| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cervical Intraepithelial Neoplasia | D018290 | 1 associated lipids |
| Migraine with Aura | D020325 | 1 associated lipids |
| Porokeratosis | D017499 | 1 associated lipids |
| Lentigo | D007911 | 1 associated lipids |
| Mutism | D009155 | 1 associated lipids |
| Amyloid Neuropathies | D017772 | 1 associated lipids |
| Meningitis, Fungal | D016921 | 1 associated lipids |
| Malocclusion, Angle Class II | D008312 | 1 associated lipids |
| Flaviviridae Infections | D018178 | 1 associated lipids |
| Idiopathic Interstitial Pneumonias | D054988 | 1 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Abu Zaid M et al. | Plasma biomarkers of risk for death in a multicenter phase 3 trial with uniform transplant characteristics post-allogeneic HCT. | 2017 | Blood | pmid:27827824 |
| Suetsugu K et al. | Analysis of the variable factors influencing tacrolimus blood concentration during the switch from continuous intravenous infusion to oral administration after allogeneic hematopoietic stem cell transplantation. | 2017 | Int. J. Hematol. | pmid:27822915 |
| Kharfan-Dabaja MA et al. | Tacrolimus plus sirolimus with or without ATG as GVHD prophylaxis in HLA-mismatched unrelated donor allogeneic stem cell transplantation. | 2017 | Bone Marrow Transplant. | pmid:27819684 |
| Trasi NS et al. | Non-Sink Dissolution Behavior and Solubility Limit of Commercial Tacrolimus Amorphous Formulations. | 2017 | J Pharm Sci | pmid:27816263 |
| Kurzawski M et al. | Analysis of common polymorphisms within NR1I2 and NR1I3 genes and tacrolimus dose-adjusted concentration in stable kidney transplant recipients. | 2017 | Pharmacogenet. Genomics | pmid:28777242 |
| Wang C et al. | Combining metabolomics and network analysis to improve tacrolimus production in Streptomyces tsukubaensis using different exogenous feedings. | 2017 | J. Ind. Microbiol. Biotechnol. | pmid:28776273 |
| Lim SW et al. | Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K/AKT pathway during tacrolimus-induced oxidative stress. | 2017 | Cell Death Dis | pmid:28771227 |
| Lim SW et al. | Ginseng extract reduces tacrolimus-induced oxidative stress by modulating autophagy in pancreatic beta cells. | 2017 | Lab. Invest. | pmid:28759009 |
| Alloway RR | Mounting Clinical Evidence With Tacrolimus Generic Products. | 2017 | Transplantation | pmid:28749820 |
| Willerth SM | Localized Tacrolimus Delivery Repairs the Damaged Central Nervous System. | 2017 | EBioMedicine | pmid:29195745 |
| Savaj S et al. | Irreversible Lesions of Tacrolimus-induced Posterior Reversible Leukoencephalopathy Syndrome. | 2017 | Iran J Kidney Dis | pmid:29190599 |
| Rhu J et al. | Clinical Implication of Mycophenolic Acid Trough Concentration Monitoring in Kidney Transplant Patients on a Tacrolimus Triple Maintenance Regimen: A Single-Center Experience. | 2017 | Ann. Transplant. | pmid:29180612 |
| Martial LC et al. | Dried Blood Spot Sampling for Tacrolimus and Mycophenolic Acid in Children: Analytical and Clinical Validation. | 2017 | Ther Drug Monit | pmid:28700522 |
| Wei L et al. | Therapeutic Effects of FK506 on IgA Nephropathy Rat. | 2017 | Kidney Blood Press. Res. | pmid:29179182 |
| Shahid S et al. | Chronic hepatitis in the transplant patient. | 2017 | Br J Hosp Med (Lond) | pmid:28692371 |
| Liao JH et al. | Gene Variations of Sixth Complement Component Affecting Tacrolimus Metabolism in Patients with Liver Transplantation for Hepatocellular Carcinoma. | 2017 | Chin. Med. J. | pmid:28685716 |
| An Q et al. | High Colonization and Impaired Permeability Barrier in Facial Seborrheic Dermatitis. | 2017 | Chin. Med. J. | pmid:28685715 |
