| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arm Injuries | D001134 | 1 associated lipids |
| Intussusception | D007443 | 1 associated lipids |
| Thrombotic Microangiopathies | D057049 | 1 associated lipids |
| Autoimmune Diseases of the Nervous System | D020274 | 1 associated lipids |
| Lupus Erythematosus, Discoid | D008179 | 1 associated lipids |
| Lymphocytic Choriomeningitis | D008216 | 1 associated lipids |
| Erythroplasia | D004919 | 1 associated lipids |
| Hepatic Veno-Occlusive Disease | D006504 | 1 associated lipids |
| West Nile Fever | D014901 | 1 associated lipids |
| Hypoalbuminemia | D034141 | 1 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Huang K et al. | Novel role for NFAT3 in ERK-mediated regulation of CXCR4. | 2014 | PLoS ONE | pmid:25514788 |
| Saito K et al. | Severe diffuse duodenitis successfully treated with intravenous tacrolimus after colectomy for ulcerative colitis. | 2014 | Intern. Med. | pmid:25366006 |
| Labrador J et al. | Risk factors for thrombotic microangiopathy in allogeneic hematopoietic stem cell recipients receiving GVHD prophylaxis with tacrolimus plus MTX or sirolimus. | 2014 | Bone Marrow Transplant. | pmid:24566710 |
| Liu Y et al. | Role of retrograde trafficking in stress response, host cell interactions, and virulence of Candida albicans. | 2014 | Eukaryotic Cell | pmid:24363364 |
| Singh K et al. | Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer. | 2014 | Am. J. Transplant. | pmid:25359003 |
| Siebelt M et al. | FK506 protects against articular cartilage collagenous extra-cellular matrix degradation. | 2014 | Osteoarthr. Cartil. | pmid:24561282 |
| Wei TQ et al. | Sandwich assay for tacrolimus using 2 antitacrolimus antibodies. | 2014 | Clin. Chem. | pmid:24381229 |
| Tang Q | Pharmacokinetics of therapeutic Tregs. | 2014 | Am. J. Transplant. | pmid:25358900 |
| Hamzah S et al. | Pharmacogenotyping of CYP3A5 in predicting dose-adjusted trough levels of tacrolimus among Malaysian kidney-transplant patients. | 2014 | Can. J. Physiol. Pharmacol. | pmid:24383873 |
| Amorim J et al. | Tacrolimus-induced neutropenia in a cardiac transplant patient. | 2014 | Pediatr Transplant | pmid:24384051 |
| Silva HT et al. | Long-term follow-up of a phase III clinical trial comparing tacrolimus extended-release/MMF, tacrolimus/MMF, and cyclosporine/MMF in de novo kidney transplant recipients. | 2014 | Transplantation | pmid:24521771 |
| Kurzawski M et al. | CYP3A5 and CYP3A4, but not ABCB1 polymorphisms affect tacrolimus dose-adjusted trough concentrations in kidney transplant recipients. | 2014 | Pharmacogenomics | pmid:24444408 |
| Xue F et al. | CYP3A5 genotypes affect tacrolimus pharmacokinetics and infectious complications in Chinese pediatric liver transplant patients. | 2014 | Pediatr Transplant | pmid:24438215 |
| Lapeyraque AL et al. | Conversion from twice- to once-daily tacrolimus in pediatric kidney recipients: a pharmacokinetic and bioequivalence study. | 2014 | Pediatr. Nephrol. | pmid:24435759 |
| Højfeldt JW et al. | Bifunctional ligands allow deliberate extrinsic reprogramming of the glucocorticoid receptor. | 2014 | Mol. Endocrinol. | pmid:24422633 |
| Chen YK et al. | Personalized tacrolimus dose requirement by CYP3A5 but not ABCB1 or ACE genotyping in both recipient and donor after pediatric liver transplantation. | 2014 | PLoS ONE | pmid:25310192 |
| Saso S et al. | Uterine allotransplantation in a rabbit model using aorto-caval anastomosis: a long-term viability study. | 2014 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:25306223 |
