tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Immunoblastic Lymphadenopathy D007119 2 associated lipids
Ileal Neoplasms D007078 2 associated lipids
Hypothermia D007035 19 associated lipids
Hypotension D007022 41 associated lipids
Hypoglycemia D007003 13 associated lipids
Hypertension, Renal D006977 9 associated lipids
Hypertension, Portal D006975 12 associated lipids
Hypertension D006973 115 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypersensitivity D006967 22 associated lipids
Hyperparathyroidism, Secondary D006962 4 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hyperkalemia D006947 3 associated lipids
Hyperglycemia D006943 21 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hypercalcemia D006934 13 associated lipids
Hyperbilirubinemia D006932 11 associated lipids
Hyperalgesia D006930 42 associated lipids
Hydronephrosis D006869 4 associated lipids
Deltaretrovirus Infections D006800 1 associated lipids
HIV Seropositivity D006679 15 associated lipids
Herpesviridae Infections D006566 4 associated lipids
Herpes Labialis D006560 1 associated lipids
Hernia, Ventral D006555 1 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hepatolenticular Degeneration D006527 3 associated lipids
Hepatitis C D006526 7 associated lipids
Hepatitis, Viral, Animal D006524 4 associated lipids
Hepatic Veno-Occlusive Disease D006504 1 associated lipids
Budd-Chiari Syndrome D006502 1 associated lipids
Hemorrhage D006470 15 associated lipids
Hemophilia A D006467 10 associated lipids
Hemolytic-Uremic Syndrome D006463 2 associated lipids
Hemolysis D006461 131 associated lipids
Hematuria D006417 13 associated lipids
Hematoma D006406 5 associated lipids
Hematologic Diseases D006402 3 associated lipids
Heart Injuries D006335 6 associated lipids
Heart Failure D006333 36 associated lipids
Cardiomegaly D006332 31 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Hearing Loss, Noise-Induced D006317 4 associated lipids
Hearing Loss, Bilateral D006312 1 associated lipids
Headache D006261 4 associated lipids
Hand Injuries D006230 1 associated lipids
Hand Dermatoses D006229 5 associated lipids
Hallucinations D006212 4 associated lipids
Gynecomastia D006177 6 associated lipids
Graves Disease D006111 6 associated lipids
Granuloma, Giant Cell D006101 7 associated lipids
Graft Occlusion, Vascular D006083 11 associated lipids
Gout D006073 4 associated lipids
Glycosuria D006029 10 associated lipids
Glomerulosclerosis, Focal Segmental D005923 4 associated lipids
Glomerulonephritis D005921 35 associated lipids
Gliosis D005911 6 associated lipids
Glioma D005910 112 associated lipids
Gingivitis D005891 3 associated lipids
Gingival Hyperplasia D005885 3 associated lipids
Castleman Disease D005871 3 associated lipids
Genital Diseases, Female D005831 7 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Gastroenteritis D005759 4 associated lipids
Fractures, Spontaneous D005598 4 associated lipids
Fox-Fordyce Disease D005588 2 associated lipids
Foot Dermatoses D005533 3 associated lipids
Foot Deformities, Acquired D005531 2 associated lipids
Food Hypersensitivity D005512 7 associated lipids
Folliculitis D005499 7 associated lipids
Fistula D005402 8 associated lipids
Fibrosis D005355 23 associated lipids
Fever D005334 35 associated lipids
Fetal Hypoxia D005311 3 associated lipids
Femur Head Necrosis D005271 5 associated lipids
Fatty Liver D005234 48 associated lipids
Fatigue D005221 10 associated lipids
Facial Neoplasms D005153 3 associated lipids
Facial Dermatoses D005148 7 associated lipids
Eye Diseases D005128 12 associated lipids
Exanthema D005076 11 associated lipids
Esophageal Perforation D004939 1 associated lipids
Erythroplasia D004919 1 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Erythema Nodosum D004893 5 associated lipids
Erythema D004890 22 associated lipids
Epilepsy, Temporal Lobe D004833 4 associated lipids
Epididymitis D004823 1 associated lipids
Epidermolysis Bullosa D004820 3 associated lipids
Enterobacteriaceae Infections D004756 5 associated lipids
Endomyocardial Fibrosis D004719 4 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Encephalitis D004660 15 associated lipids
Edema D004487 152 associated lipids