| Wang Y et al. | Calcineurin Antagonizes AMPK to Regulate Lipolysis in Caenorhabditis elegans. | 2017 | Molecules | pmid:28672869 |
| Lee D et al. | Age and Early Graft Function Relate With Risk-Benefit Ratio of Allogenic Islet Transplantation Under Antithymocyte Globulin-Mycophenolate Mofetil-Tacrolimus Immune Suppression. | 2017 | Transplantation | pmid:27779572 |
| Li X et al. | Tacrolimus induces fibroblasts apoptosis and reduces epidural fibrosis by regulating miR-429 and its target of RhoE. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28669722 |
| Gao L et al. | Synergistic Effects of Tacrolimus and Azoles against Exophiala dermatitidis. | 2017 | Antimicrob. Agents Chemother. | pmid:28923863 |
| Ginocchio L et al. | Refractory Ulcerated Necrobiosis Lipoidica: Closure of a Difficult Wound with Topical Tacrolimus. | 2017 | Adv Skin Wound Care | pmid:28914682 |
| Lee JE et al. | A Case of Rheumatoid Vasculitis Involving Hepatic Artery in Early Rheumatoid Arthritis. | 2017 | J. Korean Med. Sci. | pmid:28581281 |
| Riva N et al. | Pharmacoepidemiology of tacrolimus in pediatric liver transplantation. | 2017 | Pediatr Transplant | pmid:28574195 |
| Filipec Kanizaj T and Mijic M | Inflammatory bowel disease in liver transplanted patients. | 2017 | World J. Gastroenterol. | pmid:28566881 |
| Liang Q et al. | The efficacy and safety of tacrolimus monotherapy in adult-onset nephrotic syndrome caused by idiopathic membranous nephropathy. | 2017 | Ren Fail | pmid:28562168 |
| Zhang J et al. | MicroRNA expression analysis during FK506-induced osteogenic differentiation in rat bone marrow stromal cells. | 2017 | Mol Med Rep | pmid:28560399 |
| Asada A et al. | The effect of CYP3A5 genetic polymorphisms on adverse events in patients with ulcerative colitis treated with tacrolimus. | 2017 | Dig Liver Dis | pmid:27717793 |
| Park SS et al. | Beneficial Role of Low-Dose Antithymocyte Globulin in Unrelated Stem Cell Transplantation for Adult Patients with Acquired Severe Aplastic Anemia: Reduction of Graft-versus-Host Disease and Improvement of Graft-versus-Host Disease-Free, Failure-Free Survival Rate. | 2017 | Biol. Blood Marrow Transplant. | pmid:28554856 |
| Kim HS et al. | The Protective Effect of Febuxostat on Chronic Tacrolimus-Induced Nephrotoxicity in Rats. | 2017 | Nephron | pmid:27701176 |
| Berntsen HF et al. | The fungal neurotoxin penitrem A induces the production of reactive oxygen species in human neutrophils at submicromolar concentrations. | 2017 | Toxicology | pmid:29037868 |
| Damon C et al. | Predictive Modeling of Tacrolimus Dose Requirement Based on High-Throughput Genetic Screening. | 2017 | Am. J. Transplant. | pmid:27597269 |
| Jin H et al. | Inappropriate amounts of topical tacrolimus applied on Korean patients with eczema. | 2017 | J Dermatolog Treat | pmid:27588441 |
| Donati M et al. | Resolution of Benign and Malignant Sebaceous Neoplasms, in a Renal Transplant Patient Treated With Everolimus. | 2017 | Exp Clin Transplant | pmid:25924010 |
| Zong YP et al. | Effects of CYP3A5 polymorphisms on tacrolimus pharmacokinetics in pediatric kidney transplantation: a systematic review and meta-analysis of observational studies. | 2017 | World J Pediatr | pmid:28540692 |
| Seo SR et al. | Disrupted Skin Barrier is Associated with Burning Sensation after Topical Tacrolimus Application in Atopic Dermatitis. | 2017 | Acta Derm. Venereol. | pmid:28512670 |
| Shen CL et al. | Tacrolimus Blood Level Fluctuation Predisposes to Coexisting BK Virus Nephropathy and Acute Allograft Rejection. | 2017 | Sci Rep | pmid:28512328 |
| Egeland EJ et al. | High Tacrolimus Clearance Is a Risk Factor for Acute Rejection in the Early Phase After Renal Transplantation. | 2017 | Transplantation | pmid:28452920 |