| Mekaj AY et al. | Application of topical pharmacological agents at the site of peripheral nerve injury and methods used for evaluating the success of the regenerative process. | 2014 | J Orthop Surg Res | pmid:25303779 |
| Steinebrunner N et al. | Pharmacodynamic monitoring of nuclear factor of activated T cell-regulated gene expression in liver allograft recipients on immunosuppressive therapy with calcineurin inhibitors in the course of time and correlation with acute rejection episodes--a prospective study. | 2014 | Ann. Transplant. | pmid:24457606 |
| Müller GG et al. | Topical tacrolimus 0.03% as sole therapy in vernal keratoconjunctivitis: a randomized double-masked study. | 2014 | Eye Contact Lens | pmid:24418865 |
| Meyer KC et al. | An international ISHLT/ATS/ERS clinical practice guideline: diagnosis and management of bronchiolitis obliterans syndrome. | 2014 | Eur. Respir. J. | pmid:25359357 |
| Hesselink DA et al. | The role of pharmacogenetics in the disposition of and response to tacrolimus in solid organ transplantation. | 2014 | Clin Pharmacokinet | pmid:24249597 |
| Ahmed S et al. | Photocleavable dimerizer for the rapid reversal of molecular trap antagonists. | 2014 | J. Biol. Chem. | pmid:24421317 |
| Souto-RodrÃguez R et al. | Differences in the incidence and clinical evolution of early neurotoxicity after liver transplantation based on tacrolimus formulation used in the immunosuppressive induction protocol. | 2014 | Transplant. Proc. | pmid:25420839 |
| Al-Amri AM | Long-term follow-up of tacrolimus ointment for treatment of atopic keratoconjunctivitis. | 2014 | Am. J. Ophthalmol. | pmid:24439439 |
| Kim JR et al. | 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol-fortified ginseng extract attenuates the development of atopic dermatitis-like symptoms in NC/Nga mice. | 2014 | J Ethnopharmacol | pmid:24269244 |
| Tavira B et al. | Mitochondrial DNA haplogroups and risk of new-onset diabetes among tacrolimus-treated renal transplanted patients. | 2014 | Gene | pmid:24445060 |
| Lin Y et al. | PERK activation preserves the viability and function of remyelinating oligodendrocytes in immune-mediated demyelinating diseases. | 2014 | Am. J. Pathol. | pmid:24269558 |
| Barreiro C and MartÃnez-Castro M | Trends in the biosynthesis and production of the immunosuppressant tacrolimus (FK506). | 2014 | Appl. Microbiol. Biotechnol. | pmid:24272367 |
| Xu W et al. | Toward immunosuppressive effects on liver transplantation in rat model: tacrolimus loaded poly(ethylene glycol)-poly(D,L-lactide) nanoparticle with longer survival time. | 2014 | Int J Pharm | pmid:24172796 |
| Zhu X et al. | Pilot study using tacrolimus rather than cyclosporine plus antithymocyte globulin as an immunosuppressive therapy regimen option for severe aplastic anemia in adults. | 2014 | Blood Cells Mol. Dis. | pmid:24931461 |
| Salehi-Najafabadi Z et al. | The gamma-butyrolactone receptors BulR1 and BulR2 of Streptomyces tsukubaensis: tacrolimus (FK506) and butyrolactone synthetases production control. | 2014 | Appl. Microbiol. Biotechnol. | pmid:24562179 |
| Xue W et al. | Effects of tacrolimus and cyclosporine treatment on metabolic syndrome and cardiovascular risk factors after renal transplantation: a meta-analysis. | 2014 | Chin. Med. J. | pmid:24931259 |
| Taguchi K et al. | False tacrolimus concentrations measured by antibody-conjugated magnetic immunoassay in liver transplant patient: 2 case reports and literature review. | 2014 | Exp Clin Transplant | pmid:24206050 |
