| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Nocardia Infections | D009617 | 6 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Graft Occlusion, Vascular | D006083 | 11 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Thomson AW et al. | FK 506: a novel immunosuppressant for treatment of autoimmune disease. Rationale and preliminary clinical experience at the University of Pittsburgh. | 1993 | Springer Semin. Immunopathol. | pmid:7686690 |
| Ueno M et al. | [Immunosuppressive effect in combination therapy of cyclosporine A, FK506 and 15-deoxyspergualin on a pancreatic islet xenotransplantation]. | 1993 | Nihon Geka Gakkai Zasshi | pmid:7686615 |
| Fujisawa T et al. | Dose study of the immunosuppression of FK 506 in canine lung allo-transplantation. | 1993 | Surg. Today | pmid:7686416 |
| Langer A et al. | Humoral and cellular immunopathology of hepatic and cardiac hamster-into-rat xenograft rejection. Marked stimulation of IgM++bright/IgD+dull splenic B cells. | 1993 | Am. J. Pathol. | pmid:7686346 |
| Calne RY et al. | Intestinal transplant for recurring mesenteric desmoid tumour. | 1993 | Lancet | pmid:7686241 |
| Sakr MF et al. | FK 506 pre-treatment is associated with reduced levels of tumor necrosis factor and interleukin 6 following hepatic ischemia/reperfusion. | 1993 | J. Hepatol. | pmid:7686193 |
| Wong PY et al. | Recurrence of primary biliary cirrhosis after liver transplantation following FK506-based immunosuppression. | 1993 | J. Hepatol. | pmid:7686192 |
| Li W and Handschumacher RE | Specific interaction of the cyclophilin-cyclosporin complex with the B subunit of calcineurin. | 1993 | J. Biol. Chem. | pmid:7686148 |
| Murphy MP and Morris RE | Brequinar sodium effectively and potently suppresses allograft rejection in a heterotopic mouse heart transplant model. | 1993 | Transplant. Proc. | pmid:7685955 |
| Takaya S et al. | Use of prostaglandin E1 in crossmatch-negative liver transplant recipients treated with FK 506. | 1993 | Transplant. Proc. | pmid:7685953 |
| Moutabarrik A et al. | Effect of FK 506 and cyclosporine on the expression of IL-6 and its receptor on stimulated monocytes. | 1993 | Transplant. Proc. | pmid:7685949 |
| Moutabarrik A et al. | Use of FK 506 in kidney transplantation. | 1993 | Transplant. Proc. | pmid:7685946 |
| Textor SC et al. | Systemic and renal hemodynamic differences between FK506 and cyclosporine in liver transplant recipients. | 1993 | Transplantation | pmid:7685934 |
| McDiarmid SV et al. | Differences in oral FK506 dose requirements between adult and pediatric liver transplant patients. | 1993 | Transplantation | pmid:7685933 |
| Suzuki S et al. | Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury. Modulating effects of FK506 and cyclosporine. | 1993 | Transplantation | pmid:7685932 |
| Sykes K et al. | Proline isomerases function during heat shock. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7685914 |
| Partaledis JA and Berlin V | The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7685904 |
| Akamine S et al. | [Effect of FK-506 on bronchial healing of canine lung allografts]. | 1993 | Nihon Kyobu Geka Gakkai Zasshi | pmid:7685803 |
| Pilot-Matias TJ et al. | High-level synthesis of the 12-kDa human FK506-binding protein in Escherichia coli using translational coupling. | 1993 | Gene | pmid:7685727 |
| Wagner JA et al. | Failure of FK 506 to suppress the T cell-mediated immunity of mice to Listeria monocytogenes. | 1993 | Clin. Exp. Immunol. | pmid:7685672 |
| Sewell KL | Immunotherapy and other novel therapies, including biologic response modifiers, apheresis, and dietary modifications. | 1993 | Curr Opin Rheumatol | pmid:7685614 |
| Ahmed SS et al. | Adrenochrome reaction implicates oxygen radicals in metabolism of cyclosporine A and FK-506 in rat and human liver microsomes. | 1993 | J. Pharmacol. Exp. Ther. | pmid:7685382 |
| Bumgardner GL and Roberts JP | New immunosuppressive agents. | 1993 | Gastroenterol. Clin. North Am. | pmid:7685324 |
| Metcalfe S et al. | Prodigiosin 25C: effect in in vitro models for T cell activation and T cell cycling and in vivo for rat heart allografts. | 1993 | Int. Arch. Allergy Immunol. | pmid:7685216 |