| Eleftheriadis T et al. | In human cell cultures, everolimus is inferior to tacrolimus in inhibiting cellular alloimmunity, but equally effective as regards humoral alloimmunity. | 2017 | Int Urol Nephrol | pmid:28508247 |
| Kofod L et al. | Endometrial immune markers are potential predictors of normal fertility and pregnancy after in vitro fertilization. | 2017 | Am. J. Reprod. Immunol. | pmid:28440588 |
| Banovic F et al. | Therapeutic effectiveness of calcineurin inhibitors in canine vesicular cutaneous lupus erythematosus. | 2017 | Vet. Dermatol. | pmid:28439997 |
| Vanhove T et al. | Fexofenadine, a Putative In Vivo P-glycoprotein Probe, Fails to Predict Clearance of the Substrate Tacrolimus in Renal Recipients. | 2017 | Clin. Pharmacol. Ther. | pmid:28437851 |
| Labroo P et al. | Effect Of combining FK506 and neurotrophins on neurite branching and elongation. | 2017 | Muscle Nerve | pmid:27503321 |
| Bhari N et al. | Tacrolimus induced dermatophyte infection overlying a plaque morphea. | 2017 | Dermatol Ther | pmid:27502443 |
| Zhang H et al. | Multitarget Therapy for Maintenance Treatment of Lupus Nephritis. | 2017 | J. Am. Soc. Nephrol. | pmid:28760751 |
| Ciftci HS et al. | Influence of Proton Pump Inhibitors on Mycophenolic Acid Pharmacokinetics in Patients With Renal Transplantation and the Relationship With Cytochrome 2C19 Gene Polymorphism. | 2017 | Transplant. Proc. | pmid:28340819 |
| Aktürk S et al. | Average Tacrolimus Trough Level in the First Month After Transplantation May Predict Acute Rejection. | 2017 | Transplant. Proc. | pmid:28340806 |
| Calo S et al. | A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides. | 2017 | PLoS Genet. | pmid:28339467 |
| Vanhove T et al. | Effect of ABCB1 diplotype on tacrolimus disposition in renal recipients depends on CYP3A5 and CYP3A4 genotype. | 2017 | Pharmacogenomics J. | pmid:27378609 |
| Peng T et al. | Protective effects of tacrolimus on podocytes in early diabetic nephropathy in rats. | 2017 | Mol Med Rep | pmid:28339051 |
| Huang TQ et al. | Protection of FK506 against neuronal apoptosis and axonal injury following experimental diffuse axonal injury. | 2017 | Mol Med Rep | pmid:28339015 |
| Varela-Veiga A et al. | Long-standing Papules on the Scrotum. | 2017 | Actas Dermosifiliogr | pmid:27328825 |
| Rodrigues N et al. | Serum Magnesium and Related Factors in Long-Term Renal Transplant Recipients: An Observational Study. | 2017 | Transplant. Proc. | pmid:28457398 |
| Mashayekhi S et al. | The treatment of vulval lichen sclerosus in prepubertal girls: a critically appraised topic. | 2017 | Br. J. Dermatol. | pmid:28244087 |
| Guttman-Yassky E et al. | Molecular signatures order the potency of topically applied anti-inflammatory drugs in patients with atopic dermatitis. | 2017 | J. Allergy Clin. Immunol. | pmid:28238742 |
| Takagi K et al. | Syndrome of Inappropriate Antidiuretic Hormone Secretion Following Liver Transplantation. | 2017 | Acta Med. Okayama | pmid:28238015 |
| Riva N et al. | Therapeutic monitoring of pediatric transplant patients with conversion to generic tacrolimus. | 2017 | Farm Hosp | pmid:28236795 |
| Madsen MJ et al. | The Pharmacogenetics of Tacrolimus in Corticosteroid-Sparse Pediatric and Adult Kidney Transplant Recipients. | 2017 | Drugs R D | pmid:28229376 |
| Vanhove T et al. | Determinants of the Magnitude of Interaction Between Tacrolimus and Voriconazole/Posaconazole in Solid Organ Recipients. | 2017 | Am. J. Transplant. | pmid:28224698 |
| Sahutoglu T et al. | Tac-MMF Versus CsA-MMF/CsA-AZA-Based Regimens in Development of De Novo Complement-Binding Anti-HLA Antibodies After Kidney Transplantation. | 2017 | Transplant. Proc. | pmid:28340811 |