| Gomez-Moyano E et al. | Periorbital granuloma annulare successfully treated with tacrolimus 0.1% ointment. | 2014 | Int. J. Dermatol. | pmid:23432464 |
| Doligalski CT et al. | Sublingual administration of tacrolimus: current trends and available evidence. | 2014 | Pharmacotherapy | pmid:25251980 |
| Koren G and Rieder M | Measuring oral bioavailability of tacrolimus. | 2014 | Pediatr Transplant | pmid:25250966 |
| Souza MC et al. | Tacrolimus-loaded PLGA implants: in vivo release and ocular toxicity. | 2014 | Curr. Eye Res. | pmid:24325382 |
| Talreja N et al. | Successful desensitization to agalsidase beta after anaphylaxis. | 2014 | Ann. Allergy Asthma Immunol. | pmid:24331397 |
| Chen Z et al. | Mutations adjacent to the end of transmembrane helices 6 and 7 independently affect drug efflux capacity of yeast ABC transporter Pdr5p. | 2014 | Biochim. Biophys. Acta | pmid:24333836 |
| Ueda K et al. | Early corticosteroid withdrawal in the real world: a long-term analysis of kidney transplant recipients from the Mycophenolic Acid Observational Renal Transplant Registry. | 2014 | Ann. Transplant. | pmid:24535029 |
| Musuamba FT et al. | Population pharmacokinetic analysis of tacrolimus early after pediatric liver transplantation. | 2014 | Ther Drug Monit | pmid:24081207 |
| Ricciardelli I et al. | Towards gene therapy for EBV-associated posttransplant lymphoma with genetically modified EBV-specific cytotoxic T cells. | 2014 | Blood | pmid:25185261 |
| Mujtaba MA et al. | Conversion from tacrolimus to belatacept to prevent the progression of chronic kidney disease in pancreas transplantation: case report of two patients. | 2014 | Am. J. Transplant. | pmid:25179306 |
| Rahman Z et al. | Determination of tacrolimus crystalline fraction in the commercial immediate release amorphous solid dispersion products by a standardized X-ray powder diffraction method with chemometrics. | 2014 | Int J Pharm | pmid:25173870 |
| Jia JJ et al. | ''Minimizing tacrolimus'' strategy and long-term survival after liver transplantation. | 2014 | World J. Gastroenterol. | pmid:25170223 |
| Takeuchi T et al. | Tacrolimus-induced left ventricular apical hypertrophy in a patient with post-allogeneic hematopoietic stem cell transplantation. | 2014 | Int. J. Cardiol. | pmid:25131917 |
| Huang H et al. | Effect and mechanism of tacrolimus on melanogenesis on A375 human melanoma cells. | 2014 | Chin. Med. J. | pmid:25131236 |
| Choi SW et al. | Vorinostat plus tacrolimus and mycophenolate to prevent graft-versus-host disease after related-donor reduced-intensity conditioning allogeneic haemopoietic stem-cell transplantation: a phase 1/2 trial. | 2014 | Lancet Oncol. | pmid:24295572 |
| Görzer I et al. | Plasma DNA levels of Torque teno virus and immunosuppression after lung transplantation. | 2014 | J. Heart Lung Transplant. | pmid:24559947 |
| Barnieh L et al. | The cost of kidney transplant over time. | 2014 | Prog Transplant | pmid:25193726 |
| Guy S et al. | Successful treatment of acute severe graft-versus-host-disease in a pancreas-after-kidney transplant recipient: case report. | 2014 | Transplant. Proc. | pmid:25179161 |
| Yuan C et al. | A simple and robust LC-MS/MS method for measuring sirolimus and everolimus in whole blood. | 2014 | Bioanalysis | pmid:25077621 |
| Aulagnon F et al. | Diarrhea after kidney transplantation: a new look at a frequent symptom. | 2014 | Transplantation | pmid:25073040 |
