| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Nocardia Infections | D009617 | 6 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Graft Occlusion, Vascular | D006083 | 11 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ericzon BG | Early graft function in liver transplantation patients. | 1994 | Transplant. Proc. | pmid:7527965 |
| Ricordi C et al. | Donor bone marrow cell infusion without recipient cytoablation induces acceptance of rat islet allografts. | 1994 | Transplant. Proc. | pmid:7527967 |
| Tsugita M et al. | Hepatocytes or liver nonparenchymal cells plus FK 506 prolong liver xenograft survival. | 1994 | Transplant. Proc. | pmid:7527969 |
| Alessiani M et al. | Infections with FK 506 immunosuppression: preliminary results with primary therapy. | 1990 | Transplant. Proc. | pmid:1689895 |
| Japanese study of FK 506 on kidney transplantation: results of late phase II study. | 1993 | Transplant. Proc. | pmid:7679831 | |
| Kobayashi M et al. | Production of monoclonal antibody against recombinant human FKBP-12 and subcellular localization of FKBP-12 in human mononuclear and polymorphonuclear cells. | 1993 | Transplant. Proc. | pmid:7679832 |
| Grenier FC et al. | A whole blood FK 506 assay for the IMx analyzer. | 1991 | Transplant. Proc. | pmid:1721264 |
| Friob MC et al. | A combined HPLC-ELISA evaluation of FK 506 in transplant patients. | 1991 | Transplant. Proc. | pmid:1721265 |
| Tomikawa S et al. | Immunosuppressive effects of bactobolamine in vitro and in vivo. | 1996 | Transplant. Proc. | pmid:8623223 |
| Rossi G et al. | Three-year follow-up of low dose tacrolimus oral therapy after liver transplantation: a single-centre experience. | 1998 | Transplant. Proc. | pmid:9636562 |
| Wong KM et al. | Tacrolimus versus cyclosporine as primary prophylactic therapy after cadaveric renal transplant: two-year survival study. | 2000 | Transplant. Proc. | pmid:11119907 |
| Nakajima H and Oka T | The inhibition of T-cell-receptor-induced Fas ligand upregulation by cyclosporine and FK 506. | 1996 | Transplant. Proc. | pmid:8623224 |
| Samuel D et al. | Tacrolimus (FK506)-based dual versus triple therapy following liver transplantation. | 1998 | Transplant. Proc. | pmid:9636563 |
| Goto Y et al. | Outcome of tacrolimus-treated renal transplantation from elderly donors. | 2000 | Transplant. Proc. | pmid:11119908 |
| Chang HY et al. | Long-term follow-up of arrhythmia characteristics and clinical outcomes in heart transplant patients. | 2013 Jan-Feb | Transplant. Proc. | pmid:23375324 |
| Matevossian E et al. | Liver transplantation in the rat: single-center experience with technique, long-term survival, and functional and histologic findings. | 2009 Jul-Aug | Transplant. Proc. | pmid:19715990 |
| Müller H et al. | Immunosuppression with generic tacrolimus and mycophenolate mofetil in renal transplant recipients: preliminary report in Chile. | 2008 | Transplant. Proc. | pmid:18454992 |
| Thomas FT et al. | Comparative efficacy of immunosuppressive drugs in xenografting. | 1990 | Transplant. Proc. | pmid:1693452 |
| de la Fuente S et al. | Long-term survivors after pediatric liver transplatation are at increased risk for development of cardiovascular disease events: analysis of 30 cases. | 2014 | Transplant. Proc. | pmid:25420837 |
| McKenna BA et al. | Tacrolimus (FK 506): a whole blood assay as measured on the Abbott IMx analyzer. | 1996 | Transplant. Proc. | pmid:8623491 |
| Tanida I et al. | Yeast cyclophilin-related gene encodes a nonessential second peptidyl-prolyl cis-trans isomerase associated with the secretory pathway. | 1991 | Transplant. Proc. | pmid:1721297 |
| Walker S et al. | Clinical use and bioavailability of tacrolimus in heart-lung and double lung transplant recipients with cystic fibrosis. | 1998 | Transplant. Proc. | pmid:9636618 |
| Watanabe K et al. | Donor bone marrow cell infusion is effective in inducing tolerance in dogs treated with fractionated lymphoid irradiation and FK506. | 2000 | Transplant. Proc. | pmid:11120286 |
| Perrella A et al. | Cytomegalovirus infection after liver transplantation: prophylaxis and preemptive treatment--a single-center experience. | 2010 | Transplant. Proc. | pmid:20534267 |
| Akiyama T et al. | Mizoribine in combination therapy with tacrolimus for living donor renal transplantation: analysis of a nationwide study in Japan. | 2005 | Transplant. Proc. | pmid:15848551 |
