tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- J. Pharmacol. Exp. Ther. (1)
- Am. J. Physiol. Renal Physiol. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fukuda T et al. | Inhibition of antigen-induced late asthmatic response and bronchial hyperresponsiveness by cyclosporin and FK 506. | 1991 | Int. Arch. Allergy Appl. Immunol. | pmid:1718889 |
| Murase N et al. | FK 506 prevents spontaneous diabetes in the BB rat. | 1991 | Transplant. Proc. | pmid:1703705 |
| Meiser BM et al. | Effects of cyclosporin, FK506, and rapamycin on graft-vessel disease. | 1991 | Lancet | pmid:1719321 |
| Watanabe K et al. | Donor bone marrow cell facilitates induction of tolerance to kidney allografts in dogs treated with fractionated lymphoid irradiation and FK 506. | 1991 | Transplant. Proc. | pmid:1703706 |
| Ali Shah I et al. | Effects of FK 506 on human hepatic microsomal cytochrome P-450-dependent drug metabolism in vitro. | 1991 | Transplant. Proc. | pmid:1721276 |
| Moochhala SM et al. | Inhibition of drug metabolism in rat and human liver microsomes by FK 506 and cyclosporine. | 1991 | Transplant. Proc. | pmid:1721277 |
| Katz HR et al. | Mast cell biochemical and functional heterogeneity. | 1991 | Transplant. Proc. | pmid:1721308 |
| de Paulis A et al. | Antiinflammatory effect of FK 506 on human basophils. | 1991 | Transplant. Proc. | pmid:1721309 |
| Rucay P et al. | FK 506 rescue therapy for refractory acute rejection in five liver recipients. | 1991 | Transplant. Proc. | pmid:1721340 |
| Macleod AM and Thomson AW | FK 506: an immunosuppressant for the 1990s? | 1991 | Lancet | pmid:1702172 |
| Reding R et al. | Compassionate use of FK 506 in pediatric liver transplantation: a pilot study. | 1991 | Transplant. Proc. | pmid:1721341 |
| Fung JJ et al. | Adverse effects associated with the use of FK 506. | 1991 | Transplant. Proc. | pmid:1721372 |
| Omar G et al. | FK 506 inhibition of cyclosporine metabolism by human liver microsomes. | 1991 | Transplant. Proc. | pmid:1703356 |
| Hebert MF et al. | Efficacy and toxicity of FK 506 for the treatment of resistant rejection in liver transplant patients. | 1991 | Transplant. Proc. | pmid:1721373 |
| Eiras G et al. | Effects of FK 506 and cyclosporine on T-cell activation: integrin-mediated adhesion of T cells, proliferation, and maturation of cytotoxic T cells. | 1991 | Transplant. Proc. | pmid:1703357 |
| Jacobs TW et al. | The effect of FK 506, cyclosporine A, and cyclosporine G on serum 1,25-dihydroxyvitamin D levels. | 1991 | Transplant. Proc. | pmid:1721403 |
| Abu-Elmagd KM et al. | Acute hemolytic anemia in liver and bone marrow transplant patients under FK 506 therapy. | 1991 | Transplant. Proc. | pmid:1721404 |
| Brabletz T et al. | The immunosuppressives FK 506 and cyclosporin A inhibit the generation of protein factors binding to the two purine boxes of the interleukin 2 enhancer. | 1991 | Nucleic Acids Res. | pmid:1707162 |
| Iwaki Y et al. | Replacement of donor lymphoid tissue in small-bowel transplants. | 1991 | Lancet | pmid:1707470 |
| Wada H et al. | An attempt to induce tolerance to skin grafts in congenic mice with FK 506. | 1991 | Transplant. Proc. | pmid:1721435 |
| Kuroki H et al. | Synergistic effect of FK 506 and donor-specific blood transfusion on rat skin but not on composite tissue (limb) allograft survival. | 1991 | Transplant. Proc. | pmid:1721436 |
| Markus PM et al. | FK 506 reverses acute graft-versus-host disease after allogeneic bone marrow transplantation in rats. | 1991 | Surgery | pmid:1713358 |
| Farley DE et al. | The effect of two new immunosuppressive agents, FK506 and didemnin B, in murine pregnancy. | 1991 | Transplantation | pmid:1713360 |
| Morris PJ | Cyclosporine, FK-506 and other drugs in organ transplantation. | 1991 | Curr. Opin. Immunol. | pmid:1721824 |
| Lhoëst G et al. | Isolation and mass spectrometric identification of five metabolites of FK-506, a novel macrolide immunosuppressive agent, from human plasma. | 1991 | Pharm Acta Helv | pmid:1722046 |