| Beermann KJ et al. | Tacrolimus dose requirements in African-American and Caucasian kidney transplant recipients on mycophenolate and prednisone. | 2014 | Clin Transplant | pmid:24754564 |
| Zwiech R | [The early C4d urinary excretion and long-term kidney graft survival in patients treated with tacrolimus and mycophenolate mophetil]. | 2014 | Pol. Merkur. Lekarski | pmid:24779215 |
| Matia I et al. | Immunosuppressive protocol with delayed use of low-dose tacrolimus after aortic transplantation suppresses donor-specific anti-MHC class I and class II antibody production in rats. | 2014 | Ann. Transplant. | pmid:24815872 |
| Harada N et al. | [Follow-up study on patients with vernal keratoconjunctivitis undergoing topical 0.1% tacrolimus treatment]. | 2014 | Nippon Ganka Gakkai Zasshi | pmid:24864437 |
| Denfield SW | Oxidative and other stresses following pediatric heart transplantation. | 2014 | Pediatr Transplant | pmid:25250969 |
| Izumi Y et al. | Safety of tacrolimus treatment during pregnancy and lactation in systemic lupus erythematosus: a report of two patients. | 2014 | Tohoku J. Exp. Med. | pmid:25175032 |
| Boschetti G et al. | Tacrolimus induction followed by maintenance monotherapy is useful in selected patients with moderate-to-severe ulcerative colitis refractory to prior treatment. | 2014 | Dig Liver Dis | pmid:25023007 |
| Piao SG et al. | Combined treatment of tacrolimus and everolimus increases oxidative stress by pharmacological interactions. | 2014 | Transplantation | pmid:24825522 |
| Personett HA et al. | Impact of molecular adsorbent recirculating system therapy on tacrolimus elimination: a case report. | 2014 | Transplant. Proc. | pmid:25017243 |
| Gujadhur A et al. | CMV sinusitis in a HIV-negative renal transplant recipient. | 2014 | Transplantation | pmid:24827770 |
| Anderson JS et al. | Statistical allosteric coupling to the active site indole ring flip equilibria in the FK506-binding domain. | 2014 | Biophys. Chem. | pmid:25016286 |
| Navas-López VM et al. | Oral tacrolimus for pediatric steroid-resistant ulcerative colitis. | 2014 | J Crohns Colitis | pmid:23582736 |
| van Gelder T et al. | Pharmacogenetics and immunosuppressive drugs in solid organ transplantation. | 2014 | Nat Rev Nephrol | pmid:25247332 |
| Tapirdamaz Ö et al. | Genetic variance in ABCB1 and CYP3A5 does not contribute toward the development of chronic kidney disease after liver transplantation. | 2014 | Pharmacogenet. Genomics | pmid:25014506 |
| Matsuda Y et al. | Once-daily oral administration of cyclosporine in a lung transplant patient with a history of renal toxicity of calcineurin inhibitors. | 2014 | Interact Cardiovasc Thorac Surg | pmid:24659549 |
| Lunde I et al. | The influence of CYP3A, PPARA, and POR genetic variants on the pharmacokinetics of tacrolimus and cyclosporine in renal transplant recipients. | 2014 | Eur. J. Clin. Pharmacol. | pmid:24658827 |
| Picchianti-Diamanti A et al. | P-glycoprotein and drug resistance in systemic autoimmune diseases. | 2014 | Int J Mol Sci | pmid:24658440 |
| Enderby CY et al. | Tacrolimus dosage requirements in lung transplant recipients receiving antifungal prophylaxis with voriconazole followed by itraconazole: a preliminary prospective study. | 2014 | Clin Transplant | pmid:24931421 |
| Webster P et al. | Tacrolimus is an effective treatment for lupus nephritis in pregnancy. | 2014 | Lupus | pmid:24928830 |
| Wolfram D et al. | Insights from computational modeling in inflammation and acute rejection in limb transplantation. | 2014 | PLoS ONE | pmid:24926998 |