| Meçule A et al. | Once daily tacrolimus formulation: monitoring of plasma levels, graft function, and cardiovascular risk factors. | 2010 | Transplant. Proc. | pmid:20534290 |
| Alloway R et al. | Conversion of stable kidney transplant recipients from a twice daily Prograf-based regimen to a once daily modified release tacrolimus-based regimen. | 2005 | Transplant. Proc. | pmid:15848559 |
| Chen JS et al. | Effect of CYP3A5 genotype on renal allograft recipients treated with tacrolimus. | 2009 | Transplant. Proc. | pmid:19545678 |
| Andrés A et al. | Extended-release tacrolimus therapy in de novo kidney transplant recipients: single-center experience. | 2010 | Transplant. Proc. | pmid:20970602 |
| Bakar F et al. | Low-density lipoprotein oxidizability and the alteration of its fatty acid content in renal transplant recipients treated with cyclosporine/tacrolimus. | 2009 | Transplant. Proc. | pmid:19545695 |
| Cabello M et al. | Pharmacokinetics of once- versus twice-daily tacrolimus formulations in kidney transplant patients receiving expanded criteria deceased donor organs: a single-center, randomized study. | 2010 | Transplant. Proc. | pmid:20970603 |
| Erickson L et al. | Gene expression profiling of acute rejection and mixed lymphocyte reaction with tacrolimus immunosuppression. | 2002 | Transplant. Proc. | pmid:12176407 |
| Ippoliti G et al. | Serum cytokine levels after small bowel transplantation in pigs. | 1994 | Transplant. Proc. | pmid:7518146 |
| Orita T et al. | Effect of FK 506 in combination with prednisolone on the graft-vs-host reaction after small bowel transplantation in rats. | 1994 | Transplant. Proc. | pmid:7518147 |
| Teraoka S et al. | Effect of rescue therapy using FK 506 on relapsing rejection after combined pancreas and kidney transplantation. | 1995 | Transplant. Proc. | pmid:7533381 |
| Graeb C et al. | Cytoimmunologic monitoring of small bowel allograft recipients. | 1992 | Transplant. Proc. | pmid:1376515 |
| Fay JW et al. | FK 506-based immunosuppression for prevention of graft versus host disease after unrelated donor marrow transplantation. | 1995 | Transplant. Proc. | pmid:7533383 |
| Takai K et al. | Immunosuppressive effects of FK 506 on rat lymphoid organs. | 1991 | Transplant. Proc. | pmid:1721329 |
| Mizuta K et al. | Increase of bile acid production by tacrolimus in the rat liver. | 2003 | Transplant. Proc. | pmid:12591477 |
| van Hooff JP and Christiaans MH | Use of tacrolimus in renal transplantation. | 1999 | Transplant. Proc. | pmid:10616483 |
| Loucaidou M et al. | Cytokine polymorphisms do not influence acute rejection in renal transplantation under tacrolimus-based immunosuppression. | 2005 | Transplant. Proc. | pmid:15919456 |
| Ping X et al. | Antigen sampling on the Peyer's patches in a murine small bowel transplantation model. | 2010 | Transplant. Proc. | pmid:21094860 |
| Hanafusa T et al. | Long-term impact of hepatitis virus infection on kidney transplant recipients and a pilot study of the effects of interferon alpha on chronic hepatitis C. | 1995 | Transplant. Proc. | pmid:7533440 |
| Yagihashi A et al. | HLA matching effect in liver transplantation. | 1992 | Transplant. Proc. | pmid:1281569 |
| Gordon RD et al. | Liver transplantation under cyclosporine: a decade of experience. | 1991 | Transplant. Proc. | pmid:1703339 |
| Shapiro R et al. | FK 506 in clinical kidney transplantation. | 1991 | Transplant. Proc. | pmid:1721361 |
| Todo S et al. | One hundred ten consecutive primary orthotopic liver transplants under FK 506 in adults. | 1991 | Transplant. Proc. | pmid:1703340 |
| McCauley J et al. | Renal transplantation under FK 506 in patients with previous loss of renal function due to hemolytic uremic syndrome. | 1991 | Transplant. Proc. | pmid:1721362 |
| Zeevi A et al. | Correlation between bioassayed plasma levels of FK 506 and lymphocyte growth from liver transplant biopsies with histological evidence of rejection. | 1991 | Transplant. Proc. | pmid:1703341 |
| Solà R et al. | Tacrolimus in induction immunosuppressive treatment in renal transplantation: comparison with cyclosporine. | 2003 | Transplant. Proc. | pmid:12962763 |
| Pascual J et al. | Comparison between a two-drug regimen with tacrolimus and steroids and a triple one with azathioprine in kidney transplantation: results of a European trial with 3-year follow up. | 2003 | Transplant. Proc. | pmid:12962764 |
