tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Nocardia Infections D009617 6 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Graft Occlusion, Vascular D006083 11 associated lipids
Hypercalcemia D006934 13 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

Download all related citations
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Authors Title Published Journal PubMed Link
Knechtle SJ Guidance for liver transplant immunosuppression. 2011 Am. J. Transplant. pmid:21466652
Gupta G et al. Safe Conversion From Tacrolimus to Belatacept in High Immunologic Risk Kidney Transplant Recipients With Allograft Dysfunction. 2015 Am. J. Transplant. pmid:25988397
Damon C et al. Predictive Modeling of Tacrolimus Dose Requirement Based on High-Throughput Genetic Screening. 2017 Am. J. Transplant. pmid:27597269
Shuker N et al. A Randomized Controlled Trial Comparing the Efficacy of Cyp3a5 Genotype-Based With Body-Weight-Based Tacrolimus Dosing After Living Donor Kidney Transplantation. 2016 Am. J. Transplant. pmid:26714287
Forns X and Navasa M Cyclosporine A or tacrolimus for hepatitis C recurrence? An old debate. 2011 Am. J. Transplant. pmid:21797970
Arnold R et al. Association between calcineurin inhibitor treatment and peripheral nerve dysfunction in renal transplant recipients. 2013 Am. J. Transplant. pmid:23841745
Hirsch HH et al. BK Polyomavirus Replication in Renal Tubular Epithelial Cells Is Inhibited by Sirolimus, but Activated by Tacrolimus Through a Pathway Involving FKBP-12. 2016 Am. J. Transplant. pmid:26639422
Lemahieu WP et al. CYP3A4 and P-glycoprotein activity in healthy controls and transplant patients on cyclosporin vs. tacrolimus vs. sirolimus. 2004 Am. J. Transplant. pmid:15307840
Luther P and Baldwin D Pioglitazone in the management of diabetes mellitus after transplantation. 2004 Am. J. Transplant. pmid:15575920
Cherukuri A et al. An analysis of lymphocyte phenotype after steroid avoidance with either alemtuzumab or basiliximab induction in renal transplantation. 2012 Am. J. Transplant. pmid:22390816
Pascher A et al. Protein kinase C inhibitor sotrastaurin in de novo liver transplant recipients: a randomized phase II trial. 2015 Am. J. Transplant. pmid:25677074
Grenda R et al. A randomized trial to assess the impact of early steroid withdrawal on growth in pediatric renal transplantation: the TWIST study. 2010 Am. J. Transplant. pmid:20420639
van Hooff JP et al. Glucose metabolic disorder after transplantation. 2007 Am. J. Transplant. pmid:17511670
Silva HT et al. One-year results with extended-release tacrolimus/MMF, tacrolimus/MMF and cyclosporine/MMF in de novo kidney transplant recipients. 2007 Am. J. Transplant. pmid:17217442
Heffron TG et al. Once-daily tacrolimus extended-release formulation: 1-year post-conversion in stable pediatric liver transplant recipients. 2007 Am. J. Transplant. pmid:17511684
Lacaille F et al. Severe dysimmune cytopenia in children treated with tacrolimus after organ transplantation. 2006 Am. J. Transplant. pmid:16611346
Brennan DC et al. Incidence of BK with tacrolimus versus cyclosporine and impact of preemptive immunosuppression reduction. 2005 Am. J. Transplant. pmid:15707414
Arango C et al. A 29-year-old renal transplant recipient with acute respiratory failure. 2012 Am. J. Trop. Med. Hyg. pmid:22665592
Kyles AE et al. Comparison of the in vitro antiproliferative effects of five immunosuppressive drugs on lymphocytes in whole blood from cats. 2000 Am. J. Vet. Res. pmid:10951980
Kyles AE et al. Pharmacokinetics of tacrolimus after multidose oral administration and efficacy in the prevention of allograft rejection in cats with renal transplants. 2003 Am. J. Vet. Res. pmid:12856780
Holmgren G et al. Successful pregnancies and fatherhood in familial amyloidotic polyneuropathy (FAP Val30Met) patients with liver transplantation. 2004 Amyloid pmid:15478469
Fix OK et al. Liver transplant alone without kidney transplant for fibrinogen Aα-chain (AFib) renal amyloidosis. 2016 Amyloid pmid:26972447
