tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Cervical Intraepithelial Neoplasia D018290 1 associated lipids
Migraine with Aura D020325 1 associated lipids
Porokeratosis D017499 1 associated lipids
Lentigo D007911 1 associated lipids
Mutism D009155 1 associated lipids
Amyloid Neuropathies D017772 1 associated lipids
Orchitis D009920 1 associated lipids
Phyllodes Tumor D003557 1 associated lipids
Meningitis, Fungal D016921 1 associated lipids
Malocclusion, Angle Class II D008312 1 associated lipids
Flaviviridae Infections D018178 1 associated lipids
Idiopathic Interstitial Pneumonias D054988 1 associated lipids
Dysuria D053159 1 associated lipids
Denys-Drash Syndrome D030321 1 associated lipids
Akinetic Mutism D000405 1 associated lipids
Sleep Apnea, Central D020182 1 associated lipids
Ecthyma, Contagious D004474 1 associated lipids
Priapism D011317 1 associated lipids
Vulvar Lichen Sclerosus D007724 1 associated lipids
Cardiomyopathy, Restrictive D002313 1 associated lipids
Paraparesis, Tropical Spastic D015493 1 associated lipids
Neurodermatitis D009450 1 associated lipids
Posterior Leukoencephalopathy Syndrome D054038 1 associated lipids
Coproporphyria, Hereditary D046349 1 associated lipids
Ichthyosiform Erythroderma, Congenital D016113 1 associated lipids
Panniculitis, Lupus Erythematosus D015435 1 associated lipids
Retrognathia D063173 1 associated lipids
Mediastinal Diseases D008477 1 associated lipids
Hypophosphatemia D017674 1 associated lipids
Leukemia, Myeloid, Chronic-Phase D015466 1 associated lipids
Myelinolysis, Central Pontine D017590 1 associated lipids
Protoporphyria, Erythropoietic D046351 1 associated lipids
Smooth Muscle Tumor D018235 1 associated lipids
Poxviridae Infections D011213 1 associated lipids
Kaposi Varicelliform Eruption D007617 1 associated lipids
Lacerations D022125 1 associated lipids
Megacolon, Toxic D008532 1 associated lipids
Tinea Capitis D014006 1 associated lipids
Digestive System Fistula D016154 1 associated lipids
Crigler-Najjar Syndrome D003414 1 associated lipids
Leukoplakia, Oral D007972 1 associated lipids
Peroneal Neuropathies D020427 1 associated lipids
Polyomavirus Infections D027601 1 associated lipids
Lymphohistiocytosis, Hemophagocytic D051359 1 associated lipids
Rheumatoid Nodule D012218 1 associated lipids
Hernia, Ventral D006555 1 associated lipids
Hepatitis, Autoimmune D019693 1 associated lipids
Moyamoya Disease D009072 1 associated lipids
Hearing Loss, Bilateral D006312 1 associated lipids
Nocturia D053158 1 associated lipids
Echinostomiasis D004451 1 associated lipids
Multiple Endocrine Neoplasia Type 2a D018813 1 associated lipids
Apraxias D001072 1 associated lipids
Hypertensive Encephalopathy D020343 1 associated lipids
Hearing Loss, Sudden D003639 1 associated lipids
Rectal Diseases D012002 1 associated lipids
Citrullinemia D020159 1 associated lipids
Pulmonary Veno-Occlusive Disease D011668 1 associated lipids
Sweet Syndrome D016463 1 associated lipids
Optic Neuritis D009902 1 associated lipids
Granuloma Annulare D016460 1 associated lipids
Paraneoplastic Syndromes, Nervous System D020361 1 associated lipids
Intestinal Fistula D007412 1 associated lipids
Latent Tuberculosis D055985 1 associated lipids
Nephritis, Hereditary D009394 1 associated lipids
Mastocytosis, Cutaneous D034701 1 associated lipids
Pancreatitis, Graft D055589 1 associated lipids
Hepatic Insufficiency D048550 1 associated lipids
Lung Abscess D008169 1 associated lipids
Central Nervous System Viral Diseases D020805 1 associated lipids
Facial Nerve Injuries D020220 1 associated lipids
Intertrigo D007402 1 associated lipids
Miller Fisher Syndrome D019846 1 associated lipids
Cholangitis, Sclerosing D015209 1 associated lipids
Angiolymphoid Hyperplasia with Eosinophilia D000796 1 associated lipids
Eye Infections, Viral D015828 1 associated lipids
Dysplastic Nevus Syndrome D004416 1 associated lipids
Hypoplastic Left Heart Syndrome D018636 1 associated lipids
Mite Infestations D008924 1 associated lipids