| Lyne JC et al. | Cadaveric renal transplantation against a positive historic crossmatch under tacrolimus immunosuppression: long-term follow-up. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123015 |
| Bardella MT et al. | FK 506 and cyclosporine: effect on D-xylose absorption in pigs with orthotopic liver-small bowel allotransplants. | 1996 | Transplant. Proc. | pmid:8907937 |
| Ciancio G et al. | Effect of daclizumab, tacrolimus and mycophenolate mofetil in racial minority first renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176508 |
| Sugitani A et al. | Intestinal neurons in acute and chronic rejection after small bowel transplantation in dogs. | 1996 | Transplant. Proc. | pmid:8907941 |
| Charpentier B | A three arm study comparing immediate tacrolimus therapy with ATG induction therapy followed by either tacrolimus or cyclosporine in adult renal transplant recipients. | 2002 | Transplant. Proc. | pmid:12176511 |
| Gringeri E et al. | Neoadjuvant therapy protocol and liver transplantation in combination with pancreatoduodenectomy for the treatment of hilar cholangiocarcinoma occurring in a case of primary sclerosing cholangitis: case report with a more than 8-year disease-free survival. | 2011 | Transplant. Proc. | pmid:21620084 |
| Borda B et al. | Functional and histopathologic changes in renal transplant patients with new-onset diabetes and dyslipidemia. | 2011 | Transplant. Proc. | pmid:21620104 |
| Krzyżowska K et al. | No Significant Influence of Reduced Initial Tacrolimus Dose on Risk of Underdosing and Early Graft Function in Older and Overweight Kidney Transplant Recipients. | Transplant. Proc. | pmid:30056895 | |
| Kim K et al. | Everolimus-Induced Systemic Serositis After Simultaneous Liver and Kidney Transplantation: A Case Report. | Transplant. Proc. | pmid:28104132 | |
| Weir M | Impact of immunosuppressive regimes on posttransplant diabetes mellitus. | 2001 | Transplant. Proc. | pmid:11498201 |
| Kaibori M et al. | Inhibition of iNOS induction by FK506, but not by cyclosporine, in rat hepatocytes. | 1999 Feb-Mar | Transplant. Proc. | pmid:10083347 |
| Yokota K et al. | Comparative studies of FK506 and cyclosporine in canine orthotopic hepatic allograft survival. | 1989 | Transplant. Proc. | pmid:2468209 |
| Carroll PB et al. | Synexin: a target protein for toxic effects of cyclosporine and FK 506 in endocrine cells. | 1991 | Transplant. Proc. | pmid:1721394 |
| Lee S et al. | Mycophenolic acid trough level measurements and clinical outcomes in kidney transplantation recipients on a fixed dose (1.5 g/d) of mycophenolate mofetil in Korea. | 2010 | Transplant. Proc. | pmid:20430174 |
| el-Ghoroury M et al. | Efficacy and safety of tacrolimus versus cyclosporine in kidney and pancreas transplant recipients. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123461 |
| Ali IH et al. | Incidence and risk factors for post-renal transplant diabetes mellitus. | 2011 | Transplant. Proc. | pmid:21440763 |
| McGrath JS and Shehata M | Chronic allograft nephropathy: prospective randomised trial of cyclosporin withdrawal and mycophenolate mofetil or tacrolimus substitution. | 2001 | Transplant. Proc. | pmid:11377500 |
| Mueller AR et al. | Long-term follow-up in hepatitis C patients with respect to immunosuppression. | 1996 | Transplant. Proc. | pmid:8962255 |
| Baid S et al. | Tacrolimus-associated posttransplant diabetes mellitus in renal transplant recipients: role of hepatitis C infection. | 2002 | Transplant. Proc. | pmid:12176569 |
| Tsai SF et al. | Trends in maintenance immunosuppressive drugs used in taiwanese kidney transplant recipients: an analysis of the national health insurance research database. | 2012 | Transplant. Proc. | pmid:22310612 |
| Pretagostini R et al. | Conversion from cyclosporin to tacrolimus in chronic allograft nephropathy. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267174 |
| Abouljoud M et al. | Conversion to neoral provides effective rescue therapy for liver and kidney transplant patients intolerant of Prograf. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267175 |
| Santiago SF et al. | Effect of donor pretreatment with FK 506 upon small intestine allotransplantation in rats. | 1991 | Transplant. Proc. | pmid:1721423 |