| Altmeyer A et al. | Unexpected up-regulation of gene expression by cyclosporin A and FK-506 in a T-cell lymphoma: both immunosuppressants augment Ly-6E antigen induction by interferon-gamma in the presence of ionomycin. | 1991 | Int. J. Immunopharmacol. | pmid:1726093 |
| Gordon RD et al. | Liver transplantation at the University of Pittsburgh, 1984 to 1990. | 1991 | Clin Transpl | pmid:1726458 |
| Jordan ML et al. | Initial studies with FK506 in renal transplantation. | 1991 Sep-Oct | Cleve Clin J Med | pmid:1718631 |
| Kuo CJ et al. | Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. | 1992 | Nature | pmid:1614535 |
| Thomson AW et al. | FK 506, cardiac transplantation, and graft-vessel disease. | 1992 | Lancet | pmid:1370563 |
| Jiang H et al. | Control of humoral and cellular immunity-mediated accelerated heart allograft rejection in sensitized rats by low dose FK 506 and splenectomy. | 1992 | Transpl. Int. | pmid:14621859 |
| Kobayashi N et al. | Abdominal organ cluster transplantation in pigs and FK506. | 1992 | Transpl. Int. | pmid:14621861 |
| Metcalfe S et al. | FK506 and rapamycin: differential sensitivity of human, baboon, cynomolgus monkey, dog and pig lymphocytes. | 1992 | Transpl. Int. | pmid:14621863 |
| Japanese study of kidney transplantation: 1. Results of early phase II study. | 1992 | Transpl. Int. | pmid:14621866 | |
| Japanese study of FK 506 on kidney transplantation: 2. Follow-up study of FK 506-treated patients. | 1992 | Transpl. Int. | pmid:14621874 | |
| Chen TS et al. | Microbial transformation of immunosuppressive compounds. I. Desmethylation of FK506 and immunomycin (FR 900520) by Actinoplanes sp. ATCC 53771. | 1992 | J. Antibiot. | pmid:1372307 |
| Walpoth B et al. | Prevention of cardiac allograft rejection by FK506 and rapamycin: assessment by histology and nuclear magnetic resonance. | 1992 | Transpl. Int. | pmid:14621877 |
| Morisaki M and Arai T | Identity of immunosuppressant FR-900520 with ascomycin. | 1992 | J. Antibiot. | pmid:1372308 |
| Asako H et al. | Reduction of leukocyte adherence and emigration by cyclosporine and L683,590 (FK506) in postcapillary venules. | 1992 | Transplantation | pmid:1384191 |
| Doi R et al. | Effects of FK506 on exocrine pancreas in rats. | 1992 | Pancreas | pmid:1372739 |
| Kawano K et al. | FK 506 ameliorates normothermic liver ischemia in rats by suppressing production of tumor necrosis factor. | 1992 | Transpl. Int. | pmid:14621904 |
| Furukawa H et al. | The effect of bile duct ligation and bile diversion on FK506 pharmacokinetics in dogs. | 1992 | Transplantation | pmid:1373531 |
| Sakr M et al. | Cytomegalovirus infection of the upper gastrointestinal tract following liver transplantation--incidence, location, and severity in cyclosporine- and FK506-treated patients. | 1992 | Transplantation | pmid:1373535 |
| Hirano Y et al. | Morphological and functional changes of islets of Langerhans in FK506-treated rats. | 1992 | Transplantation | pmid:1373536 |
| Takahara S et al. | The in vitro immunosuppressive effect of deoxymethylspergualin in man as compared with FK506 and cyclosporine. | 1992 | Transplantation | pmid:1373537 |
| Johnson MC et al. | QT prolongation and Torsades de Pointes after administration of FK506. | 1992 | Transplantation | pmid:1373538 |
| Kim YI et al. | Stimulation of liver regeneration by pretreatment with azathioprine as well as cyclosporine and FK506. | 1992 | Transplantation | pmid:1373539 |
| Yamada K et al. | New morphological changes induced by FK506 in a short period in the rat kidney and the effect of superoxide dismutase and OKY-046 on THEM: the relationship of FK506 nephrotoxicity to lipid peroxidation and change in production of thromboxane A2 in the kidney. | 1992 | Transpl. Int. | pmid:14621878 |
| Sigal NH and Dumont FJ | Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction. | 1992 | Annu. Rev. Immunol. | pmid:1375473 |