| Asami M et al. | Detection of the FK506-FKBP-calcineurin complex by a simple binding assay. | 1993 | Biochem. Biophys. Res. Commun. | pmid:7685169 |
| Ocain TD et al. | A nonimmunosuppressive triene-modified rapamycin analog is a potent inhibitor of peptidyl prolyl cis-trans isomerase. | 1993 | Biochem. Biophys. Res. Commun. | pmid:7685167 |
| Mochizuki M et al. | A clinical trial of FK506 in refractory uveitis. | 1993 | Am. J. Ophthalmol. | pmid:7685147 |
| Wallemacq PE et al. | Improvement and assessment of enzyme-linked immunosorbent assay to detect low FK506 concentrations in plasma or whole blood within 6 hours. | 1993 | Clin. Chem. | pmid:7684956 |
| Connelly PR et al. | Probing hydration contributions to the thermodynamics of ligand binding by proteins. Enthalpy and heat capacity changes of tacrolimus and rapamycin binding to FK506 binding protein in D2O and H2O. | 1993 | Biochemistry | pmid:7684925 |
| Francavilla A et al. | Hepatic regeneration and growth factors. | 1993 | J Surg Oncol Suppl | pmid:7684910 |
| Dickey JB et al. | Periocular FK-506 delays allograft rejection in rat penetrating keratoplasty. | 1993 | Cornea | pmid:7684663 |
| Becker JW et al. | FK-506-binding protein: three-dimensional structure of the complex with the antagonist L-685,818. | 1993 | J. Biol. Chem. | pmid:7684380 |
| Shapiro R et al. | FK 506 interaction with danazol. | 1993 | Lancet | pmid:7684106 |
| Jachez B et al. | Reversion of the P-glycoprotein-mediated multidrug resistance of cancer cells by FK-506 derivatives. | 1993 | Anticancer Drugs | pmid:7683935 |
| Mukai H et al. | FKBP12-FK506 complex inhibits phosphatase activity of two mammalian isoforms of calcineurin irrespective of their substrates or activation mechanisms. | 1993 | J. Biochem. | pmid:7683641 |
| Natazuka T et al. | FK506 and cyclosporin a regulate proliferation and proto-oncogene expression in HTLV-1-associated myelopathy/tropical-spastic-paraparesis-derived T cells. | 1993 | Int. J. Cancer | pmid:7683633 |
| Ohnishi H et al. | Natural killer cell may impair liver regeneration in fulminant hepatic failure. | 1993 | Gastroenterol. Jpn. | pmid:7683619 |
| Ohtake M et al. | Enhanced liver regeneration in rats treated with 15-deoxyspergualin alone and in combination with FK 506. | 1993 | Gastroenterol. Jpn. | pmid:7683616 |
| Waschulewski IH et al. | Effects of the immunosuppressants cyclosporin A and FK 506 on exocytosis in the rat exocrine pancreas in vitro. | 1993 | Br. J. Pharmacol. | pmid:7683567 |
| Denesyuk AI et al. | Structural similarity of the binding sites of cyclophilin A-cyclosporin A and FKBP-FK506 systems. | 1993 | Biochem. Biophys. Res. Commun. | pmid:7683466 |
| Kadmon M et al. | Inhibition by cyclosporin A of adenosine triphosphate-dependent transport from the hepatocyte into bile. | 1993 | Gastroenterology | pmid:7683296 |
| Blaehr H et al. | Acute effects of FK506 and cyclosporine A on cultured human proximal tubular cells. | 1993 | Eur. J. Pharmacol. | pmid:7683267 |
| Kai N et al. | Prevention of insulitis and diabetes in nonobese diabetic mice by administration of FK506. | 1993 | Transplantation | pmid:7682740 |
| Emond JC et al. | Improved results of living-related liver transplantation with routine application in a pediatric program. | 1993 | Transplantation | pmid:7682738 |
| Murase N et al. | Hamster-to-rat heart and liver xenotransplantation with FK506 plus antiproliferative drugs. | 1993 | Transplantation | pmid:7682735 |
| Shorrock C and Neuberger J | The changing face of liver transplantation. | 1993 | Gut | pmid:7682532 |
| Hutchison KA et al. | FK506 binding to the 56-kilodalton immunophilin (Hsp56) in the glucocorticoid receptor heterocomplex has no effect on receptor folding or function. | 1993 | Biochemistry | pmid:7682438 |
| Rao PN et al. | Prediction of early graft function by effluent levels of hyaluronic acid in clinical liver transplantation. | 1993 | Transplant. Proc. | pmid:7682366 |
| Yu Y et al. | Mutagenicity of the new immunosuppressive drugs, FK 506, and spergualin. | 1993 | Transplant. Proc. | pmid:7682364 |
| Meiser BM et al. | Simvastatin decreases accelerated graft vessel disease after heart transplantation in an animal model. | 1993 | Transplant. Proc. | pmid:7682363 |
