| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Nocardia Infections | D009617 | 6 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Graft Occlusion, Vascular | D006083 | 11 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lionetti P et al. | Mucosal adaptation and destruction in response to lamina propria T cell activation in explants of human fetal intestine. | 1995 | Adv. Exp. Med. Biol. | pmid:8525974 |
| Ku YM et al. | Compatibility of tacrolimus injection with cimetidine hydrochloride injection in 0.9% sodium chloride injection. | 1995 | Am J Health Syst Pharm | pmid:8528874 |
| Arreaza G et al. | Expression of intercellular adhesion molecule-1 on human thyroid cells from patients with autoimmune thyroid disease: study of thyroid xenografts in nude and severe combined immunodeficient mice and treatment with FK-506. | 1995 | J. Clin. Endocrinol. Metab. | pmid:8530625 |
| Fruman DA et al. | The complex of FK506-binding protein 12 and FK506 inhibits calcineurin phosphatase activity and IgE activation-induced cytokine transcripts, but not exocytosis, in mouse mast cells. | 1995 | J. Immunol. | pmid:7530743 |
| Neuhaus P et al. | Comparison of FK506- and cyclosporine-based immunosuppression in primary orthotopic liver transplantation. A single center experience. | 1995 | Transplantation | pmid:7530868 |
| Heeckt PF et al. | Functional impairment of enteric smooth muscle and nerves caused by chronic intestinal allograft rejection regresses after FK506 rescue. | 1995 | Transplantation | pmid:7530870 |
| Gruessner RW et al. | A prospective study of FK506 versus CsA and pig ATG in a porcine model of small bowel transplantation. | 1995 | Transplantation | pmid:7530871 |
| Zarnt T et al. | Time-dependent inhibition of peptidylprolyl cis-trans-isomerases by FK506 is probably due to cis-trans isomerization of the inhibitor's imide bond. | 1995 | Biochem. J. | pmid:7529995 |
| Wera S et al. | Rapamycin, FK506 and cyclosporin A inhibit human prolactin gene expression. | 1995 | FEBS Lett. | pmid:7530217 |
| Cao W et al. | Effects of rapamycin on growth factor-stimulated vascular smooth muscle cell DNA synthesis. Inhibition of basic fibroblast growth factor and platelet-derived growth factor action and antagonism of rapamycin by FK506. | 1995 | Transplantation | pmid:7532879 |
| Van Thiel DH et al. | Tacrolimus (FK 506), a treatment for primary sclerosing cholangitis: results of an open-label preliminary trial. | 1995 | Am. J. Gastroenterol. | pmid:7532912 |
| Ning YM and Sanchez ER | Stabilization in vitro of the untransformed glucocorticoid receptor complex of S49 lymphocytes by the immunophilin ligand FK506. | 1995 | J. Steroid Biochem. Mol. Biol. | pmid:7532989 |
| Fruman DA et al. | FK506 binding protein 12 mediates sensitivity to both FK506 and rapamycin in murine mast cells. | 1995 | Eur. J. Immunol. | pmid:7533090 |
| Cameron AM et al. | Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7533300 |
| Shapiro R et al. | A prospective randomized trial of FK506-based immunosuppression after renal transplantation. | 1995 | Transplantation | pmid:7533343 |
| Cox KL et al. | An increased incidence of Epstein-Barr virus infection and lymphoproliferative disorder in young children on FK506 after liver transplantation. | 1995 | Transplantation | pmid:7533344 |
| Fay JW et al. | FK 506-based immunosuppression for prevention of graft versus host disease after unrelated donor marrow transplantation. | 1995 | Transplant. Proc. | pmid:7533383 |
| Murase N et al. | Bone marrow augmentation for heart, liver, and small bowel transplantation: prolongation of graft survival and incidence of graft-versus-host disease. | 1995 | Transplant. Proc. | pmid:7533386 |
| Zeevi A et al. | Serial evaluation of immune profiles of simultaneous bone marrow and whole organ transplant recipients. | 1995 | Transplant. Proc. | pmid:7533388 |