Polyendocrinopathies, Autoimmune D016884 1 associated lipids
Leukoplakia D007971 1 associated lipids
Fasciitis, Necrotizing D019115 1 associated lipids
Mediastinal Emphysema D008478 1 associated lipids
Malacoplakia D008287 1 associated lipids
Myoclonic Cerebellar Dyssynergia D002527 1 associated lipids
Lichen Nitidus D017513 1 associated lipids
Lichenoid Eruptions D017512 1 associated lipids
Lymphocele D008210 1 associated lipids
Colitis, Collagenous D046729 1 associated lipids
Invasive Pulmonary Aspergillosis D055744 1 associated lipids
Intestinal Volvulus D045822 1 associated lipids
Hand Injuries D006230 1 associated lipids
Beckwith-Wiedemann Syndrome D001506 1 associated lipids
Eye Diseases, Hereditary D015785 1 associated lipids
Feline Infectious Peritonitis D016766 1 associated lipids
Meningitis, Cryptococcal D016919 1 associated lipids
Oculomotor Nerve Diseases D015840 1 associated lipids
Cutis Laxa D003483 1 associated lipids
Uveomeningoencephalitic Syndrome D014607 1 associated lipids
Myelitis D009187 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

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Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Klintmalm GB et al. Prognostic factors for successful conversion from cyclosporine to FK 506-based immunosuppressive therapy for refractory rejection after liver transplantation. US Multicenter FK 506 Liver Study Group. 1993 Transplant. Proc. pmid:7679828
Lane BC et al. Evaluation of calcineurin's role in the immunosuppressive activity of FK 506, related macrolactams, and cyclosporine. 1993 Transplant. Proc. pmid:7679829
Celli S et al. Long-term survival of heart and liver xenografts with splenectomy and FK 506. 1993 Transplant. Proc. pmid:7679830
Japanese study of FK 506 on kidney transplantation: results of late phase II study. 1993 Transplant. Proc. pmid:7679831
Kobayashi M et al. Production of monoclonal antibody against recombinant human FKBP-12 and subcellular localization of FKBP-12 in human mononuclear and polymorphonuclear cells. 1993 Transplant. Proc. pmid:7679832
Kuroki H et al. Effect of FK 506 and donor-specific blood transfusion on the rat composite tissue limb allograft and the mechanism of long-term graft survival. 1993 Transplant. Proc. pmid:7679833
Azhderian EM et al. Nucleus associated FK 506 binding proteins with potential relevance to FK 506 immunosuppression. 1993 Transplant. Proc. pmid:7679834
Porayko MK et al. Nephrotoxicity of FK 506 and cyclosporine when used as primary immunosuppression in liver transplant recipients. 1993 Transplant. Proc. pmid:7679835
Shapiro R et al. Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation: preliminary report. 1993 Transplant. Proc. pmid:7679836
Propper DJ et al. Effects of the immunosuppressive macrolides rapamycin and FK 506 in high responder rats presensitized to major histocompatibility complex antigens. 1993 Transplant. Proc. pmid:7679837
Stock PG et al. Standard sequential immunosuppression with Minnesota antilymphoblast globulin and cyclosporine vs FK 506: a comparison of early nephrotoxicity. 1993 Transplant. Proc. pmid:7679838
Armitage JM et al. A decade (1982 to 1992) of pediatric cardiac transplantation and the impact of FK 506 immunosuppression. 1993 J. Thorac. Cardiovasc. Surg. pmid:7680396
Randhawa PS et al. The histopathological changes associated with allograft rejection and drug toxicity in renal transplant recipients maintained on FK506. Clinical significance and comparison with cyclosporine. 1993 Am. J. Surg. Pathol. pmid:7680544
Xu RX et al. Heteronuclear 3D NMR studies of water bound to an FK506 binding protein/immunosuppressant complex. 1993 Biochemistry pmid:7680570
Egan DA et al. Equilibrium denaturation of recombinant human FK binding protein in urea. 1993 Biochemistry pmid:7680574
Lionetti P et al. Activation of mucosal V beta 3+ T cells and tissue damage in human small intestine by the bacterial superantigen, Staphylococcus aureus enterotoxin B. 1993 Eur. J. Immunol. pmid:7680613