| Chen TS et al. | Microbial transformation of immunosuppressive compounds. II. Specific desmethylation of 13-methoxy group of FK 506 and FR 900520 by an unidentified Actinomycete ATCC 53828 [corrected]. | 1992 | J. Antibiot. | pmid:1375593 |
| Meingassner JG and Stütz A | Immunosuppressive macrolides of the type FK 506: a novel class of topical agents for treatment of skin diseases? | 1992 | J. Invest. Dermatol. | pmid:1375617 |
| Schneck FX et al. | Pediatric renal transplantation under FK-506 immunosuppression. | 1992 | J. Urol. | pmid:1375663 |
| Connelly PR and Thomson JA | Heat capacity changes and hydrophobic interactions in the binding of FK506 and rapamycin to the FK506 binding protein. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1375751 |
| Lancaster JR et al. | EPR detection of heme and nonheme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft. | 1992 | J. Biol. Chem. | pmid:1375934 |
| Hirai T et al. | The immunosuppressive effect of FK 506 on canine lung transplantation. | 1992 | J. Thorac. Cardiovasc. Surg. | pmid:1375967 |
| Tai PK et al. | Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex. | 1992 | Science | pmid:1376003 |
| Jegasothy BV et al. | Tacrolimus (FK 506)--a new therapeutic agent for severe recalcitrant psoriasis. | 1992 | Arch Dermatol | pmid:1376102 |
| de Paulis A et al. | Anti-inflammatory effect of FK-506 on human skin mast cells. | 1992 | J. Invest. Dermatol. | pmid:1281861 |
| Wiederrecht G et al. | Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1376117 |
| O'Keefe SJ et al. | FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. | 1992 | Nature | pmid:1377361 |
| Clipstone NA and Crabtree GR | Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. | 1992 | Nature | pmid:1377362 |
| Hasegawa S et al. | Combination use of suboptimal dose of FK 506 and cyclosporine in canine lung transplantation. | 1992 | J. Thorac. Cardiovasc. Surg. | pmid:1279319 |
| Peattie DA et al. | Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1279700 |
| Lhoëst G et al. | Isolation and mass spectrometric identification of two metabolites of FK 506 from rat liver microsomal incubation media. | 1992 | Pharm Acta Helv | pmid:1279730 |
| Benigni A et al. | The acute effect of FK506 and cyclosporine on endothelial cell function and renal vascular resistance. | 1992 | Transplantation | pmid:1279848 |
| Mor E et al. | Late-onset acute rejection in orthotopic liver transplantation--associated risk factors and outcome. | 1992 | Transplantation | pmid:1279849 |
| Hirano Y et al. | The effects of FK506 and cyclosporine on the exocrine function of the rat pancreas. | 1992 | Transplantation | pmid:1279850 |
| Takaya S et al. | Liver transplantation in positive cytotoxic crossmatch cases using FK506, high-dose steroids, and prostaglandin E1. | 1992 | Transplantation | pmid:1279851 |
| Minoda M et al. | Effects of gamma-interferon and FK506 on resting B cell proliferation of New Zealand black/white F1 mice. | 1992 | Microbiol. Immunol. | pmid:1282197 |
| Min DI et al. | Visual compatibility of tacrolimus with commonly used drugs during simulated Y-site injection. | 1992 | Am J Hosp Pharm | pmid:1282779 |
| Mochizuki M | [Immunotherapy in ocular diseases]. | 1992 | Nippon Ganka Gakkai Zasshi | pmid:1283052 |
| Olejniczak ET et al. | A 4D HCCH-TOCSY experiment for assigning the side chain 1H and 13C resonances of proteins. | 1992 | J. Biomol. NMR | pmid:1283353 |
| Bauer S et al. | The effect of the new immunosuppressive drug FK506 on the formation of secondary metabolites of cyclosporin A. | 1992 | Int J Clin Pharmacol Ther Toxicol | pmid:1283385 |
| Renoir JM et al. | [Effect of immunosuppressants FK506 and rapamycin on the function of progesterone receptor: protein "p59-HBI", intersection between immunology and endocrinology?]. | 1992 | C. R. Acad. Sci. III, Sci. Vie | pmid:1284044 |
| Natazuka T | FK506 reverses adriamycin resistance in a multidrug-resistant human leukemia cell line. | 1992 | Kobe J Med Sci | pmid:1284834 |