| Watanabe K et al. | Factors influencing long-term operational tolerance in dogs treated with fractionated lymphoid irradiation, donor bone marrow cell infusion and FK506. | 1995 | Transplant. Proc. | pmid:7533389 |
| Wennberg L et al. | Efficacy of various immunosuppressive drugs in preventing pig-to-rat islet xenograft rejection. | 1995 | Transplant. Proc. | pmid:7533391 |
| Tanaka M et al. | Effect of anticomplement agent K-76 COOH in hamster-to-rat and guinea pig-to-rat xenotransplantation. | 1995 | Transplant. Proc. | pmid:7533392 |
| Tsugita M et al. | Prevention of sensitization and hyperacute rejection in liver and heart xenografts by FK 506 plus donor antigens. | 1995 | Transplant. Proc. | pmid:7533393 |
| Sakimoto H et al. | Prolonged survival of hamster-to-rat pancreas xenografts by FK 506 and splenectomy. | 1995 | Transplant. Proc. | pmid:7533394 |
| Celli S et al. | Mechanisms of protection from humoral rejection by a xenografted liver. | 1995 | Transplant. Proc. | pmid:7533395 |
| Bundick RV et al. | The effect of cyclosporin A, FK506, and rapamycin on the murine chronic graft-versus-host response--an in vivo model of Th2-like activity. | 1995 | Clin. Exp. Immunol. | pmid:7533681 |
| Hirakata Y et al. | Influence of various immunosuppressive agents on the occurrence of endogenous bacteraemia in mice. | 1995 | J. Med. Microbiol. | pmid:7533840 |
| Gregory CR et al. | Treatment with rapamycin and mycophenolic acid reduces arterial intimal thickening produced by mechanical injury and allows endothelial replacement. | 1995 | Transplantation | pmid:7533955 |
| Egawa H et al. | Isolated alkaline phosphatemia following pediatric liver transplantation in the FK506 ERA. | 1995 | Transplantation | pmid:7533958 |
| Molenaar JC | [Transplantation of the small intestine]. | 1995 | Ned Tijdschr Geneeskd | pmid:7534380 |
| Swenson JM et al. | Immunosuppression switch in pediatric heart transplant recipients: cyclosporine to FK 506. | 1995 | J. Am. Coll. Cardiol. | pmid:7534779 |
| Furukawa F et al. | FK506: therapeutic effects on lupus dermatoses in autoimmune-prone MRL/Mp-lpr/lpr mice. | 1995 | Arch. Dermatol. Res. | pmid:7487142 |
| Lapa e Silva JR et al. | Modulation of the bronchial inflammation in sensitized guinea-pigs by FK506, nedocromil sodium and dexamethasone. | 1995 | Eur. Respir. J. | pmid:7489798 |
| Shackleton CR et al. | Lack of correlation between the magnitude of preservation injury and the incidence of acute rejection, need for OKT3, and conversion to FK506 in cyclosporine-treated primary liver allograft recipients. | 1995 | Transplantation | pmid:7570950 |
| Petrides AS | [Do immunosuppressive agents really impair glucose tolerance in liver transplant patients?]. | 1995 | Z Gastroenterol | pmid:7571761 |
| Lyons WE et al. | Neuronal regeneration enhances the expression of the immunophilin FKBP-12. | 1995 | J. Neurosci. | pmid:7536825 |
| Thomson AW and Bonham CA | Inhibition of T lymphocyte activation and apoptotic cell death by cyclosporin A and tacrolimus (FK506). Its relevance to therapy of HIV infection. | 1995 | Adv. Exp. Med. Biol. | pmid:7572394 |
| Wortis HH et al. | B-cell activation by crosslinking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B-cell phenotypes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7536930 |
| Paterson JM et al. | Control of a novel adenylyl cyclase by calcineurin. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7575502 |
| Bang H et al. | Activation of Ca2+ signaling in neutrophils by the mast cell-released immunophilin FKBP12. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7536932 |
| Cunningham EB | The human erythrocyte membrane contains a novel 12-kDa inositolphosphate-binding protein that is an immunophilin. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7575593 |
| Ellis D | Clinical use of tacrolimus (FK-506) in infants and children with renal transplants. | 1995 | Pediatr. Nephrol. | pmid:7577418 |