Nelson PA et al. Immunosuppressive activity of [MeBm2t]1-, D-diaminobutyryl-8-, and D-diaminopropyl-8-cyclosporin analogues correlates with inhibition of calcineurin phosphatase activity. 1993 J. Immunol. pmid:7680683
Piekoszewski W and Jusko WJ Plasma protein binding of tacrolimus in humans. 1993 J Pharm Sci pmid:7680714
Ning YM and Sánchez ER Potentiation of glucocorticoid receptor-mediated gene expression by the immunophilin ligands FK506 and rapamycin. 1993 J. Biol. Chem. pmid:7681058
Saeki T et al. Human P-glycoprotein transports cyclosporin A and FK506. 1993 J. Biol. Chem. pmid:7681059
Dutz JP et al. A role for calcineurin in degranulation of murine cytotoxic T lymphocytes. 1993 J. Immunol. pmid:7681074
Kim YI et al. Augmentation of hepatocyte proliferation by immunosuppressant pretherapy is associated with up-regulation of malondialdehyde production. 1993 Res Exp Med (Berl) pmid:7506444
Hytiroglou P et al. FK506 versus cyclosporine as primary immunosuppressive agent for orthotopic liver allograft recipients. Histologic and immunopathologic observations. 1993 Transplantation pmid:7506452
Ishizuka J et al. Effects of FK506 and cyclosporine on dynamic insulin secretion from isolated dog pancreatic islets. 1993 Transplantation pmid:7506454
Shorrock C and Neuberger J The changing face of liver transplantation. 1993 Gut pmid:7682532
Dhar DK et al. Effective prevention of ischemic injury of the dearterialized canine liver by FK506 pretreatment. 1993 Transplantation pmid:7506456
Nakajima J [The immunosuppressive effects of FK506 on single lung allotransplantation in Japanese monkey (Macaca fuscata)]. 1993 Nihon Kyobu Geka Gakkai Zasshi pmid:7690829
Fabrega AJ et al. Enhancement of allograft survival by single intraoperative donor-specific blood transfusion combined with FK506. 1993 Transplantation pmid:7506458
Wenzel-Seifert K and Seifert R Partial inhibition of human neutrophil activation by FK-506 at supratherapeutic concentrations. 1993 Naunyn Schmiedebergs Arch. Pharmacol. pmid:7690907
Jain A et al. FK506 and pregnancy in liver transplant patients. 1993 Transplantation pmid:7506459
Liu J FK506 and cyclosporin, molecular probes for studying intracellular signal transduction. 1993 Immunol. Today pmid:7691065
Winkler ME et al. Successful pregnancy in a patient after liver transplantation maintained on FK 506. 1993 Transplantation pmid:7506460
Mori T et al. FK-506: a new immunosuppressive agent, failed to reduce cerebral vasospasm after experimental subarachnoid hemorrhage. 1993 J. Vet. Med. Sci. pmid:7691190
Yoshizawa K et al. Establishment of Epstein-Barr virus-associated lymphoma cell line SUBL with t(2;3)(p11;q27) from a liver transplant patient. 1993 Cancer Genet. Cytogenet. pmid:7506636
Distant DA and Gonwa TA The kidney in liver transplantation. 1993 J. Am. Soc. Nephrol. pmid:7691205
Muthukkumar S et al. Elevation of cytosolic calcium is sufficient to induce growth inhibition in a B cell lymphoma. 1993 Eur. J. Immunol. pmid:7691606
Peters DH et al. Tacrolimus. A review of its pharmacology, and therapeutic potential in hepatic and renal transplantation. 1993 Drugs pmid:7506654
Wesselborg S et al. Triggering via the alternative CD2 pathway induces apoptosis in activated human T lymphocytes. 1993 Eur. J. Immunol. pmid:7691614
Schulz BS et al. Increased expression of epidermal IL-8 receptor in psoriasis. Down-regulation by FK-506 in vitro. 1993 J. Immunol. pmid:7691948
Nagata K et al. Failure of FK-506, a new immunosuppressant, to prevent cerebral vasospasm in a canine two-hemorrhage model. 1993 J. Neurosurg. pmid:7692019
Lhoëst G et al. Isolation and identification by FAB mass spectrometry and NMR spectroscopy of a demethylated metabolite of FK506 from erythromycin-induced rabbit liver microsomes. 1993 Pharm Acta Helv pmid:7692454
Takada K et al. Distribution characteristics of immunosuppressants FK506 and cyclosporin A in the blood compartment. 1993 Biopharm Drug Dispos pmid:7508273