| Rebora A | Tacrolimus and oral lichen planus: the question remains. | 2017 | J Eur Acad Dermatol Venereol | pmid:27324047 |
| Sarier M et al. | HPV type 45-positive condyloma acuminata of the bladder in a renal transplant recipient. | 2017 | Transpl Infect Dis | pmid:28100036 |
| Hanchanale P et al. | Nocardia liver abscess post liver transplantation-A rare presentation. | 2017 | Transpl Infect Dis | pmid:28150374 |
| Størset E et al. | The CYP3A biomarker 4β-hydroxycholesterol does not improve tacrolimus dose predictions early after kidney transplantation. | 2017 | Br J Clin Pharmacol | pmid:28146606 |
| Dai Y et al. | A case report of coup de sabre patient with hair transplantation. | 2017 | J Dermatolog Treat | pmid:28142293 |
| Shihab F et al. | Association of Clinical Events With Everolimus Exposure in Kidney Transplant Patients Receiving Low Doses of Tacrolimus. | 2017 | Am. J. Transplant. | pmid:28141897 |
| Son SY et al. | Comparison of the long-term efficacy and safety of generic Tacrobell with original tacrolimus (Prograf) in kidney transplant recipients. | 2017 | Drug Des Devel Ther | pmid:28138224 |
| Hashemizadeh Z et al. | Observational Study of Associations between Voriconazole Therapeutic Drug Monitoring, Toxicity, and Outcome in Liver Transplant Patients. | 2017 | Antimicrob. Agents Chemother. | pmid:28923870 |
| Chu CH et al. | Radiation recall dermatitis induced by topical tacrolimus for post-irradiation morphea. | 2017 | J Eur Acad Dermatol Venereol | pmid:27256845 |
| Kirpalani A et al. | Idiosyncratic drug reactions and membranous glomerulopathy. | 2017 | BMJ Case Rep | pmid:28137906 |
| Pensi D et al. | First UHPLC-MS/MS method coupled with automated online SPE for quantification both of tacrolimus and everolimus in peripheral blood mononuclear cells and its application on samples from co-treated pediatric patients. | 2017 | J Mass Spectrom | pmid:28098395 |
| Lewis K et al. | Autoimmune enteropathy and hepatitis in pediatric heart transplant recipient. | 2017 | Pediatr Transplant | pmid:28097735 |
| Sommer W et al. | Irradiation before and donor splenocyte infusion immediately after transplantation induce tolerance to lung, but not heart allografts in miniature swine. | 2017 | Transpl. Int. | pmid:28095640 |
| Classen J et al. | Seasonal leukotrichia in a German shepherd dog. A case report. | 2017 | Tierarztl Prax Ausg K Kleintiere Heimtiere | pmid:28094416 |
| Kim JM et al. | Differences in Peripheral Blood Lymphocytes between Brand-Name and Generic Tacrolimus Used in Stable Liver Transplant Recipients. | 2017 | Med Princ Pract | pmid:28092916 |
| Shimizu K | Development of New Liposome Targeting Strategies for Application of Disease Therapies. | 2017 | Yakugaku Zasshi | pmid:28049894 |
| Cukor D et al. | A Pilot Randomized Controlled Trial to Promote Immunosuppressant Adherence in Adult Kidney Transplant Recipients. | 2017 | Nephron | pmid:28049201 |
| Calvo PL et al. | Donor CYP3A5 genotype influences tacrolimus disposition on the first day after paediatric liver transplantation. | 2017 | Br J Clin Pharmacol | pmid:28044353 |
| Hayes W et al. | Hypomagnesemia and increased risk of new-onset diabetes mellitus after transplantation in pediatric renal transplant recipients. | 2017 | Pediatr. Nephrol. | pmid:28039534 |
| Carnevale-Schianca F et al. | Post-Transplant Cyclophosphamide and Tacrolimus-Mycophenolate Mofetil Combination Prevents Graft-versus-Host Disease in Allogeneic Peripheral Blood Hematopoietic Cell Transplantation from HLA-Matched Donors. | 2017 | Biol. Blood Marrow Transplant. | pmid:28039079 |