| Woodle ES et al. | FK 506 rescue therapy: the rapidity of rejection reversal is related to the subsequent development of CMV disease. | 1993 | Transplant. Proc. | pmid:7682360 |
| Woodle ES et al. | FK 506 rescue therapy: early conversion improves efficacy. | 1993 | Transplant. Proc. | pmid:7682359 |
| Woodle ES et al. | Recurrent rejection following FK 506 rescue therapy for acute hepatic allograft rejection. | 1993 | Transplant. Proc. | pmid:7682358 |
| Klintmalm GB et al. | Rejection: FK 506 for rescue or maintenance. | 1993 | Transplant. Proc. | pmid:7682356 |
| Frank B et al. | Neurotoxicity of FK 506 in liver transplant recipients. | 1993 | Transplant. Proc. | pmid:7682355 |
| Wiesner RH et al. | Early cellular rejection treated with high-dose intravenous corticosteroid therapy is associated with a decrease in the incidence of steroid-resistant rejection and graft failure from rejection. | 1993 | Transplant. Proc. | pmid:7682352 |
| Lundemose AG et al. | Chlamydia trachomatis Mip-like protein has peptidyl-prolyl cis/trans isomerase activity that is inhibited by FK506 and rapamycin and is implicated in initiation of chlamydial infection. | 1993 | Mol. Microbiol. | pmid:7682281 |
| Winkler M et al. | Anaemia associated with FK 506 immunosuppression. | 1993 | Lancet | pmid:7682273 |
| Bruserud O and Pawelec G | Cyclosporine A and FK506 show similar immunosuppressive effects on long-term in vitro T-cell proliferation. | 1993 | Int. J. Immunopharmacol. | pmid:7682202 |
| Tanaka N et al. | Regulation of liver regeneration by interleukin-2 and its inhibitors: cyclosporine A and FK 506. | 1993 | Int. J. Immunopharmacol. | pmid:7682200 |
| Xu RX et al. | 1H, 13C, and 15N assignments and secondary structure of the FK506 binding protein when bound to ascomycin. | 1993 | Biopolymers | pmid:7682113 |
| Rotonda J et al. | Improved calcineurin inhibition by yeast FKBP12-drug complexes. Crystallographic and functional analysis. | 1993 | J. Biol. Chem. | pmid:7681823 |
| Doi R et al. | Structural and functional changes of exocrine pancreas induced by FK506 in rats. | 1993 | Gastroenterology | pmid:7681795 |
| Luan S et al. | Immunosuppressants implicate protein phosphatase regulation of K+ channels in guard cells. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7681590 |
| Nishinaka Y et al. | Protective effect of FK506 on ischemia/reperfusion-induced myocardial damage in canine heart. | 1993 | J. Cardiovasc. Pharmacol. | pmid:7681507 |
| Fujimura A et al. | Chronopharmacokinetic study of a new immunosuppressive agent, FK 506, in mice. | 1993 | Jpn. J. Pharmacol. | pmid:7681489 |
| Valdivia LA et al. | Successful hamster-to-rat liver xenotransplantation under FK506 immunosuppression induces unresponsiveness to hamster heart and skin. | 1993 | Transplantation | pmid:7681230 |
| Takeguchi N et al. | Inhibition of the multidrug efflux pump in isolated hepatocyte couplets by immunosuppressants FK506 and cyclosporine. | 1993 | Transplantation | pmid:7681229 |
| Dutz JP et al. | A role for calcineurin in degranulation of murine cytotoxic T lymphocytes. | 1993 | J. Immunol. | pmid:7681074 |
| Saeki T et al. | Human P-glycoprotein transports cyclosporin A and FK506. | 1993 | J. Biol. Chem. | pmid:7681059 |
| Ning YM and Sánchez ER | Potentiation of glucocorticoid receptor-mediated gene expression by the immunophilin ligands FK506 and rapamycin. | 1993 | J. Biol. Chem. | pmid:7681058 |
| Piekoszewski W and Jusko WJ | Plasma protein binding of tacrolimus in humans. | 1993 | J Pharm Sci | pmid:7680714 |
| Nelson PA et al. | Immunosuppressive activity of [MeBm2t]1-, D-diaminobutyryl-8-, and D-diaminopropyl-8-cyclosporin analogues correlates with inhibition of calcineurin phosphatase activity. | 1993 | J. Immunol. | pmid:7680683 |
| Lionetti P et al. | Activation of mucosal V beta 3+ T cells and tissue damage in human small intestine by the bacterial superantigen, Staphylococcus aureus enterotoxin B. | 1993 | Eur. J. Immunol. | pmid:7680613 |
| Egan DA et al. | Equilibrium denaturation of recombinant human FK binding protein in urea. | 1993 | Biochemistry | pmid:7680574 |
| Xu RX et al. | Heteronuclear 3D NMR studies of water bound to an FK506 binding protein/immunosuppressant complex. | 1993 | Biochemistry | pmid:7680570 |