Sperr WR et al. [Effector cells in allergy: biological principles and new pharmacologic concepts]. 1993 Wien. Klin. Wochenschr. pmid:7508662
Tzakis AG et al. Intestinal transplantation in children under FK 506 immunosuppression. 1993 J. Pediatr. Surg. pmid:7693907
Kawauchi M et al. Prolonged survival of orthotopically transplanted heart xenograft in infant baboons. 1993 J. Thorac. Cardiovasc. Surg. pmid:7693999
Shutter LA et al. Cortical blindness and white matter lesions in a patient receiving FK506 after liver transplantation. 1993 Neurology pmid:7694189
Dawson TM et al. Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:7694293
Spencer DM et al. Controlling signal transduction with synthetic ligands. 1993 Science pmid:7694365
Travis J Making molecular matches in the cell. 1993 Science pmid:7694368
Jusko WJ and Kobayashi M Therapeutic monitoring of tacrolimus (FK 506) 1993 Ther Drug Monit pmid:7694395
Kunz J and Hall MN Cyclosporin A, FK506 and rapamycin: more than just immunosuppression. 1993 Trends Biochem. Sci. pmid:7694398
Bierer BE et al. Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology. 1993 Curr. Opin. Immunol. pmid:7694595
White DJ Immunosuppression for heart transplantation. 1993 Br. J. Biomed. Sci. pmid:7694717
Parent SA et al. Calcineurin-dependent growth of an FK506- and CsA-hypersensitive mutant of Saccharomyces cerevisiae. 1993 J. Gen. Microbiol. pmid:7510323
Bumgardner GL and Roberts JP New immunosuppressive agents. 1993 Gastroenterol. Clin. North Am. pmid:7685324
Ahmed SS et al. Adrenochrome reaction implicates oxygen radicals in metabolism of cyclosporine A and FK-506 in rat and human liver microsomes. 1993 J. Pharmacol. Exp. Ther. pmid:7685382
Sewell KL Immunotherapy and other novel therapies, including biologic response modifiers, apheresis, and dietary modifications. 1993 Curr Opin Rheumatol pmid:7685614
Wagner JA et al. Failure of FK 506 to suppress the T cell-mediated immunity of mice to Listeria monocytogenes. 1993 Clin. Exp. Immunol. pmid:7685672
Pilot-Matias TJ et al. High-level synthesis of the 12-kDa human FK506-binding protein in Escherichia coli using translational coupling. 1993 Gene pmid:7685727
Akamine S et al. [Effect of FK-506 on bronchial healing of canine lung allografts]. 1993 Nihon Kyobu Geka Gakkai Zasshi pmid:7685803
Partaledis JA and Berlin V The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum. 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:7685904
Sykes K et al. Proline isomerases function during heat shock. 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:7685914
Suzuki S et al. Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury. Modulating effects of FK506 and cyclosporine. 1993 Transplantation pmid:7685932
McDiarmid SV et al. Differences in oral FK506 dose requirements between adult and pediatric liver transplant patients. 1993 Transplantation pmid:7685933
Henke W and Jung K Comparison of the effects of the immunosuppressive agents FK 506 and cyclosporin A on rat kidney mitochondria. 1993 Biochem. Pharmacol. pmid:7690566
Murase N et al. Hamster-to-rat heart and liver xenotransplantation with FK506 plus antiproliferative drugs. 1993 Transplantation pmid:7682735
Emond JC et al. Improved results of living-related liver transplantation with routine application in a pediatric program. 1993 Transplantation pmid:7682738
Kai N et al. Prevention of insulitis and diabetes in nonobese diabetic mice by administration of FK506. 1993 Transplantation pmid:7682740
Bram RJ et al. Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. 1993 Mol. Cell. Biol. pmid:7687744
Heitman J et al. The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae. 1993 Mol. Cell. Biol. pmid:7687745
Abu-Elmagd K et al. Recent advances in hepatic transplantation at the University of Pittsburgh. 1993 Clin Transpl pmid:7522528
Hirakawa K et al. [The effect of perioperative portal venous inoculation with donor lymphocytes in combination with immunosuppressive agents on rat cardiac allograft survivals]. 1993 Nihon Geka Gakkai Zasshi pmid:7688065