Zahdi MR et al. Erosive pustular dermatosis of the scalp successfully treated with oral prednisone and topical tacrolimus. 2013 Sep-Oct An Bras Dermatol pmid:24173187
Delgado L et al. Zoon's plasma cell balanitis: a report of two cases treated with pimecrolimus. 2011 Jul-Aug An Bras Dermatol pmid:22068766
Viana Fde O et al. Acral lichen sclerosus et atrophicus--case report. 2011 Jul-Aug An Bras Dermatol pmid:22068779
Cakici O et al. Periorbital discoid lupus: a rare localization in a patient with systemic lupus erythematosus. An Bras Dermatol pmid:28300917
Lima RS et al. Granuloma faciale: a good therapeutic response with the use of topical tacrolimus. An Bras Dermatol pmid:26560220
Sisti A et al. Effectiveness and safety of topical tacrolimus monotherapy for repigmentation in vitiligo: a comprehensive literature review. 2016 An Bras Dermatol pmid:27192518
Tamler C et al. Tacrolimus 0,1% ointment in the treatment of vitiligo: a series of cases. 2011 Jan-Feb An Bras Dermatol pmid:21437550
Navas López VM et al. [Safety and efficacy of oral tacrolimus in the treatment of paediatric inflammatory bowel disease]. 2009 An Pediatr (Barc) pmid:19427822
Tomás ML [Immunosuppressive agents: side effects]. 1997 An R Acad Nac Med (Madr) pmid:9616947
den Burger JC et al. Analysis of cyclosporin A, tacrolimus, sirolimus, and everolimus in dried blood spot samples using liquid chromatography tandem mass spectrometry. 2012 Anal Bioanal Chem pmid:22899246
Neu V et al. On-line solid-phase extraction high-performance liquid chromatography-tandem mass spectrometry for the quantitative analysis of tacrolimus in whole blood hemolyzate. 2012 Anal Bioanal Chem pmid:22797715
Takahashi T et al. Isolating the whole complex of target proteins of FK506 using affinity resins from novel solid phases. 2006 Anal Bioanal Chem pmid:16601955
Nozaki K et al. Elimination technique for alkali metal ion adducts from an electrospray ionization process using an on-line ion suppressor. 2010 Anal Sci pmid:20543506
Murakami Y et al. On-chip micro-flow polystyrene bead-based immunoassay for quantitative detection of tacrolimus (FK506). 2004 Anal. Biochem. pmid:15464959
Sellar KJ et al. Spectrophotometric assay for calcineurin activity in leukocytes isolated from human blood. 2006 Anal. Biochem. pmid:16979577
Cañadas O et al. Equilibrium studies of a fluorescent tacrolimus binding to surfactant protein A. 2005 Anal. Biochem. pmid:15802130
Carreras CW et al. An FKBP12 binding assay based upon biotinylated FKBP12. 2001 Anal. Biochem. pmid:11673895
Ahn SC et al. A tactic for screening inhibitors of interleukin-2 production. 2002 Anal. Biochem. pmid:12018952
Park JW et al. Liquid chromatography-mass spectrometry characterization of FK506 biosynthetic intermediates in Streptomyces clavuligerus KCTC 10561BP. 2009 Anal. Biochem. pmid:19539594
Sonatore LM et al. The utility of FK506-binding protein as a fusion partner in scintillation proximity assays: application to SH2 domains. 1996 Anal. Biochem. pmid:8811923
Blanchet B et al. Determination of serine/threonine protein phosphatase type 2B PP2B in lymphocytes by HPLC. 2003 Anal. Biochem. pmid:12479828
Ohtsu Y et al. Selective ligand purification using high-performance affinity beads. 2005 Anal. Biochem. pmid:15745744
Rupprecht KR et al. Development of a dot-blot assay for screening monoclonal antibodies to low-molecular-mass drugs. 2010 Anal. Biochem. pmid:20696124
Wada A et al. Ribosome display and photo-cross-linking techniques for in vitro identification of target proteins of bioactive small molecules. 2014 Anal. Chem. pmid:24380432
Hopper JT and Oldham NJ Alkali metal cation-induced destabilization of gas-phase protein-ligand complexes: consequences and prevention. 2011 Anal. Chem. pmid:21863818
Sage L Fishing for MAGIC targets. 2005 Anal. Chem. pmid:16285140
Menotta M et al. Label-free quantification of Tacrolimus in biological samples by atomic force microscopy. 2015 Anal. Chim. Acta pmid:26073814
Gómez-Ríos GA et al. Rapid determination of immunosuppressive drug concentrations in whole blood by coated blade spray-tandem mass spectrometry (CBS-MS/MS). 2018 Anal. Chim. Acta pmid:29254576