| Srivastava AK et al. | Serial in vivo imaging of transplanted allogeneic neural stem cell survival in a mouse model of amyotrophic lateral sclerosis. | 2017 | Exp. Neurol. | pmid:28038988 |
| Yang D et al. | JC polyomavirus nephropathy, a rare cause of transplant dysfunction: Case report and review of literature. | 2017 | Transpl Infect Dis | pmid:28036142 |
| Shi G et al. | Variation of CD4CD25Foxp3 Regulatory T Cells and Th17 Cells in the Peripheral Blood of Human Liver Allograft Patients With Long-term Survival. | 2017 | Transplant. Proc. | pmid:28923634 |
| Wang L et al. | Efficacy and safety of tacrolimus for myasthenia gravis: a systematic review and meta-analysis. | 2017 | J. Neurol. | pmid:28921038 |
| Hu Y et al. | FK506 suppresses hypoxia‑induced inflammation and protects tight junction function via the CaN‑NFATc1 signaling pathway in retinal microvascular epithelial cells. | 2017 | Mol Med Rep | pmid:28901449 |
| Spiekerkoetter E et al. | Randomised placebo-controlled safety and tolerability trial of FK506 (tacrolimus) for pulmonary arterial hypertension. | 2017 | Eur. Respir. J. | pmid:28893866 |
| Li J et al. | Wuzhi Tablet ( Extract) is a Promising Tacrolimus-Sparing Agent for Renal Transplant Recipients Who are CYP3A5 Expressers: a Two-Phase Prospective Study. | 2017 | Drug Metab. Dispos. | pmid:28864749 |
| Watanabe M et al. | Successful treatment of calcineurin inhibitor-induced pain syndrome with acute graft versus host disease by switching calcineurin inhibitors followed by pregabalin. | 2017 | Ann. Hematol. | pmid:28508935 |
| Triñanes J et al. | Deciphering Tacrolimus-Induced Toxicity in Pancreatic β Cells. | 2017 | Am. J. Transplant. | pmid:28432716 |
| Hosoi K et al. | Prolonged tacrolimus for pediatric gastrointestinal disorder: Double-edged sword? | 2017 | Pediatr Int | pmid:27935231 |
| Parrow NL and Fleming RE | Releasing the FKBP12 brake on hepcidin. | 2017 | Blood | pmid:29122771 |
| Kalt DA | Tacrolimus: A Review of Laboratory Detection Methods and Indications for Use. | 2017 | Lab Med | pmid:29096030 |
| Andrews LM et al. | Pharmacokinetic considerations related to therapeutic drug monitoring of tacrolimus in kidney transplant patients. | 2017 | Expert Opin Drug Metab Toxicol | pmid:29084469 |
| Noceti O et al. | Activity of the Calcineurin Pathway in Patients on the Liver Transplantation Waiting List: Factors of Variability and Response to Tacrolimus Inhibition. | 2017 | Clin. Chem. | pmid:29054923 |
| Soiffer RJ et al. | Prospective, Randomized, Double-Blind, Phase III Clinical Trial of Anti-T-Lymphocyte Globulin to Assess Impact on Chronic Graft-Versus-Host Disease-Free Survival in Patients Undergoing HLA-Matched Unrelated Myeloablative Hematopoietic Cell Transplantation. | 2017 | J. Clin. Oncol. | pmid:29040031 |
| Esquirol A et al. | Single-agent GvHD prophylaxis with tacrolimus after post-transplant high-dose cyclophosphamide is a valid option for haploidentical transplantation in adults with hematological malignancies. | 2017 | Bone Marrow Transplant. | pmid:28604667 |
| Vanhove T et al. | Pretransplant 4β-hydroxycholesterol does not predict tacrolimus exposure or dose requirements during the first days after kidney transplantation. | 2017 | Br J Clin Pharmacol | pmid:28603840 |
| Whitehouse G et al. | IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:28584086 |
| Al-Kadhimi Z et al. | Low incidence of severe cGvHD and late NRM in a phase II trial of thymoglobulin, tacrolimus and sirolimus for GvHD prevention. | 2017 | Bone Marrow Transplant. | pmid:28581472 |
| Dardis G et al. | Cx43 suppresses evx1 expression to regulate joint initiation in the regenerating fin. | 2017 | Dev. Dyn. | pmid:28577298 |