Entani C et al. Effect of a novel immunosuppressant, FK506, on spontaneous lupus nephritis in MRL/MpJ-lpr/lpr mice. 1993 Nephron pmid:7688103
Ueki M et al. Diabetogenic effects of FK506 on renal subcapsular islet isografts in rat. 1993 Diabetes Res. Clin. Pract. pmid:7688276
Pleyer U et al. Ocular absorption of topically applied FK506 from liposomal and oil formulations in the rabbit eye. 1993 Invest. Ophthalmol. Vis. Sci. pmid:7688360
Machida M [Effect of temperature on plasma concentration of FK506]. 1993 Nippon Hinyokika Gakkai Zasshi pmid:7688443
Schmid FX Prolyl isomerase: enzymatic catalysis of slow protein-folding reactions. 1993 Annu Rev Biophys Biomol Struct pmid:7688608
Lyson T et al. Cyclosporine- and FK506-induced sympathetic activation correlates with calcineurin-mediated inhibition of T-cell signaling. 1993 Circ. Res. pmid:7688670
Morkawa K et al. Immunosuppressive property of bromocriptine on human B lymphocyte function in vitro. 1993 Clin. Exp. Immunol. pmid:7688676
McManus BM et al. Direct myocardial injury by enterovirus: a central role in the evolution of murine myocarditis. 1993 Clin. Immunol. Immunopathol. pmid:7689428
Namiki Y et al. Tautomeric phenomenon of a novel potent immunosuppressant (FK506) in solution. I. Isolation and structure determination of tautomeric compounds. 1993 J. Antibiot. pmid:7689551
Kondo T et al. [Antitumor sensitivity test, subrenal capsule assay using FK-506: preliminary report]. 1993 Nihon Geka Gakkai Zasshi pmid:7689693
Abu-Elmagd K et al. Resolution of severe pyoderma gangrenosum in a patient with streaking leukocyte factor disease after treatment with tacrolimus (FK 506). 1993 Ann. Intern. Med. pmid:7689802
Christensen BG FK-506: its role in immunosuppression. 1993 Ann. N. Y. Acad. Sci. pmid:7689803
Kino T and Goto T Discovery of FK-506 and update. 1993 Ann. N. Y. Acad. Sci. pmid:7689804
Parsons WH et al. FK-506--a novel immunosuppressant. 1993 Ann. N. Y. Acad. Sci. pmid:7689805
Zenke G et al. Molecular mechanisms of immunosuppression by cyclosporins. 1993 Ann. N. Y. Acad. Sci. pmid:7689806
Clardy J Structural studies of complexed FK-506 binding protein. 1993 Ann. N. Y. Acad. Sci. pmid:7689808
Starzl TE et al. Allograft and xenograft acceptance under FK-506 and other immunosuppressant treatment. 1993 Ann. N. Y. Acad. Sci. pmid:7689809
Murase N et al. Graft-versus-host disease after brown Norway-to-Lewis and Lewis-to-Brown Norway rat intestinal transplantation under FK506. 1993 Transplantation pmid:7678353
Herold KC et al. Inhibition of glucose-stimulated insulin release from beta TC3 cells and rodent islets by an analog of FK506. 1993 Transplantation pmid:7678356
Holman MJ et al. FK506-associated thrombotic thrombocytopenic purpura. 1993 Transplantation pmid:7678357
Kawai M et al. Structure-activity profiles of macrolactam immunosuppressant FK-506 analogues. 1993 FEBS Lett. pmid:7678400
Van Duyne GD et al. Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin. 1993 J. Mol. Biol. pmid:7678431
Meadows RP et al. Three-dimensional structure of the FK506 binding protein/ascomycin complex in solution by heteronuclear three- and four-dimensional NMR. 1993 Biochemistry pmid:7678499
Jiang H et al. Anti-tumor-promoting action of FK506, a potent immunosuppressive agent. 1993 Carcinogenesis pmid:7678785
Naito M et al. Enhancement of cellular accumulation of cyclosporine by anti-P-glycoprotein monoclonal antibody MRK-16 and synergistic modulation of multidrug resistance. 1993 J. Natl. Cancer Inst. pmid:7678867
Barthelmess IB and Tropschug M FK506-binding protein of Neurospora crassa (NcFKBP) mediates sensitivity to the immunosuppressant FK506; resistant mutants identify two loci. 1993 Curr. Genet. pmid:7679056
Fingar DC et al. Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes. 1993 J. Biol. Chem. pmid:7679106
Griffiths EJ and Halestrap AP Protection by Cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts. 1993 J. Mol. Cell. Cardiol. pmid:7512654