| Sakimoto H et al. | Administration of tacrolimus (FK506) in hamster-to-rat pancreas xenotransplantation. | 1996 | Transplant. Proc. | pmid:8658727 |
| Dedhia P et al. | Eculizumab and Belatacept for De Novo Atypical Hemolytic Uremic Syndrome Associated With CFHR3-CFHR1 Deletion in a Kidney Transplant Recipient: A Case Report. | Transplant. Proc. | pmid:28104134 | |
| Murase N et al. | Lymphocyte traffic and graft-versus-host disease after fully allogeneic small bowel transplantation. | 1991 | Transplant. Proc. | pmid:1721424 |
| Takeda M et al. | Pretreatment with splenectomy and FK506 in xeno-lung transplantation. | 1996 | Transplant. Proc. | pmid:8658728 |
| First International Workshop on FK-506. A potential breakthrough in immunosuppression. Proceedings. | 1987 | Transplant. Proc. | pmid:2445066 | |
| Tanaka H et al. | Physicochemical properties of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis. | 1987 | Transplant. Proc. | pmid:2445067 |
| Berweck S et al. | Clinical use of the euglycemic hyperinsulinemic clamp for diagnosis of tacrolimus-induced insulin resistance after combined pancreas-kidney transplantation. | 1998 | Transplant. Proc. | pmid:9723345 |
| Neff GW et al. | Ten years of sirolimus therapy in orthotopic liver transplant recipients. | 2003 | Transplant. Proc. | pmid:12742498 |
| Petz W et al. | Experience with the use of basiliximab in liver transplantation--use in pediatric and adult recipients in combination with cyclosporine or tacrolimus. | 2002 | Transplant. Proc. | pmid:12176648 |
| Yoshimura R et al. | Effect of immunosuppressive drugs (CsA, FK 506, rapamycin) on the kidney microsomal cytochrome P-450 system in the rat. | 1994 | Transplant. Proc. | pmid:7524223 |
| Groetzner J et al. | Tacrolimus or cyclosporine for immunosuppression after cardiac transplantation: which treatment reveals more side effects during long-term follow-up? | 2001 Feb-Mar | Transplant. Proc. | pmid:11267373 |
| Sigal NH et al. | Inhibition of human T-cell activation by FK 506, rapamycin, and cyclosporine A. | 1991 | Transplant. Proc. | pmid:1712132 |
| Fung JJ et al. | Current status of FK 506 in liver transplantation. | 1991 | Transplant. Proc. | pmid:1712133 |
| Pretagostini R et al. | Delayed Introduction of Everolimus in De Novo Renal Transplanted Patients: A Single-Center Experience. | 2016 | Transplant. Proc. | pmid:27109947 |
| Mochizuki M et al. | A multicenter clinical open trial of FK 506 in refractory uveitis, including Behçet's disease. Japanese FK 506 Study Group on Refractory Uveitis. | 1991 | Transplant. Proc. | pmid:1721456 |
| Chávez R et al. | Hepatotrophic effect of cyclosporine and FK 506 is not mimicked by rapamycin. | 1999 | Transplant. Proc. | pmid:10500655 |
| EscartÃn A et al. | Orthotopic small bowel transplantation in pigs without steroids. | 1999 | Transplant. Proc. | pmid:10500720 |
| Ginevri F et al. | Expression of collagen by renal fibroblasts treated with FK 506 in vitro. | 1998 | Transplant. Proc. | pmid:9636387 |
| Hutchinson IV et al. | Differences in the mode of action of cyclosporine and FK 506. | 1998 | Transplant. Proc. | pmid:9636388 |
| Dall'Agnol DJ et al. | Effects of immunosuppressive drugs on gastrointestinal transit of rats: effects of tacrolimus, cyclosporine, and prednisone. | Transplant. Proc. | pmid:25131057 | |
| Garcia CD et al. | Pediatric renal transplantation under tacrolimus or cyclosporine immunosuppression and basiliximab induction. | 2002 | Transplant. Proc. | pmid:12431513 |
| Iwata H et al. | Prolongation of xenograft survival by combining donor-specific intravenous presensitization with FK 506. | 2002 | Transplant. Proc. | pmid:12431592 |
| Rong G et al. | Influence of CYP3A5 and MDR1(ABCB1) polymorphisms on the pharmacokinetics of tacrolimus in Chinese renal transplant recipients. | 2010 | Transplant. Proc. | pmid:21094796 |
| van Hooff JP et al. | Preservation of renal function and cardiovascular risk factors. | 2006 | Transplant. Proc. | pmid:16979974 |
| Katayama Y et al. | Immunosuppressive effects of FK 506 and 15-deoxyspergualin in rat lung transplantation. | 1991 | Transplant. Proc. | pmid:1703690 |
| Carl S et al. | Combining FK 506 and mycophenolate mofetil for the treatment of acute corticosteroid-resistant rejection following kidney transplantation: a new therapeutic concept. | 1998 | Transplant. Proc. | pmid:9636502 |