| Tocci MJ and Sigal NH | Recent advances in the mechanism of action of cyclosporine and FK506. | 1992 | Curr. Opin. Nephrol. Hypertens. | pmid:1285380 |
| First MR | Renal transplantation for the nephrologist: new immunosuppressive drugs. | 1992 | Am. J. Kidney Dis. | pmid:1371201 |
| Fukuse T et al. | Optimal dose of FK 506 in canine lung allotransplantation. | 1992 | Transplant. Proc. | pmid:1379757 |
| Wada H et al. | Combination use of suboptimal doses of FK 506 and cyclosporine in canine lung transplantation. | 1992 | Transplant. Proc. | pmid:1379758 |
| Cai X et al. | Low-dose of FK 506 and associated blood levels in allotransplantation of rat liver, heart, and skin. | 1992 | Transplant. Proc. | pmid:1379759 |
| Taki J et al. | DNA analysis of peripheral blood mononuclear cells for early detection of hepatic graft rejection. | 1992 | Transplant. Proc. | pmid:1379760 |
| Sato Y et al. | FK 506 suppresses class II antigen expression in regenerating livers following partial hepatectomy in the rat. | 1992 | Transplant. Proc. | pmid:1379761 |
| Stütz A | Immunosuppressive macrolides. | 1992 | Transplant. Proc. | pmid:1379762 |
| Leiva MC and Lyttle CR | Leukocyte chemotactic activity of FKBP and inhibition by FK506. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1379802 |
| Iwasaki K et al. | Effect of repeated oral doses of a novel immunosuppressive macrolide lactone on hepatic mixed-function oxidase system in the rat. Comparative study with ciclosporin. | 1992 | Arzneimittelforschung | pmid:1379812 |
| Takada K et al. | Distribution kinetics of FK-506, a novel immunosuppressant, after intravenous administration to rats in comparison with cyclosporin A. | 1992 | Biopharm Drug Dispos | pmid:1379839 |
| Arceci RJ et al. | Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype. | 1992 | Blood | pmid:1381629 |
| Pahl A and Keller U | FK-506-binding proteins from streptomycetes producing immunosuppressive macrolactones of the FK-506 type. | 1992 | J. Bacteriol. | pmid:1381710 |
| Takahashi N | [Cyclophilin and FK506-binding protein]. | 1992 | Seikagaku | pmid:1381737 |
| Lee TK et al. | Mucosal glutamine utilization after small-bowel transplantation: an electrophysiologic study. | 1992 | J. Surg. Res. | pmid:1382152 |
| Kaye RE et al. | Effects of cyclosporin A and FK506 on Fc epsilon receptor type I-initiated increases in cytokine mRNA in mouse bone marrow-derived progenitor mast cells: resistance to FK506 is associated with a deficiency in FK506-binding protein FKBP12. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1382293 |
| Edalji R et al. | High-level expression of recombinant human FK-binding protein from a fusion precursor. | 1992 | J. Protein Chem. | pmid:1382438 |
| Thomson AW and Starzl TE | FK 506 and autoimmune disease: perspective and prospects. | 1992 | Autoimmunity | pmid:1382646 |
| Christians U et al. | Specific and sensitive measurement of FK506 and its metabolites in blood and urine of liver-graft recipients. | 1992 | Clin. Chem. | pmid:1382896 |
| Fruman DA et al. | Correlation of calcineurin phosphatase activity and programmed cell death in murine T cell hybridomas. | 1992 | Eur. J. Immunol. | pmid:1382988 |
| Chung J et al. | Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. | 1992 | Cell | pmid:1377606 |
| Xu RX et al. | Stereospecific assignments and chi 1 rotamers for FKBP when bound to ascomycin from 3JH alpha,H beta and 3HN,H beta coupling constants. | 1992 | FEBS Lett. | pmid:1377648 |
| Petros AM et al. | NMR studies of an FK-506 analog, [U-13C]ascomycin, bound to FK-506-binding protein. | 1992 | J. Med. Chem. | pmid:1377749 |
| Strom TB | Molecular immunology and immunopharmacology of allograft rejection. | 1992 | Kidney Int. Suppl. | pmid:1383599 |
| Wang SC et al. | FK-506 inhibits proliferation and IL-4 messenger RNA production by a T-helper 2 cell line. | 1992 | J. Surg. Res. | pmid:1383612 |