Eczema D004485 4 associated lipids
Ecthyma, Contagious D004474 1 associated lipids
Echinostomiasis D004451 1 associated lipids
Earache D004433 2 associated lipids
Dyspnea D004417 10 associated lipids
Dysplastic Nevus Syndrome D004416 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

Download all related citations
Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
pmid:8615615
Payabvash S et al. Cerebellar superficial siderosis of chronic subarachnoid hemorrhage in a patient with Tacrolimus-associated posterior reversible encephalopathy. J Postgrad Med pmid:25370549
Akoglu H et al. Relationship between hemorheology and endothelial dysfunction in renal transplant patients receiving calcineurin inhibitors. J. Nephrol. pmid:23147686
Omland SH and Gniadecki R Psoriasis inversa: A separate identity or a variant of psoriasis vulgaris? Clin. Dermatol. pmid:26051061
pmid:19200227
Chia BK and Tey HL Systematic review on the efficacy, safety, and cost-effectiveness of topical calcineurin inhibitors in atopic dermatitis. Dermatitis pmid:25984688
Luger T et al. Recommendations for pimecrolimus 1% cream in the treatment of mild-to-moderate atopic dermatitis: from medical needs to a new treatment algorithm. Eur J Dermatol pmid:24185493
Park J et al. Persistent generalized lichen nitidus successfully treated with 0.03% tacrolimus ointment. Eur J Dermatol pmid:24184632
Fernández C et al. Kidney transplantation from HLA-incompatible live donors: Efficiency and outcome of 32 patients after desensitisation. Nefrologia pmid:28734583
Menéndez Valladares P et al. [Increased lipoprotein(a) in a paediatric patient associated with nephrotic syndrome]. Clin Investig Arterioscler pmid:27623226
Yigitaslan S et al. The Effect of P-Glycoprotein Inhibition and Activation on the Absorption and Serum Levels of Cyclosporine and Tacrolimus in Rats. Adv Clin Exp Med pmid:27627555
Kathuria S et al. Segmental vitiligo: a randomized controlled trial to evaluate efficacy and safety of 0.1% tacrolimus ointment vs 0.05% fluticasone propionate cream. Indian J Dermatol Venereol Leprol pmid:22199063
Jefferson J et al. Follicular Mucinosis in a Male Adolescent with a History of Acute Myelogenous Leukemia and Graft-versus-Host Disease. Pediatr Dermatol pmid:26645410
Sarvary E et al. De novo Prograf versus de novo Advagraf: are trough level profile curves similar? Transplant. Proc. pmid:25131131
Borda B et al. Early histopathological changes in new-onset diabetes after kidney transplantation. Transplant. Proc. pmid:25131129
Porubsky M et al. Excellent outcomes can be achieved in young pancreas transplant alone recipients by addition of sirolimus to maintenance immunosuppression regimen. Transplant. Proc. pmid:25131074
Tulaci KG et al. The effect of tacrolimus on facial nerve injury: Histopathological findings in a rabbit model. Am J Otolaryngol pmid:27465503
Liu JY et al. Tacrolimus Versus Cyclosporine as Primary Immunosuppressant After Renal Transplantation: A Meta-Analysis and Economics Evaluation. Am J Ther pmid:25299636
pmid:9123014
Alokaily F et al. Takayasu's arteritis and liver transplantation: Association and implications. Saudi J Gastroenterol pmid:26458863
Haroon N et al. Tacrolimus Toxicity With Minimal Clinical Manifestations: A Case Report and Literature Review. Am J Ther pmid:25730156
Krzyżowska K et al. No Significant Influence of Reduced Initial Tacrolimus Dose on Risk of Underdosing and Early Graft Function in Older and Overweight Kidney Transplant Recipients. Transplant. Proc. pmid:30056895
Zmonarski S et al. Expression of PBMC TLR4 in Renal Graft Recipients Who Experienced Delayed Graft Function Reflects Dynamic Balance Between Blood and Tissue Compartments and Helps Select a Problematic Patient. Transplant. Proc. pmid:30056893
Zulim LFDC et al. Comparison of the efficacy of 0.03% tacrolimus eye drops diluted in olive oil and linseed oil for the treatment of keratoconjunctivitis sicca in dogs. Arq Bras Oftalmol pmid:29995121
Kim K et al. Everolimus-Induced Systemic Serositis After Simultaneous Liver and Kidney Transplantation: A Case Report. Transplant. Proc. pmid:28104132