| Masaki Y et al. | Cellular basis of acquired immunologic tolerance following total bowel transplantation in rats. I. Relation between donor lymphocyte chimerism and host-cell-mediated immunity. | 1995 | Transplant. Proc. | pmid:7536971 |
| Masaki Y et al. | Cellular basis of immunologic tolerance following total bowel transplantation in rats. II. Dominant role of suppressor T cells in adoptive transfer of acquired tolerance to vascularized allografts. | 1995 | Transplant. Proc. | pmid:7536972 |
| Suzuki H et al. | Spleen grafting might induce transplantation tolerance in rats. | 1995 | Transplant. Proc. | pmid:7536973 |
| Shapiro R et al. | FK506 in pediatric kidney transplantation--primary and rescue experience. | 1995 | Pediatr. Nephrol. | pmid:7492486 |
| Ito A et al. | Induction of tolerance in rat cardiac allograft model by intrathymic injection of donor bone marrow cells. | 1995 | Transplant. Proc. | pmid:7536974 |
| Büttemeyer R et al. | Peripheral nerve allotransplant immunosuppressed with FK 506: preliminary results. | 1995 | Transplant. Proc. | pmid:7536979 |
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| Warty V et al. | Tacrolimus analysis: a comparison of different methods and matrices. | 1995 | Ther Drug Monit | pmid:7542809 |
| Freeman DJ et al. | Stability of FK 506 in whole blood samples. | 1995 | Ther Drug Monit | pmid:7542810 |
| Strumph P et al. | The effect of FK506 on glycemic response as assessed by the hyperglycemic clamp technique. | 1995 | Transplantation | pmid:7542815 |
| Dumont FJ et al. | Dominant mutations confer resistance to the immunosuppressant, rapamycin, in variants of a T cell lymphoma. | 1995 | Cell. Immunol. | pmid:7538911 |
| Sihra TS et al. | A role for calcineurin (protein phosphatase-2B) in the regulation of glutamate release. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7542882 |
| Theopold U et al. | FKBP39, a Drosophila member of a family of proteins that bind the immunosuppressive drug FK506. | 1995 | Gene | pmid:7538962 |
| Dumont FJ et al. | Increased LFA-1-mediated homotypic cell adhesion is associated with the G1 growth arrest induced by rapamycin in a T cell lymphoma. | 1995 | Exp. Cell Res. | pmid:7543051 |
| Zhao Y et al. | Calcineurin activation protects T cells from glucocorticoid-induced apoptosis. | 1995 | J. Immunol. | pmid:7539018 |
| Corey HE et al. | Renal allograft rejection in children and young adults: the Banff classification. | 1995 | Pediatr. Nephrol. | pmid:7543274 |
| Bronsther O et al. | Liver transplantation for HBV-related disease under immunosuppression with tacrolimus: an experience with 78 consecutive cases. | 1995 | J Okla State Med Assoc | pmid:7539077 |
| Griffith JP et al. | X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex. | 1995 | Cell | pmid:7543369 |
| Chen J et al. | Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7539137 |
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| Rodriguez Rilo HL et al. | Rapid hair regrowth in refractory alopecia universalis associated with autoimmune disease following liver transplantation and tacrolimus (FK506) therapy. | 1995 | Transplantation | pmid:7539169 |
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| Yang WM et al. | Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity. | 1995 | J. Biol. Chem. | pmid:7541038 |
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| Monsour HP et al. | Renal insufficiency and hypertension as long-term complications in liver transplantation. | 1995 | Semin. Liver Dis. | pmid:7544917 |
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| Vilquin JT et al. | FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfer. | 1995 | Hum. Gene Ther. | pmid:8573612 |
| Sano T et al. | FK506 and cyclosporin A inhibit granulocyte/macrophage colony-stimulating factor production by mononuclear cells in asthma. | 1995 | Eur. Respir. J. | pmid:8575571 |
| Sekigawa I et al. | Inhibitory effect of the immunosuppressant FK506 on apoptotic cell death induced by HIV-1 gp120. | 1995 | J. Clin. Immunol. | pmid:8576317 |