| Randhawa PS et al. | The histopathological changes associated with allograft rejection and drug toxicity in renal transplant recipients maintained on FK506. Clinical significance and comparison with cyclosporine. | 1993 | Am. J. Surg. Pathol. | pmid:7680544 |
| Armitage JM et al. | A decade (1982 to 1992) of pediatric cardiac transplantation and the impact of FK 506 immunosuppression. | 1993 | J. Thorac. Cardiovasc. Surg. | pmid:7680396 |
| Tamura K et al. | Suppression of autoimmune thyroid disease by FK 506: influence on thyroid-infiltrating cells, adhesion molecule expression and anti-thyroglobulin antibody production. | 1993 | Clin. Exp. Immunol. | pmid:7680293 |
| Hirao A et al. | Effects of immunosuppressants, FK506, deoxyspergualin, and cyclosporine A on immature human hematopoiesis. | 1993 | Blood | pmid:7680241 |
| Schweizer M et al. | Sensitivity of mitochondrial peptidyl-prolyl cis-trans isomerase, pyridine nucleotide hydrolysis and Ca2+ release to cyclosporine A and related compounds. | 1993 | Biochem. Pharmacol. | pmid:7680201 |
| Fukuzaki T et al. | Induction of unresponsiveness to islet allograft by preoperative donor spleen cell injection and FK 506 treatment. | 1993 | Transplant. Proc. | pmid:7680173 |
| Rilo HR et al. | Effect of intraportal human islet transplantation on kidney graft survival in simultaneous kidney-islet allografts. | 1993 | Transplant. Proc. | pmid:7680172 |
| Woan MC et al. | Characterization of the biopsy growth assay in monitoring cardiac transplant patients for rejection. | 1993 | Transplant. Proc. | pmid:7680171 |
| Mañez R et al. | Association between donor-recipient HLA-DR compatibility and cytomegalovirus hepatitis and chronic rejection in liver transplantation. | 1993 | Transplant. Proc. | pmid:7680170 |
| McCauley J et al. | FK 506 in the management of nephrotic syndrome after renal transplantation. | 1993 | Transplant. Proc. | pmid:7680154 |
| Abu-Elmagd KM et al. | Monitoring and treatment of intestinal allograft rejection in humans. | 1993 | Transplant. Proc. | pmid:7680150 |
| Reyes J et al. | Nutritional management of intestinal transplant recipients. | 1993 | Transplant. Proc. | pmid:7680149 |
| Todo S et al. | Intestinal transplantation in humans under FK 506. | 1993 | Transplant. Proc. | pmid:7680148 |
| Shibata T et al. | Does FK 506 accelerate the development of coronary artery disease in the transplanted heart as well as the native heart? | 1993 | Transplant. Proc. | pmid:7680147 |
| Fung J et al. | Randomized trial in primary liver transplantation under immunosuppression with FK 506 or cyclosporine. | 1993 | Transplant. Proc. | pmid:7680146 |
| Bonet H et al. | Survival of patients transplanted with alcoholic hepatitis plus cirrhosis as compared with those with cirrhosis alone. | 1993 | Transplant. Proc. | pmid:7680145 |
| Stephens J et al. | Effects of orthotopic liver transplantation and immunosuppression on inflammatory bowel disease in primary sclerosing cholangitis patients. | 1993 | Transplant. Proc. | pmid:7680144 |
| Inoue T et al. | Isolation of mitochondrial cyclophilin from bovine heart. | 1993 | Biochem. Biophys. Res. Commun. | pmid:7679902 |
| Zeevi A et al. | Comparative in vitro studies on the immunosuppressive effects of purine and pyrimidine synthesis inhibitors. | 1993 | Transplant. Proc. | pmid:7679843 |
| Gregory CR et al. | Effects of treatment with cyclosporine, FK 506, rapamycin, mycophenolic acid, or deoxyspergualin on vascular muscle proliferation in vitro and in vivo. | 1993 | Transplant. Proc. | pmid:7679842 |
| Gunji Y et al. | Pathologic characteristics of vasculitis in renal transplant recipient dogs receiving immunosuppressive agents, FK 506, rapamycin, or RS-61443. | 1993 | Transplant. Proc. | pmid:7679841 |
| Klintmalm GB et al. | Use of Prograf (FK 506) as rescue therapy for refractory rejection after liver transplantation. US Multicenter FK 506 Liver Study Group. | 1993 | Transplant. Proc. | pmid:7679840 |
| Tabasco-Minguillan J et al. | Long-term insulin requirement after liver transplantation with FK 506 in American veterans. | 1993 | Transplant. Proc. | pmid:7679839 |
| Stock PG et al. | Standard sequential immunosuppression with Minnesota antilymphoblast globulin and cyclosporine vs FK 506: a comparison of early nephrotoxicity. | 1993 | Transplant. Proc. | pmid:7679838 |