaxis. | 2017 | Ann. Hematol. | pmid:28343273 |
Tremblay S et al. | A Steady-State Head-to-Head Pharmacokinetic Comparison of All FK-506 (Tacrolimus) Formulations (ASTCOFF): An Open-Label, Prospective, Randomized, Two-Arm, Three-Period Crossover Study. | 2017 | Am. J. Transplant. | pmid:27340950 |
Dobbels F et al. | Efficacy of a medication adherence enhancing intervention in transplantation: The MAESTRO-Tx trial. | 2017 | J. Heart Lung Transplant. | pmid:28162931 |
Grant CR et al. | Immunosuppressive drugs affect interferon (IFN)-γ and programmed cell death 1 (PD-1) kinetics in patients with newly diagnosed autoimmune hepatitis. | 2017 | Clin. Exp. Immunol. | pmid:28257599 |
Qin HZ et al. | Evaluating tacrolimus treatment in idiopathic membranous nephropathy in a cohort of 408 patients. | 2017 | BMC Nephrol | pmid:28056860 |
Kim D et al. | FK506, an Immunosuppressive Drug, Induces Autophagy by Binding to the V-ATPase Catalytic Subunit A in Neuronal Cells. | 2017 | J. Proteome Res. | pmid:28056508 |
Dong Y et al. | Risk Factors, Clinical Features, and Treatment Outcomes of Recurrent Mooren Ulcers in China. | 2017 | Cornea | pmid:28060068 |
Noda K et al. | Tacrolimus-induced hypertrophic cardiomyopathy in a patient with dermatomyositis. | 2017 | Rheumatology (Oxford) | pmid:28977571 |
Wang J et al. | Metabolic network model guided engineering ethylmalonyl-CoA pathway to improve ascomycin production in Streptomyces hygroscopicus var. ascomyceticus. | 2017 | Microb. Cell Fact. | pmid:28974216 |
Jia Y et al. | Estimation of Mycophenolic Acid Area Under the Curve With Limited-Sampling Strategy in Chinese Renal Transplant Recipients Receiving Enteric-Coated Mycophenolate Sodium. | 2017 | Ther Drug Monit | pmid:27941535 |
Cohen JB et al. | Belatacept Compared With Tacrolimus for Kidney Transplantation: A Propensity Score Matched Cohort Study. | 2017 | Transplantation | pmid:27941427 |
Kaneko T et al. | Effectiveness of Measuring Genetic Polymorphisms in Metabolizing Enzymes of Tacrolimus within One Medical Facility. | 2017 | J Nippon Med Sch | pmid:29279557 |
Terakura S et al. | Exploratory research for optimal GvHD prophylaxis after single unit CBT in adults: short-term methotrexate reduced the incidence of severe GvHD more than mycophenolate mofetil. | 2017 | Bone Marrow Transplant. | pmid:27941766 |
Naicker D et al. | Nationwide conversion to generic tacrolimus in pediatric kidney transplant recipients. | 2017 | Pediatr. Nephrol. | pmid:28660366 |
Kannegieter NM et al. | Pharmacodynamic Monitoring of Tacrolimus-Based Immunosuppression in CD14+ Monocytes After Kidney Transplantation. | 2017 | Ther Drug Monit | pmid:28640063 |
Andrade LM et al. | Improved tacrolimus skin permeation by co-encapsulation with clobetasol in lipid nanoparticles: Study of drug effects in lipid matrix by electron paramagnetic resonance. | 2017 | Eur J Pharm Biopharm | pmid:28627400 |
Baas M et al. | Unique clinical conditions associated with different acinar regions of fibrosis in long-term surviving pediatric liver grafts. | 2017 | Pediatr Transplant | pmid:28627016 |
Vanhove T et al. | Effect of the Direct Oral Anticoagulants Rivaroxaban and Apixaban on the Disposition of Calcineurin Inhibitors in Transplant Recipients. | 2017 | Ther Drug Monit | pmid:27861314 |