| Carbajo-Lozoya J et al. | Human coronavirus NL63 replication is cyclophilin A-dependent and inhibited by non-immunosuppressive cyclosporine A-derivatives including Alisporivir. | 2014 | Virus Res. | pmid:24566223 |
| Feng S et al. | A rapidly reversible chemical dimerizer system to study lipid signaling in living cells. | 2014 | Angew. Chem. Int. Ed. Engl. | pmid:24841150 |
| Rotter D et al. | Calcineurin and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion. | 2014 | J. Mol. Cell. Cardiol. | pmid:24838101 |
| Ren Y et al. | Tolerogenic dendritic cells modified by tacrolimus suppress CD4(+) T-cell proliferation and inhibit collagen-induced arthritis in mice. | 2014 | Int. Immunopharmacol. | pmid:24836681 |
| Li H et al. | A promising approach of overcoming the intrinsic resistance of Candida krusei to fluconazole (FLC)--combining tacrolimus with FLC. | 2014 | FEMS Yeast Res. | pmid:24830342 |
| Wang YB et al. | In vitro and in vivo performance of dry powder inhalation formulations: comparison of particles prepared by thin film freezing and micronization. | 2014 | AAPS PharmSciTech | pmid:24824172 |
| Oda K et al. | In vitro experimental system for evaluating inhibitory effect of investigational drugs on P-glycoprotein-mediated transcellular transport of tacrolimus (FK506). | 2014 | Biopharm Drug Dispos | pmid:24822242 |
| Welzl K et al. | Effect of different immunosuppressive drugs on immune cells from young and old healthy persons. | 2014 | Gerontology | pmid:24434865 |
| Yang LM et al. | Experimental research on end-to-side anastomosis of peripheral nerves and effect of FK506 on end-to-side anastomosis. | 2014 | Bratisl Lek Listy | pmid:25573729 |
| Fazal MA et al. | Dyslipidaemia among renal transplant recipients: cyclosporine versus tacrolimus. | 2014 | J Pak Med Assoc | pmid:25272531 |
| Taimur S et al. | Donor T-cell chimerism and early post-transplant cytomegalovirus viremia in patients treated with myeloablative allogeneic hematopoietic stem cell transplant. | 2014 | Transpl Infect Dis | pmid:24251680 |
| Stewart JI et al. | Reverse halo sign on chest imaging in a renal transplant recipient. | 2014 | Transpl Infect Dis | pmid:24289813 |
| Muduma G et al. | A UK analysis of the cost of switching renal transplant patients from an immediate-release to a prolonged-release formulation of tacrolimus based on differences in trough concentration variability. | 2014 | J Med Econ | pmid:24754700 |
| Shihab FS et al. | Tacrolimus exposure in the real world: an analysis from the Mycophenolic acid Observational REnal transplant study. | 2014 | Clin Transplant | pmid:24754603 |
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| Bloch J et al. | Donor ABCB1 genetic polymorphisms influence epithelial-to-mesenchyme transition in tacrolimus-treated kidney recipients. | 2014 | Pharmacogenomics | pmid:25521359 |
| Nacif LS et al. | An analysis of tacrolimus-related complications in the first 30 days after liver transplantation. | 2014 | Clinics (Sao Paulo) | pmid:25518032 |
| Kawaguch K et al. | Successful treatment with allogenic hematopoietic stem cell transplantation of a severe congenital neutropenia patient harboring a novel ELANE mutation. | 2014 | Rinsho Ketsueki | pmid:25501410 |
| Cvetkovic TP et al. | Gender differences in oxidative and nitrosative stress parameters in kidney transplant patients on tacrolimus-based immunosuppression. | 2014 | Int Urol Nephrol | pmid:24101297 |
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