Yamamoto T et al. Efficacy of Eculizumab Therapy for Atypical Hemolytic Uremic Syndrome Recurrence and Antibody-Mediated Rejection Progress After Renal Transplantation With Preformed Donor-Specific Antibodies: Case Report. Transplant. Proc. pmid:28104125
Ülkümen PK et al. Annular lichenoid dermatitis of youth in a 15-year-old boy: Topical tacrolimus as a treatment option. Indian J Dermatol Venereol Leprol pmid:27279324
Takahashi Y et al. Pharmacokinetic Profile of Twice- and Once-daily Tacrolimus in Pediatric Kidney Transplant Recipients. Transplant. Proc. pmid:28104153
Shi Y et al. Comparison of Mizoribine and Mycophenolate Mofetil With a Tacrolimus-Based Immunosuppressive Regimen in Living-Donor Kidney Transplantation Recipients: A Retrospective Study in China. Transplant. Proc. pmid:28104150
Pan D et al. Tacrolimus-associated Diffuse Gastrointestinal Ulcerations and Pathergy: A Case Report. Transplant. Proc. pmid:28104141
Ash MM and Jolly PS A Case Report of the Resolution of Multiple Recalcitrant Verrucae in a Renal Transplant Recipient After a Mycophenolate Mofetil Dose Reduction. Transplant. Proc. pmid:28104140
Nayeri A et al. Acute Calcineurin Inhibitor Nephrotoxicity Secondary to Turmeric Intake: A Case Report. Transplant. Proc. pmid:28104136
Dedhia P et al. Eculizumab and Belatacept for De Novo Atypical Hemolytic Uremic Syndrome Associated With CFHR3-CFHR1 Deletion in a Kidney Transplant Recipient: A Case Report. Transplant. Proc. pmid:28104134
Zhang J et al. Chemotherapy for De Novo Gastric Adenocarcinoma After Deceased Orthotopic Liver Transplantation: A Case Report. Transplant. Proc. pmid:28104131
Britto-Williams P and Pansare M Management of chronic idiopathic urticaria in childhood: are we on the same page? J Allergy Clin Immunol Pract pmid:24565627
Nojima M et al. Immunosuppression Modification by Everolimus With Minimization of Calcineurin Inhibitors Recovers Kidney Graft Function Even in Patients With Very Late Conversion and Also With Poor Graft Function. Transplant. Proc. pmid:28104155
Ishida S et al. Calcineurin Inhibitor-Induced Pain Syndrome in ABO-Incompatible Living Kidney Transplantation: A Case Report. Transplant. Proc. pmid:28104127
Liu JY et al. Sirolimus Versus Tacrolimus as Primary Immunosuppressant After Renal Transplantation: A Meta-Analysis and Economics Evaluation. Am J Ther pmid:25569597
Norero B et al.  Conversion to mycophenolate mofetil monotherapy in liver recipients: Calcineurin inhibitor levels are key. Ann Hepatol pmid:28051798
Hirata Y et al. Antibody Drug Treatment for Steroid-Resistant Rejection After Pediatric Living Donor Liver Transplantation: A Single-Center Experience. Transplant. Proc. pmid:29407332
Back JH et al. Antiproteinuric Effects of Green Tea Extract on Tacrolimus-Induced Nephrotoxicity in Mice. Transplant. Proc. pmid:26293093
Shingaki S et al. Graft-versus-host Disease-free, Relapse-free Survival After HLA-identical Sibling Peripheral Blood Stem Cell Transplantation With Tacrolimus-based Graft-versus-host Disease Prophylaxis in Japanese Patients. Transplant. Proc. pmid:29407317
Kim SH et al. Outcomes of Early Conversion From Prograf to Generic Tacrolimus in Adult Living Donor Liver Transplant Recipients. Transplant. Proc. pmid:26293073
Falconer SJ et al. Early or Late Conversion From Tac-BD to Tac-BD in Renal Transplantation: When is the Right Time? Transplant. Proc. pmid:26293044
Dall'Agnol DJ et al. Effects of immunosuppressive drugs on gastrointestinal transit of rats: effects of tacrolimus, cyclosporine, and prednisone. Transplant. Proc. pmid:25131057
Mori F et al. Increase of natural killer cells in children with liver transplantation-acquired food allergy. Allergol Immunopathol (Madr) pmid:29456038
pmid:28422431
Yousuf Bhat Z et al. Colchicine-Induced Myopathy in a Tacrolimus-Treated Renal Transplant Recipient: Case Report and Literature Review. Am J Ther pmid:24732905
Lythgoe M and Abraham S Tacrolimus: an effective treatment in refractory psoriatic arthritis following biologic failure. Clin. Exp. Rheumatol. pmid:26211753
Leon L et al. Successfull Simultaneous Pancreas Kidney transplantation in a patient with Congenital Partial Lipodystrophy. Nefrologia pmid:27006329